PAX8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAX8_HUMAN
• UniProt AC: Q06710
• Protein Name: Paired box protein Pax-8
• Gene Name: PAX8
• Organism: Homo sapiens (Human).
• Sequence Length: 450
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells..
• Protein Sequence: MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Glutathionylation	AHQGVRPCDISRQLR HHCCCCCCHHHHHHH	5.20	15888455
57	Glutathionylation	QLRVSHGCVSKILGR HHHHHCHHHHHHHHC	2.33	15888455
59	Phosphorylation	RVSHGCVSKILGRYY HHHCHHHHHHHHCHH	20.32	22210691
68	Phosphorylation	ILGRYYETGSIRPGV HHHCHHCCCCCCCCC	21.80	22210691
70	Phosphorylation	GRYYETGSIRPGVIG HCHHCCCCCCCCCCC	23.89	22210691
85	Phosphorylation	GSKPKVATPKVVEKI CCCCCCCCHHHHHHH	26.99	20860994
126	Phosphorylation	NDTVPSVSSINRIIR CCCCCCHHHHHHHHH	29.82	-
209	Phosphorylation	DQDSCRLSIDSQSSS CCCCCEEEECCCCCC	12.66	28857561
212	Phosphorylation	SCRLSIDSQSSSSGP CCEEEECCCCCCCCC	30.23	30206219
214	Phosphorylation	RLSIDSQSSSSGPRK EEEECCCCCCCCCCH	35.82	30206219
215	Phosphorylation	LSIDSQSSSSGPRKH EEECCCCCCCCCCHH	22.38	24719451
216	Phosphorylation	SIDSQSSSSGPRKHL EECCCCCCCCCCHHC	44.56	30206219
217	Phosphorylation	IDSQSSSSGPRKHLR ECCCCCCCCCCHHCC	55.56	30206219
251	Phosphorylation	HYPEAYASPSHTKGE CCCHHHCCCCCCCCC	17.79	24719451
277	Phosphorylation	TLDDGKATLTPSNTP CCCCCCCEECCCCCC	34.35	24719451
279	Phosphorylation	DDGKATLTPSNTPLG CCCCCEECCCCCCCC	21.95	24719451
288 (in isoform 4)	Phosphorylation	-	36.22	27251275
290	Phosphorylation	TPLGRNLSTHQTYPV CCCCCCCCCCCCCCE	27.65	24719451
291	Phosphorylation	PLGRNLSTHQTYPVV CCCCCCCCCCCCCEE	22.59	28857561
297 (in isoform 4)	Phosphorylation	-	3.79	27251275
303	Phosphorylation	PVVADPHSPFAIKQE CEECCCCCCCEECCC	27.40	28355574
304 (in isoform 4)	Phosphorylation	-	21.47	27251275
307 (in isoform 4)	Phosphorylation	-	4.91	27251275
365 (in isoform 3)	Phosphorylation	-	41.57	27251275
374 (in isoform 3)	Phosphorylation	-	16.20	27251275
381 (in isoform 3)	Phosphorylation	-	24.62	27251275
384 (in isoform 3)	Phosphorylation	-	26.58	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAX8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAX8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAX8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NKX21_HUMAN	NKX2-1	physical	12441357
KPYM_HUMAN	PKM	physical	21988832
SERC1_HUMAN	SERINC1	physical	20195357
ANXA7_HUMAN	ANXA7	physical	20195357

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.