| UniProt ID | SERC1_HUMAN | |
|---|---|---|
| UniProt AC | Q9NRX5 | |
| Protein Name | Serine incorporator 1 | |
| Gene Name | SERINC1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 453 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Enhances the incorporation of serine into phosphatidylserine and sphingolipids.. | |
| Protein Sequence | MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLCVGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTTSTVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARSDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGSVLGLCS ------CCCHHHHHH | 26.85 | 24223779 | |
| 2 | N-myristoyl glycine | ------MGSVLGLCS ------CCCHHHHHH | 26.85 | - | |
| 31 | Phosphorylation | LLCRCCPSGNNSTVT EEEEECCCCCHHHHH | 39.99 | - | |
| 35 | Phosphorylation | CCPSGNNSTVTRLIY ECCCCCHHHHHHHHH | 28.40 | - | |
| 36 | Phosphorylation | CPSGNNSTVTRLIYA CCCCCHHHHHHHHHH | 28.20 | - | |
| 38 | Phosphorylation | SGNNSTVTRLIYALF CCCHHHHHHHHHHHH | 21.61 | - | |
| 81 | S-palmitoylation | NEKGVVPCNILVGYK CCCCCCCCCHHCCHH | 3.14 | 29575903 | |
| 105 | Phosphorylation | AMFYLLLSLLMIKVK HHHHHHHHHHHHHHC | 21.30 | 26267517 | |
| 298 | N-linked_Glycosylation | LLSIIGYNTTSTVPK HHHHHCEECCCCCCC | 31.50 | 19159218 | |
| 343 | Ubiquitination | SNNSQVNKLTLTSDE CCCCCCCEEEECCCC | 43.95 | 23000965 | |
| 345 | Phosphorylation | NSQVNKLTLTSDEST CCCCCEEEECCCCCE | 29.60 | 25850435 | |
| 347 | Phosphorylation | QVNKLTLTSDESTLI CCCEEEECCCCCEEE | 28.97 | 30266825 | |
| 348 | Phosphorylation | VNKLTLTSDESTLIE CCEEEECCCCCEEEE | 42.36 | 30266825 | |
| 351 | Phosphorylation | LTLTSDESTLIEDGG EEECCCCCEEEECCC | 33.24 | 30266825 | |
| 352 | Phosphorylation | TLTSDESTLIEDGGA EECCCCCEEEECCCC | 29.70 | 30266825 | |
| 361 | Phosphorylation | IEDGGARSDGSLEDG EECCCCCCCCCCCCC | 45.87 | 22167270 | |
| 364 | Phosphorylation | GGARSDGSLEDGDDV CCCCCCCCCCCCCCC | 33.31 | 29255136 | |
| 410 | Phosphorylation | TLTNWYRYEPSREMK HHHCHHHCCCCHHHH | 19.25 | 18669648 | |
| 413 | Phosphorylation | NWYRYEPSREMKSQW CHHHCCCCHHHHHCC | 29.00 | 18669648 | |
| 418 | Phosphorylation | EPSREMKSQWTAVWV CCCHHHHHCCEEEEE | 29.64 | 20068231 | |
| 421 | Phosphorylation | REMKSQWTAVWVKIS HHHHHCCEEEEEEEC | 12.05 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SERC1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SERC1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SERC1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TMCO1_HUMAN | TMCO1 | physical | 22939629 | |
| ZMY10_HUMAN | ZMYND10 | physical | 21988832 | |
| NDUV3_HUMAN | NDUFV3 | physical | 28514442 | |
| LEG3_HUMAN | LGALS3 | physical | 28514442 | |
| GBB2_HUMAN | GNB2 | physical | 28514442 | |
| GPHRA_HUMAN | GPR89B | physical | 28514442 | |
| GPHRB_HUMAN | GPR89B | physical | 28514442 | |
| AAAT_HUMAN | SLC1A5 | physical | 28514442 | |
| METL9_HUMAN | METTL9 | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Myristoylation | |
| Reference | PubMed |
| "Strategy for comprehensive identification of human N-myristoylatedproteins using an insect cell-free protein synthesis system."; Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,Tsunasawa S., Utsumi T.; Proteomics 10:1780-1793(2010). Cited for: MYRISTOYLATION AT GLY-2. | |
| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-298, AND MASSSPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351; THR-352; SER-361;SER-364; TYR-410 AND SER-413, AND MASS SPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, AND MASSSPECTROMETRY. | |
