| UniProt ID | GPHRA_HUMAN | |
|---|---|---|
| UniProt AC | B7ZAQ6 | |
| Protein Name | Golgi pH regulator A | |
| Gene Name | GPR89A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 455 | |
| Subcellular Localization |
Golgi apparatus membrane Multi-pass membrane protein. |
|
| Protein Description | Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.. | |
| Protein Sequence | MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIFSVTFAFSCTMFELIIFEILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIRLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASGSENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPEKQMAP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 135 | Phosphorylation | GDPFPILSPKHGILS CCCCCCCCCCCCCCC | 32.40 | 24719451 | |
| 180 | N-linked_Glycosylation | YMSYFLRNVTDTDIL HHHHHHHCCCHHHHH | 43.09 | UniProtKB CARBOHYD | |
| 182 | Phosphorylation | SYFLRNVTDTDILAL HHHHHCCCHHHHHHH | 36.41 | - | |
| 203 | Acetylation | TMDMIISKKKRMAMA HHHHHHHHHHHHHHH | 52.48 | 11174259 | |
| 203 | Ubiquitination | TMDMIISKKKRMAMA HHHHHHHHHHHHHHH | 52.48 | 21906983 | |
| 204 | Acetylation | MDMIISKKKRMAMAR HHHHHHHHHHHHHHH | 38.53 | 11174269 | |
| 204 | Ubiquitination | MDMIISKKKRMAMAR HHHHHHHHHHHHHHH | 38.53 | - | |
| 217 | Ubiquitination | ARRTMFQKGEVHNKP HHHHHHHHCCCCCCC | 45.86 | - | |
| 223 | Ubiquitination | QKGEVHNKPSGFWGM HHCCCCCCCCCCCCC | 26.19 | - | |
| 243 | N-linked_Glycosylation | TSASGSENLTLIQQE ECCCCCCCEEHHHHH | 39.77 | UniProtKB CARBOHYD | |
| 272 | Ubiquitination | TADLYATKERIEYSK HHHHHHCHHHHHHCH | 36.50 | 21906983 | |
| 279 | Ubiquitination | KERIEYSKTFKGKYF HHHHHHCHHHCCCCH | 58.01 | 2190698 | |
| 285 | Phosphorylation | SKTFKGKYFNFLGYF CHHHCCCCHHHHHHH | 16.66 | 25907765 | |
| 291 | Phosphorylation | KYFNFLGYFFSIYCV CCHHHHHHHHHHHHH | 12.00 | 25907765 | |
| 294 | Phosphorylation | NFLGYFFSIYCVWKI HHHHHHHHHHHHHHH | 11.62 | 25907765 | |
| 296 | Phosphorylation | LGYFFSIYCVWKIFM HHHHHHHHHHHHHHH | 4.63 | 25907765 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPHRA_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPHRA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPHRA_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GPHRA_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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