dbPTM

LEG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LEG3_HUMAN
UniProt AC	P17931
Protein Name	Galectin-3
Gene Name	LGALS3
Organism	Homo sapiens (Human).
Sequence Length	250
Subcellular Localization	Cytoplasm. Nucleus. Secreted. Secreted by a non-classical secretory pathway and associates with the cell surface.
Protein Description	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells..
Protein Sequence	MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADNFSLHD ------CCCCCCHHH	22.06	-
6	Phosphorylation	--MADNFSLHDALSG --CCCCCCHHHHHCC	30.92	8253806
12	Phosphorylation	FSLHDALSGSGNPNP CCHHHHHCCCCCCCC	32.41	8253806
79	Phosphorylation	GAPAPGVYPGPPSGP CCCCCCCCCCCCCCC	14.37	20600357
107	Phosphorylation	AYPATGPYGAPAGPL CCCCCCCCCCCCCCE	27.54	20600357
118	Phosphorylation	AGPLIVPYNLPLPGG CCCEEEECCCCCCCC	20.59	20600357
133	Phosphorylation	VVPRMLITILGTVKP HHHHHEEEHHEECCC	13.24	20068231
137	Phosphorylation	MLITILGTVKPNANR HEEEHHEECCCCCCE	23.16	20068231
175	Phosphorylation	RRVIVCNTKLDNNWG CEEEEECCCCCCCCC	28.05	-
176	Acetylation	RVIVCNTKLDNNWGR EEEEECCCCCCCCCH	39.59	26051181
176	Ubiquitination	RVIVCNTKLDNNWGR EEEEECCCCCCCCCH	39.59	-
176	Malonylation	RVIVCNTKLDNNWGR EEEEECCCCCCCCCH	39.59	26320211
188	Phosphorylation	WGREERQSVFPFESG CCHHHHCCEEECCCC	31.76	26657352
196	Acetylation	VFPFESGKPFKIQVL EEECCCCCCEEEEEE	57.47	26051181
196	Malonylation	VFPFESGKPFKIQVL EEECCCCCCEEEEEE	57.47	26320211
196	Ubiquitination	VFPFESGKPFKIQVL EEECCCCCCEEEEEE	57.47	-
210	Ubiquitination	LVEPDHFKVAVNDAH EECCCCEEEEECHHH	26.34	-
210	2-Hydroxyisobutyrylation	LVEPDHFKVAVNDAH EECCCCEEEEECHHH	26.34	-
221	Phosphorylation	NDAHLLQYNHRVKKL CHHHHHHHHHHHHHH	16.95	28152594
227	Ubiquitination	QYNHRVKKLNEISKL HHHHHHHHHHHHHHC	54.40	-
227	Malonylation	QYNHRVKKLNEISKL HHHHHHHHHHHHHHC	54.40	26320211
247	Phosphorylation	IDLTSASYTMI---- CCCCCCEEECC----	10.47	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
6	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
6	S	Phosphorylation	Kinase	CK1A	P97633	PSP
12	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
79	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
79	Y	Phosphorylation	Kinase	ABL2	P42684	GPS
107	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
118	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
118	Y	Phosphorylation	Kinase	ABL2	P42684	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LEG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LEG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FCG2A_HUMAN	FCGR2A	physical	10704522
ELN_HUMAN	ELN	physical	10536372
LG3BP_HUMAN	LGALS3BP	physical	1917996
LG3BP_HUMAN	LGALS3BP	physical	8390986
GTF2I_HUMAN	GTF2I	physical	18662664
ACTS_HUMAN	ACTA1	physical	18662664
A4_HUMAN	APP	physical	21832049
EGFR_HUMAN	EGFR	physical	21258405
SQSTM_HUMAN	SQSTM1	physical	24619419
RAB7A_HUMAN	RAB7A	physical	24619419
LAMP1_HUMAN	LAMP1	physical	24619419
MLP3A_HUMAN	MAP1LC3A	physical	24619419
LEG3_HUMAN	LGALS3	physical	25416956
PPIG_HUMAN	PPIG	physical	25416956
CREST_HUMAN	SS18L1	physical	25416956
PRR13_HUMAN	PRR13	physical	25416956
COL12_HUMAN	COLEC12	physical	26186194
LAMB1_HUMAN	LAMB1	physical	26186194
MRP4_HUMAN	ABCC4	physical	26186194
K319L_HUMAN	KIAA0319L	physical	26186194
AT2B4_HUMAN	ATP2B4	physical	26186194
SL9A6_HUMAN	SLC9A6	physical	26186194
LAMA4_HUMAN	LAMA4	physical	26186194
RRAGC_HUMAN	RRAGC	physical	26186194
S12A2_HUMAN	SLC12A2	physical	26186194
MDR1_HUMAN	ABCB1	physical	26186194
ITA2_HUMAN	ITGA2	physical	26186194
PTPRZ_HUMAN	PTPRZ1	physical	26186194
MFAP3_HUMAN	MFAP3	physical	26186194
NID2_HUMAN	NID2	physical	26186194
CD166_HUMAN	ALCAM	physical	26186194
B3A2_HUMAN	SLC4A2	physical	26186194
CD109_HUMAN	CD109	physical	26186194
S4A7_HUMAN	SLC4A7	physical	26186194
S15A4_HUMAN	SLC15A4	physical	26186194
ADCY9_HUMAN	ADCY9	physical	26186194
CAN1_HUMAN	CAPN1	physical	26186194
ITA1_HUMAN	ITGA1	physical	26186194
PODXL_HUMAN	PODXL	physical	26186194
SCAR3_HUMAN	SCARA3	physical	26186194
PTPRJ_HUMAN	PTPRJ	physical	26186194
SDK1_HUMAN	SDK1	physical	26186194
SDK2_HUMAN	SDK2	physical	26186194
K1549_HUMAN	KIAA1549	physical	26186194
FINC_HUMAN	FN1	physical	26186194
LFA3_HUMAN	CD58	physical	26186194
S12A6_HUMAN	SLC12A6	physical	26186194
S12A4_HUMAN	SLC12A4	physical	26186194
S12A7_HUMAN	SLC12A7	physical	26186194
ADCY6_HUMAN	ADCY6	physical	26186194
ZNT1_HUMAN	SLC30A1	physical	26186194
VGFR3_HUMAN	FLT4	physical	26186194
ENPP4_HUMAN	ENPP4	physical	26186194
LAMA1_HUMAN	LAMA1	physical	26186194
LCAP_HUMAN	LNPEP	physical	26186194
PTN11_HUMAN	PTPN11	physical	26186194
S17A5_HUMAN	SLC17A5	physical	26186194
MRC2_HUMAN	MRC2	physical	26186194
CTR2_HUMAN	SLC7A2	physical	26186194
ADCY3_HUMAN	ADCY3	physical	26186194
CSPG4_HUMAN	CSPG4	physical	26186194
HEG1_HUMAN	HEG1	physical	26186194
PTPRK_HUMAN	PTPRK	physical	26186194
AT133_HUMAN	ATP13A3	physical	26186194
RRAGB_HUMAN	RRAGB	physical	26186194
S38A9_HUMAN	SLC38A9	physical	26186194
NPTN_HUMAN	NPTN	physical	26186194
MPZL1_HUMAN	MPZL1	physical	26186194
EMB_HUMAN	EMB	physical	26186194
FPRP_HUMAN	PTGFRN	physical	26186194
T179B_HUMAN	TMEM179B	physical	26186194
ATG9A_HUMAN	ATG9A	physical	26186194
OSTM1_HUMAN	OSTM1	physical	26186194
CD63_HUMAN	CD63	physical	26186194
CSCL1_HUMAN	TMEM63A	physical	26186194
S26A2_HUMAN	SLC26A2	physical	26186194
CLCN3_HUMAN	CLCN3	physical	26186194
PPAL_HUMAN	ACP2	physical	26186194
R4RL2_HUMAN	RTN4RL2	physical	26186194
BARD1_HUMAN	BARD1	physical	24755837
AT1A1_HUMAN	ATP1A1	physical	24755837
BASI_HUMAN	BSG	physical	24755837
CADM1_HUMAN	CADM1	physical	24755837
TCPG_HUMAN	CCT3	physical	24755837
ITB1_HUMAN	ITGB1	physical	24755837
LAMC1_HUMAN	LAMC1	physical	24755837
S12A2_HUMAN	SLC12A2	physical	24755837
4F2_HUMAN	SLC3A2	physical	24755837
SAHH_HUMAN	AHCY	physical	24755837
CKAP4_HUMAN	CKAP4	physical	24755837
OST48_HUMAN	DDOST	physical	24755837
BGAL_HUMAN	GLB1	physical	24755837
HS90B_HUMAN	HSP90AB1	physical	24755837
IPO5_HUMAN	IPO5	physical	24755837
IMB1_HUMAN	KPNB1	physical	24755837
MYL6_HUMAN	MYL6	physical	24755837
RL35_HUMAN	RPL35	physical	24755837
RS20_HUMAN	RPS20	physical	24755837
LAMP2_HUMAN	LAMP2	physical	24755837
MYH10_HUMAN	MYH10	physical	24755837
NP1L1_HUMAN	NAP1L1	physical	24755837
VIME_HUMAN	VIM	physical	24755837
ATPG_HUMAN	ATP5C1	physical	24755837
HORN_HUMAN	HRNR	physical	24755837
MCCA_HUMAN	MCCC1	physical	24755837
ODPX_HUMAN	PDHX	physical	24755837
ACTA_HUMAN	ACTA2	physical	24755837
CDC5L_HUMAN	CDC5L	physical	24755837
K1549_HUMAN	KIAA1549	physical	24755837
LG3BP_HUMAN	LGALS3BP	physical	24755837
MCCB_HUMAN	MCCC2	physical	24755837
ML12B_HUMAN	MYL12B	physical	24755837
PARP1_HUMAN	PARP1	physical	24755837
PRP19_HUMAN	PRPF19	physical	24755837
RL7A_HUMAN	RPL7A	physical	24755837
EAA1_HUMAN	SLC1A3	physical	24755837
AAAT_HUMAN	SLC1A5	physical	24755837
LAP2A_HUMAN	TMPO	physical	24755837
LAP2B_HUMAN	TMPO	physical	24755837
ECE1_HUMAN	ECE1	physical	24755837
NICA_HUMAN	NCSTN	physical	24755837
PCCA_HUMAN	PCCA	physical	24755837
RL12_HUMAN	RPL12	physical	24755837
SERPH_HUMAN	SERPINH1	physical	24755837
COX17_HUMAN	COX17	physical	26344197
MYO1E_HUMAN	MYO1E	physical	26344197
PCBP2_HUMAN	PCBP2	physical	26344197
THIO_HUMAN	TXN	physical	26344197
SDK1_HUMAN	SDK1	physical	28514442
CSPG4_HUMAN	CSPG4	physical	28514442
PTPRJ_HUMAN	PTPRJ	physical	28514442
S12A6_HUMAN	SLC12A6	physical	28514442
LAMA1_HUMAN	LAMA1	physical	28514442
SDK2_HUMAN	SDK2	physical	28514442
K1549_HUMAN	KIAA1549	physical	28514442
ITA1_HUMAN	ITGA1	physical	28514442
LAMA4_HUMAN	LAMA4	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
CD166_HUMAN	ALCAM	physical	28514442
FINC_HUMAN	FN1	physical	28514442
CD109_HUMAN	CD109	physical	28514442
S12A7_HUMAN	SLC12A7	physical	28514442
PODXL_HUMAN	PODXL	physical	28514442
MDR1_HUMAN	ABCB1	physical	28514442
ATG9A_HUMAN	ATG9A	physical	28514442
MRP4_HUMAN	ABCC4	physical	28514442
S12A4_HUMAN	SLC12A4	physical	28514442
SCAR3_HUMAN	SCARA3	physical	28514442
ENPP4_HUMAN	ENPP4	physical	28514442
NID2_HUMAN	NID2	physical	28514442
CLCN3_HUMAN	CLCN3	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
S4A7_HUMAN	SLC4A7	physical	28514442
HEG1_HUMAN	HEG1	physical	28514442
S38A9_HUMAN	SLC38A9	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
MRC2_HUMAN	MRC2	physical	28514442
LCAP_HUMAN	LNPEP	physical	28514442
RRAGC_HUMAN	RRAGC	physical	28514442
ADCY9_HUMAN	ADCY9	physical	28514442
EMB_HUMAN	EMB	physical	28514442
SL9A6_HUMAN	SLC9A6	physical	28514442
OSTM1_HUMAN	OSTM1	physical	28514442
RRAGB_HUMAN	RRAGB	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
ADCY3_HUMAN	ADCY3	physical	28514442
S15A4_HUMAN	SLC15A4	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
ITA2_HUMAN	ITGA2	physical	28514442
R4RL2_HUMAN	RTN4RL2	physical	28514442
RN167_HUMAN	RNF167	physical	28514442
S12A2_HUMAN	SLC12A2	physical	28514442
B3A2_HUMAN	SLC4A2	physical	28514442
S26A2_HUMAN	SLC26A2	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
LFA3_HUMAN	CD58	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
CAN1_HUMAN	CAPN1	physical	28514442
AT133_HUMAN	ATP13A3	physical	28514442
LAMB1_HUMAN	LAMB1	physical	28514442
CTR2_HUMAN	SLC7A2	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
CD63_HUMAN	CD63	physical	28514442
PTPRK_HUMAN	PTPRK	physical	28514442
PTPRZ_HUMAN	PTPRZ1	physical	28514442
ECE1_HUMAN	ECE1	physical	28514442
FPRP_HUMAN	PTGFRN	physical	28514442
VGFR3_HUMAN	FLT4	physical	28514442
TRIM5_HUMAN	TRIM5	physical	27693506
TRIM6_HUMAN	TRIM6	physical	27693506
TRI17_HUMAN	TRIM17	physical	27693506
MEFV_HUMAN	MEFV	physical	27693506
TRI22_HUMAN	TRIM22	physical	27693506
TRI23_HUMAN	TRIM23	physical	27693506
TRI49_HUMAN	TRIM49	physical	27693506
TRI16_HUMAN	TRIM16	physical	27693506

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LEG3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6and serine 12 in vivo and by casein kinase I."; Huflejt M.E., Turck C.W., Lindstedt R., Barondes S.H., Leffler H.; J. Biol. Chem. 268:26712-26718(1993). Cited for: PHOSPHORYLATION AT SER-6 AND SER-12.	8253806 [Abstract]