S17A5_HUMAN - dbPTM
S17A5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S17A5_HUMAN
UniProt AC Q9NRA2
Protein Name Sialin
Gene Name SLC17A5
Organism Homo sapiens (Human).
Sequence Length 495
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Multi-pass membrane protein . Lysosome membrane
Multi-pass membrane protein .
Protein Description Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva..
Protein Sequence MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MRSPVRDLAR
-----CCCHHHHHHC		26.8420424173
16PhosphorylationARNDGEESTDRTPLL
HCCCCCCCCCCCCCC		31.1623401153
17PhosphorylationRNDGEESTDRTPLLP
CCCCCCCCCCCCCCC		32.5530266825
20PhosphorylationGEESTDRTPLLPGAP
CCCCCCCCCCCCCCC		22.5429255136
71N-linked_GlycosylationLVDMVDSNTTLEDNR
EEEECCCCCCCCCCC		32.40UniProtKB CARBOHYD
77N-linked_GlycosylationSNTTLEDNRTSKACP
CCCCCCCCCCCCCCC		39.49UniProtKB CARBOHYD
95N-linked_GlycosylationAPIKVHHNQTGKKYQ
CCCEEEECCCCCEEE		26.65UniProtKB CARBOHYD
132UbiquitinationPGGYVASKIGGKMLL
CCCEEHHHHCCEEEC		35.3221890473
147UbiquitinationGFGILGTAVLTLFTP
CCCCHHHHHHHHHHH		7.7921890473
157UbiquitinationTLFTPIAADLGVGPL
HHHHHHHHHCCCHHH		17.1833845483
172UbiquitinationIVLRALEGLGEGVTF
HHHHHHCCCCCCCCH		39.5733845483
186UbiquitinationFPAMHAMWSSWAPPL
HHHHHHHHHHCCCCC		7.0433845483
197UbiquitinationAPPLERSKLLSISYA
CCCCHHHHCCEEEEC		60.7221890473
201UbiquitinationERSKLLSISYAGAQL
HHHHCCEEEECCCCC		3.5433845483
212UbiquitinationGAQLGTVISLPLSGI
CCCCCCEEECCCCHH		3.3421890473
234UbiquitinationTYVFYFFGTIGIFWF
CHHHHHHHHHHHHHH		13.4133845483
246UbiquitinationFWFLLWIWLVSDTPQ
HHHHHHHHHHCCCCC		4.5121890473
249UbiquitinationLLWIWLVSDTPQKHK
HHHHHHHCCCCCHHC		33.3333845483
261UbiquitinationKHKRISHYEKEYILS
HHCCCCHHHHHHHHH		23.1621890473
261PhosphorylationKHKRISHYEKEYILS
HHCCCCHHHHHHHHH		23.16-
262UbiquitinationHKRISHYEKEYILSS
HCCCCHHHHHHHHHH		33.7133845483
263 (in isoform 2)Ubiquitination-48.9621890473
263UbiquitinationKRISHYEKEYILSSL
CCCCHHHHHHHHHHH		48.9633845483
265PhosphorylationISHYEKEYILSSLRN
CCHHHHHHHHHHHHH		20.45-
268PhosphorylationYEKEYILSSLRNQLS
HHHHHHHHHHHHHHH		20.1217081983
269PhosphorylationEKEYILSSLRNQLSS
HHHHHHHHHHHHHHC		28.0925954137
270UbiquitinationKEYILSSLRNQLSSQ
HHHHHHHHHHHHHCC		5.5333845483
277UbiquitinationLRNQLSSQKSVPWVP
HHHHHHCCCCCCCHH		38.3733845483
278UbiquitinationRNQLSSQKSVPWVPI
HHHHHCCCCCCCHHH		56.2027667366
285UbiquitinationKSVPWVPILKSLPLW
CCCCCHHHHHHCCHH		5.6833845483
304 (in isoform 1)Ubiquitination-11.7921890473
315PhosphorylationLLTLLPTYMKEILRF
HHHHHHHHHHHHHHC		12.30-
319 (in isoform 1)Ubiquitination-2.5321890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S17A5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S17A5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S17A5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
H00147 Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sial
OMIM Disease
604369Salla disease (SD)
269920Infantile sialic acid storage disorder (ISSD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S17A5_HUMAN

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Related Literatures of Post-Translational Modification

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