TRIM6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIM6_HUMAN
• UniProt AC: Q9C030
• Protein Name: Tripartite motif-containing protein 6
• Gene Name: TRIM6
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response. [PubMed: 24882218]
• Protein Sequence: MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Ubiquitination	EVVLGPGKQLKAVLC HHHCCCCCEEEEEEE	56.44	33845483
91	Ubiquitination	VVLGPGKQLKAVLCA HHCCCCCEEEEEEEC	54.86	33845483
93	Acetylation	LGPGKQLKAVLCADH CCCCCEEEEEEECCC	33.67	7693231
118	Ubiquitination	DGKVICWLCERSQEH CCCEEEEECCCCCHH	1.56	33845483
245	Phosphorylation	ERRCQGSTMELLQDV HHHHCHHHHHHHHCH	22.84	-
266	Ubiquitination	SEFWTLRKPEALPTK CCCCCCCCCCCCCHH	50.77	33845483
294	Ubiquitination	LRVCRELTDVQSYWV HHHHHHCCCCCEEEE	29.39	33845483
340	Phosphorylation	PSCLEKHYDCSVLGS HHHHHHHCCEEEEEC	29.70	-
343	Phosphorylation	LEKHYDCSVLGSQHF HHHHCCEEEEECCCC	19.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRIM6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIM6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIM6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRIM6_HUMAN	TRIM6	physical	11331580
TRI23_HUMAN	TRIM23	physical	11331580
TIF1B_HUMAN	TRIM28	physical	11331580
MYC_HUMAN	MYC	physical	22328504
TRIM5_HUMAN	TRIM5	physical	16828831
TRIM6_HUMAN	TRIM6	physical	17156811
TRIM6_HUMAN	TRIM6	physical	21680743
TRIM5_HUMAN	TRIM5	physical	16775307
IKKE_HUMAN	IKBKE	physical	24882218

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.