dbPTM

TRI23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRI23_HUMAN
UniProt AC	P36406
Protein Name	E3 ubiquitin-protein ligase TRIM23
Gene Name	TRIM23
Organism	Homo sapiens (Human).
Sequence Length	574
Subcellular Localization	Cytoplasm . Endomembrane system . Golgi apparatus membrane . Lysosome membrane . Membrane-associated with the Golgi complex and lysosomal structures.
Protein Description	Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. [PubMed: 28871090; (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.]
Protein Sequence	MATLVVNKLGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERLQNGPIGQYGAAEESIGISGESIIRCDEDEAHLASVYCTVCATHLCSECSQVTHSTKTLAKHRRVPLADKPHEKTMCSQHQVHAIEFVCLEEGCQTSPLMCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEHVPGTAENARSCIRAYFYDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSEVSAACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTFTKDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALLLIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQLVAAGVLDVA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MATLVVNKLGAGVDS CCEEEEECCCCCCCC	36.37	22505724
15	Phosphorylation	KLGAGVDSGRQGSRG CCCCCCCCCCCCCCC	33.21	-
20	Phosphorylation	VDSGRQGSRGTAVVK CCCCCCCCCCCEEEE	21.14	-
171	Ubiquitination	RRVPLADKPHEKTMC CCCCCCCCCCHHCCC	42.54	29967540
325	Ubiquitination	LIWLRQQQEDMTILL HHHHHHHHCCHHHHH	40.08	27667366
357	Ubiquitination	DCRVVLAKQEITRLL CCEEEEHHHHHHHHH	44.28	30230243
386	Phosphorylation	DHIQLDASIPVTFTK HHCEECCCCCEEEEC	27.39	-
442	Phosphorylation	TIGFNVETVEYKNLK CCCEEEEEEEEECCE	17.85	22468782
445	Phosphorylation	FNVETVEYKNLKFTI EEEEEEEEECCEEEE	10.80	22468782
458	Acetylation	TIWDVGGKHKLRPLW EEEECCCCCCCCCCH	31.47	7978559
468	Phosphorylation	LRPLWKHYYLNTQAV CCCCHHEEECCCCEE	13.11	22817900
469	Phosphorylation	RPLWKHYYLNTQAVV CCCHHEEECCCCEEE	8.00	22817900
501	Ubiquitination	LAKLLTEKELRDALL HHHHHCHHHHHHHHH	57.73	33845483
550	Phosphorylation	IQGCDARSGMGLYEG EECCCCCCCCCHHHC	34.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRI23_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRI23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRI23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIBC2_HUMAN	RIBC2	physical	16189514
TRI23_HUMAN	TRIM23	physical	16189514
FAD1_HUMAN	FLAD1	physical	16189514
CS057_HUMAN	C19orf57	physical	16189514
GEM_HUMAN	GEM	physical	16189514
SF01_HUMAN	SF1	physical	16189514
P121A_HUMAN	POM121	physical	16189514
GGA2_HUMAN	GGA2	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
ZN581_HUMAN	ZNF581	physical	16189514
ZN250_HUMAN	ZNF250	physical	16189514
TRI23_HUMAN	TRIM23	physical	11331580
TRI29_HUMAN	TRIM29	physical	11331580
TRI31_HUMAN	TRIM31	physical	11331580
CYH1_HUMAN	CYTH1	physical	10748148
CYH2_HUMAN	CYTH2	physical	10748148
TRI23_HUMAN	TRIM23	physical	15684077
NEMO_HUMAN	IKBKG	physical	20724660
TRI23_HUMAN	TRIM23	physical	17118964
TRI23_HUMAN	TRIM23	physical	8700863
TRI23_HUMAN	TRIM23	physical	9446556
UB2E1_HUMAN	UBE2E1	physical	17118964
UB2E1_HUMAN	UBE2E1	physical	15684077
UB2D1_HUMAN	UBE2D1	physical	15684077
UB2D2_HUMAN	UBE2D2	physical	15684077
UB2D3_HUMAN	UBE2D3	physical	15684077
GPSM1_HUMAN	GPSM1	physical	23718855
RAD18_HUMAN	RAD18	physical	22493164
TRI23_HUMAN	TRIM23	physical	22493164
RNF37_HUMAN	UBOX5	physical	22493164
RN126_HUMAN	RNF126	physical	22493164
TRAIP_HUMAN	TRAIP	physical	22493164
UB2D1_HUMAN	UBE2D1	physical	16413270
UB2D2_HUMAN	UBE2D2	physical	16413270
UB2D3_HUMAN	UBE2D3	physical	16413270
UB2E1_HUMAN	UBE2E1	physical	16413270
TRI23_HUMAN	TRIM23	physical	25416956
BAG1_HUMAN	BAG1	physical	25416956
CDR2_HUMAN	CDR2	physical	25416956
COX5B_HUMAN	COX5B	physical	25416956
DCX_HUMAN	DCX	physical	25416956
DOCK2_HUMAN	DOCK2	physical	25416956
GATA2_HUMAN	GATA2	physical	25416956
HXB5_HUMAN	HOXB5	physical	25416956
KIFC3_HUMAN	KIFC3	physical	25416956
K2C6A_HUMAN	KRT6A	physical	25416956
LEG8_HUMAN	LGALS8	physical	25416956
RBTN2_HUMAN	LMO2	physical	25416956
PHF1_HUMAN	PHF1	physical	25416956
P85B_HUMAN	PIK3R2	physical	25416956
PSA1_HUMAN	PSMA1	physical	25416956
SIAH1_HUMAN	SIAH1	physical	25416956
SNAI2_HUMAN	SNAI2	physical	25416956
SNAI1_HUMAN	SNAI1	physical	25416956
RSMB_HUMAN	SNRPB	physical	25416956
TYB4_HUMAN	TMSB4X	physical	25416956
TNAP3_HUMAN	TNFAIP3	physical	25416956
TRAF1_HUMAN	TRAF1	physical	25416956
UBC9_HUMAN	UBE2I	physical	25416956
GPAN1_HUMAN	GPANK1	physical	25416956
PKP4_HUMAN	PKP4	physical	25416956
STK19_HUMAN	STK19	physical	25416956
PIAS2_HUMAN	PIAS2	physical	25416956
CXL14_HUMAN	CXCL14	physical	25416956
CREB5_HUMAN	CREB5	physical	25416956
JOS1_HUMAN	JOSD1	physical	25416956
TROAP_HUMAN	TROAP	physical	25416956
VINEX_HUMAN	SORBS3	physical	25416956
KAT5_HUMAN	KAT5	physical	25416956
NEK6_HUMAN	NEK6	physical	25416956
UBP20_HUMAN	USP20	physical	25416956
DMC1_HUMAN	DMC1	physical	25416956
TRI29_HUMAN	TRIM29	physical	25416956
PPIL2_HUMAN	PPIL2	physical	25416956
HSPB7_HUMAN	HSPB7	physical	25416956
GPKOW_HUMAN	GPKOW	physical	25416956
NFU1_HUMAN	NFU1	physical	25416956
DPOLL_HUMAN	POLL	physical	25416956
ARHG3_HUMAN	ARHGEF3	physical	25416956
RM04_HUMAN	MRPL4	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
ZN581_HUMAN	ZNF581	physical	25416956
F193B_HUMAN	FAM193B	physical	25416956
F208B_HUMAN	FAM208B	physical	25416956
F90A1_HUMAN	FAM90A1	physical	25416956
CCD25_HUMAN	CCDC25	physical	25416956
TB22B_HUMAN	TBC1D22B	physical	25416956
ARFG1_HUMAN	ARFGAP1	physical	25416956
EAF2_HUMAN	EAF2	physical	25416956
NXT2_HUMAN	NXT2	physical	25416956
SMG9_HUMAN	SMG9	physical	25416956
KLH42_HUMAN	KLHL42	physical	25416956
TSH3_HUMAN	TSHZ3	physical	25416956
CC146_HUMAN	CCDC146	physical	25416956
RN213_HUMAN	RNF213	physical	25416956
DMRT3_HUMAN	DMRT3	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
CARD9_HUMAN	CARD9	physical	25416956
RSRC2_HUMAN	RSRC2	physical	25416956
CH033_HUMAN	C8orf33	physical	25416956
CS057_HUMAN	C19orf57	physical	25416956
WDR25_HUMAN	WDR25	physical	25416956
ZC21C_HUMAN	ZC2HC1C	physical	25416956
TXND5_HUMAN	TXNDC5	physical	25416956
F110A_HUMAN	FAM110A	physical	25416956
RAM_HUMAN	FAM103A1	physical	25416956
UTP23_HUMAN	UTP23	physical	25416956
FA83A_HUMAN	FAM83A	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956
MTFR2_HUMAN	MTFR2	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
EXAS1_HUMAN	EXOC3-AS1	physical	25416956
MORN4_HUMAN	MORN4	physical	25416956
IQUB_HUMAN	IQUB	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
CD20B_HUMAN	CDC20B	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
CFA53_HUMAN	CFAP53	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
F133A_HUMAN	FAM133A	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
PDE4D_HUMAN	PDE4D	physical	21516116
UBC9_HUMAN	UBE2I	physical	21516116
POTB3_HUMAN	POTEB3	physical	28514442
POTB2_HUMAN	POTEB2	physical	28514442
TXND3_HUMAN	NME8	physical	28514442
RB15B_HUMAN	RBM15B	physical	28514442
SET_HUMAN	SET	physical	28514442
TRI23_HUMAN	TRIM23	physical	28681414
UBC_HUMAN	UBC	physical	28681414
UB2D2_HUMAN	UBE2D2	physical	28681414
UB2D3_HUMAN	UBE2D3	physical	28681414
UB2D4_HUMAN	UBE2D4	physical	28681414
UB2E1_HUMAN	UBE2E1	physical	28681414
UBE2N_HUMAN	UBE2N	physical	28681414
UBE2W_HUMAN	UBE2W	physical	28681414
TBK1_HUMAN	TBK1	physical	28871090
SQSTM_HUMAN	SQSTM1	physical	28871090

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRI23_HUMAN

Related Literatures of Post-Translational Modification