POTB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POTB3_HUMAN
• UniProt AC: A0JP26
• Protein Name: POTE ankyrin domain family member B3 {ECO:0000312|HGNC:HGNC:51240}
• Gene Name: POTEB3 {ECO:0000312|HGNC:HGNC:51240}
• Organism: Homo sapiens (Human).
• Sequence Length: 581
• Protein Sequence: MVAEVCSMPAASAVKKPFDLRSKMGKWCHHRFPCCRGSGKSNMGTSGDHDDSFMKTLRSKMGKCCHHCFPCCRGSGTSNVGTSGDHDNSFMKTLRSKMGKWCCHCFPCCRGSGKSNVGTWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEEYHSDEQNDTQKQLSEEQNTGISQDEILTNKQKQIEVAEKEMNSKLSLSHKKEEDLLRENSMLREEIAMLRLELDETKHQNQLRENKILEEIESVKEKLLKAIQLNEEALTKTSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Acetylation	KPFDLRSKMGKWCHH CCCCHHHHCCCCCCC		-
52	Phosphorylation	TSGDHDDSFMKTLRS CCCCCCHHHHHHHHH		-
175	Phosphorylation	KRDKQKRTALHLASA HHHHHHHHHHHHHHC		-
231	Ubiquitination	MLLEHGADGNIQDEY EEHHHCCCCCCCCCC		-
258	Ubiquitination	DKLMAKALLLYGADI HHHHHHHHHHHCCCC		-
267	Phosphorylation	LYGADIESKNKCGLT HHCCCCCCCCCCCCH		26074081
267	Phosphorylation	LYGADIESKNKCGLT HHCCCCCCCCCCCCH		26074081
344	Phosphorylation	SGQTAREYAVSSHHH CCCHHHHHHHHCCHH		26270265
344	Phosphorylation	SGQTAREYAVSSHHH CCCHHHHHHHHCCHH		26270265
347	Phosphorylation	TAREYAVSSHHHVIC HHHHHHHHCCHHHHH		26270265
347	Phosphorylation	TAREYAVSSHHHVIC HHHHHHHHCCHHHHH		26270265
348	Phosphorylation	AREYAVSSHHHVICE HHHHHHHCCHHHHHH		26270265
348	Phosphorylation	AREYAVSSHHHVICE HHHHHHHCCHHHHHH		26270265
358	Phosphorylation	HVICELLSDYKEKQM HHHHHHHCHHHHHHC		26270265
358	Phosphorylation	HVICELLSDYKEKQM HHHHHHHCHHHHHHC		26270265
360	Phosphorylation	ICELLSDYKEKQMLK HHHHHCHHHHHHCHH		26270265
360	Phosphorylation	ICELLSDYKEKQMLK HHHHHCHHHHHHCHH		26270265
370	Phosphorylation	KQMLKISSENSNPEQ HHCHHCCCCCCCHHH		-
383	Phosphorylation	EQDLKLTSEEESQRL HHHCCCCCHHHHHHH		-
577	Phosphorylation	QLNEEALTKTSI--- HCCHHHHHHCCC---		-
580	Phosphorylation	EEALTKTSI------ HHHHHHCCC------		27134283
580	Phosphorylation	EEALTKTSI------ HHHHHHCCC------		27134283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POTB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POTB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POTB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POTED_HUMAN	POTED	physical	28514442
POTB2_HUMAN	POTEB2	physical	28514442
POTEC_HUMAN	POTEC	physical	28514442
FA83B_HUMAN	FAM83B	physical	28514442
SLAI1_HUMAN	SLAIN1	physical	28514442
SCML2_HUMAN	SCML2	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
CKAP5_HUMAN	CKAP5	physical	28514442
UBP7_HUMAN	USP7	physical	28514442
SNX6_HUMAN	SNX6	physical	28514442
SNX2_HUMAN	SNX2	physical	28514442
PZRN3_HUMAN	PDZRN3	physical	28514442
KC1A_HUMAN	CSNK1A1	physical	28514442
SNX1_HUMAN	SNX1	physical	28514442
HMMR_HUMAN	HMMR	physical	28514442
GEMI_HUMAN	GMNN	physical	28514442
GIT1_HUMAN	GIT1	physical	28514442
FA83D_HUMAN	FAM83D	physical	28514442
CDR2_HUMAN	CDR2	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442
AP1G1_HUMAN	AP1G1	physical	28514442
CUX1_HUMAN	CUX1	physical	28514442
CASP_HUMAN	CUX1	physical	28514442
TRI27_HUMAN	TRIM27	physical	28514442
AP1S2_HUMAN	AP1S2	physical	28514442
ARHG7_HUMAN	ARHGEF7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.