POTED_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POTED_HUMAN
• UniProt AC: Q86YR6
• Protein Name: POTE ankyrin domain family member D
• Gene Name: POTED
• Organism: Homo sapiens (Human).
• Sequence Length: 584
• Subcellular Localization: Cell membrane ; Peripheral membrane protein .
• Protein Sequence: MVAEVCSMPTASTVKKPFDLRSKMGKWCHHRFPCCRGSGKSNMGTSGDHDDSFMKMLRSKMGKCCRHCFPCCRGSGTSNVGTSGDHENSFMKMLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDHSAFMEPRYHIRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECVLMLLEHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRRSRKPENQQFPDTENEEYHSDEQNDTRKQLSEEQNTGISQDEILTNKQKQIEVAEQKMNSELSLSHKKEEDLLRENSVLQEEIAMLRLELDETKHQNQLRENKILEEIESVKEKTDKLLRAMQLNEEALTKTNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVAEVCSMPTASTV -CCCCCCCCCCCCCC	32.73	25072903
10	Phosphorylation	AEVCSMPTASTVKKP CCCCCCCCCCCCCCC	25.30	100646255
12	Phosphorylation	VCSMPTASTVKKPFD CCCCCCCCCCCCCCC	35.89	100646251
13	Phosphorylation	CSMPTASTVKKPFDL CCCCCCCCCCCCCCH	33.60	100646259
52	Phosphorylation	TSGDHDDSFMKMLRS CCCCCCHHHHHHHHH	33.04	-
114	Ubiquitination	PCCRGSGKSNVGAWG CCCCCCCCCCCCCCC	40.32	32142685
175	Phosphorylation	KRDKEKRTALHLASA HHHHHHHHHHHHHHC	44.64	-
267	Phosphorylation	LYGADIESKNKCGLT HHCCCCCCCCCCCCH	41.69	26074081
268	Ubiquitination	YGADIESKNKCGLTP HCCCCCCCCCCCCHH	47.86	-
295	Acetylation	VKFLIKKKANLNVLD HHHHHHHHCCCCCHH	37.19	90647
344	Phosphorylation	SGQTAREYAVSSHHH CCCHHHHHHHHCCHH	13.52	26270265
347	Phosphorylation	TAREYAVSSHHHVIC HHHHHHHHCCHHHHH	18.78	26270265
348	Phosphorylation	AREYAVSSHHHVICE HHHHHHHCCHHHHHH	21.90	26270265
358	Phosphorylation	HVICELLSDYKEKQM HHHHHHHCHHHHHHC	52.06	26270265
360	Phosphorylation	ICELLSDYKEKQMLK HHHHHCHHHHHHCHH	20.05	26270265
370	Phosphorylation	KQMLKISSENSNPEQ HHCHHCCCCCCCHHH	44.25	-
383	Phosphorylation	EQDLKLTSEEESQRL HHHCCCCCHHHHHHH	54.14	-
478	Acetylation	DEQNDTRKQLSEEQN CCCCHHHHHHHHHHH	58.65	18529153
499	Acetylation	EILTNKQKQIEVAEQ HHHHHHHHHHHHHHH	55.65	18529159
510	Phosphorylation	VAEQKMNSELSLSHK HHHHHHHHHHCCCCH	36.09	29083192
513	Phosphorylation	QKMNSELSLSHKKEE HHHHHHHCCCCHHHH	24.63	29083192
515	Phosphorylation	MNSELSLSHKKEEDL HHHHHCCCCHHHHHH	29.86	29083192
580	Phosphorylation	QLNEEALTKTNI--- HHCHHHHHHCCC---	42.76	46164059
582	Phosphorylation	NEEALTKTNI----- CHHHHHHCCC-----	32.67	46164063

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POTED_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POTED_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POTED_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of POTED_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.