dbPTM

HMMR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HMMR_HUMAN
UniProt AC	O75330
Protein Name	Hyaluronan mediated motility receptor
Gene Name	HMMR
Organism	Homo sapiens (Human).
Sequence Length	724
Subcellular Localization	Cell surface . Cytoplasm .
Protein Description	Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity)..
Protein Sequence	MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFPKAPLK ------CCCCCCCCC	50.70	24719451
15	Phosphorylation	LKRFNDPSGCAPSPG CCCCCCCCCCCCCCC	49.74	24732914
20	Phosphorylation	DPSGCAPSPGAYDVK CCCCCCCCCCCCCCC	19.90	23401153
24	Phosphorylation	CAPSPGAYDVKTLEV CCCCCCCCCCCEEEH	27.47	24732914
28	Ubiquitination	PGAYDVKTLEVLKGP CCCCCCCEEEHHCCC	28.18	29967540
37	Phosphorylation	EVLKGPVSFQKSQRF EHHCCCCCHHHHHHH	25.70	24719451
41	Phosphorylation	GPVSFQKSQRFKQQK CCCCHHHHHHHHHHH	18.79	27422710
52	Ubiquitination	KQQKESKQNLNVDKD HHHHHHHHCCCCCCC	69.76	29967540
60	Phosphorylation	NLNVDKDTTLPASAR CCCCCCCCCCCHHHH	35.65	29978859
61	Phosphorylation	LNVDKDTTLPASARK CCCCCCCCCCHHHHH	40.66	29978859
65	Phosphorylation	KDTTLPASARKVKSS CCCCCCHHHHHCCCC	27.02	25159151
65 (in isoform 2)	Phosphorylation	-	27.02	25849741
65 (in isoform 3)	Phosphorylation	-	27.02	25056879
72	Phosphorylation	SARKVKSSESKESQK HHHHCCCCCCHHHHC	39.92	26657352
99	Ubiquitination	RVLLQERGAQDRRIQ HHHHHHCCCCHHHHH	27.17	29967540
110	Phosphorylation	RRIQDLETELEKMEA HHHHHHHHHHHHHHH	53.84	18452278
114	Ubiquitination	DLETELEKMEARLNA HHHHHHHHHHHHHHH	55.45	29967540
115	Ubiquitination	LETELEKMEARLNAA HHHHHHHHHHHHHHH	3.39	29967540
123	Ubiquitination	EARLNAALREKTSLS HHHHHHHHHHHHCCC	7.26	29967540
127	Phosphorylation	NAALREKTSLSANNA HHHHHHHHCCCCCCH	30.10	22210691
128	Phosphorylation	AALREKTSLSANNAT HHHHHHHCCCCCCHH	31.25	22210691
129	Ubiquitination	ALREKTSLSANNATL HHHHHHCCCCCCHHH	7.30	29967540
130	Phosphorylation	LREKTSLSANNATLE HHHHHCCCCCCHHHH	28.81	22210691
133	N-linked_Glycosylation	KTSLSANNATLEKQL HHCCCCCCHHHHHHH	33.74	UniProtKB CARBOHYD
135	Phosphorylation	SLSANNATLEKQLIE CCCCCCHHHHHHHHH	37.26	24719451
135	Ubiquitination	SLSANNATLEKQLIE CCCCCCHHHHHHHHH	37.26	29967540
138	Ubiquitination	ANNATLEKQLIELTR CCCHHHHHHHHHHHH	54.22	29967540
139	Ubiquitination	NNATLEKQLIELTRT CCHHHHHHHHHHHHH	37.99	29967540
165	Ubiquitination	GNQKNLRILSLELMK CCHHHHHHHHHHHHH	3.27	29967540
198	Phosphorylation	MEMKLQVTQRSLEES HHHHHHHHHHHHHHH	12.80	30624053
200	Ubiquitination	MKLQVTQRSLEESQG HHHHHHHHHHHHHHH	33.57	29967540
201	Phosphorylation	KLQVTQRSLEESQGK HHHHHHHHHHHHHHH	30.25	30624053
205	Phosphorylation	TQRSLEESQGKIAQL HHHHHHHHHHHHHHH	34.55	29214152
206	Ubiquitination	QRSLEESQGKIAQLE HHHHHHHHHHHHHHH	61.55	29967540
215	Acetylation	KIAQLEGKLVSIEKE HHHHHHCCEEEEEHH	36.02	25953088
215	Ubiquitination	KIAQLEGKLVSIEKE HHHHHHCCEEEEEHH	36.02	29967540
216	Ubiquitination	IAQLEGKLVSIEKEK HHHHHCCEEEEEHHH	5.55	29967540
221	Ubiquitination	GKLVSIEKEKIDEKS CCEEEEEHHHCCCHH	63.74	29967540
222	Ubiquitination	KLVSIEKEKIDEKSE CEEEEEHHHCCCHHH	42.31	29967540
236	Phosphorylation	ETEKLLEYIEEISCA HHHHHHHHHHHHHCC	17.38	29083192
236	Ubiquitination	ETEKLLEYIEEISCA HHHHHHHHHHHHHCC	17.38	29967540
241	Phosphorylation	LEYIEEISCASDQVE HHHHHHHHCCHHHHH	13.60	29083192
244	Phosphorylation	IEEISCASDQVEKYK HHHHHCCHHHHHHHC	32.66	29083192
250	Phosphorylation	ASDQVEKYKLDIAQL CHHHHHHHCCCHHHH	11.86	25884760
251	Ubiquitination	SDQVEKYKLDIAQLE HHHHHHHCCCHHHHH	51.23	29967540
252	Ubiquitination	DQVEKYKLDIAQLEE HHHHHHCCCHHHHHH	5.37	29967540
264	Ubiquitination	LEENLKEKNDEILSL HHHHHHHCCHHHHHH	69.02	29967540
270	Phosphorylation	EKNDEILSLKQSLEE HCCHHHHHHHHHHHH	38.90	24719451
321	Ubiquitination	LNAEMQNLKQKFILE HHHHHHHHHHHHHHH	3.32	24816145
323	Ubiquitination	AEMQNLKQKFILEQQ HHHHHHHHHHHHHHH	49.40	29967540
335	Ubiquitination	EQQEREKLQQKELQI HHHHHHHHHHHHHHH	5.82	29967540
338	Ubiquitination	EREKLQQKELQIDSL HHHHHHHHHHHHHHH	47.64	29967540
339	Ubiquitination	REKLQQKELQIDSLL HHHHHHHHHHHHHHH	41.38	29967540
350	Ubiquitination	DSLLQQEKELSSSLH HHHHHHHHHHHHHHH	60.67	29967540
351	Ubiquitination	SLLQQEKELSSSLHQ HHHHHHHHHHHHHHH	53.80	29967540
353	Phosphorylation	LQQEKELSSSLHQKL HHHHHHHHHHHHHHH	20.97	20068231
354	Phosphorylation	QQEKELSSSLHQKLC HHHHHHHHHHHHHHH	49.93	20068231
355	Phosphorylation	QEKELSSSLHQKLCS HHHHHHHHHHHHHHH	26.88	20068231
381	Phosphorylation	FEEELKQTLDELDKL CHHHHHHHHHHHHHH	34.29	30266825
392	Ubiquitination	LDKLQQKEEQAERLV HHHHHHHHHHHHHHH	51.51	24816145
403	Ubiquitination	ERLVKQLEEEAKSRA HHHHHHHHHHHHHHH	51.83	29967540
407	Ubiquitination	KQLEEEAKSRAEELK HHHHHHHHHHHHHHH	43.69	24816145
408	Ubiquitination	QLEEEAKSRAEELKL HHHHHHHHHHHHHHH	43.71	24816145
419	Acetylation	ELKLLEEKLKGKEAE HHHHHHHHHCCCHHH	46.23	27178108
419	Ubiquitination	ELKLLEEKLKGKEAE HHHHHHHHHCCCHHH	46.23	-
445	Phosphorylation	TLLLQEKYDSMVQSL HHHHHHHHHHHHHCH	16.70	26074081
447	Phosphorylation	LLQEKYDSMVQSLED HHHHHHHHHHHCHHH	20.12	26074081
451	Phosphorylation	KYDSMVQSLEDVTAQ HHHHHHHCHHHHHHH	23.47	26074081
456	Phosphorylation	VQSLEDVTAQFESYK HHCHHHHHHHHHHHH	27.36	26074081
461	Phosphorylation	DVTAQFESYKALTAS HHHHHHHHHHCCCHH	32.97	26074081
462	Phosphorylation	VTAQFESYKALTASE HHHHHHHHHCCCHHH	7.96	26074081
466	Phosphorylation	FESYKALTASEIEDL HHHHHCCCHHHHHHH	32.75	26074081
468	Phosphorylation	SYKALTASEIEDLKL HHHCCCHHHHHHHHC	33.59	26074081
474	Ubiquitination	ASEIEDLKLENSSLQ HHHHHHHHCCCHHHH	67.10	29967540
477	N-linked_Glycosylation	IEDLKLENSSLQEKA HHHHHCCCHHHHHHH	47.54	UniProtKB CARBOHYD
478	Phosphorylation	EDLKLENSSLQEKAA HHHHCCCHHHHHHHH	24.05	26657352
489	Ubiquitination	EKAAKAGKNAEDVQH HHHHHCCCCHHHHHH	58.82	29967540
490	Ubiquitination	KAAKAGKNAEDVQHQ HHHHCCCCHHHHHHH	47.87	29967540
518	Ubiquitination	MLLDLQTKSALKETE HHHHHHHHHCCCHHH	22.29	29967540
549	Ubiquitination	NQLKQQEEDFRKQLE HHHHHCHHHHHHHHH	59.10	29967540
567	N-linked_Glycosylation	GRKAEKENTTAELTE HHHHHHHCCHHHHHH	54.52	UniProtKB CARBOHYD
568	Phosphorylation	RKAEKENTTAELTEE HHHHHHCCHHHHHHH	28.60	20860994
583	Phosphorylation	INKWRLLYEELYNKT HHHHHHHHHHHHCCC	16.37	30576142
587	Phosphorylation	RLLYEELYNKTKPFQ HHHHHHHHCCCCCEE	20.21	30576142
588	N-linked_Glycosylation	LLYEELYNKTKPFQL HHHHHHHCCCCCEEE	59.13	UniProtKB CARBOHYD
589	Ubiquitination	LYEELYNKTKPFQLQ HHHHHHCCCCCEEEE	44.35	29967540
597	Ubiquitination	TKPFQLQLDAFEVEK CCCEEEECHHHHHHH	7.53	33845483
604	Ubiquitination	LDAFEVEKQALLNEH CHHHHHHHHHHHHCC	46.15	29967540
605	Ubiquitination	DAFEVEKQALLNEHG HHHHHHHHHHHHCCC	24.60	29967540
610	Ubiquitination	EKQALLNEHGAAQEQ HHHHHHHCCCHHHHH	43.60	29967540
620	Ubiquitination	AAQEQLNKIRDSYAK HHHHHHHHHHHHHHH	47.94	29967540
635	Ubiquitination	LLGHQNLKQKIKHVV HHCCCCHHHHHHHHH	58.03	29967540
636	Ubiquitination	LGHQNLKQKIKHVVK HCCCCHHHHHHHHHH	56.74	29967540
653	Phosphorylation	DENSQLKSEVSKLRC CCCHHHHHHHHHHHH	52.39	28555341
656	Phosphorylation	SQLKSEVSKLRCQLA HHHHHHHHHHHHHHH	23.17	27251275
657	Acetylation	QLKSEVSKLRCQLAK HHHHHHHHHHHHHHH	45.16	25953088
657	Phosphorylation	QLKSEVSKLRCQLAK HHHHHHHHHHHHHHH	45.16	27251275
668	Phosphorylation	QLAKKKQSETKLQEE HHHHHHHCHHHHHHH	56.99	29396449
668	Ubiquitination	QLAKKKQSETKLQEE HHHHHHHCHHHHHHH	56.99	33845483
670	Phosphorylation	AKKKQSETKLQEELN HHHHHCHHHHHHHHH	42.15	29396449
681	Ubiquitination	EELNKVLGIKHFDPS HHHHHHHCCCCCCHH	29.86	29967540
683	Ubiquitination	LNKVLGIKHFDPSKA HHHHHCCCCCCHHHC	36.10	33845483
684	Ubiquitination	NKVLGIKHFDPSKAF HHHHCCCCCCHHHCC	30.35	33845483
696	Ubiquitination	KAFHHESKENFALKT HCCCCCCCCCCCCCC	54.41	29967540
697	Ubiquitination	AFHHESKENFALKTP CCCCCCCCCCCCCCC	67.85	29967540
702	Acetylation	SKENFALKTPLKEGN CCCCCCCCCCCCCCC	44.67	25953088
703	Phosphorylation	KENFALKTPLKEGNT CCCCCCCCCCCCCCC	34.40	22617229
704	Phosphorylation	ENFALKTPLKEGNTN CCCCCCCCCCCCCCC	39.59	24719451
713	Phosphorylation	KEGNTNCYRAPMECQ CCCCCCCCCCCCCHH	16.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HMMR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HMMR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HMMR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK01_HUMAN	MAPK1	physical	11403955
EPHB2_HUMAN	EPHB2	physical	22610405
TPX2_HUMAN	TPX2	physical	22110403
AURKA_HUMAN	AURKA	physical	22110403
BRCA1_HUMAN	BRCA1	physical	22110403
MORN4_HUMAN	MORN4	physical	25416956
CAD13_HUMAN	CDH13	physical	25640309
GREB1_HUMAN	GREB1	physical	25640309
IL24_HUMAN	IL24	physical	25640309
ITIH5_HUMAN	ITIH5	physical	25640309
ARY2_HUMAN	NAT2	physical	25640309
THRSP_HUMAN	THRSP	physical	25640309
FA83D_HUMAN	FAM83D	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB08818	Hyaluronan

Regulatory Network of HMMR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20 AND SER-65, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20 AND THR-703, AND MASSSPECTROMETRY.	16565220 [Abstract]