GREB1_HUMAN - dbPTM
GREB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GREB1_HUMAN
UniProt AC Q4ZG55
Protein Name Protein GREB1
Gene Name GREB1
Organism Homo sapiens (Human).
Sequence Length 1949
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers..
Protein Sequence MGNSYAGQLKTTRFEEVLHNSIEASLRSNNLVPRPIFSQLYLEAEQQLAALEGGSRVDNEEEEEEGEGGLETNGPPNPFQLHPLPEGCCTTDGFCQAGKDLRLVSISNEPMDVPAGFLLVGVKSPSLPDHLLVCAVDKRFLPDDNGHNALLGFSGNCVGCGKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGTLTKGPLICWKGSEFRSRQIPASTCSSSLFPALESTAAFPSEPVPGTNPSILMGAQQAGPASDHPSLNAAMGPAVFNGKDSPKCQQLAKNNLLALPRPSALGILSNSGPPKKRHKGWSPESPSAPDGGCPQGGGNRAKYESAGMSCVPQVGLVGPASVTFPVVASGEPVSVPDNLLKICKAKPVIFKGHGNFPYLCGNLNDVVVSPLLYTCYQNSQSVSRAYEQYGASAIQPISEEMQLLLTVYYLVQLAADQVPLMEDLEQIFLRSWRESHLTEIRQYQQAPPQPFPPAPSAAAPVTSAQLPWLASLAASSCNDSVHVIECAYSLAEGLSEMFRLLVEGKLAKTNYVVIICACRSAAIDSCIAVTGKYQARILSESLLTPAEYQKEVNYELVTGKVDSLGAFFSTLCPEGDIDILLDKFHQENQGHISSSLAASSVTKAASLDVSGTPVCTSYNLEPHSIRPFQLAVAQKLLSHVCSIADSSTQNLDLGSFEKVDFLICIPPSEVTYQQTLLHVWHSGVLLELGLKKEHMTKQRVEQYVLKLDTEAQTKFKAFLQNSFQNPHTLFVLIHDHAHWDLVSSTVHNLYSQSDPSVGLVDRLLNCREVKEAPNIVTLHVTSFPYALQTQHTLISPYNEIHWPASCSNGVDLYHENKKYFGLSEFIESTLSGHSLPLLRYDSSFEAMVTALGKRFPRLHSAVIRTFVLVQHYAAALMAVSGLPQMKNYTSVETLEITQNLLNSPKQCPCGHGLMVLLRVPCSPLAVVAYERLAHVRARLALEEHFEIILGSPSSGVTVGKHFVKQLRMWQKIEDVEWRPQTYLELEGLPCILIFSGMDPHGESLPRSLRYCDLRLINSSCLVRTALEQELGLAAYFVSNEVPLEKGARNEALESDAEKLSSTDNEDEELGTEGSTSEKRSPMKRERSRSHDSASSSLSSKASGSALGGESSAQPTALPQGEHARSPQPRGPAEEGRAPGEKQRPRASQGPPSAISRHSPGPTPQPDCSLRTGQRSVQVSVTSSCSQLSSSSGSSSSSVAPAAGTWVLQASQCSLTKACRQPPIVFLPKLVYDMVVSTDSSGLPKAASLLPSPSVMWASSFRPLLSKTMTSTEQSLYYRQWTVPRPSHMDYGNRAEGRVDGFHPRRLLLSGPPQIGKTGAYLQFLSVLSRMLVRLTEVDVYDEEEININLREESDWHYLQLSDPWPDLELFKKLPFDYIIHDPKYEDASLICSHYQGIKSEDRGMSRKPEDLYVRRQTARMRLSKYAAYNTYHHCEQCHQYMGFHPRYQLYESTLHAFAFSYSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKSHEYIKSPTFTPTTGRHEHGLFNLYHAMDGASHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGVGAAHFLIKELSYHNLELERNRQEELGIKPQDIWPFIVISDDSCVMWNVVDVNSAGERSREFSWSERNVSLKHIMQHIEAAPDIMHYALLGLRKWSSKTRASEVQEPFSRCHVHNFIILNVDLTQNVQYNQNRFLCDDVDFNLRVHSAGLLLCRFNRFSVMKKQIVVGGHRSFHITSKVSDNSAAVVPAQYICAPDSKHTFLAAPAQLLLEKFLQHHSHLFFPLSLKNHDHPVLSVDCYLNLGSQISVCYVSSRPHSLNISCSDLLFSGLLLYLCDSFVGASFLKKFHFLKGATLCVICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANAREDRPLFFLTGRHI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationFEEVLHNSIEASLRS
HHHHHHHHHHHHHHC		15.8524719451
169UbiquitinationKKGFCYFTEFSNHIN
CCCEEEEEECCCCEE		15.0523503661
181PhosphorylationHINLKLTTQPKKQKH
CEEEEECCCCCCHHH		54.00-
204UbiquitinationAQGTLTKGPLICWKG
CCCCCCCCCEEEECC		19.6023503661
212PhosphorylationPLICWKGSEFRSRQI
CEEEECCCHHCCCCC		29.8124719451
306PhosphorylationALGILSNSGPPKKRH
HHHHHCCCCCCCCCC		49.6624719451
317PhosphorylationKKRHKGWSPESPSAP
CCCCCCCCCCCCCCC		27.7125849741
320PhosphorylationHKGWSPESPSAPDGG
CCCCCCCCCCCCCCC		27.7825849741
322PhosphorylationGWSPESPSAPDGGCP
CCCCCCCCCCCCCCC		62.8127732954
381UbiquitinationLLKICKAKPVIFKGH
HHHHHCCCCEEEECC		25.8832015554
440UbiquitinationSEEMQLLLTVYYLVQ
CHHHHHHHHHHHHHH		4.0723503661
475UbiquitinationRESHLTEIRQYQQAP
HHHHHHHHHHHHCCC		2.5423503661
585UbiquitinationLTPAEYQKEVNYELV
CCHHHHHHHCCCEEE		63.8323503661
589PhosphorylationEYQKEVNYELVTGKV
HHHHHCCCEEECCCC		18.8025159151
626UbiquitinationFHQENQGHISSSLAA
HHHHCCCCCCHHHHH		13.6423503661
632UbiquitinationGHISSSLAASSVTKA
CCCCHHHHHHCCCCC		13.7723503661
641PhosphorylationSSVTKAASLDVSGTP
HCCCCCCCCCCCCCE		29.9324719451
651PhosphorylationVSGTPVCTSYNLEPH
CCCCEEEEECCCCCC		34.1824719451
661UbiquitinationNLEPHSIRPFQLAVA
CCCCCCCCHHHHHHH		29.0623503661
667UbiquitinationIRPFQLAVAQKLLSH
CCHHHHHHHHHHHHH		8.6723503661
673PhosphorylationAVAQKLLSHVCSIAD
HHHHHHHHHHHHHCC		25.0622210691
683PhosphorylationCSIADSSTQNLDLGS
HHHCCCCCCCCCCCC		25.9822210691
738PhosphorylationTKQRVEQYVLKLDTE
CHHHHHHHHHHCCHH		8.3428270605
744PhosphorylationQYVLKLDTEAQTKFK
HHHHHCCHHHHHHHH		43.5928270605
748PhosphorylationKLDTEAQTKFKAFLQ
HCCHHHHHHHHHHHH		45.5628270605
749UbiquitinationLDTEAQTKFKAFLQN
CCHHHHHHHHHHHHH		32.5523503661
751UbiquitinationTEAQTKFKAFLQNSF
HHHHHHHHHHHHHHC		39.5223503661
887UbiquitinationEAMVTALGKRFPRLH
HHHHHHHHHHCHHHH		19.3423503661
888UbiquitinationAMVTALGKRFPRLHS
HHHHHHHHHCHHHHH		52.2823503661
1079UbiquitinationVSNEVPLEKGARNEA
HHCCCCCCCCCCCHH		43.2923503661
1080UbiquitinationSNEVPLEKGARNEAL
HCCCCCCCCCCCHHH		66.6023503661
1089PhosphorylationARNEALESDAEKLSS
CCCHHHHHHHHHHCC		42.8625849741
1095PhosphorylationESDAEKLSSTDNEDE
HHHHHHHCCCCCCCC		42.1125849741
1096PhosphorylationSDAEKLSSTDNEDEE
HHHHHHCCCCCCCCC		50.6625849741
1097PhosphorylationDAEKLSSTDNEDEEL
HHHHHCCCCCCCCCC		39.1925849741
1106PhosphorylationNEDEELGTEGSTSEK
CCCCCCCCCCCCCCC		50.2028348404
1109PhosphorylationEELGTEGSTSEKRSP
CCCCCCCCCCCCCCC		23.6428348404
1110PhosphorylationELGTEGSTSEKRSPM
CCCCCCCCCCCCCCC		52.3324719451
1111PhosphorylationLGTEGSTSEKRSPMK
CCCCCCCCCCCCCCC		42.7028348404
1115PhosphorylationGSTSEKRSPMKRERS
CCCCCCCCCCCCHHH		40.1728348404
1122PhosphorylationSPMKRERSRSHDSAS
CCCCCHHHCCCCCCC		33.1225849741
1124PhosphorylationMKRERSRSHDSASSS
CCCHHHCCCCCCCHH		32.6625849741
1127PhosphorylationERSRSHDSASSSLSS
HHHCCCCCCCHHHCC		25.3225849741
1129PhosphorylationSRSHDSASSSLSSKA
HCCCCCCCHHHCCCC		25.1424719451
1130PhosphorylationRSHDSASSSLSSKAS
CCCCCCCHHHCCCCC		34.7126437602
1131PhosphorylationSHDSASSSLSSKASG
CCCCCCHHHCCCCCC		29.7626437602
1137PhosphorylationSSLSSKASGSALGGE
HHHCCCCCCCCCCCC		36.7026330541
1139PhosphorylationLSSKASGSALGGESS
HCCCCCCCCCCCCCC		20.1626330541
1150PhosphorylationGESSAQPTALPQGEH
CCCCCCCCCCCCCCC		28.8430278072
1160PhosphorylationPQGEHARSPQPRGPA
CCCCCCCCCCCCCCH		28.7725849741
1187PhosphorylationRASQGPPSAISRHSP
CHHCCCCCHHHCCCC		41.1726330541
1190PhosphorylationQGPPSAISRHSPGPT
CCCCCHHHCCCCCCC		24.5325849741
1193PhosphorylationPSAISRHSPGPTPQP
CCHHHCCCCCCCCCC		30.3725849741
1197PhosphorylationSRHSPGPTPQPDCSL
HCCCCCCCCCCCCCC		40.2330278072
1288PhosphorylationASLLPSPSVMWASSF
HHCCCCCCHHHHHCC		29.0117494752
1305PhosphorylationLLSKTMTSTEQSLYY
HHHHCCCCCCHHHHC		21.0822210691
1306PhosphorylationLSKTMTSTEQSLYYR
HHHCCCCCCHHHHCC		28.9522210691
1311PhosphorylationTSTEQSLYYRQWTVP
CCCCHHHHCCCCCCC		11.2322210691
1325PhosphorylationPRPSHMDYGNRAEGR
CCCCCCCCCCCCCCC		14.5530576142
1332MethylationYGNRAEGRVDGFHPR
CCCCCCCCCCCCCCH		18.17-
1339DimethylationRVDGFHPRRLLLSGP
CCCCCCCHHHHHCCC		33.05-
1339MethylationRVDGFHPRRLLLSGP
CCCCCCCHHHHHCCC		33.05-
1350UbiquitinationLSGPPQIGKTGAYLQ
HCCCCCCCCHHHHHH		19.0723503661
1351UbiquitinationSGPPQIGKTGAYLQF
CCCCCCCCHHHHHHH		45.4723503661
1352PhosphorylationGPPQIGKTGAYLQFL
CCCCCCCHHHHHHHH		23.1022210691
1355PhosphorylationQIGKTGAYLQFLSVL
CCCCHHHHHHHHHHH		11.4622210691
1363PhosphorylationLQFLSVLSRMLVRLT
HHHHHHHHHHHHHHC		17.3122210691
1419PhosphorylationYIIHDPKYEDASLIC
EEECCCCCCCCHHHH		25.1627732954
1423PhosphorylationDPKYEDASLICSHYQ
CCCCCCCHHHHHHHC		30.5027732954
1440PhosphorylationKSEDRGMSRKPEDLY
CCCCCCCCCCHHHHH		39.7228985074
1536UbiquitinationMRLPLVTDKSHEYIK
CEECEECCCCCCCCC		42.8723503661
1537UbiquitinationRLPLVTDKSHEYIKS
EECEECCCCCCCCCC		44.3323503661
1542UbiquitinationTDKSHEYIKSPTFTP
CCCCCCCCCCCCCCC		3.0323503661
1543UbiquitinationDKSHEYIKSPTFTPT
CCCCCCCCCCCCCCC		49.8623503661
1544PhosphorylationKSHEYIKSPTFTPTT
CCCCCCCCCCCCCCC		21.4424719451
1886PhosphorylationCDSFVGASFLKKFHF
HHHHCCHHHHHHHHC		25.7824961811
1912PhosphorylationDRSSLRQTVVRLELE
CHHHHHCEEEEEEEC		17.9724719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GREB1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GREB1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GREB1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GREB1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GREB1_HUMAN

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Related Literatures of Post-Translational Modification

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