ITIH5_HUMAN - dbPTM
ITIH5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITIH5_HUMAN
UniProt AC Q86UX2
Protein Name Inter-alpha-trypsin inhibitor heavy chain H5
Gene Name ITIH5
Organism Homo sapiens (Human).
Sequence Length 942
Subcellular Localization Secreted.
Protein Description May act as a tumor suppressor..
Protein Sequence MLLLLGLCLGLSLCVGSQEEAQSWGHSSEQDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNILESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAGSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPEPVVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQPGDILRLVSDHRDSGVTVNGELIGAPAPPNGHKKQRTYLRTITILINKPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQRHHLGFYIANSEGLSSNCHGLLGQFLNQDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNGEEQIDCWFARNNAAKLIDGEYKDYLAFHPFDTGMTLGQGMSREL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52PhosphorylationLKTKPLMTEFSVKST
HCCCCCCCCCEECCC		41.3729083192
55PhosphorylationKPLMTEFSVKSTIIS
CCCCCCCEECCCEEC		23.5429083192
97N-linked_GlycosylationPAAAFITNFTMLIGD
CHHHHCCCCEEEECC		26.10UniProtKB CARBOHYD
127N-linked_GlycosylationDRVKEKRNKTTEENG
HHHHHHHCCCCCHHC		58.03UniProtKB CARBOHYD
149PhosphorylationRASAVIPSKDKAAFF
EEEEECCCCCHHHHC		42.2224719451
170PhosphorylationLQRRLGKYEHSISVR
HHHHHCCCCCCCEEC		19.6426074081
173PhosphorylationRLGKYEHSISVRPQQ
HHCCCCCCCEECHHH		12.4826074081
175PhosphorylationGKYEHSISVRPQQLS
CCCCCCCEECHHHHC		18.3226074081
182PhosphorylationSVRPQQLSGRLSVDV
EECHHHHCCCEEEEE		19.9626074081
231N-linked_GlycosylationPSTVINQNETFANII
CCCEECCCCCCEEEE		45.87UniProtKB CARBOHYD
361PhosphorylationSIRDGKVYIHHMSPT
CCCCCEEEEEECCCC		9.68-
366PhosphorylationKVYIHHMSPTGGTDI
EEEEEECCCCCCCCH		18.2324719451
371PhosphorylationHMSPTGGTDINGALQ
ECCCCCCCCHHHHHH		34.7424719451
387PhosphorylationAIRLLNKYVAHSGIG
HHHHHHHHHHHCCCC		11.2022210691
391PhosphorylationLNKYVAHSGIGDRSV
HHHHHHHCCCCCCEE		23.5122210691
397PhosphorylationHSGIGDRSVSLIVFL
HCCCCCCEEEEEEEE		22.3122210691
421N-linked_GlycosylationTHTLKILNNTREAAR
EEEEEECCCCHHHHC		51.83UniProtKB CARBOHYD
484PhosphorylationEIRTPLLSDIRIDYP
HCCCCCCCCCCCCCC		38.3826091039
508N-linked_GlycosylationTLFPNYFNGSEIIIA
CCCCCCCCCCEEEEE		42.60UniProtKB CARBOHYD
557PhosphorylationQKAGKDVTGSPRPGG
CCCCCCCCCCCCCCC		41.9220071362
570PhosphorylationGGDGEGDTNHIERLW
CCCCCCCCCHHHHHH		39.2820071362
578PhosphorylationNHIERLWSYLTTKEL
CHHHHHHHHHHHHHH		18.1724719451
579PhosphorylationHIERLWSYLTTKELL
HHHHHHHHHHHHHHH		9.1124719451
587PhosphorylationLTTKELLSSWLQSDD
HHHHHHHHHHHHCCC		31.90-
588PhosphorylationTTKELLSSWLQSDDE
HHHHHHHHHHHCCCC		31.60-
640PhosphorylationLEEAHGMSAAMGPEP
HHHHHCCCCCCCCCC		19.9120873877
651PhosphorylationGPEPVVQSVRGAGTQ
CCCCCEECCCCCCCC		11.3720873877
657O-linked_GlycosylationQSVRGAGTQPGPLLK
ECCCCCCCCCCCCCC		30.93OGP
657PhosphorylationQSVRGAGTQPGPLLK
ECCCCCCCCCCCCCC		30.9320873877
677PhosphorylationRIKISKTSVDGDPHF
CEEEEEEECCCCCCE		23.19-
691PhosphorylationFVVDFPLSRLTVCFN
EEEEEECCEEEEEEE		26.02-
711PhosphorylationGDILRLVSDHRDSGV
CCEEEEEECCCCCCE		32.0824719451
743PhosphorylationKQRTYLRTITILINK
CCCEEEEEEEEEECC		21.6316674116
745PhosphorylationRTYLRTITILINKPE
CEEEEEEEEEECCCC		14.7625072903
754PhosphorylationLINKPERSYLEITPS
EECCCCHHCEEECCC		32.2025072903
755PhosphorylationINKPERSYLEITPSR
ECCCCHHCEEECCCE		17.9925072903
759PhosphorylationERSYLEITPSRVILD
CHHCEEECCCEEEEC		13.0625072903
776N-linked_GlycosylationDRLVLPCNQSVVVGS
CEEEEECCCEEEEEC		34.91UniProtKB CARBOHYD
795N-linked_GlycosylationVSVSANANVTVTIQG
EEEECCCCEEEEECC		29.78UniProtKB CARBOHYD
862N-linked_GlycosylationDPAGPSQNLTHPLLL
CCCCCCCCCCCCEEE		51.77UniProtKB CARBOHYD
930PhosphorylationLAFHPFDTGMTLGQG
EEECCCCCCCCCCCC		29.27-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITIH5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITIH5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITIH5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ITIH5_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITIH5_HUMAN

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Related Literatures of Post-Translational Modification

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