dbPTM

POTEF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POTEF_HUMAN
UniProt AC	A5A3E0
Protein Name	POTE ankyrin domain family member F
Gene Name	POTEF
Organism	Homo sapiens (Human).
Sequence Length	1075
Subcellular Localization	Cytoplasm, cell cortex . Colocalizes with actin filaments.
Protein Description
Protein Sequence	MVVEVDSMPAASSVKKPFGLRSKMGKWCCRCFPCCRESGKSNVGTSGDHDDSAMKTLRSKMGKWCRHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWCCHCFPCCRGSSKSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHRSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDILHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKRNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEATLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYTSGRTTGIVMDSGDGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKILTEHGYRFTTMAEREIVRDIKEKLCYVALDFEQEMATVASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVVEVDSMPAASSV -CCEEECCCCCCCCC	31.66	29083192
12	Phosphorylation	VDSMPAASSVKKPFG ECCCCCCCCCCCCCC	37.46	23663014
13	Phosphorylation	DSMPAASSVKKPFGL CCCCCCCCCCCCCCC	32.98	29083192
15	Ubiquitination	MPAASSVKKPFGLRS CCCCCCCCCCCCCCC	57.59	23000965
16	Ubiquitination	PAASSVKKPFGLRSK CCCCCCCCCCCCCCC	43.34	23000965
41	Phosphorylation	CCRESGKSNVGTSGD HCCCCCCCCCCCCCC	40.03	30576142
52	Phosphorylation	TSGDHDDSAMKTLRS CCCCCCHHHHHHHHH	36.00	30576142
55	Ubiquitination	DHDDSAMKTLRSKMG CCCHHHHHHHHHHHC	44.09	23000965
56	Phosphorylation	HDDSAMKTLRSKMGK CCHHHHHHHHHHHCH	17.83	-
60	Ubiquitination	AMKTLRSKMGKWCRH HHHHHHHHHCHHHHH	45.28	23000965
75	Phosphorylation	CFPCCRGSGKSNVGA HHHHCCCCCCCCCCC	24.56	22210691
77	Ubiquitination	PCCRGSGKSNVGASG HHCCCCCCCCCCCCC	40.32	23000965
78	Phosphorylation	CCRGSGKSNVGASGD HCCCCCCCCCCCCCC	40.03	-
83	Phosphorylation	GKSNVGASGDHDDSA CCCCCCCCCCCCHHH	38.53	22210691
92	Ubiquitination	DHDDSAMKTLRNKMG CCCHHHHHHHHHHHC	44.09	23000965
97	Ubiquitination	AMKTLRNKMGKWCCH HHHHHHHHHCCCHHH	42.46	23000965
112	Phosphorylation	CFPCCRGSSKSKVGA HCCCCCCCCCCCCCC	18.42	24260401
114	Ubiquitination	PCCRGSSKSKVGAWG CCCCCCCCCCCCCCC	56.87	23000965
116	Ubiquitination	CRGSSKSKVGAWGDY CCCCCCCCCCCCCCC	48.72	23000965
142	Ubiquitination	VRGEDLDKLHRAAWW ECCHHHHHHHHHHHC	54.19	23000965
171	Acetylation	TDVNKQDKQKRTALH CCCCHHHHHHHHHHH	56.05	11794703
175	Phosphorylation	KQDKQKRTALHLASA HHHHHHHHHHHHHHC	40.38	-
190	Acetylation	NGNSEVVKLLLDRRC CCCHHHHHHHHHCCC	38.30	11794711
266	Ubiquitination	LLYGADIESKNKHGL HHHCCCHHHCCCCCC	57.09	17370265
267	Phosphorylation	LYGADIESKNKHGLT HHCCCHHHCCCCCCC	41.69	26074081
268	Ubiquitination	YGADIESKNKHGLTP HCCCHHHCCCCCCCC	58.17	23000965
270	Ubiquitination	ADIESKNKHGLTPLL CCHHHCCCCCCCCCE	42.67	23000965
274	Phosphorylation	SKNKHGLTPLLLGVH HCCCCCCCCCEEEHH	19.24	-
278	Ubiquitination	HGLTPLLLGVHEQKQ CCCCCCEEEHHHHHH	9.92	23000965
280	Ubiquitination	LTPLLLGVHEQKQQV CCCCEEEHHHHHHHH	4.53	23000965
284	Ubiquitination	LLGVHEQKQQVVKFL EEEHHHHHHHHHHHH	39.45	17370265
295	Ubiquitination	VKFLIKKKANLNALD HHHHHHHCCCCCHHH	37.19	-
300	Ubiquitination	KKKANLNALDRYGRT HHCCCCCHHHHHCCH	17.63	22817900
318	Ubiquitination	LAVCCGSASIVSLLL HHHHCCCHHHHHHHH	6.64	22817900
366	Ubiquitination	DYKEKQMLKISSENS CHHHHHCCCCCCCCC	4.06	22817900
370	Phosphorylation	KQMLKISSENSNPEQ HHCCCCCCCCCCHHH	44.25	-
383	Phosphorylation	EQDLKLTSEEESQRF HHHCCCCCHHHHHHH	54.14	-
384	Ubiquitination	QDLKLTSEEESQRFK HHCCCCCHHHHHHHC	61.62	22817900
468	Phosphorylation	PDNESEEYHRICELL CCCCCHHHHHHHHHH	7.73	18180459
478	Phosphorylation	ICELLSDYKEKQMPK HHHHHHHHHHHHCCC	20.05	-
488	Phosphorylation	KQMPKYSSENSNPEQ HHCCCCCCCCCCHHH	37.39	-
495	Ubiquitination	SENSNPEQDLKLTSE CCCCCHHHHHCCCCH	63.69	22817900
497	Ubiquitination	NSNPEQDLKLTSEEE CCCHHHHHCCCCHHH	4.97	22817900
501	Phosphorylation	EQDLKLTSEEESQRL HHHHCCCCHHHHHHH	54.14	-
513	Ubiquitination	QRLKGSENGQPEKRS HHHCCCCCCCCCCCC	56.98	22817900
515	Ubiquitination	LKGSENGQPEKRSQE HCCCCCCCCCCCCCC	55.34	22817900
520	Ubiquitination	NGQPEKRSQEPEINK CCCCCCCCCCCCCCC	50.38	22817900
538	Ubiquitination	RELENFMAIEEMKKH HHHHHHHHHHHHHHH	11.25	22817900
547	Phosphorylation	EEMKKHRSTHVGFPE HHHHHHCCCCCCCCC	23.68	20860994
548	Phosphorylation	EMKKHRSTHVGFPEN HHHHHCCCCCCCCCC	22.12	20860994
561	Phosphorylation	ENLTNGATAGNGDDG CCCCCCCCCCCCCCC	36.17	20860994
676	Phosphorylation	SQLREKKYLEDIESV HHHHHHHHHHHHHHH	26.79	28258704
682	Phosphorylation	KYLEDIESVKKRNDN HHHHHHHHHHHHCHH	39.30	20068231
684	Ubiquitination	LEDIESVKKRNDNLL HHHHHHHHHHCHHHH	56.12	17370265
694	Ubiquitination	NDNLLKALQLNELTM CHHHHHHHHCCCCCC	5.94	17370265
705	Phosphorylation	ELTMDDDTAVLVIDN CCCCCCCCEEEEEEC	26.17	24850871
714	Phosphorylation	VLVIDNGSGMCKAGF EEEEECCCCCCCCCC	29.61	-
718	Ubiquitination	DNGSGMCKAGFAGDD ECCCCCCCCCCCCCC	42.52	22817900
728	Ubiquitination	FAGDDAPRAVFPSIV CCCCCCCHHHCHHHC	45.14	22817900
733	Phosphorylation	APRAVFPSIVGRPRQ CCHHHCHHHCCCCCC	20.59	30266825
752	Phosphorylation	GGMHQKESYVGKEAQ CCCCCCCCCCCHHHH	31.96	29978859
753	Phosphorylation	GMHQKESYVGKEAQS CCCCCCCCCCHHHHC	17.82	29978859
760	Phosphorylation	YVGKEAQSKRGILTL CCCHHHHCCCCEEEE	31.22	29978859
766	Phosphorylation	QSKRGILTLKYPMEH HCCCCEEEEECCCHH	21.20	23403867
768	Methylation	KRGILTLKYPMEHGI CCCEEEEECCCHHCC	41.91	-
769	Phosphorylation	RGILTLKYPMEHGII CCEEEEECCCHHCCC	15.78	-
777	Phosphorylation	PMEHGIITNWDDMEK CCHHCCCCCHHHHHH	28.47	22817900
784	Sumoylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-
784	Ubiquitination	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	22817900
789	Phosphorylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	27273156
791	Phosphorylation	KIWHHTFYNELRVAP HHHHHHHHCCCCCCC	14.64	27273156
794	Ubiquitination	HHTFYNELRVAPEEH HHHHHCCCCCCCCCC	4.80	22817900
820	Phosphorylation	KANREKMTQIMFETF CCCHHHHHHHHHHHC	26.47	-
855	Phosphorylation	TTGIVMDSGDGVTHT CEEEEEECCCCCEEE	22.23	30140170
860	Phosphorylation	MDSGDGVTHTVPIYE EECCCCCEEEEEEEC	19.84	-
862	Phosphorylation	SGDGVTHTVPIYEGN CCCCCEEEEEEECCC	20.72	30140170
866	Phosphorylation	VTHTVPIYEGNALPH CEEEEEEECCCCCCC	16.24	22817900
875	Phosphorylation	GNALPHATLRLDLAG CCCCCCCEEEHHHCC	14.91	22817900
901	Phosphorylation	TEHGYRFTTMAEREI HHCCCCCCCHHHHHH	13.48	23403867
902	Phosphorylation	EHGYRFTTMAEREIV HCCCCCCCHHHHHHH	16.21	23403867
913	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	11920763
913	Ubiquitination	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	21906983
915	Ubiquitination	IVRDIKEKLCYVALD HHHHHHHHHHEEECC	38.56	22817900
918	Phosphorylation	DIKEKLCYVALDFEQ HHHHHHHEEECCHHH	10.13	17360941
923	Ubiquitination	LCYVALDFEQEMATV HHEEECCHHHHHHHH	12.42	22817900
925	Ubiquitination	YVALDFEQEMATVAS EEECCHHHHHHHHHC	45.84	22817900
929	Phosphorylation	DFEQEMATVASSSSL CHHHHHHHHHCCCCC	18.46	28348404
932	Phosphorylation	QEMATVASSSSLEKS HHHHHHHCCCCCCCE	26.81	28348404
933	Phosphorylation	EMATVASSSSLEKSY HHHHHHCCCCCCCEE	17.76	26657352
934	Phosphorylation	MATVASSSSLEKSYE HHHHHCCCCCCCEEE	36.13	26657352
935	Phosphorylation	ATVASSSSLEKSYEL HHHHCCCCCCCEEEC	42.36	27461979
938	Ubiquitination	ASSSSLEKSYELPDG HCCCCCCCEEECCCC	64.73	22817900
939	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCCEEECCCCC	17.92	29255136
940	Phosphorylation	SSSLEKSYELPDGQV CCCCCCEEECCCCCE	32.33	29255136
948	Ubiquitination	ELPDGQVITIGNERF ECCCCCEEEECCCEE	1.46	22817900
949	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	26846344
971	Phosphorylation	PCFLGMESCGIHETT CCCCCHHHCCCCHHH	14.57	23684312
977	Phosphorylation	ESCGIHETTFNSIMK HHCCCCHHHHHHHHH	23.64	30140170
978	Phosphorylation	SCGIHETTFNSIMKS HCCCCHHHHHHHHHC	20.17	30140170
985	Phosphorylation	TFNSIMKSDVDIRKD HHHHHHHCCCCCCHH	26.03	-
991	Sumoylation	KSDVDIRKDLYTNTV HCCCCCCHHHCCCCE	53.04	-
994	Phosphorylation	VDIRKDLYTNTVLSG CCCCHHHCCCCEECC	14.21	18083107
997	Phosphorylation	RKDLYTNTVLSGGTT CHHHCCCCEECCCCC	18.28	20068231
1000	Phosphorylation	LYTNTVLSGGTTMYP HCCCCEECCCCCCCC	30.73	20068231
1003	Phosphorylation	NTVLSGGTTMYPGMA CCEECCCCCCCCCHH	16.35	20068231
1004	Phosphorylation	TVLSGGTTMYPGMAH CEECCCCCCCCCHHH	20.27	20068231
1006	Phosphorylation	LSGGTTMYPGMAHRM ECCCCCCCCCHHHHH	8.44	19534553
1059	Ubiquitination	FQQMWISKQEYDESG HHHHHHHCCCCCCCC	37.71	-
1062	Phosphorylation	MWISKQEYDESGPSI HHHHCCCCCCCCCCC	23.63	23401153
1065	Phosphorylation	SKQEYDESGPSIVHR HCCCCCCCCCCCCCC	53.78	23401153
1068	Phosphorylation	EYDESGPSIVHRKCL CCCCCCCCCCCCCCC	40.54	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of POTEF_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POTEF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POTEF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of POTEF_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POTEF_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1006, AND MASSSPECTROMETRY.	19534553 [Abstract]