POTEC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POTEC_HUMAN
• UniProt AC: B2RU33
• Protein Name: POTE ankyrin domain family member C
• Gene Name: POTEC
• Organism: Homo sapiens (Human).
• Sequence Length: 542
• Protein Sequence: MVTEVCSMPAASAVKKPFDLRSKMGKWFHHRFPCCKGSGKSNMGTSGDHDDSFMKMLRSKMGKCCHHCFPCCRGSGTSNVGTSGDHDNSFMKTLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADQNIPDEYGNTTLHYAVHNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRRSRKPENQQFPDTENEEYHSDEQNDTRKQLSEEQNTGISQDEILTNKQKQIEVAEKKMNSELSLSHKKEEDLLRENSMLQEEIAMLISGDWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVTEVCSMPAASAV -CCCCCCCCCCHHHC	32.73	25627689
12	Phosphorylation	VCSMPAASAVKKPFD CCCCCCHHHCCCCCC	35.38	25627689
52	Phosphorylation	TSGDHDDSFMKMLRS CCCCCCHHHHHHHHH	33.04	-
114	Ubiquitination	PCCRGSGKSNVGAWG CCCCCCCCCCCCCCC	40.32	32142685
175	Phosphorylation	KRDKQKRTALHLASA HHHHHHHHHHHHHHC	40.38	-
267	Phosphorylation	LYGADIESKNKCGLT HHCCCCCCCCCCCCH	41.69	26074081
268	Ubiquitination	YGADIESKNKCGLTP HCCCCCCCCCCCCHH	47.86	-
295	Ubiquitination	VKFLIKKKANLNALD HHHHHHHHCCCCHHH	37.19	-
344	Phosphorylation	SGQTAREYAVSSHHH CCCHHHHHHHHCCHH	13.52	26270265
347	Phosphorylation	TAREYAVSSHHHVIC HHHHHHHHCCHHHHH	18.78	26270265
348	Phosphorylation	AREYAVSSHHHVICE HHHHHHHCCHHHHHH	21.90	26270265
358	Phosphorylation	HVICELLSDYKEKQM HHHHHHHCHHHHHHC	52.06	26270265
360	Phosphorylation	ICELLSDYKEKQMLK HHHHHCHHHHHHCHH	20.05	26270265
370	Phosphorylation	KQMLKISSENSNPEQ HHCHHCCCCCCCHHH	44.25	-
383	Phosphorylation	EQDLKLTSEEESQRL HHHCCCCCHHHHHHH	54.14	-
510	Phosphorylation	VAEKKMNSELSLSHK HHHHHHCCCHHHCCH	36.09	29083192
513	Phosphorylation	KKMNSELSLSHKKEE HHHCCCHHHCCHHHH	24.63	29083192
515	Phosphorylation	MNSELSLSHKKEEDL HCCCHHHCCHHHHHH	29.86	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POTEC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POTEC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POTEC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POTED_HUMAN	POTED	physical	28514442
UBP7_HUMAN	USP7	physical	28514442
KC1A_HUMAN	CSNK1A1	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
HERC3_HUMAN	HERC3	physical	28514442
BAG1_HUMAN	BAG1	physical	28514442
HMMR_HUMAN	HMMR	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.