HERC3_HUMAN - dbPTM
HERC3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HERC3_HUMAN
UniProt AC Q15034
Protein Name Probable E3 ubiquitin-protein ligase HERC3
Gene Name HERC3
Organism Homo sapiens (Human).
Sequence Length 1050
Subcellular Localization Cytoplasm. Cytoplasmic vesicle. Also found in vesicular-like structures.
Protein Description E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates..
Protein Sequence MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37UbiquitinationFISDRSVKEVACGGN
EECCCCCEEEECCCC		47.95-
63UbiquitinationYTCGLNTKGQLGHER
EEEECCCCCCCCCCC		43.52-
74UbiquitinationGHEREGNKPEQIGAL
CCCCCCCCHHHHHHH		61.87-
107PhosphorylationSDRGQLFSWGAGSDG
CCCCCEEEECCCCCC		32.94-
173UbiquitinationHGQLGLGKEFPSQAS
CCCCCCCCCCCCCCC		62.3121890473
173UbiquitinationHGQLGLGKEFPSQAS
CCCCCCCCCCCCCCC		62.3121890473
177PhosphorylationGLGKEFPSQASPQRV
CCCCCCCCCCCHHHH		43.64-
237UbiquitinationRESPCHVKLLRTQKV
CCCCCEEEEEEECEE		20.38-
278PhosphorylationCGQLGHDSMNDEVNP
CCCCCCCCCCCCCCH		17.51-
336UbiquitinationTGHTCNVKCPSPVKG
CCCCCCCCCCCCCCC		26.83-
342UbiquitinationVKCPSPVKGYWAAHS
CCCCCCCCCEEECCC		50.06-
353PhosphorylationAAHSGQLSARADRFK
ECCCCCCCCCHHHHH		14.0728857561
361PhosphorylationARADRFKYHIVKQIF
CCHHHHHHHHEEHHH		8.2822817900
374PhosphorylationIFSGGDQTFVLCSKY
HHCCCCCEEEEEECC		22.0522817900
444UbiquitinationNGSFLEKKIDEHFKT
CCHHHHHHHHHHHCC		46.12-
450UbiquitinationKKIDEHFKTSPKIPG
HHHHHHHCCCCCCCC		50.42-
454UbiquitinationEHFKTSPKIPGIDLN
HHHCCCCCCCCCCCC		62.39-
521PhosphorylationPLLQDSKYYITLTIP
CCCCCCCEEEEEEHH		12.2124043423
522PhosphorylationLLQDSKYYITLTIPL
CCCCCCEEEEEEHHH		7.3824043423
524PhosphorylationQDSKYYITLTIPLAM
CCCCEEEEEEHHHHH		11.1724043423
526PhosphorylationSKYYITLTIPLAMAI
CCEEEEEEHHHHHHH		16.3424043423
563PhosphorylationFMKLVNLYKGAVLYL
HHHHHHHHHHHHHHH		11.3730257219
569PhosphorylationLYKGAVLYLLRGRKT
HHHHHHHHHHCCCCC		9.3330257219
662UbiquitinationFIFDAQAKTKMLQTD
EEECHHHCCCCCCCC		36.28-
816UbiquitinationFPLALYKKLLNVKPG
HHHHHHHHHHCCCCC		44.65-
821UbiquitinationYKKLLNVKPGLEDLK
HHHHHCCCCCHHHHH		32.0921890473
831PhosphorylationLEDLKELSPTEGRSL
HHHHHHHCCCCCCCH		30.7623090842
833PhosphorylationDLKELSPTEGRSLQE
HHHHHCCCCCCCHHH		47.9323090842
863PhosphorylationNFTICRESYGVIEQK
EEEEEHHHCCEECCC		14.08-
864PhosphorylationFTICRESYGVIEQKK
EEEEHHHCCEECCCE		15.62-
871UbiquitinationYGVIEQKKLIPGGDN
CCEECCCEECCCCCC		51.87-
880PhosphorylationIPGGDNVTVCKDNRQ
CCCCCCEEEECCCHH		26.83-
896PhosphorylationFVDAYVNYVFQISVH
HHHHHHHHEEEEEHH		7.81-
906PhosphorylationQISVHEWYTAFSSGF
EEEHHHHHHHHHCCC		5.79-
920UbiquitinationFLKVCGGKVLELFQP
CEEECCCEEEEECCH		29.00-
952UbiquitinationLEETAIYKGDYSATH
HHHHEEEECCCCCCC		38.91-
976UbiquitinationFHEFPLEKKKKFLLF
HHHCCHHHHCCEEEE		77.04-
985PhosphorylationKKFLLFLTGSDRIPI
CCEEEEEECCCCCEE		27.57-
1030UbiquitinationDLPKYSSKEILSARL
CCCCCCCHHHHHHHH		42.72-
1034PhosphorylationYSSKEILSARLTQAL
CCCHHHHHHHHHHHH		19.6024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HERC3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HERC3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HERC3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBQL2_HUMANUBQLN2physical
18535780
NDKB_HUMANNME2physical
18535780
UB2D1_HUMANUBE2D1physical
9575161
UB2L3_HUMANUBE2L3physical
9575161
TF65_HUMANRELAphysical
26476452
PSA4_HUMANPSMA4physical
26476452
PRS7_HUMANPSMC2physical
26476452
PRS6B_HUMANPSMC4physical
26476452
PRS8_HUMANPSMC5physical
26476452
PSMD2_HUMANPSMD2physical
26476452
PSMD4_HUMANPSMD4physical
26476452
UBQL1_HUMANUBQLN1physical
26476452
NUDC2_HUMANNUDCD2physical
28514442
GUAD_HUMANGDAphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HERC3_HUMAN

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Related Literatures of Post-Translational Modification

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