SLAI1_HUMAN - dbPTM
SLAI1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLAI1_HUMAN
UniProt AC Q8ND83
Protein Name SLAIN motif-containing protein 1
Gene Name SLAIN1
Organism Homo sapiens (Human).
Sequence Length 568
Subcellular Localization Cytoplasm, cytoskeleton . Colocalizes with microtubules. Detected at the plus end of growing microtubules.
Protein Description Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation..
Protein Sequence MMAEQVKCASAGVSSGAGSGPVVNAELEVKKLQELVRKLEKQNEQLRSRAASAAAAPHLLLLPPPPPAAPPPAGLQPLGPRSPPAATATAAASGGLGPAFPGTFCLPSPAPSLLCSLAQPPEAPFVYFKPAAGFFGAGGGGPEPGGAGTPPGAAAAPPSPPPTLLDEVELLDLESVAAWRDEDDYTWLYIGSSKTFTSSEKSLTPLQWCRHVLDNPTPEMEAARRSLCFRLEQGYTSRGSPLSPQSSIDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASVSRHSSSVSLSSGKKGTCSDQEYDQYSLEDEEEFDHLPPPQPRLPRCSPFQRGIPHSQTFSSIRECRRSPSSQYFPSNNYQQQQYYSPQAQTPDQQPNRTNGDKLRRSMPNLARMPSTTAISSNISSPVTVRNSQSFDSSLHGAGNGISRIQSCIPSPGQLQHRVHSVGHFPVSIRQPLKATAYVSPTVQGSSNMPLSNGLQLYSNTGIPTPNKAAASGIMGRSALPRPSLAINGSNLPRSKIAQPVRSFLQPPKPLSSLSTLRDGNWRDGCY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81MethylationGLQPLGPRSPPAATA
CCCCCCCCCCCCHHH		61.06-
202PhosphorylationTFTSSEKSLTPLQWC
EECCCCCCCCHHHHH		33.1630108239
204PhosphorylationTSSEKSLTPLQWCRH
CCCCCCCCHHHHHHH		29.1030108239
217PhosphorylationRHVLDNPTPEMEAAR
HHHHHCCCHHHHHHH		37.8328555341
236PhosphorylationFRLEQGYTSRGSPLS
HHHHCCCCCCCCCCC		20.8327732954
237PhosphorylationRLEQGYTSRGSPLSP
HHHCCCCCCCCCCCC		26.5927732954
240PhosphorylationQGYTSRGSPLSPQSS
CCCCCCCCCCCCCHH		22.8928450419
243PhosphorylationTSRGSPLSPQSSIDS
CCCCCCCCCCHHCCC		25.0328450419
246PhosphorylationGSPLSPQSSIDSELS
CCCCCCCHHCCCCCC		32.4228450419
247PhosphorylationSPLSPQSSIDSELST
CCCCCCHHCCCCCCC		25.7624719451
250PhosphorylationSPQSSIDSELSTSEL
CCCHHCCCCCCCCCC		38.4728450419
253PhosphorylationSSIDSELSTSELEDD
HHCCCCCCCCCCCCC		26.3228450419
254PhosphorylationSIDSELSTSELEDDS
HCCCCCCCCCCCCCC		38.5528450419
255PhosphorylationIDSELSTSELEDDSI
CCCCCCCCCCCCCCC		36.4928348404
266PhosphorylationDDSISMGYKLQDLTD
CCCCCCCCCHHCCCH		10.4118083107
277SulfoxidationDLTDVQIMARLQEES
CCCHHHHHHHHHHHH		0.7121406390
289PhosphorylationEESLRQDYASTSASV
HHHHHHHHHHCCHHH		8.3028796482
291PhosphorylationSLRQDYASTSASVSR
HHHHHHHHCCHHHHC		19.3728796482
291O-linked_GlycosylationSLRQDYASTSASVSR
HHHHHHHHCCHHHHC		19.3723301498
292PhosphorylationLRQDYASTSASVSRH
HHHHHHHCCHHHHCC		21.8228796482
293PhosphorylationRQDYASTSASVSRHS
HHHHHHCCHHHHCCC		18.9528796482
293O-linked_GlycosylationRQDYASTSASVSRHS
HHHHHHCCHHHHCCC		18.9523301498
295PhosphorylationDYASTSASVSRHSSS
HHHHCCHHHHCCCCC		22.0127251275
297PhosphorylationASTSASVSRHSSSVS
HHCCHHHHCCCCCEE		23.0627251275
300PhosphorylationSASVSRHSSSVSLSS
CHHHHCCCCCEECCC		24.1727732954
301PhosphorylationASVSRHSSSVSLSSG
HHHHCCCCCEECCCC		28.7427732954
302PhosphorylationSVSRHSSSVSLSSGK
HHHCCCCCEECCCCC		20.8127732954
304PhosphorylationSRHSSSVSLSSGKKG
HCCCCCEECCCCCCC		25.2027732954
306PhosphorylationHSSSVSLSSGKKGTC
CCCCEECCCCCCCCC		29.5527732954
307PhosphorylationSSSVSLSSGKKGTCS
CCCEECCCCCCCCCC		60.9827732954
309AcetylationSVSLSSGKKGTCSDQ
CEECCCCCCCCCCCC		50.4025953088
312PhosphorylationLSSGKKGTCSDQEYD
CCCCCCCCCCCCCCC		20.0927732954
314PhosphorylationSGKKGTCSDQEYDQY
CCCCCCCCCCCCCCC		42.0127732954
318PhosphorylationGTCSDQEYDQYSLED
CCCCCCCCCCCCCCC		11.6027251275
321PhosphorylationSDQEYDQYSLEDEEE
CCCCCCCCCCCCHHH		16.6027732954
322PhosphorylationDQEYDQYSLEDEEEF
CCCCCCCCCCCHHHH		21.4628985074
347MethylationPRCSPFQRGIPHSQT
CCCCCCCCCCCCCCC		45.44115387733
352PhosphorylationFQRGIPHSQTFSSIR
CCCCCCCCCCHHHHH		26.0927080861
354PhosphorylationRGIPHSQTFSSIREC
CCCCCCCCHHHHHHH		28.6228857561
356PhosphorylationIPHSQTFSSIRECRR
CCCCCCHHHHHHHHC		28.3927080861
357PhosphorylationPHSQTFSSIRECRRS
CCCCCHHHHHHHHCC		22.8227080861
364PhosphorylationSIRECRRSPSSQYFP
HHHHHHCCCCHHCCC		15.1326552605
366PhosphorylationRECRRSPSSQYFPSN
HHHHCCCCHHCCCCC		31.1826552605
367PhosphorylationECRRSPSSQYFPSNN
HHHCCCCHHCCCCCC		32.0826552605
369PhosphorylationRRSPSSQYFPSNNYQ
HCCCCHHCCCCCCCC		21.2926552605
372PhosphorylationPSSQYFPSNNYQQQQ
CCHHCCCCCCCCCCE		28.0126552605
375PhosphorylationQYFPSNNYQQQQYYS
HCCCCCCCCCCEEEC		16.3726552605
380PhosphorylationNNYQQQQYYSPQAQT
CCCCCCEEECCCCCC		11.1126552605
381PhosphorylationNYQQQQYYSPQAQTP
CCCCCEEECCCCCCC		14.9926552605
382PhosphorylationYQQQQYYSPQAQTPD
CCCCEEECCCCCCCC		12.9526552605
387PhosphorylationYYSPQAQTPDQQPNR
EECCCCCCCCCCCCC		31.6726552605
403PhosphorylationNGDKLRRSMPNLARM
CHHHHHHHCCCHHCC		31.9627499020
412PhosphorylationPNLARMPSTTAISSN
CCHHCCCCCCCCCCC		29.1024043423
413O-linked_GlycosylationNLARMPSTTAISSNI
CHHCCCCCCCCCCCC		17.8623301498
413PhosphorylationNLARMPSTTAISSNI
CHHCCCCCCCCCCCC		17.8628122231
414O-linked_GlycosylationLARMPSTTAISSNIS
HHCCCCCCCCCCCCC		26.7423301498
414PhosphorylationLARMPSTTAISSNIS
HHCCCCCCCCCCCCC		26.7424043423
417PhosphorylationMPSTTAISSNISSPV
CCCCCCCCCCCCCCE		18.1824043423
418PhosphorylationPSTTAISSNISSPVT
CCCCCCCCCCCCCEE		31.8824043423
421PhosphorylationTAISSNISSPVTVRN
CCCCCCCCCCEEEEC		32.6024043423
422PhosphorylationAISSNISSPVTVRNS
CCCCCCCCCEEEECC		21.4224043423
425PhosphorylationSNISSPVTVRNSQSF
CCCCCCEEEECCCCC		19.6828122231
429PhosphorylationSPVTVRNSQSFDSSL
CCEEEECCCCCCHHC		19.3522496350
431O-linked_GlycosylationVTVRNSQSFDSSLHG
EEEECCCCCCHHCCC		30.7323301498
431PhosphorylationVTVRNSQSFDSSLHG
EEEECCCCCCHHCCC		30.7323401153
434PhosphorylationRNSQSFDSSLHGAGN
ECCCCCCHHCCCCCC		32.5630108239
435O-linked_GlycosylationNSQSFDSSLHGAGNG
CCCCCCHHCCCCCCC		26.6523301498
435PhosphorylationNSQSFDSSLHGAGNG
CCCCCCHHCCCCCCC		26.6530108239
452PhosphorylationRIQSCIPSPGQLQHR
HHHHCCCCCCCCEEE		23.0428674419
462PhosphorylationQLQHRVHSVGHFPVS
CCEEEEEECCCCCCE		27.2628450419
471Asymmetric dimethylarginineGHFPVSIRQPLKATA
CCCCCEECCCCEEEE		25.26-
471MethylationGHFPVSIRQPLKATA
CCCCCEECCCCEEEE		25.2654549505
475MethylationVSIRQPLKATAYVSP
CEECCCCEEEEEECC		50.83115917045
477PhosphorylationIRQPLKATAYVSPTV
ECCCCEEEEEECCCC		19.5526552605
479PhosphorylationQPLKATAYVSPTVQG
CCCEEEEEECCCCCC		9.3426552605
481PhosphorylationLKATAYVSPTVQGSS
CEEEEEECCCCCCCC		11.3726552605
483PhosphorylationATAYVSPTVQGSSNM
EEEEECCCCCCCCCC		20.2526552605
487PhosphorylationVSPTVQGSSNMPLSN
ECCCCCCCCCCCCCC		11.0526552605
488PhosphorylationSPTVQGSSNMPLSNG
CCCCCCCCCCCCCCC		43.9326552605
493PhosphorylationGSSNMPLSNGLQLYS
CCCCCCCCCCEEEEE		23.9926552605
499PhosphorylationLSNGLQLYSNTGIPT
CCCCEEEEECCCCCC		6.2126552605
500PhosphorylationSNGLQLYSNTGIPTP
CCCEEEEECCCCCCC		36.1926552605
502PhosphorylationGLQLYSNTGIPTPNK
CEEEEECCCCCCCCH		30.4626552605
506PhosphorylationYSNTGIPTPNKAAAS
EECCCCCCCCHHHHC		37.2626552605
513PhosphorylationTPNKAAASGIMGRSA
CCCHHHHCCCCCCCC		24.9126552605
518MethylationAASGIMGRSALPRPS
HHCCCCCCCCCCCCC		11.02115917049
519PhosphorylationASGIMGRSALPRPSL
HCCCCCCCCCCCCCE		28.5524719451
543MethylationSKIAQPVRSFLQPPK
HHCCHHHHHHCCCCC		28.51-
543Asymmetric dimethylarginineSKIAQPVRSFLQPPK
HHCCHHHHHHCCCCC		28.51-
544PhosphorylationKIAQPVRSFLQPPKP
HCCHHHHHHCCCCCC		30.46-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLAI1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLAI1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLAI1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SLAI1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLAI1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND MASSSPECTROMETRY.

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