PZRN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PZRN3_HUMAN
• UniProt AC: Q9UPQ7
• Protein Name: E3 ubiquitin-protein ligase PDZRN3
• Gene Name: PDZRN3
• Organism: Homo sapiens (Human).
• Sequence Length: 1066
• Subcellular Localization: Cell junction, synapse . Cytoplasm . Localizes to the postsynaptic region of neuromuscular junctions.
• Protein Description: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation..
• Protein Sequence: MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAEGISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	PWVVQEGSCPARCRG HHHHHCCCCCHHHCC	19.04	27251275
221	Phosphorylation	LRYQKKFTEYSARLD HHHHHHHHHHHHHHH	42.78	23663014
223	Phosphorylation	YQKKFTEYSARLDSL HHHHHHHHHHHHHHH	12.46	23663014
224	Phosphorylation	QKKFTEYSARLDSLS HHHHHHHHHHHHHHH	10.73	23663014
229	Phosphorylation	EYSARLDSLSRCVAA HHHHHHHHHHHHEEC	32.60	24719451
231	Phosphorylation	SARLDSLSRCVAAPP HHHHHHHHHHEECCC	27.82	22673903
247	Phosphorylation	GKGEETKSLTLVLHR CCCCCCEEEEEEEEC	33.72	23312004
249	Phosphorylation	GEETKSLTLVLHRDS CCCCEEEEEEEECCC	23.16	23312004
346	Phosphorylation	TPRTKMFTPPSESQL CCCCCCCCCCCHHHC	30.69	28348404
427	Phosphorylation	VDLYRMNSQDKLGLT HHHEECCCCCCCCCE	30.34	24719451
489	Phosphorylation	EEAVALLTSEENKNF HHHHEEECCCCCCCE	34.64	18452278
574	Phosphorylation	KDSGVGRTDESTRND CCCCCCCCCCCCCCC	37.88	30177828
577	Phosphorylation	GVGRTDESTRNDESS CCCCCCCCCCCCCCC	35.16	30177828
578	Phosphorylation	VGRTDESTRNDESSE CCCCCCCCCCCCCCC	31.29	30177828
583	Phosphorylation	ESTRNDESSEQENNG CCCCCCCCCCCCCCC	41.88	25850435
584	Phosphorylation	STRNDESSEQENNGD CCCCCCCCCCCCCCC	41.05	25850435
594	Phosphorylation	ENNGDDATASSNPLA CCCCCCCCHHCCCCC	33.78	25850435
676	Phosphorylation	GPLDAGKSDPESVDK CCCCCCCCCHHHHHH	58.44	29507054
701	Phosphorylation	SIELECLSIVRAHKM HHHHHHHHHHHHHHH	30.60	24719451
731	Phosphorylation	SGFRNYNTSIDVRRH CCCCCCCEECEEEHH	19.39	28348404
732	Phosphorylation	GFRNYNTSIDVRRHE CCCCCCEECEEEHHH	17.10	28348404
750	Phosphorylation	ITELPEKSDKDSSSA CCCCCCCCCCCCCCC	48.51	30576142
754	Phosphorylation	PEKSDKDSSSAYNTG CCCCCCCCCCCCCCC	31.75	30576142
755	Phosphorylation	EKSDKDSSSAYNTGE CCCCCCCCCCCCCCC	29.17	30576142
756	Phosphorylation	KSDKDSSSAYNTGES CCCCCCCCCCCCCCC	38.43	30576142
758	Phosphorylation	DKDSSSAYNTGESCR CCCCCCCCCCCCCCC	18.40	30576142
760	Phosphorylation	DSSSAYNTGESCRST CCCCCCCCCCCCCCC	29.65	30576142
763	Phosphorylation	SAYNTGESCRSTPLT CCCCCCCCCCCCCEE	19.04	30576142
766	Phosphorylation	NTGESCRSTPLTLEI CCCCCCCCCCEEEEE	38.41	29052541
767	Phosphorylation	TGESCRSTPLTLEIS CCCCCCCCCEEEEEC	11.72	29052541
770	Phosphorylation	SCRSTPLTLEISPDN CCCCCCEEEEECCCC	24.45	29255136
774	Phosphorylation	TPLTLEISPDNSLRR CCEEEEECCCCHHHH	19.47	19664994
778	Phosphorylation	LEISPDNSLRRAAEG EEECCCCHHHHHHCC	30.54	24670416
819	Phosphorylation	TEDPEVGTPTYSPSL CCCCCCCCCCCCCCH	20.03	24719451
821	Phosphorylation	DPEVGTPTYSPSLKE CCCCCCCCCCCCHHH	36.15	27732954
822	Phosphorylation	PEVGTPTYSPSLKEL CCCCCCCCCCCHHHC	21.56	27732954
823	Phosphorylation	EVGTPTYSPSLKELD CCCCCCCCCCHHHCC	15.53	27251275
825	Phosphorylation	GTPTYSPSLKELDPN CCCCCCCCHHHCCCC	46.24	27251275
837	Phosphorylation	DPNQPLESKERRASD CCCCCCCCHHHHHCC	47.72	25159151
846	Phosphorylation	ERRASDGSRSPTPSQ HHHHCCCCCCCCHHH	34.28	28102081
848	Phosphorylation	RASDGSRSPTPSQKL HHCCCCCCCCHHHHH	34.52	26657352
850	Phosphorylation	SDGSRSPTPSQKLGS CCCCCCCCHHHHHCC	36.50	28102081
859	Phosphorylation	SQKLGSAYLPSYHHS HHHHCCCCCCCCCCC	22.35	27732954
862	Phosphorylation	LGSAYLPSYHHSPYK HCCCCCCCCCCCCCC	34.21	27732954
863	Phosphorylation	GSAYLPSYHHSPYKH CCCCCCCCCCCCCCC	11.12	27732954
866	Phosphorylation	YLPSYHHSPYKHAHI CCCCCCCCCCCCCCC	19.33	27732954
868	Phosphorylation	PSYHHSPYKHAHIPA CCCCCCCCCCCCCCH	20.58	27732954
898	Phosphorylation	SAVEYAQSQMSLVSM HHHHHHHHHHHHHHH	21.48	27251275
901	Phosphorylation	EYAQSQMSLVSMCKD HHHHHHHHHHHHHCC	20.27	28348404
910	Phosphorylation	VSMCKDLSSPTPSEP HHHHCCCCCCCCCCC	44.39	27732954
911	Phosphorylation	SMCKDLSSPTPSEPR HHHCCCCCCCCCCCC	39.84	27732954
913	Phosphorylation	CKDLSSPTPSEPRME HCCCCCCCCCCCCCE	41.20	27732954
915	Phosphorylation	DLSSPTPSEPRMEWK CCCCCCCCCCCCEEE	63.81	27251275
955	Phosphorylation	LKIREERSGMTTDDD HHHHHHHCCCCCCHH	35.87	29083192
958	Phosphorylation	REERSGMTTDDDAVS HHHHCCCCCCHHHHH	30.51	29083192
959	Phosphorylation	EERSGMTTDDDAVSE HHHCCCCCCHHHHHH	28.65	26471730
965	Phosphorylation	TTDDDAVSEMKMGRY CCCHHHHHHHHHHCC	33.42	29083192
972	Phosphorylation	SEMKMGRYWSKEERK HHHHHHCCCCHHHHH	14.33	29083192
974	Phosphorylation	MKMGRYWSKEERKQH HHHHCCCCHHHHHHH	22.66	29083192
1023	Acetylation	NILELSHKKMMKKRN CHHHHHHHHHHHHHC	38.70	19815759
1045	Phosphorylation	MTIQELLTHGTKSPD HHHHHHHHCCCCCCC	30.77	24719451
1048	Phosphorylation	QELLTHGTKSPDGTR HHHHHCCCCCCCCCE	22.27	28348404
1050	Phosphorylation	LLTHGTKSPDGTRVY HHHCCCCCCCCCEEE	28.23	28348404
1062	Phosphorylation	RVYNSFLSVTTV--- EEECCCEEEEEC---	18.53	30257219
1064	Phosphorylation	YNSFLSVTTV----- ECCCEEEEEC-----	20.61	30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PZRN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PZRN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PZRN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUSK_HUMAN	MUSK	physical	17576800
UB2D2_HUMAN	UBE2D2	physical	17576800
DVL3_MOUSE	Dvl3	physical	25198863

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.