DVL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DVL3_MOUSE
• UniProt AC: Q61062
• Protein Name: Segment polarity protein dishevelled homolog DVL-3
• Gene Name: Dvl3
• Organism: Mus musculus (Mouse).
• Sequence Length: 716
• Subcellular Localization: Cytoplasm .
• Protein Description: Involved in the signal transduction pathway mediated by multiple Wnt genes..
• Protein Sequence: MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQENLDNDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLTSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LDGQETPYLVKLPLP CCCCCCCEEEECCCC	31.39	29514104
27	Methylation	KLPLPAERVTLADFK ECCCCHHHEEHHHHC	28.91	-
34	Ubiquitination	RVTLADFKGVLQRPS HEEHHHHCHHHCCCC	48.97	-
48	Phosphorylation	SYKFFFKSMDDDFGV CEEEEEEECCCCCCE	23.45	27180971
106	Phosphorylation	LPPSMERTGGIGDSR CCCCCCCCCCCCCCC	26.84	27087446
112	Phosphorylation	RTGGIGDSRPPSFHP CCCCCCCCCCCCCCC	41.28	26160508
116	Phosphorylation	IGDSRPPSFHPHASG CCCCCCCCCCCCCCC	38.58	26160508
122	Phosphorylation	PSFHPHASGGSQENL CCCCCCCCCCCCCCC	40.42	30352176
125	Phosphorylation	HPHASGGSQENLDND CCCCCCCCCCCCCCC	37.53	27087446
133	Phosphorylation	QENLDNDTETDSLVS CCCCCCCCHHHHHHH	47.22	30372032
135	Phosphorylation	NLDNDTETDSLVSAQ CCCCCCHHHHHHHHH	32.74	26160508
137	Phosphorylation	DNDTETDSLVSAQRE CCCCHHHHHHHHHHH	37.78	26643407
186	Phosphorylation	LMSSELETTSFFDSD HCCCCCEECCCCCCC	40.12	30635358
187	Phosphorylation	MSSELETTSFFDSDE CCCCCEECCCCCCCC	17.73	30635358
188	Phosphorylation	SSELETTSFFDSDED CCCCEECCCCCCCCC	31.19	30635358
192	Phosphorylation	ETTSFFDSDEDDSTS EECCCCCCCCCCCCC	37.43	22802335
197	Phosphorylation	FDSDEDDSTSRFSSS CCCCCCCCCCCCCCC	40.37	30635358
198	Phosphorylation	DSDEDDSTSRFSSST CCCCCCCCCCCCCCC	30.80	30635358
199	Phosphorylation	SDEDDSTSRFSSSTE CCCCCCCCCCCCCCC	34.97	30635358
203	Phosphorylation	DSTSRFSSSTEQSSA CCCCCCCCCCCHHHH	38.27	-
209	Phosphorylation	SSSTEQSSASRLMRR CCCCCHHHHHHHHHH	29.92	22006019
212	Methylation	TEQSSASRLMRRHKR CCHHHHHHHHHHHHH	32.02	-
242	Phosphorylation	FSSITDSTMSLNIIT CCCCCCCCCCEEEEE	17.37	-
271	Asymmetric dimethylarginine	IVGQSNERGDGGIYI EEECCCCCCCCCEEE	53.40	-
271	Methylation	IVGQSNERGDGGIYI EEECCCCCCCCCEEE	53.40	-
311	Phosphorylation	EINFENMSNDDAVRV EECCCCCCCHHHHHH	49.00	-
340	Phosphorylation	VAKCWDPSPRGCFTL EEECCCCCCCCCEEC	25.42	23684622
342	Symmetric dimethylarginine	KCWDPSPRGCFTLPR ECCCCCCCCCEECCC	59.87	-
342	Methylation	KCWDPSPRGCFTLPR ECCCCCCCCCEECCC	59.87	-
346	Phosphorylation	PSPRGCFTLPRSEPI CCCCCCEECCCCCCC	39.67	22006019
466	Ubiquitination	TDRREARKYASNLLK CCHHHHHHHHHHHHH	52.82	-
473	Ubiquitination	KYASNLLKAGFIRHT HHHHHHHHHHHHHHH	50.02	-
598	Phosphorylation	PKAGDSKSGGSGSES CCCCCCCCCCCCCCC	52.95	26824392
601	Phosphorylation	GDSKSGGSGSESDHT CCCCCCCCCCCCCCC	42.54	26824392
603	Phosphorylation	SKSGGSGSESDHTTR CCCCCCCCCCCCCCH	35.31	29514104
605	Phosphorylation	SGGSGSESDHTTRSS CCCCCCCCCCCCHHH	36.07	27841257
612	Phosphorylation	SDHTTRSSLRGPRER CCCCCHHHCCCCCCC	20.85	29899451
614	Symmetric dimethylarginine	HTTRSSLRGPRERAP CCCHHHCCCCCCCCC	55.83	-
614	Methylation	HTTRSSLRGPRERAP CCCHHHCCCCCCCCC	55.83	-
622	Phosphorylation	GPRERAPSERSGPAA CCCCCCCCCCCCCCC	44.66	25338131
625	Phosphorylation	ERAPSERSGPAASEH CCCCCCCCCCCCCCC	45.11	25338131
639	Phosphorylation	HSHRSHHSLTSSLRS CCCCCHHCHHHHHHH	28.11	29176673
641	Phosphorylation	HRSHHSLTSSLRSHH CCCHHCHHHHHHHCC	21.20	29176673
642	Phosphorylation	RSHHSLTSSLRSHHT CCHHCHHHHHHHCCC	32.44	29176673
643	Phosphorylation	SHHSLTSSLRSHHTH CHHCHHHHHHHCCCC	23.67	28418008
695	Phosphorylation	ASVPPELTASRQSFR CCCCHHHHHCHHHHH	22.41	26824392
697	Phosphorylation	VPPELTASRQSFRMA CCHHHHHCHHHHHHH	26.14	26824392
698	Methylation	PPELTASRQSFRMAM CHHHHHCHHHHHHHC	33.43	-
700	Phosphorylation	ELTASRQSFRMAMGN HHHHCHHHHHHHCCC	17.45	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DVL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DVL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DVL3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VANG2_MOUSE	Vangl2	genetic	19008950
PZRN3_MOUSE	Pdzrn3	physical	25198863
PZRN3_HUMAN	PDZRN3	physical	25198863

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.