VANG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VANG2_MOUSE
• UniProt AC: Q91ZD4
• Protein Name: Vang-like protein 2
• Gene Name: Vangl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 521
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear. [PubMed: 16495441]
• Protein Sequence: MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGSRGDKSVTIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLDCSRHLGVAAGAILALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVISYWLFYGVRILDARERSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKFVMRLQSETSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDTESQYSGYSY ---CCCCCHHCCCCC	36.19	21316585
7	Phosphorylation	-MDTESQYSGYSYKS -CCCCCHHCCCCCCC	17.22	-
8	Phosphorylation	MDTESQYSGYSYKSG CCCCCHHCCCCCCCC	24.50	-
10	Phosphorylation	TESQYSGYSYKSGHS CCCHHCCCCCCCCCC	11.68	29514104
43	Phosphorylation	DGSRGDKSVTIQAPG CCCCCCCEEEEECCC	29.27	27566939
58	Phosphorylation	EPLLDNESTRGDERD CCCCCCCCCCCCCCC	29.65	28066266
59	Phosphorylation	PLLDNESTRGDERDD CCCCCCCCCCCCCCC	32.28	28066266
79	Phosphorylation	TTVVTGTSEHSISHD EEEEEECCCCCCCHH	34.36	25338131
82	Phosphorylation	VTGTSEHSISHDDLT EEECCCCCCCHHHHH	23.02	21316585
84	Phosphorylation	GTSEHSISHDDLTRI ECCCCCCCHHHHHHH	24.71	21316585
103	S-palmitoylation	EDSVPLDCSRHLGVA CCCCCCCHHHHHHHH	5.19	28680068
303	Phosphorylation	SVLAKKVSGFKVYSL HHHHHHCCCCEEEEC	47.60	-
308	Phosphorylation	KVSGFKVYSLGEENS HCCCCEEEECCCCCC	9.96	29514104
309	Phosphorylation	VSGFKVYSLGEENST CCCCEEEECCCCCCC	32.65	25338131
315	Phosphorylation	YSLGEENSTNNSTGQ EECCCCCCCCCCCHH	35.47	25338131
319	Phosphorylation	EENSTNNSTGQSRAV CCCCCCCCCHHHHHH	35.66	25338131
341	Phosphorylation	RDNSHNEYYYEEAEH CCCCCCCCCCHHHHH	19.37	29514104
379	Ubiquitination	RLQEEEQKNPREVMD HHHHHHHHCHHHHCC	72.67	27667366
464	Phosphorylation	AKQWTLVSEEPVTNG HHCEEECCCCCCCCC	39.08	21316586
492	Acetylation	FSLVVSTKKVPFFKL EEEEEECCCCCCEEC	44.24	6571649
507	Ubiquitination	SEEFVDPKSHKFVMR CHHHCCCCCCCHHHH	61.81	27667366
517	Phosphorylation	KFVMRLQSETSV--- CHHHHHHHCCCC---	47.65	25521595
519	Phosphorylation	VMRLQSETSV----- HHHHHHCCCC-----	39.78	29550500
520	Phosphorylation	MRLQSETSV------ HHHHHCCCC------	23.06	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	CSNK1D	Q9DC28	GPS
82	S	Phosphorylation	Kinase	CSNK1D	Q9DC28	GPS
84	S	Phosphorylation	Kinase	CSNK1D	Q9DC28	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VANG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VANG2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DVL2_MOUSE	Dvl2	genetic	16571627
DVL1_MOUSE	Dvl1	physical	15456783
DVL2_MOUSE	Dvl2	physical	15456783
DVL3_MOUSE	Dvl3	physical	15456783
SCRIB_MOUSE	Scrib	physical	16687519
FZD3_MOUSE	Fzd3	physical	16687519
RNF41_MOUSE	Rnf41	physical	28481871

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.