dbPTM

SCRIB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SCRIB_MOUSE
UniProt AC	Q80U72
Protein Name	Protein scribble homolog
Gene Name	Scrib
Organism	Mus musculus (Mouse).
Sequence Length	1612
Subcellular Localization	Cell membrane Peripheral membrane protein. Cell junction, adherens junction. Cytoplasm. Cell projection, lamellipodium. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post-
Protein Description	Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity..
Protein Sequence	MLKCIPLWRCNRHVESVDKRHCSLQVVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELGGLALLTDLLLSQNLLQRLPEGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLTALPHSLGKLTKLTNLNVDRNHLEVLPPEIGGCVALSVLSLRDNRLAVLPPELAHTAELHVLDVAGNRLRSLPFALTHLNLKALWLAENQAQPMLRFQTEDDAQTGEKVLTCYLLPQQPLPSLEDAGQQSSPSESCSDAPLSRVSVIQFEDTLEGEEDAEEAAAEKRGLQRRATPHPSELKVMKRGIEERRNEAFVCKPDPSPPSPSEEEKRLSAESALSGGSVPSASTASEGEPEILPAEVQGLGQHEAMPAQEEYTEDDYNEPTVHFAEDTLIPREDGESEEGQPEAAWPLPSGRQRLIRKDTPHYKKHFKISKLPQPEAVVALLQGVQTDREGPTAGWHNGPHTPWAPRAHEEEEEEEEENRDEEEGEATTEEDDKEEAVASAPSVKGVSFDQANNLLIEPARIEEEELTLTIVRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQDAEHHEAVEALRGAGAAVQMRVWRERMVEPENAVTITPLRPEDDYSPREWRGGGLRLPLLQPETPVSLRQRHAACLVRSEKGLGFSIAGGKGSTPYRAGDGGIFISRIAEGGAAHRAGTLQVGDRVLSINGVDMTEARHDHAVSLLTAASPTISLLLERETGGTYPPSPPPHSSPTPAATVAATVSTAVPGEPLLPRLSPSLLATALEGPYPVEEICLPRAGGPLGLSIVGGSDHSSHPFGVQDPGVFISKVLPRGLAARCGLRVGDRILAVNGQDVREATHQEAVSALLRPCLELCLLVRRDPPPPGMRELCIQKAPGEKLGISIRGGAKGHAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHAEAVQLLRSVGDTLTVLVCDGFDTSTTTALEVSPGVIANPFAAGLGHRNSLESISSIDRELSPEGPGKEKELASQALPWESESAETTGRNLEPLKLDYRALAALPSAGSLQRGPSATTGGKTTEAPCSPGSQQPPSPDELPANVKQAYRAFAAVPTVHPPENSATQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREEAVTSGPDMGLASDRESPDDQQEAEQPWAVPSHAGGSSPSSPPPLGGNAPVRTAKAERRHQERLRMQSPELPAPERALSPAERRALEAEKRALWRAARMKSLEQDALRAQMVLSKSQEGRGKRGPLERLAEAPSPAPTPSPTPLEDFGLQTSASPGRLSPDFVEELRTLEASPSPGSQEEDGEVALVLLGRPSPGAVGPEDMTLCSSRRSVRPGRRGLGPVPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	SVDKRHCSLQVVPEE HCCCCCCCEEECCHH	18.73	22817900
34	Phosphorylation	VPEEIYRYSRSLEEL CCHHHHHHCCCHHHH	7.46	26239621
35	Phosphorylation	PEEIYRYSRSLEELL CHHHHHHCCCHHHHH	13.34	26239621
37	Phosphorylation	EIYRYSRSLEELLLD HHHHHCCCHHHHHCC	33.90	21082442
53	Ubiquitination	NQLRELPKPFFRLLN HHHHCCCHHHHHHHH	68.06	22790023
53 (in isoform 3)	Ubiquitination	-	68.06	22790023
105	Ubiquitination	PESIKFCKALEIADF CHHHHHHHHHHEECC	60.17	22790023
105 (in isoform 3)	Ubiquitination	-	60.17	22790023
164	Ubiquitination	ELRENLLKSLPASLS HHHHHHHHHCCHHHH	53.78	22790023
164 (in isoform 3)	Ubiquitination	-	53.78	22790023
224	S-palmitoylation	GNLRRLVCLDVSENR CCCCEEEEEECCCCH	2.96	28526873
269	Phosphorylation	IGQLKQLSILKVDQN CHHHHHHEEEEECHH	24.31	23140645
378	Phosphorylation	RSLPFALTHLNLKAL HHCCHHHHHHCHHHH	22.38	-
412	Phosphorylation	QTGEKVLTCYLLPQQ HCCCEEEEEEECCCC	11.33	25293948
414	Phosphorylation	GEKVLTCYLLPQQPL CCEEEEEEECCCCCC	13.16	25293948
423	Phosphorylation	LPQQPLPSLEDAGQQ CCCCCCCCHHHCCCC	52.66	25293948
431	Phosphorylation	LEDAGQQSSPSESCS HHHCCCCCCCCCCCC	36.01	26643407
432	Phosphorylation	EDAGQQSSPSESCSD HHCCCCCCCCCCCCC	28.27	26643407
434	Phosphorylation	AGQQSSPSESCSDAP CCCCCCCCCCCCCCC	44.05	26643407
436	Phosphorylation	QQSSPSESCSDAPLS CCCCCCCCCCCCCCC	24.21	26643407
438	Phosphorylation	SSPSESCSDAPLSRV CCCCCCCCCCCCCCE	46.19	25293948
443	Phosphorylation	SCSDAPLSRVSVIQF CCCCCCCCCEEEEEE	29.58	25293948
446	Phosphorylation	DAPLSRVSVIQFEDT CCCCCCEEEEEEECC	16.64	28066266
453	Phosphorylation	SVIQFEDTLEGEEDA EEEEEECCCCCCHHH	21.36	26370283
475	Phosphorylation	RGLQRRATPHPSELK HCCCHHCCCCHHHHH	21.96	26824392
479	Phosphorylation	RRATPHPSELKVMKR HHCCCCHHHHHHHHH	53.15	28725479
503	Phosphorylation	FVCKPDPSPPSPSEE CEECCCCCCCCCCHH	57.74	27742792
506	Phosphorylation	KPDPSPPSPSEEEKR CCCCCCCCCCHHHHH	44.43	25521595
508	Phosphorylation	DPSPPSPSEEEKRLS CCCCCCCCHHHHHHC	63.08	25521595
583	Phosphorylation	IPREDGESEEGQPEA EECCCCCCCCCCCCC	46.61	25521595
606	Phosphorylation	QRLIRKDTPHYKKHF HHHHCCCCCHHHHHC	18.26	27149854
674	Phosphorylation	DEEEGEATTEEDDKE CHHCCCCCCCHHHHH	30.36	23684622
675	Phosphorylation	EEEGEATTEEDDKEE HHCCCCCCCHHHHHH	44.41	23684622
686	Phosphorylation	DKEEAVASAPSVKGV HHHHHHHCCCCCCCC	33.83	23984901
689	Phosphorylation	EAVASAPSVKGVSFD HHHHCCCCCCCCCHH	35.86	25159016
694	Phosphorylation	APSVKGVSFDQANNL CCCCCCCCHHHHCCE	31.60	28973931
727	Phosphorylation	QTGGLGISIAGGKGS ECCCCCEEECCCCCC	12.46	25338131
734	Phosphorylation	SIAGGKGSTPYKGDD EECCCCCCCCCCCCC	29.69	28066266
735	Phosphorylation	IAGGKGSTPYKGDDE ECCCCCCCCCCCCCC	39.03	28066266
737	Phosphorylation	GGKGSTPYKGDDEGI CCCCCCCCCCCCCCE	27.91	26643407
747	Phosphorylation	DDEGIFISRVSEEGP CCCCEEEEEECCCCH	18.84	26643407
750	Phosphorylation	GIFISRVSEEGPAAR CEEEEEECCCCHHHH	28.90	27600695
810	Phosphorylation	VEPENAVTITPLRPE CCCCCCEEECCCCCC	19.40	28066266
812	Phosphorylation	PENAVTITPLRPEDD CCCCEEECCCCCCCC	13.60	29472430
820	Phosphorylation	PLRPEDDYSPREWRG CCCCCCCCCCCCCCC	32.66	21082442
821	Phosphorylation	LRPEDDYSPREWRGG CCCCCCCCCCCCCCC	25.19	26824392
839	Phosphorylation	LPLLQPETPVSLRQR CCCCCCCCCCCHHHH	35.36	26824392
842	Phosphorylation	LQPETPVSLRQRHAA CCCCCCCCHHHHHHH	21.02	23984901
854	Phosphorylation	HAACLVRSEKGLGFS HHHHEEECCCCCCEE	35.86	29514104
861	Phosphorylation	SEKGLGFSIAGGKGS CCCCCCEEECCCCCC	15.10	29514104
868	Phosphorylation	SIAGGKGSTPYRAGD EECCCCCCCCCCCCC	29.69	26643407
869	Phosphorylation	IAGGKGSTPYRAGDG ECCCCCCCCCCCCCC	32.76	26643407
871	Phosphorylation	GGKGSTPYRAGDGGI CCCCCCCCCCCCCCE	17.12	26643407
922	Phosphorylation	DHAVSLLTAASPTIS HHHHHHHHHCCHHHH	26.02	26239621
925	Phosphorylation	VSLLTAASPTISLLL HHHHHHCCHHHHHEE	21.80	26824392
927	Phosphorylation	LLTAASPTISLLLER HHHHCCHHHHHEEEC	22.24	26239621
929	Phosphorylation	TAASPTISLLLERET HHCCHHHHHEEECCC	18.55	23984901
936	Phosphorylation	SLLLERETGGTYPPS HHEEECCCCCCCCCC	47.32	26239621
939	Phosphorylation	LERETGGTYPPSPPP EECCCCCCCCCCCCC	33.91	26239621
940	Phosphorylation	ERETGGTYPPSPPPH ECCCCCCCCCCCCCC	19.20	26239621
943	Phosphorylation	TGGTYPPSPPPHSSP CCCCCCCCCCCCCCC	45.60	21082442
948	Phosphorylation	PPSPPPHSSPTPAAT CCCCCCCCCCCCCHH	43.73	26643407
949	Phosphorylation	PSPPPHSSPTPAATV CCCCCCCCCCCCHHE	29.74	26643407
951	Phosphorylation	PPPHSSPTPAATVAA CCCCCCCCCCHHEEE	27.75	26643407
955	Phosphorylation	SSPTPAATVAATVST CCCCCCHHEEEEEEC	16.88	26643407
959	Phosphorylation	PAATVAATVSTAVPG CCHHEEEEEECCCCC	12.78	26643407
961	Phosphorylation	ATVAATVSTAVPGEP HHEEEEEECCCCCCC	13.29	26643407
962	Phosphorylation	TVAATVSTAVPGEPL HEEEEEECCCCCCCC	27.60	21659605
974	Phosphorylation	EPLLPRLSPSLLATA CCCCCCCCHHHHHHH	17.45	26824392
976	Phosphorylation	LLPRLSPSLLATALE CCCCCCHHHHHHHHC	32.41	28507225
980	Phosphorylation	LSPSLLATALEGPYP CCHHHHHHHHCCCCC	31.57	26160508
986	Phosphorylation	ATALEGPYPVEEICL HHHHCCCCCHHHCCC	30.66	29119230
1096 (in isoform 3)	Malonylation	-	58.91	32601280
1100	Phosphorylation	PGEKLGISIRGGAKG CCCCCCEEECCCCCC	12.39	-
1123	Phosphorylation	TDEGIFISKVSPTGA CCCCEEEEEECCCCC	19.09	25619855
1126	Phosphorylation	GIFISKVSPTGAAGR CEEEEEECCCCCCCC	22.08	25619855
1128	Phosphorylation	FISKVSPTGAAGRDG EEEEECCCCCCCCCC	31.76	28066266
1206	Phosphorylation	AGLGHRNSLESISSI CCCCCCCCHHHHHHC	33.21	25521595
1209	Phosphorylation	GHRNSLESISSIDRE CCCCCHHHHHHCCHH	32.82	27087446
1211	Phosphorylation	RNSLESISSIDRELS CCCHHHHHHCCHHHC	30.44	27087446
1212	Phosphorylation	NSLESISSIDRELSP CCHHHHHHCCHHHCC	27.17	27087446
1218	Phosphorylation	SSIDRELSPEGPGKE HHCCHHHCCCCCCCH	19.02	25168779
1254	Phosphorylation	LEPLKLDYRALAALP CCCCCCCHHHHHCCC	14.28	29514104
1257 (in isoform 4)	Phosphorylation	-	1.80	26745281
1258 (in isoform 4)	Phosphorylation	-	13.13	26745281
1262	Phosphorylation	RALAALPSAGSLQRG HHHHCCCCCCCCCCC	46.22	28725479
1263 (in isoform 4)	Phosphorylation	-	15.06	26745281
1265	Phosphorylation	AALPSAGSLQRGPSA HCCCCCCCCCCCCCC	22.50	27087446
1266 (in isoform 4)	Phosphorylation	-	3.83	25293948
1269 (in isoform 4)	Phosphorylation	-	13.93	25293948
1271	Phosphorylation	GSLQRGPSATTGGKT CCCCCCCCCCCCCCC	40.86	24759943
1278	Phosphorylation	SATTGGKTTEAPCSP CCCCCCCCCCCCCCC	32.89	25619855
1278 (in isoform 3)	Phosphorylation	-	32.89	26745281
1279	Phosphorylation	ATTGGKTTEAPCSPG CCCCCCCCCCCCCCC	33.37	25619855
1279 (in isoform 3)	Phosphorylation	-	33.37	26745281
1284	Phosphorylation	KTTEAPCSPGSQQPP CCCCCCCCCCCCCCC	31.10	25521595
1284 (in isoform 3)	Phosphorylation	-	31.10	26745281
1285 (in isoform 4)	Phosphorylation	-	53.85	26643407
1287	Phosphorylation	EAPCSPGSQQPPSPD CCCCCCCCCCCCCCC	29.09	25521595
1287 (in isoform 3)	Phosphorylation	-	29.09	25293948
1290 (in isoform 3)	Phosphorylation	-	24.57	25293948
1291 (in isoform 4)	Methylation	-	54.90	24129315
1292	Phosphorylation	PGSQQPPSPDELPAN CCCCCCCCCCCCCCC	52.22	25521595
1296 (in isoform 4)	Phosphorylation	-	6.73	26745281
1299 (in isoform 4)	Phosphorylation	-	39.31	25521595
1306 (in isoform 3)	Phosphorylation	-	5.93	26643407
1312	Phosphorylation	RAFAAVPTVHPPENS HHHHCCCCCCCCCCC	25.50	25619855
1312 (in isoform 3)	Methylation	-	25.50	24129315
1317 (in isoform 3)	Phosphorylation	-	69.16	26745281
1319	Phosphorylation	TVHPPENSATQPPTP CCCCCCCCCCCCCCC	30.91	25619855
1320 (in isoform 3)	Phosphorylation	-	23.10	25521595
1321	Phosphorylation	HPPENSATQPPTPGP CCCCCCCCCCCCCCC	41.24	25619855
1325	Phosphorylation	NSATQPPTPGPAASP CCCCCCCCCCCCCCH	47.78	27087446
1331	Phosphorylation	PTPGPAASPEQLSFR CCCCCCCCHHHCCHH	30.95	27087446
1336	Phosphorylation	AASPEQLSFRERQKY CCCHHHCCHHHHHHE	23.19	25619855
1343	Phosphorylation	SFRERQKYFELEVRV CHHHHHHEEEEEEEC	8.24	29514104
1361	Phosphorylation	EGPPKRVSLVGADDL CCCCCEEEEECHHHH	22.75	26824392
1393	Phosphorylation	MLREEAVTSGPDMGL HHHHHHHHHCCCCCC	34.71	25338131
1402	Phosphorylation	GPDMGLASDRESPDD CCCCCCCCCCCCCCC	42.09	25338131
1406	Phosphorylation	GLASDRESPDDQQEA CCCCCCCCCCCHHHH	34.23	25338131
1421	Phosphorylation	EQPWAVPSHAGGSSP HCCCCCCCCCCCCCC	21.26	19060867
1426	Phosphorylation	VPSHAGGSSPSSPPP CCCCCCCCCCCCCCC	37.85	25293948
1427	Phosphorylation	PSHAGGSSPSSPPPL CCCCCCCCCCCCCCC	31.88	25293948
1429	Phosphorylation	HAGGSSPSSPPPLGG CCCCCCCCCCCCCCC	58.38	19060867
1430	Phosphorylation	AGGSSPSSPPPLGGN CCCCCCCCCCCCCCC	44.82	22006019
1457	Phosphorylation	QERLRMQSPELPAPE HHHHHHCCCCCCCCH	15.82	27087446
1468	Phosphorylation	PAPERALSPAERRAL CCCHHCCCHHHHHHH	22.53	29895711
1490	Phosphorylation	WRAARMKSLEQDALR HHHHHCHHHHHHHHH	28.00	25521595
1503	Phosphorylation	LRAQMVLSKSQEGRG HHHHHHHCCCCCCCC	20.89	24759943
1505	Phosphorylation	AQMVLSKSQEGRGKR HHHHHCCCCCCCCCC	30.04	22942356
1511	Acetylation	KSQEGRGKRGPLERL CCCCCCCCCCHHHHH	53.47	19858577
1523	Phosphorylation	ERLAEAPSPAPTPSP HHHHCCCCCCCCCCC	40.52	26824392
1527	Phosphorylation	EAPSPAPTPSPTPLE CCCCCCCCCCCCCHH	38.21	26824392
1529	Phosphorylation	PSPAPTPSPTPLEDF CCCCCCCCCCCHHHC	43.83	26824392
1531	Phosphorylation	PAPTPSPTPLEDFGL CCCCCCCCCHHHCCC	44.86	26824392
1540	Phosphorylation	LEDFGLQTSASPGRL HHHCCCCCCCCCCCC	31.16	25619855
1541	Phosphorylation	EDFGLQTSASPGRLS HHCCCCCCCCCCCCC	17.49	21082442
1543	Phosphorylation	FGLQTSASPGRLSPD CCCCCCCCCCCCCHH	27.88	26824392
1543 (in isoform 2)	Phosphorylation	-	27.88	29899451
1548	Phosphorylation	SASPGRLSPDFVEEL CCCCCCCCHHHHHHH	22.51	25521595
1557	Phosphorylation	DFVEELRTLEASPSP HHHHHHHHCCCCCCC	41.39	25293948
1561	Phosphorylation	ELRTLEASPSPGSQE HHHHCCCCCCCCCCC	19.28	26643407
1563	Phosphorylation	RTLEASPSPGSQEED HHCCCCCCCCCCCCC	39.12	26643407
1566	Phosphorylation	EASPSPGSQEEDGEV CCCCCCCCCCCCCCE	37.49	27818261
1571 (in isoform 3)	Phosphorylation	-	34.26	29899451
1573 (in isoform 2)	Phosphorylation	-	6.45	29899451
1582	Phosphorylation	LVLLGRPSPGAVGPE EEEECCCCCCCCCHH	34.31	25338131
1582 (in isoform 2)	Phosphorylation	-	34.31	30352176
1586 (in isoform 2)	Phosphorylation	-	19.06	27818261
1601 (in isoform 3)	Phosphorylation	-	29.24	29899451
1610 (in isoform 3)	Phosphorylation	-	7.44	30352176
1614 (in isoform 3)	Phosphorylation	-		27818261

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SCRIB_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SCRIB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SCRIB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VANG2_MOUSE	Vangl2	physical	16687519

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SCRIB_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1206; SER-1457 ANDSER-1548, AND MASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1361, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-674; THR-675 ANDSER-1206, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1548, AND MASSSPECTROMETRY.	15345747 [Abstract]