RNF41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF41_MOUSE
• UniProt AC: Q8BH75
• Protein Name: E3 ubiquitin-protein ligase NRDP1
• Gene Name: Rnf41
• Organism: Mus musculus (Mouse).
• Sequence Length: 317
• Protein Description: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. [PubMed: 19483718 Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages]
• Protein Sequence: MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
271	Phosphorylation	TRQMNRRYYENYVAK HHHHHHHHHHHHCHH	16.34	-
272	Phosphorylation	RQMNRRYYENYVAKR HHHHHHHHHHHCHHC	8.90	-
275	Phosphorylation	NRRYYENYVAKRIPG HHHHHHHHCHHCCCC	6.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Rnf41	Q8BH75	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF41_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BIRC6_MOUSE	Birc6	physical	19527720
UBP8_MOUSE	Usp8	physical	19527720
AR6P4_MOUSE	Arl6ip4	physical	18986647
KDM3B_MOUSE	Kdm3b	physical	18986647
RTN4_MOUSE	Rtn4	physical	18986647
COG2_MOUSE	Cog2	physical	18986647
HBB1_MOUSE	Hbb-b1	physical	18986647
OGFD1_MOUSE	Ogfod1	physical	18986647
SP130_MOUSE	Sap130	physical	18986647
SMCE1_MOUSE	Smarce1	physical	18986647
ENOPH_MOUSE	Enoph1	physical	18986647
DCLK2_MOUSE	Dclk2	physical	18986647
MYD88_MOUSE	Myd88	physical	19483718
IRAK1_MOUSE	Irak1	physical	19483718
TRAF6_MOUSE	Traf6	physical	19483718
TCAM1_MOUSE	Ticam1	physical	19483718
TBK1_MOUSE	Tbk1	physical	19483718
TRAF3_MOUSE	Traf3	physical	19483718
IRF3_MOUSE	Irf3	physical	19483718
CEBPB_MOUSE	Cebpb	physical	22707723
CL16A_MOUSE	Clec16a	physical	24949970
UB2D1_MOUSE	Ube2d1	physical	19483718
UBE2N_MOUSE	Ube2n	physical	19483718

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.