OGFD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OGFD1_MOUSE
• UniProt AC: Q3U0K8
• Protein Name: Prolyl 3-hydroxylase OGFOD1
• Gene Name: Ogfod1
• Organism: Mus musculus (Mouse).
• Sequence Length: 545
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation..
• Protein Sequence: MNGKRPADPGPARPMKKGKKQVSAEFSDAVTEEILRKQVAEAWSCRTPFSHEAIALDMDPFLHCVIPNFIQSQDFLEGLHKELLSLDFHEKYNDLYKFQQSDDLKNRKEPHISALRKLMFEDFRAWLSKVSGIDLEPTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEETSRLSISGWFYGPSLTRPPTYFEPPIPRNPHIPQDHEILYEWINPAYLEMDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPNKRFYEKAEENNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTEEGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHYTLVHDNTKTEFALDLFLYCGCEGWEPEYGGFTSYIAKGEDEELLIVNPENNSLALVYRDRETLRFVKHINHRSLEQSKAFPSRSGFWDFAFIYYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
371	Phosphorylation	KLHFLAPSEDDETEE EEEEECCCCCCCCCC	48.31	24899341
376	Phosphorylation	APSEDDETEEKGEGE CCCCCCCCCCCCCCC	57.34	29899451
400	Phosphorylation	EGTSRRPSGPENNQV CCCCCCCCCCCCCCC	66.23	26824392
411	Phosphorylation	NNQVAAGSHSQENGE CCCCCCCCCCCCCCC	18.42	25338131
413	Phosphorylation	QVAAGSHSQENGEQA CCCCCCCCCCCCCCC	40.67	25338131
429	Ubiquitination	PEAQEEEAKKESSVP HHHHHHHHHHHCCCC	31.34	27667366
471	Ubiquitination	DLFLYCGCEGWEPEY HHHHHCCCCCCCCCC	3.79	27667366
485	Ubiquitination	YGGFTSYIAKGEDEE CCCEEEEEEECCCCC	2.98	27667366
528	Ubiquitination	HRSLEQSKAFPSRSG CCCHHHHCCCCCCCC	54.46	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OGFD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OGFD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OGFD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of OGFD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.