SP130_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP130_MOUSE
• UniProt AC: Q8BIH0
• Protein Name: Histone deacetylase complex subunit SAP130
• Gene Name: Sap130
• Organism: Mus musculus (Mouse).
• Sequence Length: 1057
• Subcellular Localization: Nucleus.
• Protein Description: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity)..
• Protein Sequence: MSSQQFPRLGTPSPGLSQPPSQIASSGSAGLINQVATVNDEAGRDADVGTREHVGPSSSLPPREEKQEPVVVRPYPQVQMLPAHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHLIHQPIQSRPPVTTSSTIPPAVVATVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTLPSTTTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPPERSSLIPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSTITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTSGIQPAPIGTPGIHSAAPINTQGLQPAAMANQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSILRKKPATDGMAVRKTLLPPQPPDVATPRVESSMRSASGSPRPAGAKPKSEVHVSIATPVTVSLETISNQNAEQPTVAVPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVTPPITTIAATPTLSAPVGGTPSTVLGPPVPEIKVKEEAEPVDITRPVSTVPPLATNTVSPSLALLASNLSMPPSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSQQFPRL ------CCCCCCCCC	48.43	29109428
3	Phosphorylation	-----MSSQQFPRLG -----CCCCCCCCCC	39.60	29109428
11	Phosphorylation	QQFPRLGTPSPGLSQ CCCCCCCCCCCCCCC	25.78	25777480
13	Phosphorylation	FPRLGTPSPGLSQPP CCCCCCCCCCCCCCH	31.29	25777480
17	Phosphorylation	GTPSPGLSQPPSQIA CCCCCCCCCCHHHHH	46.70	25777480
21	Phosphorylation	PGLSQPPSQIASSGS CCCCCCHHHHHCCCC	40.68	25777480
25	Phosphorylation	QPPSQIASSGSAGLI CCHHHHHCCCCHHHC	36.54	25777480
26	Phosphorylation	PPSQIASSGSAGLIN CHHHHHCCCCHHHCC	27.95	25777480
28	Phosphorylation	SQIASSGSAGLINQV HHHHCCCCHHHCCEE	22.55	25777480
37	Phosphorylation	GLINQVATVNDEAGR HHCCEEEECCCCCCC	22.45	25777480
57	Phosphorylation	TREHVGPSSSLPPRE CCCCCCCCCCCCCCC	26.99	29895711
59	Phosphorylation	EHVGPSSSLPPREEK CCCCCCCCCCCCCCC	49.59	29895711
206	Methylation	IGASHLPRGAAAAAV ECCCCCCHHHHHHHH	54.46	-
274	Phosphorylation	VSATRAQSPVITTTA ECCCCCCCCEEEEHH	21.83	26824392
278	Phosphorylation	RAQSPVITTTAAHAA CCCCCEEEEHHHHHC	20.51	20469934
279	O-linked_Glycosylation	AQSPVITTTAAHAAD CCCCEEEEHHHHHCC	11.87	22517741
279	Phosphorylation	AQSPVITTTAAHAAD CCCCEEEEHHHHHCC	11.87	20469934
280	O-linked_Glycosylation	QSPVITTTAAHAADS CCCEEEEHHHHHCCC	17.13	51588417
280	Phosphorylation	QSPVITTTAAHAADS CCCEEEEHHHHHCCC	17.13	20469934
320	O-linked_Glycosylation	RDVTTRITLPSHPAL CCCCCEEECCCCCCC	29.35	22517741
323	Phosphorylation	TTRITLPSHPALGTP CCEEECCCCCCCCCH	45.26	28066266
329	Phosphorylation	PSHPALGTPKQQLHT CCCCCCCCHHHHHHH	28.32	26745281
413	Phosphorylation	KVVPQQITHTSPRIQ EECCCCCCCCCCCCC	18.11	30635358
415	Phosphorylation	VPQQITHTSPRIQPD CCCCCCCCCCCCCCC	31.60	26824392
416	Phosphorylation	PQQITHTSPRIQPDY CCCCCCCCCCCCCCC	12.46	25521595
428	Phosphorylation	PDYPPERSSLIPISG CCCCCCCCCCCEECC	28.03	26643407
429	Phosphorylation	DYPPERSSLIPISGH CCCCCCCCCCEECCC	36.22	26643407
434	Phosphorylation	RSSLIPISGHRASPN CCCCCEECCCCCCCC	24.16	26643407
439	Phosphorylation	PISGHRASPNPVAME EECCCCCCCCCEEEC	25.76	23527152
447	Phosphorylation	PNPVAMETRNDNRPS CCCEEECCCCCCCCC	22.99	26643407
679	Phosphorylation	RVESSMRSASGSPRP CCHHHHHCCCCCCCC	20.39	29899451
680	Phosphorylation	VESSMRSASGSPRPA CHHHHHCCCCCCCCC	13.93	24719451
681	Phosphorylation	ESSMRSASGSPRPAG HHHHHCCCCCCCCCC	40.84	25266776
683	Phosphorylation	SMRSASGSPRPAGAK HHHCCCCCCCCCCCC	18.42	26824392
840	Phosphorylation	SDLPPGASPRKKPRK HHCCCCCCCCCCCCC	31.02	22006019
853	Phosphorylation	RKQQHVISTEEGDMM CCCCCEEECCCCCCC	28.78	25619855
854	Phosphorylation	KQQHVISTEEGDMME CCCCEEECCCCCCCC	27.25	25619855
862	Phosphorylation	EEGDMMETNSTDDEK CCCCCCCCCCCHHHH	19.30	23684622
864	Phosphorylation	GDMMETNSTDDEKSA CCCCCCCCCHHHHHH	40.40	25521595
865	Phosphorylation	DMMETNSTDDEKSAA CCCCCCCCHHHHHHH	49.92	25521595
870	Phosphorylation	NSTDDEKSAAKSLLV CCCHHHHHHHHHHHH	31.26	25159016
884	Phosphorylation	VKAEKRKSPPKEYID HHHHHCCCCCHHHCC	50.93	27742792
889	Phosphorylation	RKSPPKEYIDEEGVR CCCCCHHHCCCCCCE	21.57	28066266
927	Phosphorylation	YHHFQRYSDVRVKEE HHHHHHHHCCCHHHH	31.64	25338131
1019	Phosphorylation	KLVMDQISEARDSML HHHHHHHHHHHHHHH	21.41	29895711

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP130_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP130_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP130_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SP130_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, AND MASSSPECTROMETRY.
PubMed: 19367708