TCAM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCAM1_MOUSE
• UniProt AC: Q80UF7
• Protein Name: TIR domain-containing adapter molecule 1
• Gene Name: Ticam1
• Organism: Mus musculus (Mouse).
• Sequence Length: 732
• Subcellular Localization: Cytoplasmic vesicle, autophagosome . Colocalizes with UBQLN1 in the autophagosome.
• Protein Description: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively..
• Protein Sequence: MDNPGPSLRGAFGILGALERDRLTHLKHKLGSLCSGSQESKLLHAMVLLALGQDTEARVSLESLKMNTVAQLVAHQWADMETTEGPEEPPDLSWTVARLYHLLAEENLCPASTRDMAYQVALRDFASQGDHQLGQLQNEAWDRCSSDIKGDPSGFQPLHSHQGSLQPPSASPAVTRSQPRPIDTPDWSWGHTLHSTNSTASLASHLEISQSPTLAFLSSHHGTHGPSKLCNTPLDTQEPQLVPEGCQEPEEISWPPSVETSVSLGLPHEISVPEVSPEEASPILPDALAAPDTSVHCPIECTELSTNSRSPLTSTTESVGKQWPITSQRSPQVPVGDDSLQNTTSSSPPAQPPSLQASPKLPPSPLSSASSPSSYPAPPTSTSPVLDHSETSDQKFYNFVVIHARADEQVALRIREKLETLGVPDGATFCEEFQVPGRGELHCLQDAIDHSGFTILLLTASFDCSLSLHQINHALMNSLTQSGRQDCVIPLLPLECSQAQLSPDTTRLLHSIVWLDEHSPIFARKVANTFKTQKLQAQRVRWKKAQEARTLKEQSIQLEAERQNVAAISAAYTAYVHSYRAWQAEMNKLGVAFGKNLSLGTPTPSWPGCPQPIPSHPQGGTPVFPYSPQPPSFPQPPCFPQPPSFPQPPSFPLPPVSSPQSQSFPSASSPAPQTPGPQPLIIHHAQMVQLGVNNHMWGHTGAQSSDDKTECSENPCMGPLTDQGEPLLETPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
209	Phosphorylation	LASHLEISQSPTLAF HHHHCEECCCCCHHH	18.41	-
310	Phosphorylation	ELSTNSRSPLTSTTE ECCCCCCCCCCCCCC	24.88	28066266
313	Phosphorylation	TNSRSPLTSTTESVG CCCCCCCCCCCCCCC	27.66	28066266
339	Phosphorylation	QVPVGDDSLQNTTSS CCCCCCCCCCCCCCC	36.27	26160508
343	Phosphorylation	GDDSLQNTTSSSPPA CCCCCCCCCCCCCCC	18.33	26160508
344	Phosphorylation	DDSLQNTTSSSPPAQ CCCCCCCCCCCCCCC	33.87	26160508
345	Phosphorylation	DSLQNTTSSSPPAQP CCCCCCCCCCCCCCC	27.12	26160508
346	Phosphorylation	SLQNTTSSSPPAQPP CCCCCCCCCCCCCCC	44.78	26160508
347	Phosphorylation	LQNTTSSSPPAQPPS CCCCCCCCCCCCCCC	34.37	24453211
354	Phosphorylation	SPPAQPPSLQASPKL CCCCCCCCCCCCCCC	39.53	25293948
358	Phosphorylation	QPPSLQASPKLPPSP CCCCCCCCCCCCCCC	15.03	25293948
364	Phosphorylation	ASPKLPPSPLSSASS CCCCCCCCCCCCCCC	36.21	26643407
367	Phosphorylation	KLPPSPLSSASSPSS CCCCCCCCCCCCCCC	27.52	26643407
368	Phosphorylation	LPPSPLSSASSPSSY CCCCCCCCCCCCCCC	39.59	26643407
370	Phosphorylation	PSPLSSASSPSSYPA CCCCCCCCCCCCCCC	44.74	26643407
371	Phosphorylation	SPLSSASSPSSYPAP CCCCCCCCCCCCCCC	28.63	26643407
373	Phosphorylation	LSSASSPSSYPAPPT CCCCCCCCCCCCCCC	44.44	26643407
374	Phosphorylation	SSASSPSSYPAPPTS CCCCCCCCCCCCCCC	38.22	26643407
375	Phosphorylation	SASSPSSYPAPPTST CCCCCCCCCCCCCCC	14.04	26643407
380	Phosphorylation	SSYPAPPTSTSPVLD CCCCCCCCCCCCCCC	43.51	26643407
381	Phosphorylation	SYPAPPTSTSPVLDH CCCCCCCCCCCCCCC	32.44	26643407
382	Phosphorylation	YPAPPTSTSPVLDHS CCCCCCCCCCCCCCC	39.26	26643407
383	Phosphorylation	PAPPTSTSPVLDHSE CCCCCCCCCCCCCCC	16.87	26643407
389	Phosphorylation	TSPVLDHSETSDQKF CCCCCCCCCCCCCCE	42.09	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCAM1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
6	K	ubiquitylation	Polyubiquitinated with 'Lys-6'- and 'Lys-33'-linked chains in a TRIM8-dependent manner; ubiquitination disrupts the interaction with TBK1 and subsequent interferon production.	-
209	S	Phosphorylation	Following activation, phosphorylated by TBK1 at Ser-209 in the pLxIS motif.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCAM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF3_MOUSE	Traf3	physical	19898473
TRAF6_MOUSE	Traf6	physical	19898473
TRAF6_MOUSE	Traf6	physical	14530355
BECN1_MOUSE	Becn1	physical	18772134

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.