TRAF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRAF3_MOUSE
• UniProt AC: Q60803
• Protein Name: TNF receptor-associated factor 3
• Gene Name: Traf3
• Organism: Mus musculus (Mouse).
• Sequence Length: 567
• Subcellular Localization: Cytoplasm . Endosome . Undergoes endocytosis together with TLR4 upon LPS signaling.
• Protein Description: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14..
• Protein Sequence: MESSKKMDAAGTLQPNPPLKLQPDRGAGSVLVPEQGGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	VPEQGGYKEKFVKTV CCCCCCCCHHHCCCH	58.67	-
41	Ubiquitination	EQGGYKEKFVKTVED CCCCCCHHHCCCHHH	51.83	-
63	Ubiquitination	RLVLCNPKQTECGHR EEEEECCCCCHHHHH	56.72	-
81	Phosphorylation	SCMAALLSSSSPKCT HHHHHHHCCCCCCCC	29.08	29899451
106	Ubiquitination	VFKDNCCKREILALQ CCCCCCCHHHHHHHH	56.09	PubMed
155	Ubiquitination	LRADCKEKVLRKDLR CCCHHHHHHHHHHHH	31.87	PubMed
268	Phosphorylation	LLKEWSNSLEKKVSL HHHHHHHHHHHHHHH	32.18	29899451
328	Acetylation	VIDSQAEKLKELDKE HHHHHHHHHHHHHHH	68.80	7614265
348	Phosphorylation	QNWEEADSMKSSVES HCHHHHHHHHHHHHH	34.85	-
368	Ubiquitination	TELESVDKSAGQAAR HHHHHHHHHHHHHHH	39.80	-
494	Phosphorylation	WPFKQKVTLMLMDQG CCCCCCEEEEEECCC	17.31	-
503	Phosphorylation	MLMDQGSSRRHLGDA EEECCCCCCCCCCCC	39.91	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Traf2	P39429	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Hectd3	Q3U487	PMID:29920190

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRAF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRAF3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KSYK_MOUSE	Syk	physical	23962979
TNR5_MOUSE	Cd40	physical	25072696
NEDD4_MOUSE	Nedd4	physical	25072696
ASPP1_MOUSE	Ppp1r13b	physical	25072696
MYSM1_MOUSE	Mysm1	physical	26474655
TRAF6_MOUSE	Traf6	physical	26474655
TBK1_MOUSE	Tbk1	physical	26474655
ASC_MOUSE	Pycard	physical	25847972
STK38_MOUSE	Stk38	physical	28219902
I17RA_MOUSE	Il17ra	physical	28219902

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.