STK38_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STK38_MOUSE
• UniProt AC: Q91VJ4
• Protein Name: Serine/threonine-protein kinase 38
• Gene Name: Stk38 {ECO:0000312|EMBL:AAH09658.1}
• Organism: Mus musculus (Mouse).
• Sequence Length: 465
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity)..
• Protein Sequence: MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKNNLFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVTTSSHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMTGSTPC ------CCCCCCCCC	12.30	-
74	Phosphorylation	SAHARKETEFLRLKR HHHHHHHHHHHHHHC	34.76	-
223	Acetylation	DNLLLDSKGHVKLSD CCEEECCCCCEEHHH	53.34	2394321
252	Phosphorylation	FYRNLNHSLPSDFTF HHHHCCCCCCCCCCC	40.68	25338131
255	Phosphorylation	NLNHSLPSDFTFQNM HCCCCCCCCCCCCCC	51.12	29472430
258	Phosphorylation	HSLPSDFTFQNMNSK CCCCCCCCCCCCCCH	29.33	29472430
264	Phosphorylation	FTFQNMNSKRKAETW CCCCCCCCHHHHHHH	24.06	21082442
270	Phosphorylation	NSKRKAETWKRNRRQ CCHHHHHHHHHHHHH	40.94	-
281	Phosphorylation	NRRQLAFSTVGTPDY HHHHHHHCCCCCCCC	19.31	27087446
282	Phosphorylation	RRQLAFSTVGTPDYI HHHHHHCCCCCCCCC	19.25	26239621
285	Phosphorylation	LAFSTVGTPDYIAPE HHHCCCCCCCCCCHH	14.51	26239621
288	Phosphorylation	STVGTPDYIAPEVFM CCCCCCCCCCHHHHH	10.53	28833060
297	Phosphorylation	APEVFMQTGYNKLCD CHHHHHHCCCHHHHH	29.82	20531401
299	Phosphorylation	EVFMQTGYNKLCDWW HHHHHCCCHHHHHHH	16.71	20531401
354	Malonylation	VPVSEKAKGLILRFC CCCCHHCCCHHHHHH	66.38	26320211
433	Phosphorylation	SSHPETDYKNKDWVF CCCCCCCCCCCCEEE	24.71	29514104
443	Phosphorylation	KDWVFINYTYKRFEG CCEEEEEEEEEECCC	13.46	22322096
444	Phosphorylation	DWVFINYTYKRFEGL CEEEEEEEEEECCCC	20.34	22322096
445	Phosphorylation	WVFINYTYKRFEGLT EEEEEEEEEECCCCC	6.98	23140645
452	Phosphorylation	YKRFEGLTARGAIPS EEECCCCCCCCCCCH	25.76	24899341
460	Phosphorylation	ARGAIPSYMKAAK-- CCCCCCHHHHHCC--	9.40	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
281	S	Phosphorylation	Kinase	NDR1	Q91VJ4	PSP
444	T	Phosphorylation	Kinase	MST3	Q99KH8	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STK38_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STK38_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MOB1B_HUMAN	MOB1B	physical	20360068
MOB2_HUMAN	MOB2	physical	20360068
STK38_HUMAN	STK38	physical	20360068
MOB1A_HUMAN	MOB1A	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.