dbPTM

MOB1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MOB1B_HUMAN
UniProt AC	Q7L9L4
Protein Name	MOB kinase activator 1B
Gene Name	MOB1B
Organism	Homo sapiens (Human).
Sequence Length	216
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L..
Protein Sequence	MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSFLFGSRS ------CCCCCCCCC	30.56	22814378
2	Phosphorylation	------MSFLFGSRS ------CCCCCCCCC	30.56	20068231
7	Phosphorylation	-MSFLFGSRSSKTFK -CCCCCCCCCCCCCC	22.96	28450419
9	Phosphorylation	SFLFGSRSSKTFKPK CCCCCCCCCCCCCCC	37.57	28450419
10	Phosphorylation	FLFGSRSSKTFKPKK CCCCCCCCCCCCCCC	34.31	28450419
11	Acetylation	LFGSRSSKTFKPKKN CCCCCCCCCCCCCCC	60.26	19822991
12	Phosphorylation	FGSRSSKTFKPKKNI CCCCCCCCCCCCCCC	38.55	29116813
16	Acetylation	SSKTFKPKKNIPEGS CCCCCCCCCCCCCCC	60.07	19823001
17	Acetylation	SKTFKPKKNIPEGSH CCCCCCCCCCCCCCH	69.50	19823011
17	Ubiquitination	SKTFKPKKNIPEGSH CCCCCCCCCCCCCCH	69.50	-
23	Phosphorylation	KKNIPEGSHQYELLK CCCCCCCCHHHHHHH	13.02	17287340
26	Phosphorylation	IPEGSHQYELLKHAE CCCCCHHHHHHHHHH	11.79	28796482
28 (in isoform 2)	Phosphorylation	-	7.03	27642862
30	Ubiquitination	SHQYELLKHAEATLG CHHHHHHHHHHHHCC	54.09	-
31 (in isoform 2)	Phosphorylation	-	28.86	27642862
35	Phosphorylation	LLKHAEATLGSGNLR HHHHHHHHCCCCCEE	24.13	29255136
38	Phosphorylation	HAEATLGSGNLRMAV HHHHHCCCCCEEEEE	27.85	25159151
40 (in isoform 2)	Phosphorylation	-	26.60	27251275
43 (in isoform 2)	Phosphorylation	-	3.57	27251275
74	Phosphorylation	QINMLYGTITDFCTE HHHHHHHHHHHHCCC	13.72	-
95	Phosphorylation	SAGPKYEYHWADGTN CCCCCEEEECCCCCC	10.28	-
98 (in isoform 2)	Phosphorylation	-	7.64	27642862
104	Ubiquitination	WADGTNIKKPIKCSA CCCCCCCCCCCCCCC	55.34	21890473
105	Ubiquitination	ADGTNIKKPIKCSAP CCCCCCCCCCCCCCC	48.45	-
109	Ubiquitination	NIKKPIKCSAPKYID CCCCCCCCCCCHHHH	4.31	21890473
142	Ubiquitination	KIGVPFPKNFMSVAK HCCCCCCHHHHHHHH	64.30	21890473
147	Ubiquitination	FPKNFMSVAKTILKR CCHHHHHHHHHHHHH	4.21	21890473
149	Acetylation	KNFMSVAKTILKRLF HHHHHHHHHHHHHHH	33.66	19608861
181	Phosphorylation	QEEAHLNTSFKHFIF CHHHHCCCCHHHHHH	41.73	18362890

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	T	Phosphorylation	Kinase	MST1	P26927	Uniprot
12	T	Phosphorylation	Kinase	STK3	Q13188	GPS
12	T	Phosphorylation	Kinase	STK4	Q13043	GPS
35	T	Phosphorylation	Kinase	MST1	P26927	Uniprot
35	T	Phosphorylation	Kinase	STK3	Q13188	GPS
35	T	Phosphorylation	Kinase	STK4	Q13043	GPS
74	T	Phosphorylation	Kinase	STK3	Q13188	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MOB1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MOB1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LATS1_HUMAN	LATS1	physical	19739119
LATS2_HUMAN	LATS2	physical	19739119
STK38_HUMAN	STK38	physical	19919647
LATS2_HUMAN	LATS2	physical	19919647
A4_HUMAN	APP	physical	21832049
ST38L_HUMAN	STK38L	physical	15067004
STK38_HUMAN	STK38	physical	15067004
LATS1_HUMAN	LATS1	physical	18328708
ANR28_HUMAN	ANKRD28	physical	24255178
ANR52_HUMAN	ANKRD52	physical	24255178
CRLF3_HUMAN	CRLF3	physical	24255178
DOCK6_HUMAN	DOCK6	physical	24255178
DOCK7_HUMAN	DOCK7	physical	24255178
DOCK8_HUMAN	DOCK8	physical	24255178
DYST_HUMAN	DST	physical	24255178
IPO11_HUMAN	IPO11	physical	24255178
LATS1_HUMAN	LATS1	physical	24255178
LATS2_HUMAN	LATS2	physical	24255178
LRCH1_HUMAN	LRCH1	physical	24255178
LRCH2_HUMAN	LRCH2	physical	24255178
LRCH3_HUMAN	LRCH3	physical	24255178
M4K4_HUMAN	MAP4K4	physical	24255178
MOB2_HUMAN	MOB2	physical	24255178
PPP6_HUMAN	PPP6C	physical	24255178
PP6R1_HUMAN	PPP6R1	physical	24255178
PP6R2_HUMAN	PPP6R2	physical	24255178
PP6R3_HUMAN	PPP6R3	physical	24255178
PTN14_HUMAN	PTPN14	physical	24255178
RASF2_HUMAN	RASSF2	physical	24255178
RASF5_HUMAN	RASSF5	physical	24255178
SAV1_HUMAN	SAV1	physical	24255178
STK3_HUMAN	STK3	physical	24255178
ST38L_HUMAN	STK38L	physical	24255178
STK4_HUMAN	STK4	physical	24255178
LATS1_HUMAN	LATS1	physical	24366813
MOB1A_HUMAN	MOB1A	physical	24366813
ST38L_HUMAN	STK38L	physical	24366813
ST38L_HUMAN	STK38L	physical	28514442
MOB1A_HUMAN	MOB1A	physical	28514442
LATS1_HUMAN	LATS1	physical	28514442
LATS2_HUMAN	LATS2	physical	28514442
STK38_HUMAN	STK38	physical	28514442
LRCH2_HUMAN	LRCH2	physical	28514442
DOCK7_HUMAN	DOCK7	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MOB1B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cellproliferation."; Praskova M., Xia F., Avruch J.; Curr. Biol. 18:311-321(2008). Cited for: PHOSPHORYLATION AT THR-12 AND THR-35.	18328708 [Abstract]