PPP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPP6_HUMAN
• UniProt AC: O00743
• Protein Name: Serine/threonine-protein phosphatase 6 catalytic subunit
• Gene Name: PPP6C
• Organism: Homo sapiens (Human).
• Sequence Length: 305
• Subcellular Localization: Mitochondrion . Cytoplasm .
• Protein Description: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation..
• Protein Sequence: MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPLDLDK -------CCCCCHHH	8.60	22814378
8	Ubiquitination	MAPLDLDKYVEIARL CCCCCHHHHHHHHHH	59.50	21890473
8 (in isoform 2)	Ubiquitination	-	59.50	21890473
8 (in isoform 1)	Ubiquitination	-	59.50	21890473
8	Ubiquitination	MAPLDLDKYVEIARL CCCCCHHHHHHHHHH	59.50	21890473
8 (in isoform 3)	Ubiquitination	-	59.50	-
17	Ubiquitination	VEIARLCKYLPENDL HHHHHHHHHCCHHHH	55.18	-
17	Acetylation	VEIARLCKYLPENDL HHHHHHHHHCCHHHH	55.18	26051181
17 (in isoform 3)	Ubiquitination	-	55.18	-
18	Phosphorylation	EIARLCKYLPENDLK HHHHHHHHCCHHHHH	26.88	26437602
25	Acetylation	YLPENDLKRLCDYVC HCCHHHHHHHHHHHH	46.30	25953088
25	Ubiquitination	YLPENDLKRLCDYVC HCCHHHHHHHHHHHH	46.30	-
111	Methylation	PDRITLLRGNHESRQ CCCEEEECCCCCHHH	47.16	115488633
120	Phosphorylation	NHESRQITQVYGFYD CCCHHHHHEEEEECH	12.02	30631047
123	Phosphorylation	SRQITQVYGFYDECQ HHHHHEEEEECHHHH	7.53	30631047
131	Phosphorylation	GFYDECQTKYGNANA EECHHHHHHCCCCHH	37.58	30631047
132	Ubiquitination	FYDECQTKYGNANAW ECHHHHHHCCCCHHH	25.86	21906983
178	Phosphorylation	KTLDQIRTIERNQEI HHHHHHHCHHHCCCC	28.90	28348404
188	Ubiquitination	RNQEIPHKGAFCDLV HCCCCCCCCCCCCEE	46.72	-
192	Glutathionylation	IPHKGAFCDLVWSDP CCCCCCCCCEEECCH	3.81	22555962
197	Phosphorylation	AFCDLVWSDPEDVDT CCCCEEECCHHHCCC	35.49	28464451
208	Phosphorylation	DVDTWAISPRGAGWL HCCCEEECCCCCCCC	10.78	-
209 (in isoform 2)	Ubiquitination	-	32.39	21890473
219	Ubiquitination	AGWLFGAKVTNEFVH CCCCCCEEEECCEEE	50.39	-
231 (in isoform 1)	Ubiquitination	-	37.62	21890473
231	Acetylation	FVHINNLKLICRAHQ EEEECHHHHHHHHHH	37.62	26051181
231	Ubiquitination	FVHINNLKLICRAHQ EEEECHHHHHHHHHH	37.62	2189047
234	Phosphorylation	INNLKLICRAHQLVH ECHHHHHHHHHHHHH	4.57	27251275
244	Phosphorylation	HQLVHEGYKFMFDEK HHHHHCCCCCCCCCC	9.69	28102081
245	Acetylation	QLVHEGYKFMFDEKL HHHHCCCCCCCCCCE	41.01	26051181
245	Ubiquitination	QLVHEGYKFMFDEKL HHHHCCCCCCCCCCE	41.01	-
254	Phosphorylation	MFDEKLVTVWSAPNY CCCCCEEEEECCCCC	27.05	20068231
257	Phosphorylation	EKLVTVWSAPNYCYR CCEEEEECCCCCCCC	29.52	20068231
261	Phosphorylation	TVWSAPNYCYRCGNI EEECCCCCCCCCCCE	6.98	20090780
263	Phosphorylation	WSAPNYCYRCGNIAS ECCCCCCCCCCCEEE	9.89	20068231
268	Ubiquitination	YCYRCGNIASIMVFK CCCCCCCEEEEEEEE	1.61	21890473
268 (in isoform 3)	Ubiquitination	-	1.61	-
275	Acetylation	IASIMVFKDVNTREP EEEEEEEECCCCCCC	49.72	26051181
283	Ubiquitination	DVNTREPKLFRAVPD CCCCCCCCEEEECCC	56.35	-
301	Phosphorylation	VIPPRTTTPYFL--- CCCCCCCCCCCC---	18.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGBP1_HUMAN	IGBP1	physical	9647778
PP6R3_HUMAN	PPP6R3	physical	21187329
PP6R1_HUMAN	PPP6R1	physical	21187329
PP6R2_HUMAN	PPP6R2	physical	21187329
ANR52_HUMAN	ANKRD52	physical	21187329
ANR28_HUMAN	ANKRD28	physical	21187329
ANR44_HUMAN	ANKRD44	physical	21187329
PRKDC_HUMAN	PRKDC	physical	20065038
PP6R1_HUMAN	PPP6R1	physical	20065038
PP6R2_HUMAN	PPP6R2	physical	20065038
PP6R3_HUMAN	PPP6R3	physical	20065038
M3K7_HUMAN	MAP3K7	physical	19955178
TAB2_HUMAN	TAB2	physical	19955178
PP6R3_HUMAN	PPP6R3	physical	22939629
M3K7_HUMAN	MAP3K7	physical	17079228
ANR28_HUMAN	ANKRD28	physical	24255178
ANR44_HUMAN	ANKRD44	physical	24255178
ANR52_HUMAN	ANKRD52	physical	24255178
ARHG2_HUMAN	ARHGEF2	physical	24255178
IGBP1_HUMAN	IGBP1	physical	24255178
PP6R1_HUMAN	PPP6R1	physical	24255178
PP6R2_HUMAN	PPP6R2	physical	24255178
PP6R3_HUMAN	PPP6R3	physical	24255178
PRKDC_HUMAN	PRKDC	physical	24255178
TIPRL_HUMAN	TIPRL	physical	24255178
TBB6_HUMAN	TUBB6	physical	24255178
ACLY_HUMAN	ACLY	physical	22863883
KC1D_HUMAN	CSNK1D	physical	23864707
ZNRF2_HUMAN	ZNRF2	physical	27244671
ANR28_HUMAN	ANKRD28	physical	27880917
ANR52_HUMAN	ANKRD52	physical	27880917
ARHG2_HUMAN	ARHGEF2	physical	27880917
IGBP1_HUMAN	IGBP1	physical	27880917
K2C8_HUMAN	KRT8	physical	27880917
PP6R1_HUMAN	PPP6R1	physical	27880917
PP6R2_HUMAN	PPP6R2	physical	27880917
PP6R3_HUMAN	PPP6R3	physical	27880917
TIPRL_HUMAN	TIPRL	physical	27880917

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.