| UniProt ID | TAB2_HUMAN | |
|---|---|---|
| UniProt AC | Q9NYJ8 | |
| Protein Name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | |
| Gene Name | TAB2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 693 | |
| Subcellular Localization |
Membrane Peripheral membrane protein . Cytoplasm, cytosol . Following IL1 stimulation, translocation occurs from the membrane to cytosol. |
|
| Protein Description | Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.. | |
| Protein Sequence | MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 53 | Phosphorylation | LSQESTRYLYGEGDL CCCCCCCHHCCCCCC | 12.36 | 27642862 | |
| 69 | Phosphorylation | FSDDSGISGLRNHMT CCCCCCCHHHHHHHH | 34.99 | 24719451 | |
| 77 | Phosphorylation | GLRNHMTSLNLDLQS HHHHHHHHCCCCCHH | 14.00 | 28555341 | |
| 84 | Phosphorylation | SLNLDLQSQNIYHHG HCCCCCHHCCCCCCC | 32.27 | 29978859 | |
| 88 | Phosphorylation | DLQSQNIYHHGREGS CCHHCCCCCCCCCCC | 8.70 | 27642862 | |
| 104 | Phosphorylation | MNGSRTLTHSISDGQ CCCCEEEEEECCCCC | 16.99 | 26074081 | |
| 106 | Phosphorylation | GSRTLTHSISDGQLQ CCEEEEEECCCCCCC | 20.67 | 26074081 | |
| 108 | Phosphorylation | RTLTHSISDGQLQGG EEEEEECCCCCCCCC | 38.41 | 26074081 | |
| 166 | O-linked_Glycosylation | LGSKGTSSLSQQTPR CCCCCCCCHHCCCCC | 31.70 | 30059200 | |
| 168 | Phosphorylation | SKGTSSLSQQTPRFN CCCCCCHHCCCCCCC | 23.38 | 27251275 | |
| 171 | Phosphorylation | TSSLSQQTPRFNPIM CCCHHCCCCCCCCEE | 14.59 | 27251275 | |
| 173 | Methylation | SLSQQTPRFNPIMVT CHHCCCCCCCCEEEE | 47.57 | 24129315 | |
| 173 | Asymmetric dimethylarginine | SLSQQTPRFNPIMVT CHHCCCCCCCCEEEE | 47.57 | - | |
| 180 | O-linked_Glycosylation | RFNPIMVTLAPNIQT CCCCEEEEECCCCCC | 10.38 | 30059200 | |
| 207 | Phosphorylation | VPPPVLNSPQGNSIY CCCCCCCCCCCCEEE | 17.90 | 29523821 | |
| 212 | Phosphorylation | LNSPQGNSIYIRPYI CCCCCCCEEEEEEEE | 24.48 | 29523821 | |
| 329 | Sumoylation | RKNQIEIKLEPPQRN CCCEEEEECCCCCCC | 33.73 | - | |
| 329 | Sumoylation | RKNQIEIKLEPPQRN CCCEEEEECCCCCCC | 33.73 | - | |
| 343 | Phosphorylation | NNSSKLRSSGPRTSS CCCHHCCCCCCCCCC | 50.51 | 26699800 | |
| 344 | Phosphorylation | NSSKLRSSGPRTSST CCHHCCCCCCCCCCC | 46.51 | 26699800 | |
| 348 | Phosphorylation | LRSSGPRTSSTSSSV CCCCCCCCCCCCCCC | 30.11 | 28450419 | |
| 349 | Phosphorylation | RSSGPRTSSTSSSVN CCCCCCCCCCCCCCC | 32.66 | 28450419 | |
| 350 | O-linked_Glycosylation | SSGPRTSSTSSSVNS CCCCCCCCCCCCCCH | 31.53 | 30059200 | |
| 350 | Phosphorylation | SSGPRTSSTSSSVNS CCCCCCCCCCCCCCH | 31.53 | 25394399 | |
| 351 | Phosphorylation | SGPRTSSTSSSVNSQ CCCCCCCCCCCCCHH | 32.18 | 30576142 | |
| 352 | Phosphorylation | GPRTSSTSSSVNSQT CCCCCCCCCCCCHHC | 23.67 | 28450419 | |
| 353 | Phosphorylation | PRTSSTSSSVNSQTL CCCCCCCCCCCHHCC | 38.09 | 29083192 | |
| 354 | O-linked_Glycosylation | RTSSTSSSVNSQTLN CCCCCCCCCCHHCCC | 25.70 | 30059200 | |
| 354 | Phosphorylation | RTSSTSSSVNSQTLN CCCCCCCCCCHHCCC | 25.70 | 29083192 | |
| 366 | Phosphorylation | TLNRNQPTVYIAASP CCCCCCCEEEEEECC | 19.04 | 25002506 | |
| 368 | Phosphorylation | NRNQPTVYIAASPPN CCCCCEEEEEECCCC | 6.32 | 27794612 | |
| 372 | Phosphorylation | PTVYIAASPPNTDEL CEEEEEECCCCHHHH | 31.69 | 28355574 | |
| 376 | Phosphorylation | IAASPPNTDELMSRS EEECCCCHHHHHHCC | 36.30 | 22199227 | |
| 381 | Phosphorylation | PNTDELMSRSQPKVY CCHHHHHHCCCCEEE | 41.21 | 30576142 | |
| 388 | Phosphorylation | SRSQPKVYISANAAT HCCCCEEEEECCCCC | 8.69 | 28176443 | |
| 390 | Phosphorylation | SQPKVYISANAATGD CCCEEEEECCCCCCC | 9.59 | 28176443 | |
| 395 | Phosphorylation | YISANAATGDEQVMR EEECCCCCCCHHHHH | 42.63 | 28176443 | |
| 406 | Phosphorylation | QVMRNQPTLFISTNS HHHHHCCEEEEECCC | 25.24 | 28176443 | |
| 410 | Phosphorylation | NQPTLFISTNSGASA HCCEEEEECCCCCCH | 17.75 | 28176443 | |
| 411 | Phosphorylation | QPTLFISTNSGASAA CCEEEEECCCCCCHH | 28.70 | 28176443 | |
| 413 | Phosphorylation | TLFISTNSGASAASR EEEEECCCCCCHHHC | 35.51 | 28176443 | |
| 416 | Phosphorylation | ISTNSGASAASRNMS EECCCCCCHHHCCCC | 28.08 | 28176443 | |
| 419 | Phosphorylation | NSGASAASRNMSGQV CCCCCHHHCCCCCCC | 24.73 | 28176443 | |
| 423 | Phosphorylation | SAASRNMSGQVSMGP CHHHCCCCCCCCCCC | 29.62 | 22817900 | |
| 427 | Phosphorylation | RNMSGQVSMGPAFIH CCCCCCCCCCCCCCC | 15.33 | 28555341 | |
| 440 | Phosphorylation | IHHHPPKSRAIGNNS CCCCCCCCCCCCCCC | 32.49 | - | |
| 441 | Methylation | HHHPPKSRAIGNNSA CCCCCCCCCCCCCCC | 36.03 | 115918093 | |
| 447 | O-linked_Glycosylation | SRAIGNNSATSPRVV CCCCCCCCCCCCEEE | 36.60 | 30059200 | |
| 447 | Phosphorylation | SRAIGNNSATSPRVV CCCCCCCCCCCCEEE | 36.60 | 21955146 | |
| 449 | Phosphorylation | AIGNNSATSPRVVVT CCCCCCCCCCEEEEE | 38.80 | 25159151 | |
| 450 | Phosphorylation | IGNNSATSPRVVVTQ CCCCCCCCCEEEEEC | 15.49 | 28355574 | |
| 456 | O-linked_Glycosylation | TSPRVVVTQPNTKYT CCCEEEEECCCCEEE | 27.05 | 30059200 | |
| 456 | Phosphorylation | TSPRVVVTQPNTKYT CCCEEEEECCCCEEE | 27.05 | - | |
| 460 | O-linked_Glycosylation | VVVTQPNTKYTFKIT EEEECCCCEEEEEEE | 31.92 | 30059200 | |
| 467 | Phosphorylation | TKYTFKITVSPNKPP CEEEEEEEECCCCCC | 18.60 | 25921289 | |
| 469 | Phosphorylation | YTFKITVSPNKPPAV EEEEEEECCCCCCCC | 17.69 | 28464451 | |
| 477 | Phosphorylation | PNKPPAVSPGVVSPT CCCCCCCCCCCCCCC | 20.31 | 29496963 | |
| 482 | Phosphorylation | AVSPGVVSPTFELTN CCCCCCCCCCEEHHH | 18.80 | 29496963 | |
| 484 | Phosphorylation | SPGVVSPTFELTNLL CCCCCCCCEEHHHHH | 23.41 | 20068231 | |
| 488 | Phosphorylation | VSPTFELTNLLNHPD CCCCEEHHHHHCCCC | 19.34 | 20068231 | |
| 497 | Phosphorylation | LLNHPDHYVETENIQ HHCCCCCEEECCCCC | 13.83 | 28464451 | |
| 500 | Phosphorylation | HPDHYVETENIQHLT CCCCEEECCCCCCCC | 25.04 | 20068231 | |
| 507 | Phosphorylation | TENIQHLTDPTLAHV CCCCCCCCCCCHHCH | 37.50 | 20068231 | |
| 510 | Phosphorylation | IQHLTDPTLAHVDRI CCCCCCCCHHCHHHH | 39.11 | 20068231 | |
| 522 | Ubiquitination | DRISETRKLSMGSDD HHHHHHHCCCCCCCC | 52.94 | - | |
| 524 | Phosphorylation | ISETRKLSMGSDDAA HHHHHCCCCCCCCHH | 24.92 | 25159151 | |
| 527 | Phosphorylation | TRKLSMGSDDAAYTQ HHCCCCCCCCHHHHH | 24.55 | 23401153 | |
| 532 | Phosphorylation | MGSDDAAYTQALLVH CCCCCHHHHHHHHHH | 10.91 | 23927012 | |
| 533 | Phosphorylation | GSDDAAYTQALLVHQ CCCCHHHHHHHHHHH | 11.57 | 23927012 | |
| 580 | Phosphorylation | TRRRLKRSNSISQIP HHHHHHHCCCHHHCC | 33.08 | 30266825 | |
| 582 | Phosphorylation | RRLKRSNSISQIPSL HHHHHCCCHHHCCCH | 25.51 | 30266825 | |
| 584 | Phosphorylation | LKRSNSISQIPSLEE HHHCCCHHHCCCHHH | 23.13 | 30266825 | |
| 588 | Phosphorylation | NSISQIPSLEEMQQL CCHHHCCCHHHHHHH | 50.47 | 28450419 | |
| 597 | Phosphorylation | EEMQQLRSCNRQLQI HHHHHHHHCCCCCEE | 25.08 | 29978859 | |
| 611 | Ubiquitination | IDIDCLTKEIDLFQA EEHHHHHCCCCHHHH | 39.46 | - | |
| 632 | Phosphorylation | PSAIHNFYDNIGFVG HHHHHHHHCCCCCCC | 17.25 | 27642862 | |
| 644 | Ubiquitination | FVGPVPPKPKDQRSI CCCCCCCCCCCHHCC | 59.64 | - | |
| 650 | Phosphorylation | PKPKDQRSIIKTPKT CCCCCHHCCCCCCCC | 24.04 | 24719451 | |
| 653 | Ubiquitination | KDQRSIIKTPKTQDT CCHHCCCCCCCCCCC | 58.04 | - | |
| 654 | Phosphorylation | DQRSIIKTPKTQDTE CHHCCCCCCCCCCCC | 21.43 | 24719451 | |
| 656 | Ubiquitination | RSIIKTPKTQDTEDD HCCCCCCCCCCCCCC | 65.14 | - | |
| 657 | Phosphorylation | SIIKTPKTQDTEDDE CCCCCCCCCCCCCCC | 32.64 | 22210691 | |
| 660 | Phosphorylation | KTPKTQDTEDDEGAQ CCCCCCCCCCCCCCE | 31.34 | 22210691 | |
| 671 | Phosphorylation | EGAQWNCTACTFLNH CCCEEECCCCCCCCC | 22.89 | 22210691 | |
| 674 | Phosphorylation | QWNCTACTFLNHPAL EEECCCCCCCCCCEE | 28.79 | 22210691 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAB2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAB2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614980 | Congenital heart defects, multiple types, 2 (CHTD2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, AND MASSSPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, AND MASSSPECTROMETRY. | |
