TR30A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR30A_MOUSE
• UniProt AC: P15533
• Protein Name: Tripartite motif-containing protein 30A
• Gene Name: Trim30a
• Organism: Mus musculus (Mouse).
• Sequence Length: 496
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses..
• Protein Sequence: MASSVLEMIKEEVTCPICLELLKEPVSADCNHSFCRACITLNYESNRNTDGKGNCPVCRVPYPFGNLRPNLHVANIVERLKGFKSIPEEEQKVNICAQHGEKLRLFCRKDMMVICWLCERSQEHRGHQTALIEEVDQEYKEKLQGALWKLMKKAKICDEWQDDLQLQRVDWENQIQINVENVQRQFKGLRDLLDSKENEELQKLKKEKKEVMEKLEESENELEDQTELVRDLISDVEHHLELSTLEMLQGANCVLRRSQSLSLQQPQTVPQKRKRTFQAPDLKGMLQVYQGLMDIQQYWVHMTLHARNNAVIAINKEKRQIQYRSYNTVPVSEIYHLGVLGYPALSSGKHYWEVDISRSDAWLLGLNDGKCAQPQLHSKEEMGIKKNLHSQIKQNVLFQPKCGYWVIGMKNPSVYKAFDECSITHNSSILVISLPDRPSRVGVFLDRKAGTLSFYDVSNCGALIYRFYDPAFPVEVYPYFNPMKCSEPMTICGPPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
218	Phosphorylation	VMEKLEESENELEDQ HHHHHHHHCHHHHHH	36.02	26525534
258	Phosphorylation	ANCVLRRSQSLSLQQ CCEEEEECCCCCCCC	20.07	25338131
260	Phosphorylation	CVLRRSQSLSLQQPQ EEEEECCCCCCCCCC	22.60	22942356
262	Phosphorylation	LRRSQSLSLQQPQTV EEECCCCCCCCCCCC	29.40	20531401
268	Phosphorylation	LSLQQPQTVPQKRKR CCCCCCCCCCHHHCC	40.62	20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TR30A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR30A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR30A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SQSTM_MOUSE	Sqstm1	physical	18598672
M3K7_HUMAN	MAP3K7	physical	18345001
TAB2_HUMAN	TAB2	physical	18345001
STING_MOUSE	Tmem173	physical	26114947

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.