dbPTM

HDAC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HDAC5_HUMAN
UniProt AC	Q9UQL6
Protein Name	Histone deacetylase 5
Gene Name	HDAC5
Organism	Homo sapiens (Human).
Sequence Length	1122
Subcellular Localization	Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its p
Protein Description	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer..
Protein Sequence	MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 3)	Phosphorylation	-	40.75	22210691
3	Phosphorylation	-----MNSPNESDGM -----CCCCCCCCCC	40.75	21081666
7 (in isoform 3)	Phosphorylation	-	46.21	24043423
7	Phosphorylation	-MNSPNESDGMSGRE -CCCCCCCCCCCCCC	46.21	21081666
12 (in isoform 3)	Phosphorylation	-	29.13	24043423
16	Phosphorylation	GMSGREPSLEILPRT CCCCCCCCCEECCCC	33.60	22210691
23	Phosphorylation	SLEILPRTSLHSIPV CCEECCCCCCCCCCE	33.43	27251275
24	Phosphorylation	LEILPRTSLHSIPVT CEECCCCCCCCCCEE	25.93	28555341
25	Phosphorylation	EILPRTSLHSIPVTV EECCCCCCCCCCEEE	3.48	27251275
32 (in isoform 3)	Phosphorylation	-	8.95	22210691
35	Sumoylation	IPVTVEVKPVLPRAM CCEEEEEECCCCCCC	18.86	28112733
35	Sumoylation	IPVTVEVKPVLPRAM CCEEEEEECCCCCCC	18.86	-
44	Phosphorylation	VLPRAMPSSMGGGGG CCCCCCCCCCCCCCC	21.63	29214152
45	Phosphorylation	LPRAMPSSMGGGGGG CCCCCCCCCCCCCCC	18.64	24043423
53	Phosphorylation	MGGGGGGSPSPVELR CCCCCCCCCCCHHHH	26.02	25850435
54	Phosphorylation	GGGGGGSPSPVELRG CCCCCCCCCCHHHHH	46.02	24719451
55	Phosphorylation	GGGGGSPSPVELRGA CCCCCCCCCHHHHHH	43.18	25850435
56	Phosphorylation	GGGGSPSPVELRGAL CCCCCCCCHHHHHHH	27.30	27251275
66	Phosphorylation	LRGALVGSVDPTLRE HHHHHHCCCCHHHHH	18.83	21081666
70	Phosphorylation	LVGSVDPTLREQQLQ HHCCCCHHHHHHHHH	33.70	-
84	Ubiquitination	QQELLALKQQQQLQK HHHHHHHHHHHHHHH	40.22	29967540
85	Ubiquitination	QELLALKQQQQLQKQ HHHHHHHHHHHHHHH	47.36	29967540
115	Ubiquitination	QHEVQLQKHLKQQQE HHHHHHHHHHHHHHH	60.54	29967540
116	Ubiquitination	HEVQLQKHLKQQQEM HHHHHHHHHHHHHHH	25.87	29967540
136	Ubiquitination	QQEMLAAKRQQELEQ HHHHHHHHHHHHHHH	45.17	29967540
137	Ubiquitination	QEMLAAKRQQELEQQ HHHHHHHHHHHHHHH	38.39	29967540
180	Phosphorylation	SKESAIASTEVKLRL CHHHHHCHHHHHHHH	20.98	-
181	Phosphorylation	KESAIASTEVKLRLQ HHHHHCHHHHHHHHH	35.46	-
199	Phosphorylation	LSKSKEPTPGGLNHS HHCCCCCCCCCCCCC	35.34	28787133
206	Phosphorylation	TPGGLNHSLPQHPKC CCCCCCCCCCCCCCC	40.44	21081666
220	Phosphorylation	CWGAHHASLDQSSPP CCCCCCCCCCCCCCC	28.28	27080861
221	Phosphorylation	WGAHHASLDQSSPPQ CCCCCCCCCCCCCCC	7.83	27251275
224	Phosphorylation	HHASLDQSSPPQSGP CCCCCCCCCCCCCCC	44.47	27080861
225	Phosphorylation	HASLDQSSPPQSGPP CCCCCCCCCCCCCCC	34.66	27080861
229	Phosphorylation	DQSSPPQSGPPGTPP CCCCCCCCCCCCCCC	60.07	27080861
234	Phosphorylation	PQSGPPGTPPSYKLP CCCCCCCCCCCCCCC	37.49	27251275
256	Ubiquitination	RDDFPLRKTASEPNL CCCCCCCCCCCCCCH	57.01	-
257	Phosphorylation	DDFPLRKTASEPNLK CCCCCCCCCCCCCHH	29.05	30183078
259	Phosphorylation	FPLRKTASEPNLKVR CCCCCCCCCCCHHHH	59.84	25159151
260	Phosphorylation	PLRKTASEPNLKVRS CCCCCCCCCCHHHHH	35.43	24719451
278	Phosphorylation	QKVAERRSSPLLRRK HHHHHHCCCCCHHCC	42.39	25159151
279	Phosphorylation	KVAERRSSPLLRRKD HHHHHCCCCCHHCCC	20.11	26846344
288	Phosphorylation	LLRRKDGTVISTFKK CHHCCCCCEEECCCC	25.46	-
291	Phosphorylation	RKDGTVISTFKKRAV CCCCCEEECCCCCEE	24.37	-
292	Phosphorylation	KDGTVISTFKKRAVE CCCCEEECCCCCEEE	28.49	20188095
368	Phosphorylation	FSLYTSPSLPNISLG EEEEECCCCCCCEEE	57.11	21081666
458	Phosphorylation	LEQARQQSTLIAVPL HHHHHHCCCEEEEEC	19.49	24043423
459	Phosphorylation	EQARQQSTLIAVPLH HHHHHCCCEEEEECC	20.18	24043423
469	Phosphorylation	AVPLHGQSPLVTGER EEECCCCCCCCCCCH	25.46	21712546
473	Phosphorylation	HGQSPLVTGERVATS CCCCCCCCCCHHHCC	40.79	24043423
479	Phosphorylation	VTGERVATSMRTVGK CCCCHHHCCCCCCCC	21.87	24043423
480	Phosphorylation	TGERVATSMRTVGKL CCCHHHCCCCCCCCC	9.13	24043423
496	Phosphorylation	RHRPLSRTQSSPLPQ CCCCCCCCCCCCCCC	29.44	30266825
498	Phosphorylation	RPLSRTQSSPLPQSP CCCCCCCCCCCCCCH	33.05	30266825
499	Phosphorylation	PLSRTQSSPLPQSPQ CCCCCCCCCCCCCHH	22.19	30266825
500	Phosphorylation	LSRTQSSPLPQSPQA CCCCCCCCCCCCHHH	53.99	27251275
504	Phosphorylation	QSSPLPQSPQALQQL CCCCCCCCHHHHHHH	19.62	30266825
533	Sumoylation	QQQLQLGKILTKTGE HHHHHHHHHHHHCCC	43.04	-
533	Acetylation	QQQLQLGKILTKTGE HHHHHHHHHHHHCCC	43.04	19608861
533	Sumoylation	QQQLQLGKILTKTGE HHHHHHHHHHHHCCC	43.04	19608861
534	Acetylation	QQLQLGKILTKTGEL HHHHHHHHHHHCCCC	5.84	19608861
537	Ubiquitination	QLGKILTKTGELPRQ HHHHHHHHCCCCCCC	51.60	29967540
538	Ubiquitination	LGKILTKTGELPRQP HHHHHHHCCCCCCCC	30.56	29967540
546	Phosphorylation	GELPRQPTTHPEETE CCCCCCCCCCHHHCH	29.42	20736484
547	Phosphorylation	ELPRQPTTHPEETEE CCCCCCCCCHHHCHH	41.96	-
605	Sumoylation	EEDCIQVKDEEGESG HHCCEEEECCCCCCC	42.94	-
611	Phosphorylation	VKDEEGESGAEEGPD EECCCCCCCCCCCCC	54.91	23927012
612	Phosphorylation	KDEEGESGAEEGPDL ECCCCCCCCCCCCCC	32.48	24719451
650	Phosphorylation	QAPLSLATVPHQALG ECCCCCCCCCHHHCC	39.60	29514088
659	Phosphorylation	PHQALGRTQSSPAAP CHHHCCCCCCCCCCC	30.88	22115753
661	Phosphorylation	QALGRTQSSPAAPGG HHCCCCCCCCCCCCC	37.36	23401153
662	Phosphorylation	ALGRTQSSPAAPGGM HCCCCCCCCCCCCCC	14.56	22115753
671	Phosphorylation	AAPGGMKSPPDQPVK CCCCCCCCCCCCCCC	32.54	28985074
713	Phosphorylation	EHAGRIQSIWSRLQE HHHHHHHHHHHHHHH	24.53	28857561
725	Phosphorylation	LQETGLLSKCERIRG HHHHCCHHHHHHHCC	40.06	24719451
755	Phosphorylation	HTLLYGTSPLNRQKL HHHHHCCCCCCHHHC	24.03	21081666
776	Phosphorylation	GPISQKMYAVLPCGG HCHHHCEEEEEECCC	10.70	-
798	Phosphorylation	VWNEMHSSSAVRMAV HHHHHCCHHHHHHHH	13.98	-
799	Phosphorylation	WNEMHSSSAVRMAVG HHHHCCHHHHHHHHH	33.52	-
1046	Phosphorylation	PNINAVATLEKVIEI CCCCCEEEHHHHHHH	28.93	24719451
1071	Phosphorylation	FAAGLGRSLREAQAG HHHHHCHHHHHHHCC	29.94	-
1108	Phosphorylation	AAAAREHSPRPAEEP HHHHHHCCCCCCCCC	20.18	23401153
1109	Phosphorylation	AAAREHSPRPAEEPM HHHHHCCCCCCCCCC	48.45	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
259	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
259	S	Phosphorylation	Kinase	MAP3K7	O43318	GPS
259	S	Phosphorylation	Kinase	MARK2	Q7KZI7	PSP
259	S	Phosphorylation	Kinase	PRKD1	Q15139	Uniprot
259	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
259	S	Phosphorylation	Kinase	SIK1	P57059	Uniprot
259	S	Phosphorylation	Kinase	KKCC1	Q8N5S9	PhosphoELM
259	S	Phosphorylation	Kinase	CAMK4	Q16566	PSP
259	S	Phosphorylation	Kinase	QIK	Q9H0K1	PSP
259	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
259	S	Phosphorylation	Kinase	CAMK1A	Q14012	PSP
259	S	Phosphorylation	Kinase	CAMK1-FAMILY	-	GPS
259	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
259	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
259	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
278	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
279	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
279	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
279	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
292	T	Phosphorylation	Kinase	PKC	-	Uniprot
292	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
292	T	Phosphorylation	Kinase	PKN1	Q16512	PSP
498	S	Phosphorylation	Kinase	PRKD3	O94806	PSP
498	S	Phosphorylation	Kinase	PRKD2	Q9BZL6	PSP
498	S	Phosphorylation	Kinase	PRKD1	Q15139	Uniprot
498	S	Phosphorylation	Kinase	KKCC1	Q8N5S9	PhosphoELM
498	S	Phosphorylation	Kinase	SIK1	P57059	Uniprot
498	S	Phosphorylation	Kinase	CAMK4	Q16566	PSP
498	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
498	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
498	S	Phosphorylation	Kinase	CAMK1-FAMILY	-	GPS
498	S	Phosphorylation	Kinase	CAMK1A	Q14012	PSP
498	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
498	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
498	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
259	S	Phosphorylation	11081517
Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498.
498	S	Phosphorylation	11081517
Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HDAC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT16_HUMAN	ZBTB16	physical	15467736
1433T_HUMAN	YWHAQ	physical	15367659
KPCD1_HUMAN	PRKD1	physical	15367659
CTBP1_HUMAN	CTBP1	physical	11022042
GATA1_HUMAN	GATA1	physical	14668799
HDAC3_HUMAN	HDAC3	physical	10220385
HDAC3_HUMAN	HDAC3	physical	11804585
NCOR1_HUMAN	NCOR1	physical	11931768
TBL1X_HUMAN	TBL1X	physical	11931768
HDAC3_HUMAN	HDAC3	physical	11931768
GPS2_HUMAN	GPS2	physical	11931768
BCL6_HUMAN	BCL6	physical	11929873
ZBT16_HUMAN	ZBTB16	physical	11929873
IKZF1_HUMAN	IKZF1	physical	12015313
1433B_HUMAN	YWHAB	physical	10869435
1433E_HUMAN	YWHAE	physical	10869435
HDAC3_HUMAN	HDAC3	physical	10869435
SUV91_HUMAN	SUV39H1	physical	12242305
EF1G_HUMAN	EEF1G	physical	16169070
GBRAP_HUMAN	GABARAP	physical	16169070
HAIR_HUMAN	HR	physical	11641275
PKN2_HUMAN	PKN2	physical	20188095
HIF1A_HUMAN	HIF1A	physical	19071119
GATA3_HUMAN	GATA3	physical	17075044
SMAD7_HUMAN	SMAD7	physical	15831498
MAFF_HUMAN	MAFF	physical	20211142
1433G_HUMAN	YWHAG	physical	18951085
REST_HUMAN	REST	physical	17011572
SIN3A_HUMAN	SIN3A	physical	17011572
MARK3_HUMAN	MARK3	physical	16980613
KLF4_HUMAN	KLF4	physical	18768922
TYY1_HUMAN	YY1	physical	16822951
KCC1A_HUMAN	CAMK1	physical	16767219
GCM1_HUMAN	GCM1	physical	16528103
NU214_HUMAN	NUP214	physical	16356933
GBB1_HUMAN	GNB1	physical	16221676
UBC9_HUMAN	UBE2I	physical	16166628
RUNX2_HUMAN	RUNX2	physical	15990875
RFXK_HUMAN	RFXANK	physical	15964851
ANRA2_HUMAN	ANKRA2	physical	15964851
C2TA_HUMAN	CIITA	physical	15964851
SMAD7_HUMAN	SMAD7	physical	15831516
KPCD1_HUMAN	PRKD1	physical	15728188
PP2AA_HUMAN	PPP2CA	physical	18339811
1433E_RAT	Ywhae	physical	15572669
IKBA_HUMAN	NFKBIA	physical	15536134
HDAC5_HUMAN	HDAC5	physical	18332106
HDAC4_HUMAN	HDAC4	physical	18332106
AAKB1_HUMAN	PRKAB1	physical	18184930
NR2E1_HUMAN	NR2E1	physical	17873065
NFAC1_HUMAN	NFATC1	physical	21413932
1433T_HUMAN	YWHAQ	physical	20716686
HDAC5_HUMAN	HDAC5	physical	21081666
RBM25_HUMAN	RBM25	physical	21081666
NCOR1_HUMAN	NCOR1	physical	21081666
NCOR2_HUMAN	NCOR2	physical	21081666
TBL1X_HUMAN	TBL1X	physical	21081666
TBL1R_HUMAN	TBL1XR1	physical	21081666
GPS2_HUMAN	GPS2	physical	21081666
HDAC1_HUMAN	HDAC1	physical	21081666
RBBP7_HUMAN	RBBP7	physical	21081666
RBBP4_HUMAN	RBBP4	physical	21081666
MTA2_HUMAN	MTA2	physical	21081666
KPCD1_HUMAN	PRKD1	physical	21081666
KPCD2_HUMAN	PRKD2	physical	21081666
2AAA_HUMAN	PPP2R1A	physical	21081666
2ABA_HUMAN	PPP2R2A	physical	21081666
PP2AA_HUMAN	PPP2CA	physical	21081666
1433B_HUMAN	YWHAB	physical	21081666
1433E_HUMAN	YWHAE	physical	21081666
1433F_HUMAN	YWHAH	physical	21081666
1433G_HUMAN	YWHAG	physical	21081666
1433T_HUMAN	YWHAQ	physical	21081666
1433Z_HUMAN	YWHAZ	physical	21081666
PRKDC_HUMAN	PRKDC	physical	21081666
P53_HUMAN	TP53	physical	21081666
TBB5_HUMAN	TUBB	physical	21081666
TBA1A_HUMAN	TUBA1A	physical	21081666
HS90B_HUMAN	HSP90AB1	physical	21081666
RBM39_HUMAN	RBM39	physical	21081666
ROA2_HUMAN	HNRNPA2B1	physical	21081666
NUMA1_HUMAN	NUMA1	physical	21081666
H2A2C_HUMAN	HIST2H2AC	physical	21081666
H2B1K_HUMAN	HIST1H2BK	physical	21081666
H31T_HUMAN	HIST3H3	physical	21081666
HDAC3_HUMAN	HDAC3	physical	21081666
KPCD3_HUMAN	PRKD3	physical	21081666
RAD50_HUMAN	RAD50	physical	21081666
MAP1B_HUMAN	MAP1B	physical	21081666
USP9X_HUMAN	USP9X	physical	21081666
UBP7_HUMAN	USP7	physical	21081666
SYIC_HUMAN	IARS	physical	21081666
PSA5_HUMAN	PSMA5	physical	21081666
PRP39_HUMAN	PRPF39	physical	21081666
HCFC1_HUMAN	HCFC1	physical	21081666
RUVB1_HUMAN	RUVBL1	physical	21081666
BAG2_HUMAN	BAG2	physical	21081666
CCAR2_HUMAN	CCAR2	physical	21081666
RENT1_HUMAN	UPF1	physical	21081666
PRS8_HUMAN	PSMC5	physical	21081666
NUDC_HUMAN	NUDC	physical	21081666
GCN1_HUMAN	GCN1L1	physical	21081666
PSD11_HUMAN	PSMD11	physical	21081666
NEUR1_HUMAN	NEU1	physical	21081666
CDK1_HUMAN	CDK1	physical	21081666
SF3A1_HUMAN	SF3A1	physical	21081666
PRS10_HUMAN	PSMC6	physical	21081666
LKHA4_HUMAN	LTA4H	physical	21081666
ETFA_HUMAN	ETFA	physical	21081666
COPB2_HUMAN	COPB2	physical	21081666
PIMT_HUMAN	PCMT1	physical	21081666
TNPO1_HUMAN	TNPO1	physical	21081666
CSK21_HUMAN	CSNK2A1	physical	21081666
OGT1_HUMAN	OGT	physical	21081666
PGAM5_HUMAN	PGAM5	physical	21081666
SF3B1_HUMAN	SF3B1	physical	21081666
PSMD1_HUMAN	PSMD1	physical	21081666
WDR5_HUMAN	WDR5	physical	21081666
AATM_HUMAN	GOT2	physical	21081666
XPOT_HUMAN	XPOT	physical	21081666
RL9_HUMAN	RPL9	physical	21081666
ANM1_HUMAN	PRMT1	physical	21081666
EIF3L_HUMAN	EIF3L	physical	21081666
CAND1_HUMAN	CAND1	physical	21081666
DDX20_HUMAN	DDX20	physical	21081666
SAHH_HUMAN	AHCY	physical	21081666
HCD2_HUMAN	HSD17B10	physical	21081666
PP2AB_HUMAN	PPP2CB	physical	21081666
LG3BP_HUMAN	LGALS3BP	physical	21081666
SMC1A_HUMAN	SMC1A	physical	21081666
STRAP_HUMAN	STRAP	physical	21081666
RPN2_HUMAN	RPN2	physical	21081666
OST48_HUMAN	DDOST	physical	21081666
PSMD2_HUMAN	PSMD2	physical	21081666
PRS6B_HUMAN	PSMC4	physical	21081666
SF3B2_HUMAN	SF3B2	physical	21081666
ECH1_HUMAN	ECH1	physical	21081666
TPIS_HUMAN	TPI1	physical	21081666
PSMD6_HUMAN	PSMD6	physical	21081666
EFTU_HUMAN	TUFM	physical	21081666
PSMD3_HUMAN	PSMD3	physical	21081666
PCNA_HUMAN	PCNA	physical	21081666
CISY_HUMAN	CS	physical	21081666
M2OM_HUMAN	SLC25A11	physical	21081666
RAN_HUMAN	RAN	physical	21081666
ENPL_HUMAN	HSP90B1	physical	21081666
RL7_HUMAN	RPL7	physical	21081666
QCR2_HUMAN	UQCRC2	physical	21081666
SF3B3_HUMAN	SF3B3	physical	21081666
RL13_HUMAN	RPL13	physical	21081666
ANM5_HUMAN	PRMT5	physical	21081666
PHB_HUMAN	PHB	physical	21081666
SMC3_HUMAN	SMC3	physical	21081666
RL10A_HUMAN	RPL10A	physical	21081666
LDHA_HUMAN	LDHA	physical	21081666
MDHM_HUMAN	MDH2	physical	21081666
PSB5_HUMAN	PSMB5	physical	21081666
CH60_HUMAN	HSPD1	physical	21081666
HNRPF_HUMAN	HNRNPF	physical	21081666
DDB1_HUMAN	DDB1	physical	21081666
SFXN1_HUMAN	SFXN1	physical	21081666
ATPA_HUMAN	ATP5A1	physical	21081666
FLNA_HUMAN	FLNA	physical	21081666
OAT_HUMAN	OAT	physical	21081666
VDAC1_HUMAN	VDAC1	physical	21081666
HSP74_HUMAN	HSPA4	physical	21081666
TRAP1_HUMAN	TRAP1	physical	21081666
ATPB_HUMAN	ATP5B	physical	21081666
2ABD_HUMAN	PPP2R2D	physical	21081666
RPN1_HUMAN	RPN1	physical	21081666
C1TC_HUMAN	MTHFD1	physical	21081666
PDIA6_HUMAN	PDIA6	physical	21081666
SERA_HUMAN	PHGDH	physical	21081666
TCPB_HUMAN	CCT2	physical	21081666
NDKA_HUMAN	NME1	physical	21081666
SYLC_HUMAN	LARS	physical	21081666
PCBP2_HUMAN	PCBP2	physical	21081666
ALDOA_HUMAN	ALDOA	physical	21081666
TIF1B_HUMAN	TRIM28	physical	21081666
GANAB_HUMAN	GANAB	physical	21081666
ACTN4_HUMAN	ACTN4	physical	21081666
HS90A_HUMAN	HSP90AA1	physical	21081666
SYDC_HUMAN	DARS	physical	21081666
AT1A1_HUMAN	ATP1A1	physical	21081666
CALX_HUMAN	CANX	physical	21081666
PGK1_HUMAN	PGK1	physical	21081666
PDIA1_HUMAN	P4HB	physical	21081666
RS8_HUMAN	RPS8	physical	21081666
RLA0_HUMAN	RPLP0	physical	21081666
TCPZ_HUMAN	CCT6A	physical	21081666
PRP19_HUMAN	PRPF19	physical	21081666
HNRH2_HUMAN	HNRNPH2	physical	21081666
PA2G4_HUMAN	PA2G4	physical	21081666
FXR1_HUMAN	FXR1	physical	21081666
LPPRC_HUMAN	LRPPRC	physical	21081666
VDAC2_HUMAN	VDAC2	physical	21081666
EF1G_HUMAN	EEF1G	physical	21081666
XPO2_HUMAN	CSE1L	physical	21081666
KPYM_HUMAN	PKM	physical	21081666
RL3_HUMAN	RPL3	physical	21081666
PRDX3_HUMAN	PRDX3	physical	21081666
THIL_HUMAN	ACAT1	physical	21081666
COPB_HUMAN	COPB1	physical	21081666
DJB11_HUMAN	DNAJB11	physical	21081666
IF4A3_HUMAN	EIF4A3	physical	21081666
PPIA_HUMAN	PPIA	physical	21081666
C1QBP_HUMAN	C1QBP	physical	21081666
MCM3_HUMAN	MCM3	physical	21081666
TCPA_HUMAN	TCP1	physical	21081666
MCM4_HUMAN	MCM4	physical	21081666
IMDH2_HUMAN	IMPDH2	physical	21081666
RSSA_HUMAN	RPSA	physical	21081666
IF4A1_HUMAN	EIF4A1	physical	21081666
TCPH_HUMAN	CCT7	physical	21081666
DX39B_HUMAN	DDX39B	physical	21081666
AT2A2_HUMAN	ATP2A2	physical	21081666
MCM2_HUMAN	MCM2	physical	21081666
IRS4_HUMAN	IRS4	physical	21081666
TXTP_HUMAN	SLC25A1	physical	21081666
SYEP_HUMAN	EPRS	physical	21081666
MPCP_HUMAN	SLC25A3	physical	21081666
PHB2_HUMAN	PHB2	physical	21081666
PRDX4_HUMAN	PRDX4	physical	21081666
EIF3F_HUMAN	EIF3F	physical	21081666
EIF3C_HUMAN	EIF3C	physical	21081666
XRCC5_HUMAN	XRCC5	physical	21081666
RUVB2_HUMAN	RUVBL2	physical	21081666
NFS1_HUMAN	NFS1	physical	21081666
HNRLL_HUMAN	HNRNPLL	physical	21081666
PRP8_HUMAN	PRPF8	physical	21081666
CLH1_HUMAN	CLTC	physical	21081666
TCPD_HUMAN	CCT4	physical	21081666
U5S1_HUMAN	EFTUD2	physical	21081666
TCPE_HUMAN	CCT5	physical	21081666
DHE3_HUMAN	GLUD1	physical	21081666
XRCC6_HUMAN	XRCC6	physical	21081666
SYMC_HUMAN	MARS	physical	21081666
XPO1_HUMAN	XPO1	physical	21081666
UBA1_HUMAN	UBA1	physical	21081666
SYTC_HUMAN	TARS	physical	21081666
RS3A_HUMAN	RPS3A	physical	21081666
FAS_HUMAN	FASN	physical	21081666
IMB1_HUMAN	KPNB1	physical	21081666
MCM6_HUMAN	MCM6	physical	21081666
ACLY_HUMAN	ACLY	physical	21081666
SRSF1_HUMAN	SRSF1	physical	21081666
HNRPD_HUMAN	HNRNPD	physical	21081666
ADT3_HUMAN	SLC25A6	physical	21081666
TCPQ_HUMAN	CCT8	physical	21081666
PYR1_HUMAN	CAD	physical	21081666
PSA_HUMAN	NPEPPS	physical	21081666
TCPG_HUMAN	CCT3	physical	21081666
TBB4B_HUMAN	TUBB4B	physical	21081666
EIF3B_HUMAN	EIF3B	physical	21081666
PRDX6_HUMAN	PRDX6	physical	21081666
ILF2_HUMAN	ILF2	physical	21081666
CDC5L_HUMAN	CDC5L	physical	21081666
GLYM_HUMAN	SHMT2	physical	21081666
DNJA1_HUMAN	DNAJA1	physical	21081666
PTBP1_HUMAN	PTBP1	physical	21081666
GRP75_HUMAN	HSPA9	physical	21081666
RS11_HUMAN	RPS11	physical	21081666
APLP2_HUMAN	APLP2	physical	21081666
DHX15_HUMAN	DHX15	physical	21081666
RL5_HUMAN	RPL5	physical	21081666
RS3_HUMAN	RPS3	physical	21081666
SYRC_HUMAN	RARS	physical	21081666
KCRB_HUMAN	CKB	physical	21081666
P5CS_HUMAN	ALDH18A1	physical	21081666
PP1A_HUMAN	PPP1CA	physical	21081666
NONO_HUMAN	NONO	physical	21081666
U520_HUMAN	SNRNP200	physical	21081666
DDX1_HUMAN	DDX1	physical	21081666
TERA_HUMAN	VCP	physical	21081666
GRP78_HUMAN	HSPA5	physical	21081666
DDX17_HUMAN	DDX17	physical	21081666
RL7A_HUMAN	RPL7A	physical	21081666
TKT_HUMAN	TKT	physical	21081666
PABP1_HUMAN	PABPC1	physical	21081666
MCM5_HUMAN	MCM5	physical	21081666
TFR1_HUMAN	TFRC	physical	21081666
EMD_HUMAN	EMD	physical	21081666
SYQ_HUMAN	QARS	physical	21081666
MCM7_HUMAN	MCM7	physical	21081666
RS4X_HUMAN	RPS4X	physical	21081666
RL4_HUMAN	RPL4	physical	21081666
KCRU_HUMAN	CKMT1B	physical	21081666
NUP93_HUMAN	NUP93	physical	21081666
HNRPL_HUMAN	HNRNPL	physical	21081666
SFPQ_HUMAN	SFPQ	physical	21081666
RBM14_HUMAN	RBM14	physical	21081666
PARP1_HUMAN	PARP1	physical	21081666
DSRAD_HUMAN	ADAR	physical	21081666
ILF3_HUMAN	ILF3	physical	21081666
NPM_HUMAN	NPM1	physical	21081666
DHX9_HUMAN	DHX9	physical	21081666
H12_HUMAN	HIST1H1C	physical	21081666
IF2B1_HUMAN	IGF2BP1	physical	21081666
DDX3X_HUMAN	DDX3X	physical	21081666
MYH9_HUMAN	MYH9	physical	21081666
ROA1_HUMAN	HNRNPA1	physical	21081666
ECHA_HUMAN	HADHA	physical	21081666
ROA3_HUMAN	HNRNPA3	physical	21081666
DDX47_HUMAN	DDX47	physical	21081666
HNRPR_HUMAN	HNRNPR	physical	21081666
NOP2_HUMAN	NOP2	physical	21081666
RBMX_HUMAN	RBMX	physical	21081666
TOP1_HUMAN	TOP1	physical	21081666
NFKB1_HUMAN	NFKB1	physical	12917325
SF01_HUMAN	SF1	physical	12917325
KDM5B_HUMAN	KDM5B	physical	17373667
NRIP1_HUMAN	NRIP1	physical	15060175
JDP2_HUMAN	JDP2	physical	22989952
ATF3_HUMAN	ATF3	physical	22989952
ZBT7B_HUMAN	ZBTB7B	physical	22730529
HDAC4_HUMAN	HDAC4	physical	22730529
1433B_HUMAN	YWHAB	physical	23752268
1433E_HUMAN	YWHAE	physical	23752268
1433F_HUMAN	YWHAH	physical	23752268
1433G_HUMAN	YWHAG	physical	23752268
1433S_HUMAN	SFN	physical	23752268
1433T_HUMAN	YWHAQ	physical	23752268
1433Z_HUMAN	YWHAZ	physical	23752268
DP13A_HUMAN	APPL1	physical	23752268
TBL1X_HUMAN	TBL1X	physical	23752268
TBL1R_HUMAN	TBL1XR1	physical	23752268
HDAC5_HUMAN	HDAC5	physical	23752268
NCOR1_HUMAN	NCOR1	physical	23752268
PHB_HUMAN	PHB	physical	23752268
2ABA_HUMAN	PPP2R2A	physical	23752268
MYCN_HUMAN	MYCN	physical	23812427
1433T_HUMAN	YWHAQ	physical	23393134
DDIT3_HUMAN	DDIT3	physical	17872950
CBX5_MOUSE	Cbx5	physical	12242305
1433E_HUMAN	YWHAE	physical	24841198
ANRA2_HUMAN	ANKRA2	physical	25752541
CUL7_HUMAN	CUL7	physical	25752541
KPCD1_HUMAN	PRKD1	physical	26137861
TFEB_HUMAN	TFEB	physical	26137861
CING_HUMAN	CGN	physical	27173435
NR2E1_HUMAN	NR2E1	physical	26965827

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HDAC5_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-533, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-661, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Protein kinase D-dependent phosphorylation and nuclear export ofhistone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis."; Ha C.H., Wang W., Jhun B.S., Wong C., Hausser A., Pfizenmaier K.,McKinsey T.A., Olson E.N., Jin Z.G.; J. Biol. Chem. 283:14590-14599(2008). Cited for: PHOSPHORYLATION AT SER-259 AND SER-498.	18332134 [Abstract]
"AMP-activated protein kinase regulates GLUT4 transcription byphosphorylating histone deacetylase 5."; McGee S.L., van Denderen B.J., Howlett K.F., Mollica J.,Schertzer J.D., Kemp B.E., Hargreaves M.; Diabetes 57:860-867(2008). Cited for: PHOSPHORYLATION AT SER-259 AND SER-498, SUBCELLULAR LOCATION, ANDMUTAGENESIS OF SER-259 AND SER-498.	18184930 [Abstract]
"Activation of the myocyte enhancer factor-2 transcription factor bycalcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5."; McKinsey T.A., Zhang C.-L., Olson E.N.; Proc. Natl. Acad. Sci. U.S.A. 97:14400-14405(2000). Cited for: INTERACTION WITH 14-3-3, AND PHOSPHORYLATION AT SER-259 AND SER-498.	11114197 [Abstract]
"Protein kinase C-related kinase targets nuclear localization signalsin a subset of class IIa histone deacetylases."; Harrison B.C., Huynh K., Lundgaard G.L., Helmke S.M., Perryman M.B.,McKinsey T.A.; FEBS Lett. 584:1103-1110(2010). Cited for: PHOSPHORYLATION AT THR-292, AND MUTAGENESIS OF SER-259; SER-291 ANDTHR-292.	20188095 [Abstract]

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