dbPTM

PYR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PYR1_HUMAN
UniProt AC	P27708
Protein Name	CAD protein
Gene Name	CAD {ECO:0000312\|HGNC:HGNC:1424}
Organism	Homo sapiens (Human).
Sequence Length	2225
Subcellular Localization	Cytoplasm . Nucleus . Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Protein Description	This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)..
Protein Sequence	MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALVLEDG ------CCEEEECCC	22.32	22223895
10	Phosphorylation	ALVLEDGSVLRGQPF EEEECCCCEECCCCC	30.24	20068231
37	Ubiquitination	QTGMVGYPEALTDPS ECCCCCCHHHHCCCC	17.92	21890473
127	Ubiquitination	DTRELTKKLREQGSL CHHHHHHHHHHHCCH	47.76	-
133	Phosphorylation	KKLREQGSLLGKLVQ HHHHHHCCHHHHHHH	21.81	23532336
137	Ubiquitination	EQGSLLGKLVQNGTE HHCCHHHHHHHCCCC	45.51	21906983
165	Ubiquitination	LVPEVSIKTPRVFNT CCCCEEECCCCCCCC	44.99	21906983
166	Phosphorylation	VPEVSIKTPRVFNTG CCCEEECCCCCCCCC	18.04	23312004
172	Phosphorylation	KTPRVFNTGGAPRIL CCCCCCCCCCCCCEE	26.06	20068231
177	Methylation	FNTGGAPRILALDCG CCCCCCCCEEEEECC	35.70	-
183	Glutathionylation	PRILALDCGLKYNQI CCEEEEECCCCHHHH	7.76	22555962
186	Acetylation	LALDCGLKYNQIRCL EEEECCCCHHHHHHH	27.69	25953088
186	Methylation	LALDCGLKYNQIRCL EEEECCCCHHHHHHH	27.69	-
186	Ubiquitination	LALDCGLKYNQIRCL EEEECCCCHHHHHHH	27.69	-
267	Phosphorylation	LAIGAKTYKMRYGNR HHHCCEEEECCCCCC	11.33	-
285	Phosphorylation	QPCLLVGSGRCFLTS CCEEEECCCCEEECC	18.65	28857561
375	Phosphorylation	QTVRERLTERLCPPG HHHHHHHHHCCCCCC	25.86	18767875
379	Glutathionylation	ERLTERLCPPGIPTP HHHHHCCCCCCCCCC	4.84	22555962
424	Ubiquitination	SQAIKALKEENIQTL HHHHHHHHHCCCCEE	68.77	21906983
456	Phosphorylation	KVYFLPITPHYVTQV EEEEEECCHHHHHHH	11.32	15890648
475	Phosphorylation	RPDGVLLTFGGQTAL CCCCEEEEECCEEHH	18.97	-
484	Glutathionylation	GGQTALNCGVELTKA CCEEHHCCCCEEHHH	7.22	22555962
490	Ubiquitination	NCGVELTKAGVLARY CCCCEEHHHHHHHHH	56.63	-
504	Phosphorylation	YGVRVLGTPVETIEL HCEEECCCCEEEEEC	21.72	20068231
585	Phosphorylation	VAPAFAHTSQVLVDK HHHHHCCCCHHEECC	19.88	-
586	Phosphorylation	APAFAHTSQVLVDKS HHHHCCCCHHEECCC	14.39	-
592	Ubiquitination	TSQVLVDKSLKGWKE CCHHEECCCCCCCEE	50.65	21890473
598	Ubiquitination	DKSLKGWKEIEYEVV CCCCCCCEEEEEEEH	58.44	21890473
602	Phosphorylation	KGWKEIEYEVVRDAY CCCEEEEEEEHHHHC	21.49	20068231
690	Phosphorylation	VNARLSRSSALASKA EECEECCHHHHHHHC	19.31	22798277
696	Succinylation	RSSALASKATGYPLA CHHHHHHHCCCCCHH	44.34	23954790
696	Ubiquitination	RSSALASKATGYPLA CHHHHHHHCCCCCHH	44.34	21890473
698	Phosphorylation	SALASKATGYPLAYV HHHHHHCCCCCHHHH	40.77	28152594
700	Phosphorylation	LASKATGYPLAYVAA HHHHCCCCCHHHHHH	7.24	28152594
723	O-linked_Glycosylation	PELRNSVTGGTAAFE HHHHCCCCCCCCCCC	29.70	23301498
726	O-linked_Glycosylation	RNSVTGGTAAFEPSV HCCCCCCCCCCCCCC	19.02	23301498
732	Phosphorylation	GTAAFEPSVDYCVVK CCCCCCCCCCEEEEE	22.03	28152594
735	Phosphorylation	AFEPSVDYCVVKIPR CCCCCCCEEEEEECC	5.74	28152594
736	Glutathionylation	FEPSVDYCVVKIPRW CCCCCCEEEEEECCC	2.16	22555962
739	Ubiquitination	SVDYCVVKIPRWDLS CCCEEEEEECCCCHH	26.96	-
747	2-Hydroxyisobutyrylation	IPRWDLSKFLRVSTK ECCCCHHHHHHHHHH	56.57	-
747	Acetylation	IPRWDLSKFLRVSTK ECCCCHHHHHHHHHH	56.57	19608861
747	Ubiquitination	IPRWDLSKFLRVSTK ECCCCHHHHHHHHHH	56.57	21890473
754	Acetylation	KFLRVSTKIGSCMKS HHHHHHHHHHHHHHH	37.25	25953088
754	Ubiquitination	KFLRVSTKIGSCMKS HHHHHHHHHHHHHHH	37.25	-
760	Acetylation	TKIGSCMKSVGEVMG HHHHHHHHHHHHHHC	46.44	25953088
760	Ubiquitination	TKIGSCMKSVGEVMG HHHHHHHHHHHHHHC	46.44	-
761	Phosphorylation	KIGSCMKSVGEVMGI HHHHHHHHHHHHHCC	14.42	-
766	Sulfoxidation	MKSVGEVMGIGRSFE HHHHHHHHCCCCCHH	2.55	21406390
778	2-Hydroxyisobutyrylation	SFEEAFQKALRMVDE CHHHHHHHHHHHHHH	42.82	-
778	Acetylation	SFEEAFQKALRMVDE CHHHHHHHHHHHHHH	42.82	26822725
778	Ubiquitination	SFEEAFQKALRMVDE CHHHHHHHHHHHHHH	42.82	21890473
795	Ubiquitination	VGFDHTVKPVSDMEL CCCCCCCCCCCCCCC	40.64	-
808	Ubiquitination	ELETPTDKRIFVVAA CCCCCCCCCHHHHHH	50.28	-
867	Ubiquitination	PDLLQQAKCLGFSDK HHHHHHHHHHCCCHH	26.17	-
874	Ubiquitination	KCLGFSDKQIALAVL HHHCCCHHHHHHHHH	42.26	-
883	Phosphorylation	IALAVLSTELAVRKL HHHHHHCHHHHHHHH	30.75	-
889	Ubiquitination	STELAVRKLRQELGI CHHHHHHHHHHHHCC	41.23	-
897	Glutathionylation	LRQELGICPAVKQID HHHHHCCCCHHHCCC	1.35	22555962
969	Phosphorylation	LRKMGYKTIMVNYNP HHHCCCEEEEECCCC	13.06	21406692
974	Phosphorylation	YKTIMVNYNPETVST CEEEEECCCCCCCCC	22.23	21406692
978	Phosphorylation	MVNYNPETVSTDYDM EECCCCCCCCCCHHH	22.48	21406692
980	Phosphorylation	NYNPETVSTDYDMCD CCCCCCCCCCHHHCC	23.99	21406692
981	Phosphorylation	YNPETVSTDYDMCDR CCCCCCCCCHHHCCC	33.95	21406692
983	Phosphorylation	PETVSTDYDMCDRLY CCCCCCCHHHCCCEE	12.98	21406692
1037	Phosphorylation	QQCRVLGTSPEAIDS HHHHHHCCCHHHHHH	36.63	30266825
1038	Phosphorylation	QCRVLGTSPEAIDSA HHHHHCCCHHHHHHH	20.95	30266825
1044	Phosphorylation	TSPEAIDSAENRFKF CCHHHHHHHHHHHHH	31.22	23403867
1057	Phosphorylation	KFSRLLDTIGISQPQ HHHHHHHHHCCCCHH	22.52	21406692
1061	Phosphorylation	LLDTIGISQPQWREL HHHHHCCCCHHHHHH	30.51	21406692
1069	Phosphorylation	QPQWRELSDLESARQ CHHHHHHHHHHHHHH	35.08	20068231
1073	Phosphorylation	RELSDLESARQFCQT HHHHHHHHHHHHHHH	35.73	20068231
1080	O-linked_Glycosylation	SARQFCQTVGYPCVV HHHHHHHHHCCCEEE	19.65	23301498
1112	Phosphorylation	GDLERFLSSAAAVSK CCHHHHHHHHHHHCC	18.41	20068231
1113	Phosphorylation	DLERFLSSAAAVSKE CHHHHHHHHHHHCCC	24.87	23312004
1118	Phosphorylation	LSSAAAVSKEHPVVI HHHHHHHCCCCCCHH	27.83	20068231
1119	Ubiquitination	SSAAAVSKEHPVVIS HHHHHHCCCCCCHHH	54.14	21890473
1127	Acetylation	EHPVVISKFIQEAKE CCCCHHHHHHHHHHC	35.05	25953088
1127	Ubiquitination	EHPVVISKFIQEAKE CCCCHHHHHHHHHHC	35.05	21906983
1177	Ubiquitination	PPQDITAKTLERIKA CCCCCCHHHHHHHHH	45.02	-
1206	Ubiquitination	FNLQLIAKDDQLKVI CCEEEEECCCCEEEE	55.64	-
1211	Acetylation	IAKDDQLKVIECNVR EECCCCEEEEEEEEE	35.22	25953088
1211	Ubiquitination	IAKDDQLKVIECNVR EECCCCEEEEEEEEE	35.22	-
1220	Phosphorylation	IECNVRVSRSFPFVS EEEEEEECCCCCCCC	16.19	21406692
1222	Phosphorylation	CNVRVSRSFPFVSKT EEEEECCCCCCCCCC	29.75	21406692
1227	Phosphorylation	SRSFPFVSKTLGVDL CCCCCCCCCCCCCCH	21.94	22210691
1228	Ubiquitination	RSFPFVSKTLGVDLV CCCCCCCCCCCCCHH	42.33	21890473
1262	Ubiquitination	GSGVVGVKVPQFSFS CCCEEEEECCCCCHH	42.12	21890473
1267	Phosphorylation	GVKVPQFSFSRLAGA EEECCCCCHHHHCCC	19.64	28857561
1301	Methylation	SRCEAYLKAMLSTGF HHHHHHHHHHHHCCC	21.05	-
1303	Sulfoxidation	CEAYLKAMLSTGFKI HHHHHHHHHHCCCCC	2.65	21406390
1309	Acetylation	AMLSTGFKIPKKNIL HHHHCCCCCCCCCEE	60.49	25953088
1309	Ubiquitination	AMLSTGFKIPKKNIL HHHHCCCCCCCCCEE	60.49	21890473
1313	Malonylation	TGFKIPKKNILLTIG CCCCCCCCCEEEEEC	43.81	26320211
1313	Ubiquitination	TGFKIPKKNILLTIG CCCCCCCCCEEEEEC	43.81	-
1318	Phosphorylation	PKKNILLTIGSYKNK CCCCEEEEECCCCCH	21.61	30108239
1321	Phosphorylation	NILLTIGSYKNKSEL CEEEEECCCCCHHHH	29.14	30108239
1322	Phosphorylation	ILLTIGSYKNKSELL EEEEECCCCCHHHHH	17.23	22817900
1323	Malonylation	LLTIGSYKNKSELLP EEEECCCCCHHHHHH	60.64	26320211
1323	Ubiquitination	LLTIGSYKNKSELLP EEEECCCCCHHHHHH	60.64	-
1325	Malonylation	TIGSYKNKSELLPTV EECCCCCHHHHHHHH	40.95	26320211
1325	Ubiquitination	TIGSYKNKSELLPTV EECCCCCHHHHHHHH	40.95	21906983
1337	Phosphorylation	PTVRLLESLGYSLYA HHHHHHHHHCCHHHH	27.36	21601212
1343	Phosphorylation	ESLGYSLYASLGTAD HHHCCHHHHCCCCCC	6.55	21601212
1379	Phosphorylation	GECPPQRSILEQLAE CCCCCCHHHHHHHHH	26.69	28555341
1387	Ubiquitination	ILEQLAEKNFELVIN HHHHHHHCCCEEEEE	62.42	-
1406	Dephosphorylation	GAGGRRLSSFVTKGY CCCCCCHHHHHCCCH	21.66	4092695
1406	Phosphorylation	GAGGRRLSSFVTKGY CCCCCCHHHHHCCCH	21.66	29255136
1407	Phosphorylation	AGGRRLSSFVTKGYR CCCCCHHHHHCCCHH	28.47	23401153
1410	Phosphorylation	RRLSSFVTKGYRTRR CCHHHHHCCCHHHCC	19.42	23927012
1411	Acetylation	RLSSFVTKGYRTRRL CHHHHHCCCHHHCCC	48.95	19608861
1411	Ubiquitination	RLSSFVTKGYRTRRL CHHHHHCCCHHHCCC	48.95	21890473
1413	Phosphorylation	SSFVTKGYRTRRLAA HHHHCCCHHHCCCCC	15.46	22210691
1423	Phosphorylation	RRLAADFSVPLIIDI CCCCCCCCCCEEEEE	24.31	22817900
1431	Ubiquitination	VPLIIDIKCTKLFVE CCEEEEECCCHHHHH	31.91	21906983
1434	Ubiquitination	IIDIKCTKLFVEALG EEEECCCHHHHHHHH	49.77	-
1450	Sumoylation	IGPAPPLKVHVDCMT CCCCCCEEEEEEECC	35.75	-
1450	Ubiquitination	IGPAPPLKVHVDCMT CCCCCCEEEEEEECC	35.75	-
1457	Phosphorylation	KVHVDCMTSQKLVRL EEEEEECCCCHHHCC	34.05	20873877
1458	Phosphorylation	VHVDCMTSQKLVRLP EEEEECCCCHHHCCC	9.83	20873877
1460	Ubiquitination	VDCMTSQKLVRLPGL EEECCCCHHHCCCCE	49.03	-
1521	Ubiquitination	PALALAQKLAEAGAR HHHHHHHHHHHHHCC	44.02	-
1556	N6-carboxylysine	AGSAAGLKLYLNETF HHHHHHHHHHHCCCC	33.88	-
1556	Carboxylation	AGSAAGLKLYLNETF HHHHHHHHHHHCCCC	33.88	24332717
1564	Phosphorylation	LYLNETFSELRLDSV HHHCCCCHHHCHHHH	43.04	24719451
1613	S-palmitoylation	TQRSVHICHVARKEE HHCCHHHHEECCHHH	0.96	21044946
1618	Ubiquitination	HICHVARKEEILLIK HHHEECCHHHEEHHH	50.38	21906983
1625	Ubiquitination	KEEILLIKAAKARGL HHHEEHHHHHHHCCC	42.11	21906983
1636	S-palmitoylation	ARGLPVTCEVAPHHL HCCCCEEEEECCCEE	3.94	21044946
1646	Phosphorylation	APHHLFLSHDDLERL CCCEEECCHHHHHHH	19.96	-
1657	Ubiquitination	LERLGPGKGEVRPEL HHHHCCCCCCCCCCC	55.84	21890473
1698	Phosphorylation	TLEEKCGSRPPPGFP CHHHHHCCCCCCCCC	51.59	24719451
1724	Phosphorylation	AVSEGRLSLDDLLQR HHHCCCCCHHHHHHH	28.52	21712546
1778	Ubiquitination	WTPFEGQKVKGTVRR CCCCCCCCCCCEEEE	57.69	-
1794	Phosphorylation	VLRGEVAYIDGQVLV EECCEEEEEECEEEC	12.53	-
1805	Phosphorylation	QVLVPPGYGQDVRKW EEECCCCCCCCHHHC	19.86	-
1823	Phosphorylation	AVPQLPPSAPATSEM CCCCCCCCCCCCCCC	44.97	30266825
1827	Phosphorylation	LPPSAPATSEMTTTP CCCCCCCCCCCCCCC	24.94	23401153
1828	Phosphorylation	PPSAPATSEMTTTPE CCCCCCCCCCCCCCC	27.72	30266825
1831	Phosphorylation	APATSEMTTTPERPR CCCCCCCCCCCCCCC	24.38	23401153
1832	Phosphorylation	PATSEMTTTPERPRR CCCCCCCCCCCCCCC	38.76	30266825
1833	Phosphorylation	ATSEMTTTPERPRRG CCCCCCCCCCCCCCC	17.62	30266825
1839	Methylation	TTPERPRRGIPGLPD CCCCCCCCCCCCCCC	50.50	-
1856	Phosphorylation	FHLPPRIHRASDPGL CCCCCCCCCCCCCCC	22.12	-
1859	Dephosphorylation	PPRIHRASDPGLPAE CCCCCCCCCCCCCCC	44.27	4092695
1859	Phosphorylation	PPRIHRASDPGLPAE CCCCCCCCCCCCCCC	44.27	19664994
1869	Ubiquitination	GLPAEEPKEKSSRKV CCCCCCCCCHHCCCC	79.60	-
1871	Ubiquitination	PAEEPKEKSSRKVAE CCCCCCCHHCCCCCC	60.91	-
1872	Phosphorylation	AEEPKEKSSRKVAEP CCCCCCHHCCCCCCH	36.14	26074081
1873	Phosphorylation	EEPKEKSSRKVAEPE CCCCCHHCCCCCCHH	47.38	26074081
1875	Ubiquitination	PKEKSSRKVAEPELM CCCHHCCCCCCHHHC	47.98	-
1884	Phosphorylation	AEPELMGTPDGTCYP CCHHHCCCCCCCCCC	12.30	30266825
1888	Phosphorylation	LMGTPDGTCYPPPPV HCCCCCCCCCCCCCC	19.08	30266825
1889	Glutathionylation	MGTPDGTCYPPPPVP CCCCCCCCCCCCCCC	6.16	22555962
1890	Phosphorylation	GTPDGTCYPPPPVPR CCCCCCCCCCCCCCC	20.72	30266825
1900	Phosphorylation	PPVPRQASPQNLGTP CCCCCCCCCCCCCCC	20.76	25159151
1906	Phosphorylation	ASPQNLGTPGLLHPQ CCCCCCCCCCCCCCC	19.83	25159151
1914	Phosphorylation	PGLLHPQTSPLLHSL CCCCCCCCHHHHHHH	36.44	22199227
1915	Phosphorylation	GLLHPQTSPLLHSLV CCCCCCCHHHHHHHH	14.33	22199227
1920	Phosphorylation	QTSPLLHSLVGQHIL CCHHHHHHHHHHHHH	25.39	20068231
1928	Phosphorylation	LVGQHILSVQQFTKD HHHHHHHHHEEECHH	19.78	28464451
1933	Phosphorylation	ILSVQQFTKDQMSHL HHHHEEECHHHHHHH	29.40	22199227
1938	Phosphorylation	QFTKDQMSHLFNVAH EECHHHHHHHHHHHH	16.05	7766613
1953	Acetylation	TLRMMVQKERSLDIL HHHHHHHHHHHHHHH	43.62	25953088
1953	Ubiquitination	TLRMMVQKERSLDIL HHHHHHHHHHHHHHH	43.62	-
1956	Phosphorylation	MMVQKERSLDILKGK HHHHHHHHHHHHCCC	31.33	28060719
1961	Ubiquitination	ERSLDILKGKVMASM HHHHHHHCCCHHHHE	57.95	21906983
1963	Ubiquitination	SLDILKGKVMASMFY HHHHHCCCHHHHEEE	27.53	-
1967	Phosphorylation	LKGKVMASMFYEVST HCCCHHHHEEEECCC	7.42	29759185
1970	Phosphorylation	KVMASMFYEVSTRTS CHHHHEEEECCCCCC	13.54	24043423
1973	Phosphorylation	ASMFYEVSTRTSSSF HHEEEECCCCCCHHH	10.55	29759185
1974	Phosphorylation	SMFYEVSTRTSSSFA HEEEECCCCCCHHHH	43.04	24043423
1976	Phosphorylation	FYEVSTRTSSSFAAA EEECCCCCCHHHHHH	32.80	23186163
1977	Phosphorylation	YEVSTRTSSSFAAAM EECCCCCCHHHHHHH	22.24	23186163
1978	Phosphorylation	EVSTRTSSSFAAAMA ECCCCCCHHHHHHHH	28.94	23186163
2036	Acetylation	GAVELAAKHCRRPVI CHHHHHHHHCCCCEE	37.32	25953088
2036	Ubiquitination	GAVELAAKHCRRPVI CHHHHHHHHCCCCEE	37.32	-
2062	Phosphorylation	QALLDIFTIREELGT HHHHHHHHHHHHHCC	21.32	24719451
2069	Phosphorylation	TIREELGTVNGMTIT HHHHHHCCCCCEEEE	24.35	24114839
2074	Phosphorylation	LGTVNGMTITMVGDL HCCCCCEEEEEECCC	18.07	24114839
2076	Phosphorylation	TVNGMTITMVGDLKH CCCCEEEEEECCCCC	9.17	24114839
2082	Acetylation	ITMVGDLKHGRTVHS EEEECCCCCCCCHHH	49.07	25953088
2086	Phosphorylation	GDLKHGRTVHSLACL CCCCCCCCHHHHHHH	27.45	27461979
2089	Phosphorylation	KHGRTVHSLACLLTQ CCCCCHHHHHHHHHC	17.21	27461979
2095	Phosphorylation	HSLACLLTQYRVSLR HHHHHHHHCCCCEEE	15.59	27461979
2097	Phosphorylation	LACLLTQYRVSLRYV HHHHHHCCCCEEEEC	14.03	27461979
2103	Phosphorylation	QYRVSLRYVAPPSLR CCCCEEEECCCHHHC	13.27	-
2124	Phosphorylation	AFVASRGTKQEEFES HHHHCCCCCHHHHHH	28.57	22210691
2125	Ubiquitination	FVASRGTKQEEFESI HHHCCCCCHHHHHHH	59.54	2190698
2143	Phosphorylation	LPDTDVLYMTRIQKE CCCCCEEEEEEECHH	9.04	22210691
2145	Phosphorylation	DTDVLYMTRIQKERF CCCEEEEEEECHHHH	15.86	22210691
2154	Phosphorylation	IQKERFGSTQEYEAC ECHHHHCCCHHHHHH	24.97	-
2155	Phosphorylation	QKERFGSTQEYEACF CHHHHCCCHHHHHHH	26.29	-
2158	Phosphorylation	RFGSTQEYEACFGQF HHCCCHHHHHHHHHH	10.06	-
2178	Ubiquitination	IMTRAKKKMVVMHPM HHHHHCCCEEEEECC	35.90	-
2203	Phosphorylation	DSDPRAAYFRQAENG CCCCCHHHHHHHHCC	9.79	-
2212	Phosphorylation	RQAENGMYIRMALLA HHHHCCHHHHHHHHH	6.18	24144214
2220	Phosphorylation	IRMALLATVLGRF-- HHHHHHHHHHCCC--	19.08	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
456	T	Phosphorylation	Kinase	MK01	P28482	PhosphoELM
456	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
1406	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1406	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1406	S	Phosphorylation	Kinase	PKA	-	Uniprot
1406	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
1859	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1859	S	Phosphorylation	Kinase	P70S6K	P23443	PSP
1859	S	Phosphorylation	Kinase	PKA	-	Uniprot
1873	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1406	S	Phosphorylation	17485345
Phosphorylation at Ser-1406 reduces sensitivity to feedback inhibition by UTP.
1859	S	Phosphorylation	17081983
Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PYR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUVB2_HUMAN	RUVBL2	physical	22939629
TBB4B_HUMAN	TUBB4B	physical	22939629
TBA4A_HUMAN	TUBA4A	physical	22939629
RUVB1_HUMAN	RUVBL1	physical	22939629
XPO1_HUMAN	XPO1	physical	22939629
TBB2A_HUMAN	TUBB2A	physical	22939629
SMRC2_HUMAN	SMARCC2	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
SMCA4_HUMAN	SMARCA4	physical	22939629
SYVC_HUMAN	VARS	physical	22939629
ACTZ_HUMAN	ACTR1A	physical	26344197
TCPG_HUMAN	CCT3	physical	26344197
TCPD_HUMAN	CCT4	physical	26344197
TCPZ_HUMAN	CCT6A	physical	26344197
TCPQ_HUMAN	CCT8	physical	26344197
CLH1_HUMAN	CLTC	physical	26344197
COPB_HUMAN	COPB1	physical	26344197
DDX3X_HUMAN	DDX3X	physical	26344197
DNJA1_HUMAN	DNAJA1	physical	26344197
DNJA4_HUMAN	DNAJA4	physical	26344197
EF1A1_HUMAN	EEF1A1	physical	26344197
EI2BA_HUMAN	EIF2B1	physical	26344197
IF2A_HUMAN	EIF2S1	physical	26344197
SYEP_HUMAN	EPRS	physical	26344197
GFPT1_HUMAN	GFPT1	physical	26344197
HSP7C_HUMAN	HSPA8	physical	26344197
SYIC_HUMAN	IARS	physical	26344197
IDH3A_HUMAN	IDH3A	physical	26344197
IPO4_HUMAN	IPO4	physical	26344197
MCM7_HUMAN	MCM7	physical	26344197
PRS6A_HUMAN	PSMC3	physical	26344197
PRS6B_HUMAN	PSMC4	physical	26344197
PRS8_HUMAN	PSMC5	physical	26344197
PRS10_HUMAN	PSMC6	physical	26344197
PSD12_HUMAN	PSMD12	physical	26344197
PSMD2_HUMAN	PSMD2	physical	26344197
PSMD4_HUMAN	PSMD4	physical	26344197
RUVB1_HUMAN	RUVBL1	physical	26344197
RUVB2_HUMAN	RUVBL2	physical	26344197
MPCP_HUMAN	SLC25A3	physical	26344197
UBR5_HUMAN	UBR5	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
YMEL1_HUMAN	YME1L1	physical	26344197
FAS_HUMAN	FASN	physical	28775317

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00128	L-Aspartic Acid
DB00130	L-Glutamine

Regulatory Network of PYR1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-747 AND LYS-1411, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1038 AND SER-1859, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1037 AND SER-1859, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1859 AND THR-1884, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1038; SER-1859 ANDTHR-1884, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1423, AND MASSSPECTROMETRY.	18187866 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1859, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1823 AND SER-1859, ANDMASS SPECTROMETRY.	17081983 [Abstract]

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