dbPTM

FAS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FAS_HUMAN
UniProt AC	P49327
Protein Name	Fatty acid synthase
Gene Name	FASN
Organism	Homo sapiens (Human).
Sequence Length	2511
Subcellular Localization	Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description	Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein..
Protein Sequence	MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEVVIAG -------CCEEEEEC	43.05	22223895
12	Sumoylation	VIAGMSGKLPESENL EEECCCCCCCCCCCH	54.27	-
34	Phosphorylation	IGGVDMVTDDDRRWK HCCCCCCCCCCHHHH	27.37	-
41	Acetylation	TDDDRRWKAGLYGLP CCCCHHHHHHHCCCC	30.66	26051181
41	Ubiquitination	TDDDRRWKAGLYGLP CCCCHHHHHHHCCCC	30.66	23000965
45	Phosphorylation	RRWKAGLYGLPRRSG HHHHHHHCCCCCCCC	18.72	21945579
51	Phosphorylation	LYGLPRRSGKLKDLS HCCCCCCCCCCCCHH	41.37	28985074
58	Phosphorylation	SGKLKDLSRFDASFF CCCCCCHHHCCHHHC	40.82	29514088
63	Phosphorylation	DLSRFDASFFGVHPK CHHHCCHHHCCCCHH	23.97	25159151
70	Acetylation	SFFGVHPKQAHTMDP HHCCCCHHHCCCCCH	45.28	19608861
70	Malonylation	SFFGVHPKQAHTMDP HHCCCCHHHCCCCCH	45.28	26320211
70	Ubiquitination	SFFGVHPKQAHTMDP HHCCCCHHHCCCCCH	45.28	23000965
130	Phosphorylation	DPETLVGYSMVGCQR CHHHHHHHHHHHHHH	6.01	23822953
131	Phosphorylation	PETLVGYSMVGCQRA HHHHHHHHHHHHHHH	10.89	28851738
145	Phosphorylation	AMMANRLSFFFDFRG HHHHHCHHHHCCCCC	19.44	28851738
154	Phosphorylation	FFDFRGPSIALDTAC HCCCCCCCHHHHHHH	24.26	28787133
159	Phosphorylation	GPSIALDTACSSSLM CCCHHHHHHHHHHHH	30.34	28787133
162	Phosphorylation	IALDTACSSSLMALQ HHHHHHHHHHHHHHH	22.09	28787133
163	Phosphorylation	ALDTACSSSLMALQN HHHHHHHHHHHHHHH	27.63	28787133
164	Phosphorylation	LDTACSSSLMALQNA HHHHHHHHHHHHHHH	13.08	28787133
172	Phosphorylation	LMALQNAYQAIHSGQ HHHHHHHHHHHHCCC	13.16	28787133
177	Phosphorylation	NAYQAIHSGQCPAAI HHHHHHHCCCCCCEE	25.17	28787133
205	Sulfoxidation	VQFLRLGMLSPEGTC HHHHEECCCCCCCCC	3.86	28465586
207	Phosphorylation	FLRLGMLSPEGTCKA HHEECCCCCCCCCCE	16.41	19664994
211	Phosphorylation	GMLSPEGTCKAFDTA CCCCCCCCCCEECCC	14.79	30266825
212	Glutathionylation	MLSPEGTCKAFDTAG CCCCCCCCCEECCCC	4.38	22555962
212	S-nitrosylation	MLSPEGTCKAFDTAG CCCCCCCCCEECCCC	4.38	2212679
213	Acetylation	LSPEGTCKAFDTAGN CCCCCCCCEECCCCC	52.50	23954790
213	Ubiquitination	LSPEGTCKAFDTAGN CCCCCCCCEECCCCC	52.50	21906983
217	Phosphorylation	GTCKAFDTAGNGYCR CCCCEECCCCCCCCC	29.97	28152594
222	Phosphorylation	FDTAGNGYCRSEGVV ECCCCCCCCCCCCCE	6.68	19664994
225	Phosphorylation	AGNGYCRSEGVVAVL CCCCCCCCCCCEEEE	34.83	21712546
235	2-Hydroxyisobutyrylation	VVAVLLTKKSLARRV CEEEEEECHHHHHHH	40.09	-
235	Acetylation	VVAVLLTKKSLARRV CEEEEEECHHHHHHH	40.09	26051181
235	Malonylation	VVAVLLTKKSLARRV CEEEEEECHHHHHHH	40.09	26320211
235	Ubiquitination	VVAVLLTKKSLARRV CEEEEEECHHHHHHH	40.09	21963094
236	Ubiquitination	VAVLLTKKSLARRVY EEEEEECHHHHHHHH	45.53	22817900
243	Phosphorylation	KSLARRVYATILNAG HHHHHHHHHHHHCCC	9.01	28152594
245	Phosphorylation	LARRVYATILNAGTN HHHHHHHHHHCCCCC	14.33	28152594
251	Phosphorylation	ATILNAGTNTDGFKE HHHHCCCCCCCCCHH	32.32	19651622
253	Phosphorylation	ILNAGTNTDGFKEQG HHCCCCCCCCCHHCC	37.02	19651622
257	Acetylation	GTNTDGFKEQGVTFP CCCCCCCHHCCCCCC	55.44	26051181
257	Ubiquitination	GTNTDGFKEQGVTFP CCCCCCCHHCCCCCC	55.44	21906983
262	Phosphorylation	GFKEQGVTFPSGDIQ CCHHCCCCCCCCCHH	36.33	30576142
265	Phosphorylation	EQGVTFPSGDIQEQL HCCCCCCCCCHHHHH	44.93	30576142
275	Phosphorylation	IQEQLIRSLYQSAGV HHHHHHHHHHHHCCC	25.16	28796482
277	Phosphorylation	EQLIRSLYQSAGVAP HHHHHHHHHHCCCCH	11.15	28796482
279	Phosphorylation	LIRSLYQSAGVAPES HHHHHHHHCCCCHHH	17.27	28796482
286	Phosphorylation	SAGVAPESFEYIEAH HCCCCHHHHHHHHCC	23.48	28796482
289	Phosphorylation	VAPESFEYIEAHGTG CCHHHHHHHHCCCCC	11.31	28796482
295	Phosphorylation	EYIEAHGTGTKVGDP HHHHCCCCCCCCCCH	31.63	27080861
297	Phosphorylation	IEAHGTGTKVGDPQE HHCCCCCCCCCCHHH	23.53	27080861
298	Acetylation	EAHGTGTKVGDPQEL HCCCCCCCCCCHHHH	45.63	19608861
298	Malonylation	EAHGTGTKVGDPQEL HCCCCCCCCCCHHHH	45.63	26320211
298	Ubiquitination	EAHGTGTKVGDPQEL HCCCCCCCCCCHHHH	45.63	21963094
315	O-linked_Glycosylation	ITRALCATRQEPLLI HHHHHHHCCCCCEEE	31.71	23301498
324	Phosphorylation	QEPLLIGSTKSNMGH CCCEEEECCCCCCCC	26.18	21712546
325	Phosphorylation	EPLLIGSTKSNMGHP CCEEEECCCCCCCCC	33.02	21712546
326	Ubiquitination	PLLIGSTKSNMGHPE CEEEECCCCCCCCCC	41.34	21906983
347	Phosphorylation	ALAKVLLSLEHGLWA HHHHHHHHHHCCCCC	27.79	28450419
361	Phosphorylation	APNLHFHSPNPEIPA CCCCEECCCCCCCCH	25.98	28450419
419	Phosphorylation	PAPAPHATLPRLLRA CCCCCCCCHHHHHHH	33.97	24719451
436	Acetylation	RTPEAVQKLLEQGLR CCHHHHHHHHHHCCC	48.73	19608861
436	Ubiquitination	RTPEAVQKLLEQGLR CCHHHHHHHHHHCCC	48.73	23000965
463	Phosphorylation	DIAAVPATAMPFRGY HHCCCCCCCCCCCCE	19.88	-
470	Phosphorylation	TAMPFRGYAVLGGER CCCCCCCEEEECCCC	6.84	28152594
509	Phosphorylation	QWRGMGLSLMRLDRF CCCCCCHHHHHHHHH	17.87	20860994
519	Phosphorylation	RLDRFRDSILRSDEA HHHHHHHHHHCCCCC	21.19	24719451
528	2-Hydroxyisobutyrylation	LRSDEAVKPFGLKVS HCCCCCCHHHCCCHH	41.50	-
528	Acetylation	LRSDEAVKPFGLKVS HCCCCCCHHHCCCHH	41.50	19608861
528	Malonylation	LRSDEAVKPFGLKVS HCCCCCCHHHCCCHH	41.50	26320211
528	Neddylation	LRSDEAVKPFGLKVS HCCCCCCHHHCCCHH	41.50	32015554
528	Ubiquitination	LRSDEAVKPFGLKVS HCCCCCCHHHCCCHH	41.50	23000965
533	Ubiquitination	AVKPFGLKVSQLLLS CCHHHCCCHHHHHHC	39.97	23000965
611	Acetylation	YWRGQCIKEAHLPPG HHHCHHHHHCCCCCC	57.38	26051181
611	Ubiquitination	YWRGQCIKEAHLPPG HHHCHHHHHCCCCCC	57.38	-
630	Glutathionylation	VGLSWEECKQRCPPG HCCCHHHHHHHCCCC	2.85	22555962
631	Acetylation	GLSWEECKQRCPPGV CCCHHHHHHHCCCCC	44.02	26051181
631	Ubiquitination	GLSWEECKQRCPPGV CCCHHHHHHHCCCCC	44.02	21963094
634	S-nitrosocysteine	WEECKQRCPPGVVPA HHHHHHHCCCCCCCC	4.40	-
634	S-nitrosylation	WEECKQRCPPGVVPA HHHHHHHCCCCCCCC	4.40	19483679
634	S-palmitoylation	WEECKQRCPPGVVPA HHHHHHHCCCCCCCC	4.40	21044946
642	S-nitrosocysteine	PPGVVPACHNSKDTV CCCCCCCCCCCCCEE	2.27	-
642	S-nitrosylation	PPGVVPACHNSKDTV CCCCCCCCCCCCCEE	2.27	19483679
642	S-palmitoylation	PPGVVPACHNSKDTV CCCCCCCCCCCCCEE	2.27	21044946
646	Acetylation	VPACHNSKDTVTISG CCCCCCCCCEEEECC	63.84	26051181
646	Ubiquitination	VPACHNSKDTVTISG CCCCCCCCCEEEECC	63.84	21963094
667	2-Hydroxyisobutyrylation	EFVEQLRKEGVFAKE HHHHHHHHCCCCEEE	68.37	-
667	Ubiquitination	EFVEQLRKEGVFAKE HHHHHHHHCCCCEEE	68.37	21906983
673	Acetylation	RKEGVFAKEVRTGGM HHCCCCEEECCCCCC	45.32	19608861
673	Malonylation	RKEGVFAKEVRTGGM HHCCCCEEECCCCCC	45.32	26320211
673	Ubiquitination	RKEGVFAKEVRTGGM HHCCCCEEECCCCCC	45.32	21906983
699	Ubiquitination	PPLLQELKKVIREPK HHHHHHHHHHHHCCC	44.21	23503661
700	Ubiquitination	PLLQELKKVIREPKP HHHHHHHHHHHCCCC	56.36	23503661
714	Phosphorylation	PRSARWLSTSIPEAQ CCCCCCCCCCCCHHH	17.10	23403867
715	Phosphorylation	RSARWLSTSIPEAQW CCCCCCCCCCCHHHH	28.62	23403867
716	Phosphorylation	SARWLSTSIPEAQWH CCCCCCCCCCHHHHH	32.54	23403867
724	Phosphorylation	IPEAQWHSSLARTSS CCHHHHHHHCCCCCC	24.88	22617229
725	Phosphorylation	PEAQWHSSLARTSSA CHHHHHHHCCCCCCC	17.11	30183078
731	Phosphorylation	SSLARTSSAEYNVNN HHCCCCCCCCCCHHH	25.22	24275569
772	Acetylation	ALLQAVLKRGLKPSC HHHHHHHHCCCCCCC	37.51	26051181
772	Ubiquitination	ALLQAVLKRGLKPSC HHHHHHHHCCCCCCC	37.51	22817900
776	Acetylation	AVLKRGLKPSCTIIP HHHHCCCCCCCEEEE	37.40	26051181
776	Malonylation	AVLKRGLKPSCTIIP HHHHCCCCCCCEEEE	37.40	32601280
776	Ubiquitination	AVLKRGLKPSCTIIP HHHHCCCCCCCEEEE	37.40	21963094
786	Acetylation	CTIIPLMKKDHRDNL CEEEECCCCCCCCCH	63.83	23954790
786	Malonylation	CTIIPLMKKDHRDNL CEEEECCCCCCCCCH	63.83	26320211
786	Succinylation	CTIIPLMKKDHRDNL CEEEECCCCCCCCCH	63.83	23954790
786	Ubiquitination	CTIIPLMKKDHRDNL CEEEECCCCCCCCCH	63.83	27667366
787	Acetylation	TIIPLMKKDHRDNLE EEEECCCCCCCCCHH	44.81	7666977
787	Ubiquitination	TIIPLMKKDHRDNLE EEEECCCCCCCCCHH	44.81	-
827	Phosphorylation	EFPAPRGTPLISPLI CCCCCCCCCCCCCCC	19.05	20873877
831	Phosphorylation	PRGTPLISPLIKWDH CCCCCCCCCCCCCCC	22.72	21712546
854	Phosphorylation	AEDFPNGSGSPSAAI HHHCCCCCCCCCEEE	42.62	28348404
856	Phosphorylation	DFPNGSGSPSAAIYN HCCCCCCCCCEEEEE	19.85	28348404
858	Phosphorylation	PNGSGSPSAAIYNID CCCCCCCCEEEEEEC	31.84	28348404
891	Phosphorylation	VLFPATGYLSIVWKT EEEECCCHHHHHHHH	7.91	22468782
893	Phosphorylation	FPATGYLSIVWKTLA EECCCHHHHHHHHHH	13.45	22468782
897	Ubiquitination	GYLSIVWKTLARALG CHHHHHHHHHHHHCC	23.83	-
898	Phosphorylation	YLSIVWKTLARALGL HHHHHHHHHHHHCCC	15.22	22468782
927	Ubiquitination	HQATILPKTGTVSLE EEEEECCCCCEEEEE	57.02	-
928	Phosphorylation	QATILPKTGTVSLEV EEEECCCCCEEEEEE	35.82	23312004
930	Phosphorylation	TILPKTGTVSLEVRL EECCCCCEEEEEEEE	16.50	23312004
957	Ubiquitination	GNLVVSGKVYQWDDP CCEEEEEEEEEECCC	30.20	23503661
974	Phosphorylation	RLFDHPESPTPNPTE CCCCCCCCCCCCCCC	38.23	29255136
976	Phosphorylation	FDHPESPTPNPTEPL CCCCCCCCCCCCCCC	45.00	29255136
980	O-linked_Glycosylation	ESPTPNPTEPLFLAQ CCCCCCCCCCCHHHH	57.80	23301498
980	Phosphorylation	ESPTPNPTEPLFLAQ CCCCCCCCCCCHHHH	57.80	28176443
992	2-Hydroxyisobutyrylation	LAQAEVYKELRLRGY HHHHHHHHHHHHCCC	56.29	-
992	Acetylation	LAQAEVYKELRLRGY HHHHHHHHHHHHCCC	56.29	26051181
992	Ubiquitination	LAQAEVYKELRLRGY HHHHHHHHHHHHCCC	56.29	21963094
999	Phosphorylation	KELRLRGYDYGPHFQ HHHHHCCCCCCCCHH	10.27	28152594
1001	Phosphorylation	LRLRGYDYGPHFQGI HHHCCCCCCCCHHHH	24.87	28152594
1028	Phosphorylation	LWKDNWVSFMDTMLQ EECCCHHHHHHHHHH	13.38	-
1032	Phosphorylation	NWVSFMDTMLQMSIL CHHHHHHHHHHHHHH	14.16	-
1047	Phosphorylation	GSAKHGLYLPTRVTA CHHCCCEECCCEEEE	18.41	28152594
1050	Phosphorylation	KHGLYLPTRVTAIHI CCCEECCCEEEEEEE	34.87	28442448
1065	Acetylation	DPATHRQKLYTLQDK CCCCCHHHEEEHHHH	43.34	26051181
1065	Ubiquitination	DPATHRQKLYTLQDK CCCCCHHHEEEHHHH	43.34	21906983
1067	Phosphorylation	ATHRQKLYTLQDKAQ CCCHHHEEEHHHHHH	16.67	28152594
1068	Phosphorylation	THRQKLYTLQDKAQV CCHHHEEEHHHHHHH	28.51	28152594
1072	2-Hydroxyisobutyrylation	KLYTLQDKAQVADVV HEEEHHHHHHHHHHH	27.97	-
1072	Acetylation	KLYTLQDKAQVADVV HEEEHHHHHHHHHHH	27.97	23954790
1072	Malonylation	KLYTLQDKAQVADVV HEEEHHHHHHHHHHH	27.97	26320211
1072	Ubiquitination	KLYTLQDKAQVADVV HEEEHHHHHHHHHHH	27.97	23000965
1081	Phosphorylation	QVADVVVSRWLRVTV HHHHHHHHCEEEEEE	13.21	21712546
1116	Acetylation	QQVPILEKFCFTPHT HCCCCHHHHCCCCCC	43.94	26051181
1116	Ubiquitination	QQVPILEKFCFTPHT HCCCCHHHHCCCCCC	43.94	21963094
1118	S-nitrosocysteine	VPILEKFCFTPHTEE CCCHHHHCCCCCCCC	5.71	-
1118	S-nitrosylation	VPILEKFCFTPHTEE CCCHHHHCCCCCCCC	5.71	19483679
1120	Phosphorylation	ILEKFCFTPHTEEGC CHHHHCCCCCCCCCC	18.49	27251275
1127	S-nitrosocysteine	TPHTEEGCLSERAAL CCCCCCCCHHHHHHH	4.23	-
1127	S-nitrosylation	TPHTEEGCLSERAAL CCCCCCCCHHHHHHH	4.23	19483679
1141	Glutathionylation	LQEELQLCKGLVQAL HHHHHHHHHHHHHHH	1.80	22555962
1141	S-palmitoylation	LQEELQLCKGLVQAL HHHHHHHHHHHHHHH	1.80	26865113
1142	Neddylation	QEELQLCKGLVQALQ HHHHHHHHHHHHHHH	64.96	32015554
1142	Ubiquitination	QEELQLCKGLVQALQ HHHHHHHHHHHHHHH	64.96	23000965
1151	Acetylation	LVQALQTKVTQQGLK HHHHHHHHHHHCCCE	30.26	30588727
1151	Neddylation	LVQALQTKVTQQGLK HHHHHHHHHHHCCCE	30.26	32015554
1151	Ubiquitination	LVQALQTKVTQQGLK HHHHHHHHHHHCCCE	30.26	23000965
1158	Ubiquitination	KVTQQGLKMVVPGLD HHHHCCCEEEECCCC	36.15	23000965
1159	Sulfoxidation	VTQQGLKMVVPGLDG HHHCCCEEEECCCCC	4.40	28183972
1174	Phosphorylation	AQIPRDPSQQELPRL CCCCCCCCHHHHHHH	49.11	23911959
1183	Phosphorylation	QELPRLLSAACRLQL HHHHHHHHHHHHHHC	20.57	23186163
1186	Glutathionylation	PRLLSAACRLQLNGN HHHHHHHHHHHCCCC	4.45	22555962
1208	Ubiquitination	VLAQERPKLPEDPLL HHHHHCCCCCCCCCH	80.86	23503661
1216	Phosphorylation	LPEDPLLSGLLDSPA CCCCCCHHCCCCCHH	34.77	30377224
1221	Phosphorylation	LLSGLLDSPALKACL CHHCCCCCHHHHHHH	16.43	27050516
1225	Ubiquitination	LLDSPALKACLDTAV CCCCHHHHHHHHHHH	38.88	16196087
1227	Glutathionylation	DSPALKACLDTAVEN CCHHHHHHHHHHHHH	3.18	22555962
1237	Phosphorylation	TAVENMPSLKMKVVE HHHHHCCHHHHHHHH	29.83	27251275
1239	Acetylation	VENMPSLKMKVVEVL HHHCCHHHHHHHHHH	40.80	23954790
1239	Malonylation	VENMPSLKMKVVEVL HHHCCHHHHHHHHHH	40.80	26320211
1239	Ubiquitination	VENMPSLKMKVVEVL HHHCCHHHHHHHHHH	40.80	27667366
1241	Acetylation	NMPSLKMKVVEVLAG HCCHHHHHHHHHHHC	41.35	26051181
1241	Ubiquitination	NMPSLKMKVVEVLAG HCCHHHHHHHHHHHC	41.35	21963094
1253	Phosphorylation	LAGHGHLYSRIPGLL HHCCCCHHHCCCCCC	7.10	28152594
1254	Phosphorylation	AGHGHLYSRIPGLLS HCCCCHHHCCCCCCC	30.05	24719451
1261	Phosphorylation	SRIPGLLSPHPLLQL HCCCCCCCCCCCEEE	26.63	27251275
1273	Phosphorylation	LQLSYTATDRHPQAL EEEEEECCCCCHHHH	26.26	-
1367	Phosphorylation	LTSTEPQYGQGILSQ HHCCCCCCCCCCCCH	23.33	-
1373	Phosphorylation	QYGQGILSQDAWESL CCCCCCCCHHHHHHH	24.88	-
1379	Phosphorylation	LSQDAWESLFSRVSL CCHHHHHHHHHHHHH	24.82	-
1382	Phosphorylation	DAWESLFSRVSLRLV HHHHHHHHHHHHHHH	36.75	-
1392	Ubiquitination	SLRLVGLKKSFYGST HHHHHCCCCHHCCCE	40.20	23000965
1393	Ubiquitination	LRLVGLKKSFYGSTL HHHHCCCCHHCCCEE	51.33	23000965
1394	Phosphorylation	RLVGLKKSFYGSTLF HHHCCCCHHCCCEEE	23.32	28152594
1396	Phosphorylation	VGLKKSFYGSTLFLC HCCCCHHCCCEEEEE	19.77	28152594
1398	Phosphorylation	LKKSFYGSTLFLCRR CCCHHCCCEEEEEEC	15.57	28152594
1403	S-palmitoylation	YGSTLFLCRRPTPQD CCCEEEEEECCCCCC	2.44	29575903
1407	Phosphorylation	LFLCRRPTPQDSPIF EEEEECCCCCCCCCE	31.60	29255136
1411	Phosphorylation	RRPTPQDSPIFLPVD ECCCCCCCCCEEECC	18.04	30266825
1420	Phosphorylation	IFLPVDDTSFRWVES CEEECCCCCCHHHHH	25.87	29255136
1421	Phosphorylation	FLPVDDTSFRWVESL EEECCCCCCHHHHHH	21.58	29255136
1427	Phosphorylation	TSFRWVESLKGILAD CCCHHHHHHCCHHCC	26.26	24719451
1429	Acetylation	FRWVESLKGILADED CHHHHHHCCHHCCCC	53.86	23236377
1429	Ubiquitination	FRWVESLKGILADED CHHHHHHCCHHCCCC	53.86	21963094
1444	Acetylation	SSRPVWLKAINCATS CCCCHHHHHHHCCCC	31.35	26051181
1444	Ubiquitination	SSRPVWLKAINCATS CCCCHHHHHHHCCCC	31.35	32015554
1450	Phosphorylation	LKAINCATSGVVGLV HHHHHCCCCHHHHHH	28.37	21712546
1451	Phosphorylation	KAINCATSGVVGLVN HHHHCCCCHHHHHHH	15.86	21712546
1471	S-nitrosocysteine	PGGNRLRCVLLSNLS CCCCEEEEEEEECCC	2.75	-
1471	Glutathionylation	PGGNRLRCVLLSNLS CCCCEEEEEEEECCC	2.75	22555962
1471	S-nitrosylation	PGGNRLRCVLLSNLS CCCCEEEEEEEECCC	2.75	22178444
1475	Phosphorylation	RLRCVLLSNLSSTSH EEEEEEEECCCCCCC	31.40	27080861
1478	Phosphorylation	CVLLSNLSSTSHVPE EEEEECCCCCCCCCC	35.50	27080861
1479	Phosphorylation	VLLSNLSSTSHVPEV EEEECCCCCCCCCCC	36.78	27251275
1480	Phosphorylation	LLSNLSSTSHVPEVD EEECCCCCCCCCCCC	21.34	24719451
1481	Phosphorylation	LSNLSSTSHVPEVDP EECCCCCCCCCCCCC	25.16	27080861
1495	Ubiquitination	PGSAELQKVLQGDLV CCCHHHHHHHCCCCE	58.50	21963094
1506	Phosphorylation	GDLVMNVYRDGAWGA CCCEEEEEECCHHHH	9.66	-
1523	Acetylation	HFLLEEDKPEEPTAH HHHCCCCCCCCCCCH	58.57	23236377
1523	Ubiquitination	HFLLEEDKPEEPTAH HHHCCCCCCCCCCCH	58.57	21906983
1534	Phosphorylation	PTAHAFVSTLTRGDL CCCHHHEECCCCCCH	15.96	27080861
1535	Phosphorylation	TAHAFVSTLTRGDLS CCHHHEECCCCCCHH	27.18	27080861
1537	Phosphorylation	HAFVSTLTRGDLSSI HHHEECCCCCCHHHH	32.47	27080861
1542	Phosphorylation	TLTRGDLSSIRWVCS CCCCCCHHHHHHHHH	28.58	30301811
1543	Phosphorylation	LTRGDLSSIRWVCSS CCCCCHHHHHHHHHH	24.38	23401153
1549	Phosphorylation	SSIRWVCSSLRHAQP HHHHHHHHHCCCCCC	23.84	27732954
1550	Phosphorylation	SIRWVCSSLRHAQPT HHHHHHHHCCCCCCC	25.05	27732954
1552	Methylation	RWVCSSLRHAQPTCP HHHHHHCCCCCCCCC	25.66	-
1565	Phosphorylation	CPGAQLCTVYYASLN CCHHHEEEEEEEECC	21.82	28152594
1567	Phosphorylation	GAQLCTVYYASLNFR HHHEEEEEEEECCHH	3.83	28152594
1568	Phosphorylation	AQLCTVYYASLNFRD HHEEEEEEEECCHHH	5.84	28152594
1570	Phosphorylation	LCTVYYASLNFRDIM EEEEEEEECCHHHHH	14.02	28152594
1580	Phosphorylation	FRDIMLATGKLSPDA HHHHHHHCCCCCCCC	30.78	29255136
1582	Acetylation	DIMLATGKLSPDAIP HHHHHCCCCCCCCCC	41.24	23954790
1582	Malonylation	DIMLATGKLSPDAIP HHHHHCCCCCCCCCC	41.24	26320211
1582	Ubiquitination	DIMLATGKLSPDAIP HHHHHCCCCCCCCCC	41.24	23000965
1584	Phosphorylation	MLATGKLSPDAIPGK HHHCCCCCCCCCCCC	24.99	29255136
1591	Acetylation	SPDAIPGKWTSQDSL CCCCCCCCCCCCCCC	41.78	23954790
1591	Ubiquitination	SPDAIPGKWTSQDSL CCCCCCCCCCCCCCC	41.78	21906983
1593	Phosphorylation	DAIPGKWTSQDSLLG CCCCCCCCCCCCCCC	21.72	27251275
1594	Phosphorylation	AIPGKWTSQDSLLGM CCCCCCCCCCCCCCC	30.76	27050516
1597	Phosphorylation	GKWTSQDSLLGMEFS CCCCCCCCCCCCEEE	20.18	27251275
1697	Phosphorylation	SLGCRVFTTVGSAEK HCCCEEEEECCCHHH	20.09	23909892
1698	Phosphorylation	LGCRVFTTVGSAEKR CCCEEEEECCCHHHH	16.05	23909892
1701	Phosphorylation	RVFTTVGSAEKRAYL EEEEECCCHHHHHHH	28.99	23909892
1704	N6-(pyridoxal phosphate)lysine	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	-
1704	2-Hydroxyisobutyrylation	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	-
1704	Acetylation	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	19608861
1704	Other	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	-
1704	Ubiquitination	TTVGSAEKRAYLQAR EECCCHHHHHHHHHH	41.88	27667366
1717	Phosphorylation	ARFPQLDSTSFANSR HHCCCCCCCCCCCCC	34.25	25850435
1718	Phosphorylation	RFPQLDSTSFANSRD HCCCCCCCCCCCCCC	27.77	25850435
1719	Phosphorylation	FPQLDSTSFANSRDT CCCCCCCCCCCCCCC	26.72	25850435
1723	Phosphorylation	DSTSFANSRDTSFEQ CCCCCCCCCCCCHHH	28.27	25850435
1726	Phosphorylation	SFANSRDTSFEQHVL CCCCCCCCCHHHHEE	33.92	23312004
1727	Phosphorylation	FANSRDTSFEQHVLW CCCCCCCCHHHHEEE	30.95	20873877
1739	Acetylation	VLWHTGGKGVDLVLN EEECCCCCCHHHHHH	58.04	26051181
1739	Ubiquitination	VLWHTGGKGVDLVLN EEECCCCCCHHHHHH	58.04	21906983
1747	Phosphorylation	GVDLVLNSLAEEKLQ CHHHHHHHHHHHHHH	25.46	29978859
1752	2-Hydroxyisobutyrylation	LNSLAEEKLQASVRC HHHHHHHHHHHHHHH	37.09	-
1752	Acetylation	LNSLAEEKLQASVRC HHHHHHHHHHHHHHH	37.09	23954790
1752	Ubiquitination	LNSLAEEKLQASVRC HHHHHHHHHHHHHHH	37.09	21906983
1756	Phosphorylation	AEEKLQASVRCLATH HHHHHHHHHHHHHHC	9.35	29978859
1771	Acetylation	GRFLEIGKFDLSQNH CCCEEEEEEECCCCC	41.17	19608861
1771	Ubiquitination	GRFLEIGKFDLSQNH CCCEEEEEEECCCCC	41.17	23503661
1803	Phosphorylation	LDAFFNESSADWREV HHHHCCCCCCCHHHH	31.75	30387612
1804	Phosphorylation	DAFFNESSADWREVW HHHCCCCCCCHHHHH	24.86	30387612
1827	Acetylation	DGVVRPLKCTVFHGA CCCCCEEEEEEEECC	30.46	26051181
1827	Ubiquitination	DGVVRPLKCTVFHGA CCCCCEEEEEEEECC	30.46	21963094
1842	Phosphorylation	QVEDAFRYMAQGKHI CHHHHHHHHHCCCCH	7.14	22210691
1847	2-Hydroxyisobutyrylation	FRYMAQGKHIGKVVV HHHHHCCCCHHEEEH	21.70	-
1847	Acetylation	FRYMAQGKHIGKVVV HHHHHCCCCHHEEEH	21.70	19608861
1847	Ubiquitination	FRYMAQGKHIGKVVV HHHHHCCCCHHEEEH	21.70	21906983
1851	2-Hydroxyisobutyrylation	AQGKHIGKVVVQVLA HCCCCHHEEEHHHHH	31.11	-
1851	Acetylation	AQGKHIGKVVVQVLA HCCCCHHEEEHHHHH	31.11	26051181
1851	Ubiquitination	AQGKHIGKVVVQVLA HCCCCHHEEEHHHHH	31.11	21906983
1866	2-Hydroxyisobutyrylation	EEPEAVLKGAKPKLM CCHHHHHCCCCHHHH	50.66	-
1866	Malonylation	EEPEAVLKGAKPKLM CCHHHHHCCCCHHHH	50.66	26320211
1866	Neddylation	EEPEAVLKGAKPKLM CCHHHHHCCCCHHHH	50.66	32015554
1866	Ubiquitination	EEPEAVLKGAKPKLM CCHHHHHCCCCHHHH	50.66	23000965
1869	Neddylation	EAVLKGAKPKLMSAI HHHHCCCCHHHHHHH	51.89	32015554
1869	Ubiquitination	EAVLKGAKPKLMSAI HHHHCCCCHHHHHHH	51.89	23000965
1871	Ubiquitination	VLKGAKPKLMSAISK HHCCCCHHHHHHHHH	56.99	23000965
1874	Phosphorylation	GAKPKLMSAISKTFC CCCHHHHHHHHHHCC	32.65	23312004
1877	Phosphorylation	PKLMSAISKTFCPAH HHHHHHHHHHCCHHC	25.92	23312004
1878	Acetylation	KLMSAISKTFCPAHK HHHHHHHHHCCHHCC	39.24	25953088
1878	Ubiquitination	KLMSAISKTFCPAHK HHHHHHHHHCCHHCC	39.24	23000965
1911	Acetylation	LIQRGVQKLVLTSRS HHHHCCCEEEEECCC	37.85	25953088
1911	Ubiquitination	LIQRGVQKLVLTSRS HHHHCCCEEEEECCC	37.85	23000965
1916	Phosphorylation	VQKLVLTSRSGIRTG CCEEEEECCCCCCCC	21.93	23403867
1918	Phosphorylation	KLVLTSRSGIRTGYQ EEEEECCCCCCCCHH	38.04	23403867
1927	2-Hydroxyisobutyrylation	IRTGYQAKQVRRWRR CCCCHHHHHHHHHHH	33.53	-
1927	Acetylation	IRTGYQAKQVRRWRR CCCCHHHHHHHHHHH	33.53	25953088
1927	Ubiquitination	IRTGYQAKQVRRWRR CCCCHHHHHHHHHHH	33.53	21906983
1942	Phosphorylation	QGVQVQVSTSNISSL CCCEEEEECCCCHHH	14.71	29759185
1943	Phosphorylation	GVQVQVSTSNISSLE CCEEEEECCCCHHHH	27.26	29759185
1944	Phosphorylation	VQVQVSTSNISSLEG CEEEEECCCCHHHHC	25.35	29759185
1947	Phosphorylation	QVSTSNISSLEGARG EEECCCCHHHHCHHH	32.87	24043423
1948	Phosphorylation	VSTSNISSLEGARGL EECCCCHHHHCHHHH	27.00	24043423
1992	Glutathionylation	PEFFQDVCKPKYSGT HHHHHHHHCCCCCCC	9.33	22555962
1993	Acetylation	EFFQDVCKPKYSGTL HHHHHHHCCCCCCCC	44.38	25953088
1993	Ubiquitination	EFFQDVCKPKYSGTL HHHHHHHCCCCCCCC	44.38	21906983
1995	Acetylation	FQDVCKPKYSGTLNL HHHHHCCCCCCCCCC	37.23	19608861
1995	Ubiquitination	FQDVCKPKYSGTLNL HHHHHCCCCCCCCCC	37.23	27667366
1996	Phosphorylation	QDVCKPKYSGTLNLD HHHHCCCCCCCCCCH	22.36	28152594
1997	Phosphorylation	DVCKPKYSGTLNLDR HHHCCCCCCCCCCHH	31.28	28152594
1999	Phosphorylation	CKPKYSGTLNLDRVT HCCCCCCCCCCHHHH	13.41	28857561
2004	Methylation	SGTLNLDRVTREACP CCCCCCHHHHHHHCC	34.57	-
2010	Glutathionylation	DRVTREACPELDYFV HHHHHHHCCCCCEEE	2.00	22555962
2032	Phosphorylation	GRGNAGQSNYGFANS CCCCCCCCCCHHCHH	30.97	27080861
2034	Phosphorylation	GNAGQSNYGFANSAM CCCCCCCCHHCHHHH	20.90	28442448
2039	Phosphorylation	SNYGFANSAMERICE CCCHHCHHHHHHHHH	26.09	27080861
2041	Sulfoxidation	YGFANSAMERICEKR CHHCHHHHHHHHHHH	3.40	30846556
2043	Methylation	FANSAMERICEKRRH HCHHHHHHHHHHHCC	26.27	-
2047	Ubiquitination	AMERICEKRRHEGLP HHHHHHHHHCCCCCC	50.77	22817900
2091	S-nitrosylation	LPQRMASCLEVLDLF HHHHHHHHHHHHHHH	2.46	26851298
2123	Phosphorylation	AAYRDRDSQRDLVEA HHHCCCHHHHHHHHH	28.19	22617229
2156	O-(pantetheine 4'-phosphoryl)serine	LADLGLDSLMSVEVR HHHCCHHHHCCHHHH	30.89	-
2156	Phosphorylation	LADLGLDSLMSVEVR HHHCCHHHHCCHHHH	30.89	26074081
2159	Phosphorylation	LGLDSLMSVEVRQTL CCHHHHCCHHHHHHH	22.03	26074081
2175	Phosphorylation	RELNLVLSVREVRQL HHHHHHHHHHHHHHH	16.20	23403867
2183	Phosphorylation	VREVRQLTLRKLQEL HHHHHHHHHHHHHHH	19.04	25599653
2186	Acetylation	VRQLTLRKLQELSSK HHHHHHHHHHHHHHC	58.60	26051181
2186	Ubiquitination	VRQLTLRKLQELSSK HHHHHHHHHHHHHHC	58.60	21906983
2191	Phosphorylation	LRKLQELSSKADEAS HHHHHHHHHCCHHHH	29.10	25599653
2192	Phosphorylation	RKLQELSSKADEASE HHHHHHHHCCHHHHH	44.48	23312004
2193	Acetylation	KLQELSSKADEASEL HHHHHHHCCHHHHHH	57.38	26051181
2193	Malonylation	KLQELSSKADEASEL HHHHHHHCCHHHHHH	57.38	26320211
2193	Ubiquitination	KLQELSSKADEASEL HHHHHHHCCHHHHHH	57.38	21963094
2198	Phosphorylation	SSKADEASELACPTP HHCCHHHHHHCCCCC	30.97	29255136
2202	Glutathionylation	DEASELACPTPKEDG HHHHHHCCCCCCCCC	6.36	22555962
2202	S-nitrosylation	DEASELACPTPKEDG HHHHHHCCCCCCCCC	6.36	2212679
2202	S-palmitoylation	DEASELACPTPKEDG HHHHHHCCCCCCCCC	6.36	29575903
2204	Phosphorylation	ASELACPTPKEDGLA HHHHCCCCCCCCCCH	47.04	19664994
2206	Acetylation	ELACPTPKEDGLAQQ HHCCCCCCCCCCHHH	71.55	26051181
2206	Malonylation	ELACPTPKEDGLAQQ HHCCCCCCCCCCHHH	71.55	26320211
2206	Ubiquitination	ELACPTPKEDGLAQQ HHCCCCCCCCCCHHH	71.55	21963094
2215	Phosphorylation	DGLAQQQTQLNLRSL CCCHHHHHHHHHHHH	30.59	23927012
2221	Phosphorylation	QTQLNLRSLLVNPEG HHHHHHHHHHCCCCC	29.26	27499020
2236	Phosphorylation	PTLMRLNSVQSSERP CCEEECCCCCCCCCC	26.56	29255136
2239	Phosphorylation	MRLNSVQSSERPLFL EECCCCCCCCCCEEE	31.82	30183078
2240	Phosphorylation	RLNSVQSSERPLFLV ECCCCCCCCCCEEEE	22.12	24043423
2253	Phosphorylation	LVHPIEGSTTVFHSL EEEECCCCCHHHHHH	14.23	20873877
2254	Phosphorylation	VHPIEGSTTVFHSLA EEECCCCCHHHHHHH	37.52	20873877
2255	Phosphorylation	HPIEGSTTVFHSLAS EECCCCCHHHHHHHH	23.91	20873877
2259	Phosphorylation	GSTTVFHSLASRLSI CCCHHHHHHHHHCCC	17.73	20873877
2262	Phosphorylation	TVFHSLASRLSIPTY HHHHHHHHHCCCCCC	38.76	20873877
2265	Phosphorylation	HSLASRLSIPTYGLQ HHHHHHCCCCCCCCC	25.97	28152594
2268	Phosphorylation	ASRLSIPTYGLQCTR HHHCCCCCCCCCCCC	28.66	28152594
2269	Phosphorylation	SRLSIPTYGLQCTRA HHCCCCCCCCCCCCC	15.52	28152594
2273	Glutathionylation	IPTYGLQCTRAAPLD CCCCCCCCCCCCCCH	3.15	22555962
2274	Phosphorylation	PTYGLQCTRAAPLDS CCCCCCCCCCCCCHH	15.47	28152594
2354	Acetylation	YTQSYRAKLTPGCEA EEHHHHCCCCCCCCC	43.84	26051181
2356	Phosphorylation	QSYRAKLTPGCEAEA HHHHCCCCCCCCCHH	19.54	25159151
2391	2-Hydroxyisobutyrylation	LEALLPLKGLEERVA HHHHHHCCCHHHHHH	60.55	-
2391	Acetylation	LEALLPLKGLEERVA HHHHHHCCCHHHHHH	60.55	23954790
2391	Ubiquitination	LEALLPLKGLEERVA HHHHHHCCCHHHHHH	60.55	23000965
2406	2-Hydroxyisobutyrylation	AAVDLIIKSHQGLDR HHHHHHHHCCCCCCH	34.59	-
2406	Acetylation	AAVDLIIKSHQGLDR HHHHHHHHCCCCCCH	34.59	25953088
2406	Ubiquitination	AAVDLIIKSHQGLDR HHHHHHHHCCCCCCH	34.59	33845483
2413	Methylation	KSHQGLDRQELSFAA HCCCCCCHHHHHHHH	36.59	-
2417	Phosphorylation	GLDRQELSFAARSFY CCCHHHHHHHHHHHH	16.46	27499020
2424	Phosphorylation	SFAARSFYYKLRAAE HHHHHHHHHHHHHHH	10.84	28152594
2425	Phosphorylation	FAARSFYYKLRAAEQ HHHHHHHHHHHHHHH	11.09	28152594
2426	2-Hydroxyisobutyrylation	AARSFYYKLRAAEQY HHHHHHHHHHHHHHH	21.81	-
2426	Acetylation	AARSFYYKLRAAEQY HHHHHHHHHHHHHHH	21.81	26051181
2426	Ubiquitination	AARSFYYKLRAAEQY HHHHHHHHHHHHHHH	21.81	21963094
2428	Methylation	RSFYYKLRAAEQYTP HHHHHHHHHHHHHCC	27.83	-
2433	Phosphorylation	KLRAAEQYTPKAKYH HHHHHHHHCCCCEEE	19.26	-
2434	Phosphorylation	LRAAEQYTPKAKYHG HHHHHHHCCCCEEEC	20.29	28985074
2436	Acetylation	AAEQYTPKAKYHGNV HHHHHCCCCEEECCE	50.11	23749302
2436	Ubiquitination	AAEQYTPKAKYHGNV HHHHHCCCCEEECCE	50.11	23000965
2438	Acetylation	EQYTPKAKYHGNVML HHHCCCCEEECCEEE	43.86	25953088
2438	Ubiquitination	EQYTPKAKYHGNVML HHHCCCCEEECCEEE	43.86	23000965
2439	Phosphorylation	QYTPKAKYHGNVMLL HHCCCCEEECCEEEE	21.59	22817900
2449	Acetylation	NVMLLRAKTGGAYGE CEEEEEEECCCCCCC	41.07	26051181
2449	Sumoylation	NVMLLRAKTGGAYGE CEEEEEEECCCCCCC	41.07	25114211
2449	Ubiquitination	NVMLLRAKTGGAYGE CEEEEEEECCCCCCC	41.07	23000965
2450	Phosphorylation	VMLLRAKTGGAYGED EEEEEEECCCCCCCC	39.60	28442448
2454	Phosphorylation	RAKTGGAYGEDLGAD EEECCCCCCCCCCCC	25.07	28442448
2462	Phosphorylation	GEDLGADYNLSQVCD CCCCCCCCCHHHHCC	19.91	28442448
2468	Glutathionylation	DYNLSQVCDGKVSVH CCCHHHHCCCEEEEE	4.41	22555962
2471	Acetylation	LSQVCDGKVSVHVIE HHHHCCCEEEEEEEE	20.34	26051181
2471	Ubiquitination	LSQVCDGKVSVHVIE HHHHCCCEEEEEEEE	20.34	-
2483	Phosphorylation	VIEGDHRTLLEGSGL EEECCCCEECCCCCH	32.07	20068231
2488	Phosphorylation	HRTLLEGSGLESIIS CCEECCCCCHHHHHH	30.72	20068231
2492	Phosphorylation	LEGSGLESIISIIHS CCCCCHHHHHHHHHH	30.20	28270605
2495	Phosphorylation	SGLESIISIIHSSLA CCHHHHHHHHHHHHC	17.51	28270605
2499	Phosphorylation	SIISIIHSSLAEPRV HHHHHHHHHHCCCCC	19.35	20068231
2500	Phosphorylation	IISIIHSSLAEPRVS HHHHHHHHHCCCCCC	19.89	20068231
2507	Phosphorylation	SLAEPRVSVREG--- HHCCCCCCCCCC---	19.41	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF1	Q8TCQ1	PMID:14722266
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF8	Q5T0T0	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:30955223

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1471	C	S-nitrosylation	26851298
S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization.
2091	C	S-nitrosylation	26851298
S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
1927	Acetylation	1934 (7)	R ⇒ H	rs200897153	Major depressive disorder	27777418
1927	Ubiquitination	1934 (7)	R ⇒ H	rs200897153	Major depressive disorder	27777418

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAS_HUMAN	FASN	physical	11248039
UBP2_HUMAN	USP2	physical	15050917
PTN11_HUMAN	PTPN11	physical	23269672
PRR12_HUMAN	PRR12	physical	21988832
PTGR2_HUMAN	PTGR2	physical	26186194
KIF3A_HUMAN	KIF3A	physical	26186194
IMDH1_HUMAN	IMPDH1	physical	26186194
HAUS4_HUMAN	HAUS4	physical	26186194
MRP1_HUMAN	ABCC1	physical	26344197
AHSA1_HUMAN	AHSA1	physical	26344197
ASNS_HUMAN	ASNS	physical	26344197
CARM1_HUMAN	CARM1	physical	26344197
GFPT1_HUMAN	GFPT1	physical	26344197
GFPT2_HUMAN	GFPT2	physical	26344197
HPBP1_HUMAN	HSPBP1	physical	26344197
MTCH1_HUMAN	MTCH1	physical	26344197
TARB1_HUMAN	TARBP1	physical	26344197
PTGR2_HUMAN	PTGR2	physical	28514442
UBP22_HUMAN	USP22	physical	28514442
VHL_HUMAN	VHL	physical	28775317
HIF1A_HUMAN	HIF1A	physical	28775317

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB01034	Cerulenin
DB01083	Orlistat

Regulatory Network of FAS_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-207 AND THR-2204, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70; LYS-298; LYS-436;LYS-528; LYS-673; LYS-1704; LYS-1752; LYS-1771; LYS-1847 AND LYS-1995,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-207 AND THR-2204, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207; SER-2198; THR-2204AND SER-2236, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2204, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2204, AND MASSSPECTROMETRY.	16964243 [Abstract]
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