dbPTM

PRR12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRR12_HUMAN
UniProt AC	Q9ULL5
Protein Name	Proline-rich protein 12
Gene Name	PRR12 {ECO:0000312\|HGNC:HGNC:29217}
Organism	Homo sapiens (Human).
Sequence Length	1215
Subcellular Localization	Nucleus . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse, synaptosome .
Protein Description
Protein Sequence	MEQLPGVPPGPPHPVRPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVPGRLLKTRAMREMYRSYVEMLVSTALDPDMIQALEDTHDELYLPPMRKIDGLLNEHKKKVLKRLSLSPALQDALHTFPQLQVEQSGEGSPEEGAVRLRPAGEPYNRKTLSKLKRSVVRAQEFKVELEKSGYYTLYHSLHHYKYHTFLRCRDQTLAIEGGAEDLGQEEVVQQCMRNQPWLEQLFDSFSDLLAQAQAHSRCG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32 (in isoform 3)	Phosphorylation	-	16.64	17081983
35	Phosphorylation	QLEAHLRSHGLEPAA CHHHHHHHCCCCCCC	28.41	23403867
35 (in isoform 3)	Phosphorylation	-	28.41	17081983
44	Phosphorylation	GLEPAAPSPRLRPEE CCCCCCCCCCCCCHH	20.23	23401153
76	Phosphorylation	LPPAPGDTGVGPPNS CCCCCCCCCCCCCCC	39.42	26330541
83	Phosphorylation	TGVGPPNSEGKDPAG CCCCCCCCCCCCCCC	54.20	25159151
92	Phosphorylation	GKDPAGAYRSPSPQG CCCCCCCCCCCCCCC	15.65	22167270
94	Phosphorylation	DPAGAYRSPSPQGTK CCCCCCCCCCCCCCC	19.63	22167270
96	Phosphorylation	AGAYRSPSPQGTKAP CCCCCCCCCCCCCCC	30.97	22167270
100	Phosphorylation	RSPSPQGTKAPRFVP CCCCCCCCCCCCEEE	20.84	22167270
101	Acetylation	SPSPQGTKAPRFVPL CCCCCCCCCCCEEEC	64.32	7826253
101	Ubiquitination	SPSPQGTKAPRFVPL CCCCCCCCCCCEEEC	64.32	-
109	Phosphorylation	APRFVPLTSICFPDS CCCEEECCEECCCHH	15.24	26074081
110	Phosphorylation	PRFVPLTSICFPDSL CCEEECCEECCCHHH	25.66	26074081
116	Phosphorylation	TSICFPDSLLQDEER CEECCCHHHCCHHHH	31.08	21712546
166	Phosphorylation	PPPGPPAYDPYGPYC CCCCCCCCCCCCCCC	24.19	26552605
169	Phosphorylation	GPPAYDPYGPYCPGR CCCCCCCCCCCCCCC	28.03	26552605
172	Phosphorylation	AYDPYGPYCPGRASG CCCCCCCCCCCCCCC	13.60	26552605
176 (in isoform 3)	Phosphorylation	-	15.66	28348404
184	Phosphorylation	ASGAGPETPGLGLDP CCCCCCCCCCCCCCC	26.28	-
184 (in isoform 3)	Phosphorylation	-	26.28	28348404
202 (in isoform 3)	Phosphorylation	-	38.38	17081983
211	Phosphorylation	EPLGLIQSGPHQAAP CCCCCCCCCCCCCCC	47.50	-
224 (in isoform 3)	Phosphorylation	-	60.86	25159151
227 (in isoform 3)	Phosphorylation	-	43.38	22210691
239	Phosphorylation	SEPKGGLTSPIFCST CCCCCCCCCCEECCC	35.41	28450419
240	Phosphorylation	EPKGGLTSPIFCSTK CCCCCCCCCEECCCC	22.50	25159151
245	Phosphorylation	LTSPIFCSTKPKKLL CCCCEECCCCCHHHH	28.81	26552605
246	Phosphorylation	TSPIFCSTKPKKLLK CCCEECCCCCHHHHC	53.17	29083192
247	Acetylation	SPIFCSTKPKKLLKT CCEECCCCCHHHHCC	38.25	23749302
254	Phosphorylation	KPKKLLKTSSFHLLR CCHHHHCCCCHHHHH	29.58	23403867
255	Phosphorylation	PKKLLKTSSFHLLRR CHHHHCCCCHHHHHC	29.44	23403867
256	Phosphorylation	KKLLKTSSFHLLRRR HHHHCCCCHHHHHCC	23.16	23401153
261 (in isoform 3)	Phosphorylation	-	37.64	28348404
262 (in isoform 3)	Phosphorylation	-	47.53	28348404
266 (in isoform 3)	Phosphorylation	-	37.96	28348404
269	Phosphorylation	RRDPPFQTPKKLYAQ CCCCCCCCCHHHCCE	37.14	21815630
272	Acetylation	PPFQTPKKLYAQEYE CCCCCCHHHCCEEEE	48.19	26051181
305	Phosphorylation	RRLPDLVSSCRSRPA CHHHHHHHHHCCCCC	30.90	28555341
306	Phosphorylation	RLPDLVSSCRSRPAL HHHHHHHHHCCCCCC	13.18	28555341
309	Phosphorylation	DLVSSCRSRPALSPL HHHHHHCCCCCCCCC	47.12	30266825
314	Phosphorylation	CRSRPALSPLGDIDF HCCCCCCCCCCCCCC	21.86	23401153
332	Phosphorylation	NPGPDGPRRRGRKPT CCCCCCCCCCCCCCC	46.59	-
332 (in isoform 3)	Phosphorylation	-	46.59	25159151
334	Methylation	GPDGPRRRGRKPTKA CCCCCCCCCCCCCCC	51.01	24381425
340	Methylation	RRGRKPTKAKRDGPP CCCCCCCCCCCCCCC	61.51	-
340	Phosphorylation	RRGRKPTKAKRDGPP CCCCCCCCCCCCCCC	61.51	-
340 (in isoform 3)	Phosphorylation	-	61.51	21815630
342	Methylation	GRKPTKAKRDGPPRP CCCCCCCCCCCCCCC	53.21	-
347 (in isoform 3)	Phosphorylation	-	65.52	27251275
352 (in isoform 3)	Phosphorylation	-	20.71	20068231
355 (in isoform 3)	Phosphorylation	-	6.19	20068231
359 (in isoform 3)	Phosphorylation	-	49.48	20068231
363	O-linked_Glycosylation	RPLEVPTTAGPASAS CCCCCCCCCCCCCCC	24.44	31492838
363	Phosphorylation	RPLEVPTTAGPASAS CCCCCCCCCCCCCCC	24.44	24732914
363 (in isoform 3)	Phosphorylation	-	24.44	22199227
368	Phosphorylation	PTTAGPASASTPTDG CCCCCCCCCCCCCCC	26.36	29255136
370	Phosphorylation	TAGPASASTPTDGAK CCCCCCCCCCCCCCC	32.21	29255136
371	Phosphorylation	AGPASASTPTDGAKK CCCCCCCCCCCCCCC	29.89	29255136
373	Phosphorylation	PASASTPTDGAKKPR CCCCCCCCCCCCCCC	47.34	29255136
380 (in isoform 3)	Phosphorylation	-	57.21	22199227
386 (in isoform 3)	Phosphorylation	-	40.14	25159151
389 (in isoform 3)	Phosphorylation	-	64.07	22199227
391 (in isoform 3)	Phosphorylation	-	51.95	20068231
402	Acetylation	GTRLEPLKPLKIKLS CCCCCCCCCEEEEEE	60.05	19608861
409	Phosphorylation	KPLKIKLSVPKAGEG CCEEEEEECCCCCCC	31.22	23898821
419	Phosphorylation	KAGEGLGTSSGDAIS CCCCCCCCCCCCCCC	25.43	22468782
420	Phosphorylation	AGEGLGTSSGDAISG CCCCCCCCCCCCCCC	30.44	28450419
421	Phosphorylation	GEGLGTSSGDAISGT CCCCCCCCCCCCCCC	40.30	28450419
426	Phosphorylation	TSSGDAISGTDHNSL CCCCCCCCCCCCCCC	37.04	28450419
428	Phosphorylation	SGDAISGTDHNSLDS CCCCCCCCCCCCCCC	27.56	22468782
432	Phosphorylation	ISGTDHNSLDSSLTR CCCCCCCCCCCHHHH	30.08	28450419
433 (in isoform 3)	Phosphorylation	-	10.07	22199227
435	Phosphorylation	TDHNSLDSSLTREKI CCCCCCCCHHHHHHH	32.32	28450419
436	Phosphorylation	DHNSLDSSLTREKIE CCCCCCCHHHHHHHH	33.17	28450419
438	Phosphorylation	NSLDSSLTREKIEAK CCCCCHHHHHHHHHH	38.44	28450419
443 (in isoform 3)	Phosphorylation	-	55.78	30175587
444 (in isoform 3)	Phosphorylation	-	23.50	26657352
457 (in isoform 3)	Phosphorylation	-	45.85	22210691
458	Phosphorylation	EKQPEMKSGFMASFL HHCCHHHHHHHHHHH	35.63	24505115
470	Phosphorylation	SFLDFLKSGKRHPPL HHHHHHHHCCCCCCH	52.25	24505115
478	Phosphorylation	GKRHPPLYQAGLTPP CCCCCCHHHCCCCCC	11.33	23927012
483	Phosphorylation	PLYQAGLTPPLSPPK CHHHCCCCCCCCCCC	23.18	30266825
487	Phosphorylation	AGLTPPLSPPKSVPP CCCCCCCCCCCCCCC	44.95	29255136
491	Phosphorylation	PPLSPPKSVPPSVPA CCCCCCCCCCCCCCC	45.70	27174698
495	Phosphorylation	PPKSVPPSVPARGLQ CCCCCCCCCCCCCCC	34.36	27174698
508	Phosphorylation	LQPQPPATPAVPHPP CCCCCCCCCCCCCCC	19.97	27251275
517	Phosphorylation	AVPHPPPSGAFGLGG CCCCCCCCCCCCCCH	48.83	26714015
531	Phosphorylation	GALEAAESEGLGLGC HHHHHHHHCCCCCCC	32.03	26714015
540	Phosphorylation	GLGLGCPSPCKRLDE CCCCCCCCHHHHHHH	47.18	25849741
555	Phosphorylation	ELKRNLETLPSFSSD HHHHHHHHCCCCCCC	47.32	29255136
558	Phosphorylation	RNLETLPSFSSDEED HHHHHCCCCCCCHHH	40.65	29255136
560	Phosphorylation	LETLPSFSSDEEDSV HHHCCCCCCCHHHHH	41.01	29255136
561	Phosphorylation	ETLPSFSSDEEDSVA HHCCCCCCCHHHHHH	47.21	29255136
566	Phosphorylation	FSSDEEDSVAKNRDL CCCCHHHHHHHCHHH	27.53	29255136
570 (in isoform 3)	Phosphorylation	-	32.72	30206219
574 (in isoform 3)	Phosphorylation	-	46.83	25850435
576	Phosphorylation	KNRDLQESISSAISA HCHHHHHHHHHHHHH	18.14	21712546
578	Phosphorylation	RDLQESISSAISALD HHHHHHHHHHHHHHC	24.01	21712546
582 (in isoform 3)	Phosphorylation	-	23.61	25849741
589 (in isoform 3)	Phosphorylation	-	11.93	20068231
591 (in isoform 3)	Phosphorylation	-	37.16	20068231
592 (in isoform 3)	Phosphorylation	-	26.24	20068231
596 (in isoform 3)	Phosphorylation	-	48.34	20068231
607 (in isoform 3)	Phosphorylation	-	14.13	22210691
608 (in isoform 3)	Phosphorylation	-	15.33	22210691
615 (in isoform 3)	Phosphorylation	-	6.92	20068231
636 (in isoform 3)	Phosphorylation	-	43.30	22167270
651	Phosphorylation	PTPQPQPPPPPPPPQ CCCCCCCCCCCCCCC	49.10	21406692
651 (in isoform 3)	Phosphorylation	-	49.10	30266825
655 (in isoform 3)	Phosphorylation	-	60.00	22210691
656 (in isoform 3)	Phosphorylation	-	46.03	22210691
677 (in isoform 3)	Phosphorylation	-	46.67	28450419
686 (in isoform 3)	Phosphorylation	-	47.14	28796482
688 (in isoform 3)	Phosphorylation	-	4.10	28796482
709 (in isoform 3)	Phosphorylation	-	31.87	28348404
713	Phosphorylation	PEEPAAPSPEDPELP CCCCCCCCCCCCCCC	35.87	26074081
729	Ubiquitination	TRPLHLAKKQETAAV CCCCCHHCCCHHHCC	62.44	-
729 (in isoform 1)	Ubiquitination	-	62.44	21906983
729 (in isoform 3)	Ubiquitination	-	62.44	-
730	Ubiquitination	RPLHLAKKQETAAVC CCCCHHCCCHHHCCC	48.00	-
730 (in isoform 1)	Ubiquitination	-	48.00	21906983
730 (in isoform 3)	Ubiquitination	-	48.00	-
733	Phosphorylation	HLAKKQETAAVCGET CHHCCCHHHCCCCCC	19.88	30266825
738	Phosphorylation	QETAAVCGETDEEAG CHHHCCCCCCHHHHH	33.95	21406692
738 (in isoform 3)	Phosphorylation	-	33.95	30266825
740	Phosphorylation	TAAVCGETDEEAGES HHCCCCCCHHHHHHC	33.71	25159151
744 (in isoform 3)	Phosphorylation	-	25.63	27251275
745 (in isoform 3)	Phosphorylation	-	32.65	27251275
747	Phosphorylation	TDEEAGESGGEGIFR CHHHHHHCCCCCCCC	51.70	25159151
763 (in isoform 3)	Phosphorylation	-	14.00	26657352
768	Phosphorylation	IRAEDIPSLKLALQT EEHHHCCHHHHHHHH	38.17	24719451
770 (in isoform 3)	Phosphorylation	-	35.73	27251275
787	Sumoylation	PPIWRVQKALLQKFT CCHHHHHHHHHHHHC	37.84	-
818	Acetylation	LGYFGDAKNRYQRLY CCCCCCHHHHHHHHH	46.85	26051181
835	"N6,N6-dimethyllysine"	FLENVNKKDYVRVCA HHHCCCHHHCEEEEC	49.43	-
835	Methylation	FLENVNKKDYVRVCA HHHCCCHHHCEEEEC	49.43	-
844	"N6,N6-dimethyllysine"	YVRVCARKPWHRPPV CEEEECCCCCCCCCC	33.65	-
844	Methylation	YVRVCARKPWHRPPV CEEEECCCCCCCCCC	33.65	-
856	Phosphorylation	PPVPVRRSGQAKNPV CCCCCCCCCCCCCCC	25.37	23312004
864	Phosphorylation	GQAKNPVSAGGSSAP CCCCCCCCCCCCCCC	23.58	23312004
865	Phosphorylation	QAKNPVSAGGSSAPP CCCCCCCCCCCCCCC	26.97	18220336
868	Phosphorylation	NPVSAGGSSAPPPKA CCCCCCCCCCCCCCC	23.55	23312004
869	Phosphorylation	PVSAGGSSAPPPKAP CCCCCCCCCCCCCCC	48.33	23312004
881	Acetylation	KAPAPPPKPETPEKT CCCCCCCCCCCCCCC	62.35	26051181
884	Phosphorylation	APPPKPETPEKTTSE CCCCCCCCCCCCCCC	45.32	30266825
888	Phosphorylation	KPETPEKTTSEKPPE CCCCCCCCCCCCCCC	33.61	24114839
897	Phosphorylation	SEKPPEQTPETAMPE CCCCCCCCCCCCCCC	22.79	28555341
910	Acetylation	PEPPAPEKPSLLRPV CCCCCCCCCCCCCCC	38.56	26051181
922	Ubiquitination	RPVEKEKEKEKVTRG CCCHHHHHHHHCCCC	68.49	22505724
952	Phosphorylation	RPERSLATGQPATSR CCHHHHCCCCCCCCC	41.46	28634120
957	Phosphorylation	LATGQPATSRLPKAR HCCCCCCCCCCCCCC	22.51	28634120
969	Sumoylation	KARPTKVKAEPPPKK CCCCCCCCCCCCCHH	48.89	-
998	Phosphorylation	GGGPPGSSSDSESSP CCCCCCCCCCCCCCC	44.04	-
999	Phosphorylation	GGPPGSSSDSESSPG CCCCCCCCCCCCCCC	47.02	24719451
1009	Phosphorylation	ESSPGAPSEDERAVP CCCCCCCCHHHCCCC	58.08	-
1022	Phosphorylation	VPGRLLKTRAMREMY CCHHHHHHHHHHHHH	24.51	-
1031	Phosphorylation	AMREMYRSYVEMLVS HHHHHHHHHHHHHHH	18.95	23401153
1032	Phosphorylation	MREMYRSYVEMLVST HHHHHHHHHHHHHHH	7.45	23401153
1038	Phosphorylation	SYVEMLVSTALDPDM HHHHHHHHHCCCHHH	12.19	23401153
1039	Phosphorylation	YVEMLVSTALDPDMI HHHHHHHHCCCHHHH	24.62	23401153
1052	Phosphorylation	MIQALEDTHDELYLP HHHHHHHCCCHHCCC	23.11	26074081
1057	Phosphorylation	EDTHDELYLPPMRKI HHCCCHHCCCCHHHH	18.34	26074081
1063	Acetylation	LYLPPMRKIDGLLNE HCCCCHHHHHHHCHH	38.61	7290151
1063	Ubiquitination	LYLPPMRKIDGLLNE HCCCCHHHHHHHCHH	38.61	-
1072	Acetylation	DGLLNEHKKKVLKRL HHHCHHHHHHHHHHH	48.38	7290161
1073	Acetylation	GLLNEHKKKVLKRLS HHCHHHHHHHHHHHC	50.45	8082949
1077	Phosphorylation	EHKKKVLKRLSLSPA HHHHHHHHHHCCCHH	55.04	23186163
1080	Phosphorylation	KKVLKRLSLSPALQD HHHHHHHCCCHHHHH	30.73	20873877
1082	Phosphorylation	VLKRLSLSPALQDAL HHHHHCCCHHHHHHH	12.54	20873877
1091	Phosphorylation	ALQDALHTFPQLQVE HHHHHHHHCCCCCEE	37.55	20873877
1100	Phosphorylation	PQLQVEQSGEGSPEE CCCCEEECCCCCCCC	25.88	28176443
1104	Phosphorylation	VEQSGEGSPEEGAVR EEECCCCCCCCCCCE	25.49	25159151
1135	Phosphorylation	KRSVVRAQEFKVELE HHHHHHHHHHEEEEH	46.20	-
1223	Acetylation	--------------- ---------------		19608861
1304	Phosphorylation	------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------		20068231
1308	Phosphorylation	---------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------		17081983
1371	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
1381	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------		18669648
1382	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		32645325
1387	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21406692
1561	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		17081983
1568	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		17081983
1591	Ubiquitination	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
1608	Ubiquitination	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		33845483
1705	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		23186163
1884 (in isoform 3)	Ubiquitination	-		-
1893	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
1925	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		18220336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRR12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRR12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRR12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP7_HUMAN	USP7	physical	22939629
RINI_HUMAN	RNH1	physical	22939629
PUM1_HUMAN	PUM1	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRR12_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-402, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560 AND SER-561, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-558 AND SER-560, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560; SER-561; THR-740AND SER-747, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256; THR-483; SER-487;SER-560; SER-561; THR-740 AND SER-747, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND SER-1104, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487; THR-740 ANDSER-747, AND MASS SPECTROMETRY.	17081983 [Abstract]