dbPTM

PUM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUM1_HUMAN
UniProt AC	Q14671
Protein Name	Pumilio homolog 1 {ECO:0000305}
Gene Name	PUM1 {ECO:0000312\|HGNC:HGNC:14957}
Organism	Homo sapiens (Human).
Sequence Length	1186
Subcellular Localization	Cytoplasm . Cytoplasm, P-body . Cytoplasmic granule . Recruited to cytoplasmic stress granules upon viral infection.
Protein Description	Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). [PubMed: 21572425]
Protein Sequence	MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVACVLKR ------CCHHHHEEC	29.71	22814378
2	Phosphorylation	------MSVACVLKR ------CCHHHHEEC	29.71	30631047
8	Methylation	MSVACVLKRKAVLWQ CCHHHHEECCEEEEC	31.30	115975911
17	Phosphorylation	KAVLWQDSFSPHLKH CEEEECCCCCHHHCC	16.72	18669648
19	Phosphorylation	VLWQDSFSPHLKHHP EEECCCCCHHHCCCC	18.50	25159151
19 (in isoform 3)	Phosphorylation	-	18.50	24719451
39	Phosphorylation	PNMPVVLTSGTGSQA CCCCEEEECCCCCCC	17.32	18691976
44	Phosphorylation	VLTSGTGSQAQPQPA EEECCCCCCCCCCHH	23.37	20068231
60	Phosphorylation	NQALAAGTHSSPVPG HHHHHCCCCCCCCCC	17.54	29632367
60 (in isoform 3)	Phosphorylation	-	17.54	27251275
62	Phosphorylation	ALAAGTHSSPVPGSI HHHCCCCCCCCCCCE	35.85	29632367
63	Phosphorylation	LAAGTHSSPVPGSIG HHCCCCCCCCCCCEE	23.47	29632367
68	Phosphorylation	HSSPVPGSIGVAGRS CCCCCCCCEEECCCC	15.31	29632367
75	Phosphorylation	SIGVAGRSQDDAMVD CEEECCCCCCHHHHH	36.72	21712546
75 (in isoform 3)	Phosphorylation	-	36.72	27251275
83	Phosphorylation	QDDAMVDYFFQRQHG CCHHHHHHHHHHHCC	8.55	28796482
98	Phosphorylation	EQLGGGGSGGGGYNN CCCCCCCCCCCCCCC	37.22	25159151
98 (in isoform 3)	Phosphorylation	-	37.22	24719451
103	Phosphorylation	GGSGGGGYNNSKHRW CCCCCCCCCCCCCCC	17.91	20068231
106	Phosphorylation	GGGGYNNSKHRWPTG CCCCCCCCCCCCCCC	26.63	23401153
106 (in isoform 3)	Phosphorylation	-	26.63	27251275
107	Ubiquitination	GGGYNNSKHRWPTGD CCCCCCCCCCCCCCC	39.03	29967540
112	Phosphorylation	NSKHRWPTGDNIHAE CCCCCCCCCCCCCHH	50.65	27273156
112 (in isoform 3)	Phosphorylation	-	50.65	24719451
124	Phosphorylation	HAEHQVRSMDELNHD CHHHHCCCHHHCCHH	31.56	29255136
124 (in isoform 3)	Phosphorylation	-	31.56	27251275
125	Sulfoxidation	AEHQVRSMDELNHDF HHHHCCCHHHCCHHH	3.04	21406390
143	Ubiquitination	ALEGRAMGEQLLPGK HHCCHHHHHCCCCCC	20.65	-
150	Acetylation	GEQLLPGKKFWETDE HHCCCCCCCEECCCC	42.74	25953088
150	Ubiquitination	GEQLLPGKKFWETDE HHCCCCCCCEECCCC	42.74	29967540
151	Ubiquitination	EQLLPGKKFWETDES HCCCCCCCEECCCCC	62.72	29967540
158	Phosphorylation	KFWETDESSKDGPKG CEECCCCCCCCCCCC	45.56	29507054
159	Phosphorylation	FWETDESSKDGPKGI EECCCCCCCCCCCCE	32.49	23917254
160	Ubiquitination	WETDESSKDGPKGIF ECCCCCCCCCCCCEE	75.80	29967540
164	Ubiquitination	ESSKDGPKGIFLGDQ CCCCCCCCCEEECCH	70.89	-
175	Phosphorylation	LGDQWRDSAWGTSDH ECCHHHCCCCCCCCC	19.83	24719451
180	Phosphorylation	RDSAWGTSDHSVSQP HCCCCCCCCCCCCCC	29.41	28555341
183	Phosphorylation	AWGTSDHSVSQPIMV CCCCCCCCCCCCEEE	28.58	28555341
185	Phosphorylation	GTSDHSVSQPIMVQR CCCCCCCCCCEEEEE	33.00	28348404
185 (in isoform 3)	Phosphorylation	-	33.00	27251275
187 (in isoform 4)	Phosphorylation	-	14.77	28102081
197	Phosphorylation	VQRRPGQSFHVNSEV EEECCCCCEECCCHH	24.20	23927012
197 (in isoform 3)	Phosphorylation	-	24.20	27251275
202	Phosphorylation	GQSFHVNSEVNSVLS CCCEECCCHHCCCCC	41.66	23927012
206	Phosphorylation	HVNSEVNSVLSPRSE ECCCHHCCCCCCCCC	29.61	29255136
206 (in isoform 3)	Phosphorylation	-	29.61	27251275
209	Phosphorylation	SEVNSVLSPRSESGG CHHCCCCCCCCCCCC	18.99	29255136
209 (in isoform 3)	Phosphorylation	-	18.99	24719451
210	Ubiquitination	EVNSVLSPRSESGGL HHCCCCCCCCCCCCC	39.39	-
212	Phosphorylation	NSVLSPRSESGGLGV CCCCCCCCCCCCCCE	39.23	23663014
214	Phosphorylation	VLSPRSESGGLGVSM CCCCCCCCCCCCEEE	39.13	23663014
214 (in isoform 3)	Phosphorylation	-	39.13	27251275
220	Phosphorylation	ESGGLGVSMVEYVLS CCCCCCEEEEEHHHH	18.47	23663014
224	Phosphorylation	LGVSMVEYVLSSSPG CCEEEEEHHHHCCCC	8.69	28450419
227	Phosphorylation	SMVEYVLSSSPGDSC EEEEHHHHCCCCCCH	20.80	30278072
228	Phosphorylation	MVEYVLSSSPGDSCL EEEHHHHCCCCCCHH	36.07	30278072
229	Phosphorylation	VEYVLSSSPGDSCLR EEHHHHCCCCCCHHH	29.53	30278072
229 (in isoform 3)	Phosphorylation	-	29.53	24719451
233	Phosphorylation	LSSSPGDSCLRKGGF HHCCCCCCHHHCCCC	22.44	22617229
234	Glutathionylation	SSSPGDSCLRKGGFG HCCCCCCHHHCCCCC	5.18	22555962
237	Acetylation	PGDSCLRKGGFGPRD CCCCHHHCCCCCCCC	50.89	26051181
237	Ubiquitination	PGDSCLRKGGFGPRD CCCCHHHCCCCCCCC	50.89	29967540
243	Methylation	RKGGFGPRDADSDEN HCCCCCCCCCCCCCC	52.72	115489651
247	Phosphorylation	FGPRDADSDENDKGE CCCCCCCCCCCCCCC	48.85	25849741
260	Phosphorylation	GEKKNKGTFDGDKLG CCCCCCCCCCCCCCC	21.84	24719451
260 (in isoform 3)	Phosphorylation	-	21.84	24719451
265	Ubiquitination	KGTFDGDKLGDLKEE CCCCCCCCCCCCCCC	60.96	22817900
270	Ubiquitination	GDKLGDLKEEGDVMD CCCCCCCCCCCCCCC	59.46	21906983
270 (in isoform 1)	Ubiquitination	-	59.46	21890473
270 (in isoform 2)	Ubiquitination	-	59.46	21890473
276	Sulfoxidation	LKEEGDVMDKTNGLP CCCCCCCCCCCCCCC	5.35	21406390
279	Phosphorylation	EGDVMDKTNGLPVQN CCCCCCCCCCCCCCC	30.19	28555341
298	Phosphorylation	DVKDFSRTPGNCQNS CHHHHCCCCCCCCCC	34.06	25850435
305	Phosphorylation	TPGNCQNSANEVDLL CCCCCCCCCCCCCCC	13.44	25850435
514	Phosphorylation	GASQRPLTPNQNQQG CCCCCCCCCCCCCCC	23.91	21552520
580	Methylation	NGLGAPVRLVAPAPV CCCCCCCEEEECCCE	23.53	81452721
659	Ubiquitination	NSNSQSSSLFSQGSA CCCCCCCCCCCCCCC	38.39	21890473
672	Phosphorylation	SAQPANTSLGFGSSS CCCCCCCCCCCCCCC	26.71	26657352
677	Phosphorylation	NTSLGFGSSSSLGAT CCCCCCCCCCHHHHH	25.45	26074081
678	Phosphorylation	TSLGFGSSSSLGATL CCCCCCCCCHHHHHH	25.07	26074081
679	Phosphorylation	SLGFGSSSSLGATLG CCCCCCCCHHHHHHH	31.14	26074081
680	Phosphorylation	LGFGSSSSLGATLGS CCCCCCCHHHHHHHH	32.54	26074081
687	Phosphorylation	SLGATLGSALGGFGT HHHHHHHHHHCCCCE	24.35	26074081
694	Phosphorylation	SALGGFGTAVANSNT HHHCCCCEEECCCCC	18.72	26074081
699	Phosphorylation	FGTAVANSNTGSGSR CCEEECCCCCCCCCC	26.49	26074081
701	Phosphorylation	TAVANSNTGSGSRRD EEECCCCCCCCCCCC	32.33	26074081
703	Phosphorylation	VANSNTGSGSRRDSL ECCCCCCCCCCCCCC	31.40	26074081
705	Phosphorylation	NSNTGSGSRRDSLTG CCCCCCCCCCCCCCC	26.32	26074081
709	Phosphorylation	GSGSRRDSLTGSSDL CCCCCCCCCCCCHHH	26.48	29255136
709 (in isoform 3)	Phosphorylation	-	26.48	24719451
711	Phosphorylation	GSRRDSLTGSSDLYK CCCCCCCCCCHHHHH	38.68	29255136
713	Phosphorylation	RRDSLTGSSDLYKRT CCCCCCCCHHHHHHC	18.55	29255136
714	Phosphorylation	RDSLTGSSDLYKRTS CCCCCCCHHHHHHCC	32.74	20164059
717	Phosphorylation	LTGSSDLYKRTSSSL CCCCHHHHHHCCCCC	11.92	23927012
718	2-Hydroxyisobutyrylation	TGSSDLYKRTSSSLT CCCHHHHHHCCCCCC	57.40	-
718	Ubiquitination	TGSSDLYKRTSSSLT CCCHHHHHHCCCCCC	57.40	22817900
718 (in isoform 1)	Ubiquitination	-	57.40	21890473
719 (in isoform 2)	Ubiquitination	-	26.70	21890473
719	Ubiquitination	GSSDLYKRTSSSLTP CCHHHHHHCCCCCCC	26.70	21890473
735	Acetylation	GHSFYNGLSFSSSPG CCCCCCCCCCCCCCC	4.10	-
735	Ubiquitination	GHSFYNGLSFSSSPG CCCCCCCCCCCCCCC	4.10	21890473
736	Phosphorylation	HSFYNGLSFSSSPGP CCCCCCCCCCCCCCC	25.20	22798277
738	Phosphorylation	FYNGLSFSSSPGPVG CCCCCCCCCCCCCCC	26.91	26074081
739	Phosphorylation	YNGLSFSSSPGPVGM CCCCCCCCCCCCCCC	38.24	26074081
740	Phosphorylation	NGLSFSSSPGPVGMP CCCCCCCCCCCCCCC	32.45	26074081
750	Phosphorylation	PVGMPLPSQGPGHSQ CCCCCCCCCCCCCCC	56.29	26074081
756	Phosphorylation	PSQGPGHSQTPPPSL CCCCCCCCCCCCCCC	41.48	26074081
758	Phosphorylation	QGPGHSQTPPPSLSS CCCCCCCCCCCCCCC	40.55	26074081
762	Phosphorylation	HSQTPPPSLSSHGSS CCCCCCCCCCCCCCC	46.81	26074081
764	Phosphorylation	QTPPPSLSSHGSSSS CCCCCCCCCCCCCCC	25.32	26074081
765	Phosphorylation	TPPPSLSSHGSSSSL CCCCCCCCCCCCCCC	36.84	26074081
768	Phosphorylation	PSLSSHGSSSSLNLG CCCCCCCCCCCCCCC	22.94	26074081
769	Phosphorylation	SLSSHGSSSSLNLGG CCCCCCCCCCCCCCC	28.65	26074081
770	Phosphorylation	LSSHGSSSSLNLGGL CCCCCCCCCCCCCCC	40.31	26074081
771	Phosphorylation	SSHGSSSSLNLGGLT CCCCCCCCCCCCCCC	24.19	26074081
784	Phosphorylation	LTNGSGRYISAAPGA CCCCCCCEEECCCCC	11.62	28152594
786	Phosphorylation	NGSGRYISAAPGAEA CCCCCEEECCCCCCE	14.94	28442448
794	Acetylation	AAPGAEAKYRSASSA CCCCCCEECCCCCCC	32.47	23236377
794	Ubiquitination	AAPGAEAKYRSASSA CCCCCCEECCCCCCC	32.47	27667366
794 (in isoform 1)	Ubiquitination	-	32.47	21890473
795	Phosphorylation	APGAEAKYRSASSAS CCCCCEECCCCCCCH	19.49	29396449
795 (in isoform 2)	Ubiquitination	-	19.49	21890473
795	Ubiquitination	APGAEAKYRSASSAS CCCCCEECCCCCCCH	19.49	21890473
796	Methylation	PGAEAKYRSASSASS CCCCEECCCCCCCHH	25.66	24129315
797	Phosphorylation	GAEAKYRSASSASSL CCCEECCCCCCCHHH	29.43	20044836
797 (in isoform 3)	Phosphorylation	-	29.43	24719451
799	Phosphorylation	EAKYRSASSASSLFS CEECCCCCCCHHHCC	27.90	21712546
800	Phosphorylation	AKYRSASSASSLFSP EECCCCCCCHHHCCC	31.70	21712546
800 (in isoform 3)	Phosphorylation	-	31.70	27251275
802	Phosphorylation	YRSASSASSLFSPSS CCCCCCCHHHCCCCH	29.53	30183078
803	Phosphorylation	RSASSASSLFSPSST CCCCCCHHHCCCCHH	32.90	21712546
806	Phosphorylation	SSASSLFSPSSTLFS CCCHHHCCCCHHHCC	29.21	23401153
806 (in isoform 3)	Phosphorylation	-	29.21	24719451
808	Phosphorylation	ASSLFSPSSTLFSSS CHHHCCCCHHHCCCC	34.45	22617229
809	Phosphorylation	SSLFSPSSTLFSSSR HHHCCCCHHHCCCCC	32.30	30183078
809 (in isoform 3)	Phosphorylation	-	32.30	24719451
810	Ubiquitination	SLFSPSSTLFSSSRL HHCCCCHHHCCCCCH	35.84	-
810	Phosphorylation	SLFSPSSTLFSSSRL HHCCCCHHHCCCCCH	35.84	21712546
813	Phosphorylation	SPSSTLFSSSRLRYG CCCHHHCCCCCHHCC	30.43	28450419
814	Phosphorylation	PSSTLFSSSRLRYGM CCHHHCCCCCHHCCC	16.49	20044836
815	Phosphorylation	SSTLFSSSRLRYGMS CHHHCCCCCHHCCCC	33.85	29396449
818	Methylation	LFSSSRLRYGMSDVM HCCCCCHHCCCCCCC	25.50	58856365
822	Phosphorylation	SRLRYGMSDVMPSGR CCHHCCCCCCCCCCH	23.77	21572425
855	Ubiquitination	EIAGHIMEFSQDQHG HHHHHHHHHCCCCCC	41.36	-
869	Ubiquitination	GSRFIQLKLERATPA CCCEEEEHHHCCCHH	31.74	-
881	Ubiquitination	TPAERQLVFNEILQA CHHHHHHHHHHHHHH	3.51	-
904	Ubiquitination	FGNYVIQKFFEFGSL HHHHHHHHHHHCCCH	40.68	-
907	Ubiquitination	YVIQKFFEFGSLEQK HHHHHHHHCCCHHHH	52.83	-
914	Ubiquitination	EFGSLEQKLALAERI HCCCHHHHHHHHHHH	26.76	22817900
914 (in isoform 1)	Ubiquitination	-	26.76	21890473
915 (in isoform 2)	Ubiquitination	-	4.76	21890473
917	Ubiquitination	SLEQKLALAERIRGH CHHHHHHHHHHHHHH	8.03	-
940	Ubiquitination	YGCRVIQKALEFIPS HHHHHHHHHHHHCCH	43.76	22817900
941 (in isoform 2)	Ubiquitination	-	8.92	21890473
963	Acetylation	ELDGHVLKCVKDQNG HHCCEEEEEEECCCC	35.57	25953088
963	Ubiquitination	ELDGHVLKCVKDQNG HHCCEEEEEEECCCC	35.57	33845483
965	Ubiquitination	DGHVLKCVKDQNGNH CCEEEEEEECCCCCC	7.97	27667366
966	Ubiquitination	GHVLKCVKDQNGNHV CEEEEEEECCCCCCH	64.17	29967540
968	Ubiquitination	VLKCVKDQNGNHVVQ EEEEEECCCCCCHHH	54.75	29967540
976	Ubiquitination	NGNHVVQKCIECVQP CCCCHHHHHHHHHCC	26.10	-
1017	Ubiquitination	IQRILEHCLPDQTLP HHHHHHHHCCCCCHH	4.27	-
1025	Ubiquitination	LPDQTLPILEELHQH CCCCCHHHHHHHHHH	9.46	-
1058	Acetylation	EHGRPEDKSKIVAEI HCCCCCCHHHHEEEE	52.57	18603697
1068	Ubiquitination	IVAEIRGNVLVLSQH HEEEEECCEEEEECC	17.69	-
1073	Phosphorylation	RGNVLVLSQHKFASN ECCEEEEECCHHHHC	23.82	27251275
1075 (in isoform 3)	Phosphorylation	-	24.67	27251275
1076	Acetylation	VLVLSQHKFASNVVE EEEEECCHHHHCHHH	34.68	26051181
1076	Ubiquitination	VLVLSQHKFASNVVE EEEEECCHHHHCHHH	34.68	-
1084	Ubiquitination	FASNVVEKCVTHASR HHHCHHHHHHHHHCC	23.54	21906983
1084 (in isoform 1)	Ubiquitination	-	23.54	21890473
1086	Ubiquitination	SNVVEKCVTHASRTE HCHHHHHHHHHCCCC	6.96	22817900
1087 (in isoform 2)	Ubiquitination	-	22.61	21890473
1102	Glutathionylation	AVLIDEVCTMNDGPH EEEEEEEECCCCCCC	2.55	22555962
1104	Acetylation	LIDEVCTMNDGPHSA EEEEEECCCCCCCHH	3.49	-
1104	Ubiquitination	LIDEVCTMNDGPHSA EEEEEECCCCCCCHH	3.49	-
1107	Ubiquitination	EVCTMNDGPHSALYT EEECCCCCCCHHHHH	19.47	-
1113	Phosphorylation	DGPHSALYTMMKDQY CCCCHHHHHHHHHHH	7.72	20090780
1120	Phosphorylation	YTMMKDQYANYVVQK HHHHHHHHHHHHHHH	13.62	25884760
1123	Phosphorylation	MKDQYANYVVQKMID HHHHHHHHHHHHHHH	8.20	25884760
1127	Ubiquitination	YANYVVQKMIDVAEP HHHHHHHHHHHCCCC	26.64	22817900
1127 (in isoform 1)	Ubiquitination	-	26.64	21890473
1129	Ubiquitination	NYVVQKMIDVAEPGQ HHHHHHHHHCCCCCC	5.06	22817900
1130 (in isoform 2)	Ubiquitination	-	30.03	21890473
1150	Phosphorylation	KIRPHIATLRKYTYG ECHHHHHHHHHHHHH	26.88	30576142
1152 (in isoform 3)	Phosphorylation	-	26.11	27251275
1153	Ubiquitination	PHIATLRKYTYGKHI HHHHHHHHHHHHHHH	45.09	27667366
1154	Phosphorylation	HIATLRKYTYGKHIL HHHHHHHHHHHHHHH	9.96	18083107
1155	Ubiquitination	IATLRKYTYGKHILA HHHHHHHHHHHHHHH	28.91	27667366
1158	Acetylation	LRKYTYGKHILAKLE HHHHHHHHHHHHHHH	19.63	25953088
1158	Ubiquitination	LRKYTYGKHILAKLE HHHHHHHHHHHHHHH	19.63	29967540
1160	Ubiquitination	KYTYGKHILAKLEKY HHHHHHHHHHHHHHH	4.57	29967540
1163	Acetylation	YGKHILAKLEKYYMK HHHHHHHHHHHHHHH	54.45	23236377
1163	Ubiquitination	YGKHILAKLEKYYMK HHHHHHHHHHHHHHH	54.45	29967540
1165	Ubiquitination	KHILAKLEKYYMKNG HHHHHHHHHHHHHHC	38.00	29967540
1166	Ubiquitination	HILAKLEKYYMKNGV HHHHHHHHHHHHHCC	52.71	-
1168	Phosphorylation	LAKLEKYYMKNGVDL HHHHHHHHHHHCCCC	16.81	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUM1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
714	S	Phosphorylation	20818387
Following growth factor stimulation phosphorylated at Ser-714, promoting binding to the 3'-UTR of CDKN1B/p27 mRNA.
714	S	Phosphorylation	20818387
Phosphorylation at Ser-714 promotes RNA-binding activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUR6_HUMAN	PAICS	physical	22939629
VP26A_HUMAN	VPS26A	physical	22939629
SPS1_HUMAN	SEPHS1	physical	22939629
SPS1_HUMAN	SEPHS1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUM1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-209; SER-709 ANDSER-806, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-75; SER-209 ANDSER-709, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-709, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline."; Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.; Electrophoresis 28:2027-2034(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-714, AND MASSSPECTROMETRY.	17487921 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND MASSSPECTROMETRY.	17081983 [Abstract]

show

show