| UniProt ID | PTGR2_HUMAN | |
|---|---|---|
| UniProt AC | Q8N8N7 | |
| Protein Name | Prostaglandin reductase 2 | |
| Gene Name | PTGR2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 351 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).. | |
| Protein Sequence | MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Ubiquitination | VLNSRPGKNGNPVAE EECCCCCCCCCCCHH | 65.45 | - | |
| 29 | Phosphorylation | NFRMEEVYLPDNINE CCCEEEEECCCCCCC | 18.79 | - | |
| 51 | Phosphorylation | LYLSVDPYMRCRMNE EEEECCCCCCCCCCC | 7.85 | - | |
| 151 | Phosphorylation | IQEKGHITAGSNKTM CEECCEEECCCCCEE | 21.20 | 20068231 | |
| 154 | Phosphorylation | KGHITAGSNKTMVVS CCEEECCCCCEEEEE | 32.46 | 20068231 | |
| 157 | Phosphorylation | ITAGSNKTMVVSGAA EECCCCCEEEEECCC | 21.32 | 20068231 | |
| 161 | Phosphorylation | SNKTMVVSGAAGACG CCCEEEEECCCCHHH | 16.00 | 20068231 | |
| 169 | Phosphorylation | GAAGACGSVAGQIGH CCCCHHHHHHHHHHH | 14.53 | 20068231 | |
| 181 | Phosphorylation | IGHFLGCSRVVGICG HHHHHCCCCEEEECC | 26.72 | 20068231 | |
| 265 | Phosphorylation | QYNKDVPYPPPLSPA HCCCCCCCCCCCCHH | 28.37 | 29255136 | |
| 270 | Phosphorylation | VPYPPPLSPAIEAIQ CCCCCCCCHHHHHHH | 20.33 | 29255136 | |
| 292 | Phosphorylation | ERFLVLNYKDKFEPG HHEEEEECCCCCCCC | 19.19 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTGR2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTGR2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTGR2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PTGR2_HUMAN !! | ||||
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00328 | Indomethacin |
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