| UniProt ID | UBP2_HUMAN | |
|---|---|---|
| UniProt AC | O75604 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 2 | |
| Gene Name | USP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 605 | |
| Subcellular Localization |
Cytoplasm . Cytoplasm, perinuclear region . Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. Isoform 4: Nucleus . Membrane Peripheral membrane protein . Cy |
|
| Protein Description | Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. [PubMed: 17290220] | |
| Protein Sequence | MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MSQLSSTLKRYT ---CCHHHHHHHHHH | 17.40 | 23403867 | |
| 6 | Phosphorylation | --MSQLSSTLKRYTE --CCHHHHHHHHHHH | 46.48 | 23403867 | |
| 7 | Phosphorylation | -MSQLSSTLKRYTES -CCHHHHHHHHHHHH | 32.68 | 23403867 | |
| 34 (in isoform 4) | Phosphorylation | - | 28.87 | - | |
| 38 (in isoform 4) | Phosphorylation | - | 26.33 | - | |
| 39 (in isoform 4) | Phosphorylation | - | 4.11 | - | |
| 42 | Phosphorylation | YGANLAASLLEKEKL HHHHHHHHHHHHHHC | 28.07 | 24719451 | |
| 56 | Phosphorylation | LGFKPVPTSSFLTRP CCCCCCCCHHHCCCC | 36.92 | 24719451 | |
| 57 | Phosphorylation | GFKPVPTSSFLTRPR CCCCCCCHHHCCCCC | 17.02 | 24719451 | |
| 58 | Phosphorylation | FKPVPTSSFLTRPRT CCCCCCHHHCCCCCC | 27.10 | 24719451 | |
| 128 | Ubiquitination | CLSYLPINAYDQGVT CCCCCCCCCCCCCCE | 30.43 | 24816145 | |
| 138 | Ubiquitination | DQGVTLTQKLDSQSD CCCCEEEHHHCCHHH | 47.64 | 24816145 | |
| 142 | Phosphorylation | TLTQKLDSQSDLARD EEEHHHCCHHHHHHH | 41.86 | - | |
| 144 | Phosphorylation | TQKLDSQSDLARDFS EHHHCCHHHHHHHHH | 38.25 | - | |
| 149 | Ubiquitination | SQSDLARDFSSLRTS CHHHHHHHHHHCCCC | 42.02 | 24816145 | |
| 152 | Phosphorylation | DLARDFSSLRTSDSY HHHHHHHHCCCCCCC | 23.12 | 24719451 | |
| 159 | Ubiquitination | SLRTSDSYRIDPRNL HCCCCCCCCCCHHHC | 19.31 | 24816145 | |
| 169 | Phosphorylation | DPRNLGRSPMLARTR CHHHCCCCHHHHHHH | 16.92 | 26437602 | |
| 172 | Ubiquitination | NLGRSPMLARTRKEL HCCCCHHHHHHHHHH | 3.11 | 24816145 | |
| 175 | Phosphorylation | RSPMLARTRKELCTL CCHHHHHHHHHHHHH | 40.25 | 24719451 | |
| 193 | Ubiquitination | YQTASCPEYLVDYLE HHHCCCHHHHHHHHH | 56.69 | 24816145 | |
| 207 | Phosphorylation | ENYGRKGSASQVPSQ HHCCCCCCHHHCCCC | 27.99 | 26437602 | |
| 213 | Phosphorylation | GSASQVPSQAPPSRV CCHHHCCCCCCCCCC | 39.87 | 22210691 | |
| 218 | Phosphorylation | VPSQAPPSRVPEIIS CCCCCCCCCCCCCCC | 44.87 | 22210691 | |
| 225 | Phosphorylation | SRVPEIISPTYRPIG CCCCCCCCCCCCCCC | 19.49 | - | |
| 228 | Phosphorylation | PEIISPTYRPIGRYT CCCCCCCCCCCCEEE | 20.13 | 25247763 | |
| 235 | Phosphorylation | YRPIGRYTLWETGKG CCCCCEEEEEECCCC | 24.84 | 26503892 | |
| 239 | Phosphorylation | GRYTLWETGKGQAPG CEEEEEECCCCCCCC | 32.39 | 26503892 | |
| 248 | Phosphorylation | KGQAPGPSRSSSPGR CCCCCCCCCCCCCCC | 51.19 | 24719451 | |
| 250 | Phosphorylation | QAPGPSRSSSPGRDG CCCCCCCCCCCCCCC | 39.23 | 24719451 | |
| 251 | Phosphorylation | APGPSRSSSPGRDGM CCCCCCCCCCCCCCC | 39.17 | 24719451 | |
| 252 | Phosphorylation | PGPSRSSSPGRDGMN CCCCCCCCCCCCCCC | 32.40 | 26437602 | |
| 261 | Ubiquitination | GRDGMNSKSAQGLAG CCCCCCCCCHHHHHH | 44.82 | 24816145 | |
| 271 | Ubiquitination | QGLAGLRNLGNTCFM HHHHHHHHHHCCHHH | 58.29 | 24816145 | |
| 300 | Phosphorylation | DYCLQRLYMRDLHHG HHHHHHHHHHHCCCC | 7.72 | 18083107 | |
| 305 | Ubiquitination | RLYMRDLHHGSNAHT HHHHHHCCCCCCHHH | 27.79 | 24816145 | |
| 381 | Ubiquitination | NRVTLRPKSNPENLD CCEECCCCCCCCCCC | 57.33 | 24816145 | |
| 402 | Ubiquitination | KGRQMWRKYLEREDS HHHHHHHHHHHHCCC | 38.38 | 24816145 | |
| 403 | Phosphorylation | GRQMWRKYLEREDSR HHHHHHHHHHHCCCC | 12.77 | 22673903 | |
| 409 | Phosphorylation | KYLEREDSRIGDLFV HHHHHCCCCHHHHHH | 22.50 | 22673903 | |
| 514 | Ubiquitination | ESRIRTSKLTTFVNF HHHCCCCCCEEEECC | 49.60 | 24816145 | |
| 596 | Phosphorylation | SDAYLLFYELASPPS CCEEEEHHHHCCCCC | 15.25 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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