SCNNG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNNG_HUMAN
• UniProt AC: P51170
• Protein Name: Amiloride-sensitive sodium channel subunit gamma
• Gene Name: SCNN1G
• Organism: Homo sapiens (Human).
• Sequence Length: 649
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Apical membrane of epithelial cells.
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..
• Protein Sequence: MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MAPGEKIKAKIKK --CCCHHHHHHHHHH	56.26	-
8	Ubiquitination	MAPGEKIKAKIKKNL CCCHHHHHHHHHHCC	55.48	9351815
10	Ubiquitination	PGEKIKAKIKKNLPV CHHHHHHHHHHCCCC	50.48	9351815
12	Ubiquitination	EKIKAKIKKNLPVTG HHHHHHHHHCCCCCC	34.60	9351815
13	Ubiquitination	KIKAKIKKNLPVTGP HHHHHHHHCCCCCCC	68.16	9351815
26	Ubiquitination	GPQAPTIKELMRWYC CCCCCHHHHHHHHHH	47.47	9351815
47	Phosphorylation	GCRRIVVSRGRLRRL CCEEEEEECHHHHHH	20.37	24719451
98	Phosphorylation	KLDFPAVTICNINPY CCCCCEEEEECCCCC	23.17	-
108	Phosphorylation	NINPYKYSTVRHLLA CCCCCCHHHHHHHHH	19.10	-
109	Phosphorylation	INPYKYSTVRHLLAD CCCCCHHHHHHHHHH	20.61	-
142	Phosphorylation	RKRREAESWNSVSEG HHHHHHHHHCCCCCC	38.31	29978859
145	Phosphorylation	REAESWNSVSEGKQP HHHHHHCCCCCCCCC	22.29	28509920
147	Phosphorylation	AESWNSVSEGKQPRF HHHHCCCCCCCCCCC	40.21	28509920
176	Phosphorylation	GKARDFFTGRKRKVG CCCCCCCCCCCCEEC	35.75	24719451
185	Phosphorylation	RKRKVGGSIIHKASN CCCEECCCEEEECCC	16.67	22210691
209	N-linked_Glycosylation	VGFQLCSNDTSDCAT EEEEEECCCCCCCEE	56.43	UniProtKB CARBOHYD
495	Acetylation	QGRQVNKKLNKTDLA HHHHHHHHCCCCHHH	52.68	12649891
497	N-linked_Glycosylation	RQVNKKLNKTDLAKL HHHHHHCCCCHHHHH	54.80	UniProtKB CARBOHYD
498	Acetylation	QVNKKLNKTDLAKLL HHHHHCCCCHHHHHH	54.58	12649903
503	Acetylation	LNKTDLAKLLIFYKD CCCCHHHHHHHHHHC	51.64	12649915
622	Phosphorylation	LGTQVPGTPPPKYNT CCCCCCCCCCCCCCC	26.93	11805112
629	Phosphorylation	TPPPKYNTLRLERAF CCCCCCCCHHHHHHH	15.34	-
637	Phosphorylation	LRLERAFSNQLTDTQ HHHHHHHHCCCCCCH	23.76	28857561
641	Phosphorylation	RAFSNQLTDTQMLDE HHHHCCCCCCHHHHC	27.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:17013377
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:14556380

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNNG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNNG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_HUMAN	NEDD4	physical	10642508
NEDD4_HUMAN	NEDD4	physical	11244092
NED4L_HUMAN	NEDD4L	physical	11244092
EPN1_HUMAN	EPN1	physical	16574660
NED4L_HUMAN	NEDD4L	physical	16416336
UBP2_HUMAN	USP2	physical	18701608
SERP1_HUMAN	SERP1	physical	22526458

Drug and Disease Associations

• Kegg Disease
• H00242: Liddle syndrome
• H00243: Hyperkalemic distal renal tubular acidosis (RTA type 4), including: Pseudohypoaldosteronism type I
• H00892: Bronchiectasis with or without elevated sweat chloride
• OMIM Disease
• 177200: Liddle syndrome (LIDDS)
• 613071: Bronchiectasis with or without elevated sweat chloride 3 (BESC3)
• Kegg Drug
• D00386: Triamterene (JP16/USP/INN); Dyrenium (TN)
• D00649: Amiloride hydrochloride (USP); Midamor (TN)
• D07447: Amiloride (INN); Amiclaran (TN)
• DrugBank
• DB00594: Amiloride
• DB00384: Triamterene