dbPTM

SERP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SERP1_HUMAN
UniProt AC	Q9Y6X1
Protein Name	Stress-associated endoplasmic reticulum protein 1
Gene Name	SERP1
Organism	Homo sapiens (Human).
Sequence Length	66
Subcellular Localization	Membrane Single-pass type IV membrane protein. Endoplasmic reticulum membrane Single-pass membrane protein Cytoplasmic side.
Protein Description	Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity)..
Protein Sequence	MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	MANEKHSKNITQRGN HHHHHHCCCCHHHHC	52.68	24816145
21	Methylation	HSKNITQRGNVAKTS HCCCCHHHHCHHHHC	29.97	-
26	Ubiquitination	TQRGNVAKTSRNAPE HHHHCHHHHCCCCCH	42.63	29967540
37	Phosphorylation	NAPEEKASVGPWLLA CCCHHHHCHHHHHHH	38.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SERP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SERP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SERP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCNNB_HUMAN	SCNN1B	physical	22526458
A4_HUMAN	APP	physical	21832049
SGTA_HUMAN	SGTA	physical	20516149
TMM79_HUMAN	TMEM79	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SERP1_HUMAN

Related Literatures of Post-Translational Modification