TMM79_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM79_HUMAN
• UniProt AC: Q9BSE2
• Protein Name: Transmembrane protein 79
• Gene Name: TMEM79
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Lysosome. Golgi apparatus, trans-Golgi network. Membrane ; Multi-pass membrane protein . Colocalized with TGOLN2 in the trans-Golgi network. Colocalized with LAMP1 in the lysosome (By similarity)..
• Protein Description: Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity)..
• Protein Sequence: MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGAESLRVGSSAGSPTAIEGAEDGLDSTVSEAATLPWGTGPQPSAPFPDPPGWRDIEPEPPESEPLTKLEELPEDDANLLPEKAARAFVPIDLQCIERQPQEDLIVRCEAGEGECRTFMPPRVTHPDPTERKWAEAVVRPPGCSCGGCGSCGDREWLRAVASVGAALILFPCLLYGAYAFLPFDVPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIHRRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAVSRLIYWLTFAVGRSFRGFGYGLTFLPLLSMLMWNLYYMFVVEPERMLTATESRLDYPDHARSASDYRPRPWG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTEQETLAL ------CCHHHHHHH	46.50	17081983
15	Phosphorylation	ALLEVKRSDSPEKSS HHHEECCCCCCCCCC	36.40	24505115
17	Phosphorylation	LEVKRSDSPEKSSPQ HEECCCCCCCCCCCC	35.88	24719451
41	Phosphorylation	EGEGGAESPGAESLR CCCCCCCCCCCCEEE	28.27	21815630
124	Ubiquitination	DANLLPEKAARAFVP CCCCCHHHHHHHCCC	45.46	33845483
170	Phosphorylation	RVTHPDPTERKWAEA CCCCCCCCCCCHHHH	56.66	-
239	Phosphorylation	MSSRLIYTLRCGVFA CCHHHHHHCCCCHHH	10.75	24719451
317	Phosphorylation	LKLLPLLTGLFAVSR HHHHHHHHHHHHHHH	39.25	23403867
323	Phosphorylation	LTGLFAVSRLIYWLT HHHHHHHHHHHHHHH	20.24	23403867
342	Phosphorylation	RSFRGFGYGLTFLPL CCCCCCCCCHHHHHH	13.50	-
358	Phosphorylation	SMLMWNLYYMFVVEP HHHHHHHHHHHHHCH	6.94	-
384	Phosphorylation	DYPDHARSASDYRPR CCCCCCCCHHHCCCC	32.67	29978859
386	Phosphorylation	PDHARSASDYRPRPW CCCCCCHHHCCCCCC	36.10	29978859
388	Phosphorylation	HARSASDYRPRPWG- CCCCHHHCCCCCCC-	21.74	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM79_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM79_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM79_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMM79_HUMAN	TMEM79	physical	25416956
GNT2A_HUMAN	GCNT2	physical	26186194
TMM79_HUMAN	TMEM79	physical	21516116
RNF8_HUMAN	RNF8	physical	21516116
GNT2A_HUMAN	GCNT2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2, AND MASSSPECTROMETRY.
PubMed: 17081983