GNT2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNT2A_HUMAN
• UniProt AC: Q8N0V5
• Protein Name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase {ECO:0000305}
• Gene Name: GCNT2
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.; Isoform C: Determines the expression of the blood group I antigen in erythrocytes..
• Protein Sequence: MMGSWKHCLFSASLISALIFVFVYNTELWENKRFLRAALSNASLLAEACHQIFEGKVFYPTENALKTTLDEATCYEYMVRSHYVTETLSEEEAGFPLAYTVTIHKDFGTFERLFRAIYMPQNVYCVHLDQKATDAFKGAVKQLLSCFPNAFLASKKESVVYGGISRLQADLNCLEDLVASEVPWKYVINTCGQDFPLKTNREIVQYLKGFKGKNITPGVLPPDHAVGRTKYVHQELLNHKNSYVIKTTKLKTPPPHDMVIYFGTAYVALTRDFANFVLQDQLALDLLSWSKDTYSPDEHFWVTLNRIPGVPGSMPNASWTGNLRAIKWSDMEDRHGGCHGHYVHGICIYGNGDLKWLVNSPSLFANKFELNTYPLTVECLELRHRERTLNQSETAIQPSWYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-	18.30	-
4	Phosphorylation	----MMGSWKHCLFS ----CCCCHHHHHHH	18.30	-
28 (in isoform 3)	Phosphorylation	-	7.00	24719451
41	N-linked_Glycosylation	FLRAALSNASLLAEA HHHHHHHCHHHHHHH	34.10	UniProtKB CARBOHYD
61	O-linked_Glycosylation	EGKVFYPTENALKTT CCCCCCCCHHHHCCC	30.41	OGP
83	Phosphorylation	EYMVRSHYVTETLSE HHHHHHHCCEECCCH	15.43	30576142
85	Phosphorylation	MVRSHYVTETLSEEE HHHHHCCEECCCHHH	18.98	30576142
145	Phosphorylation	GAVKQLLSCFPNAFL HHHHHHHHHCCCHHH	23.46	20873877
154	Phosphorylation	FPNAFLASKKESVVY CCCHHHHCCCHHHHC	46.54	20873877
198	Ubiquitination	CGQDFPLKTNREIVQ CCCCCCCCCHHHHHH	43.95	29967540
199	Phosphorylation	GQDFPLKTNREIVQY CCCCCCCCHHHHHHH	47.38	24719451
206	Phosphorylation	TNREIVQYLKGFKGK CHHHHHHHHHCCCCC	10.25	24719451
230	Ubiquitination	DHAVGRTKYVHQELL CCCCCCHHHHHHHHH	43.87	29967540
240	Ubiquitination	HQELLNHKNSYVIKT HHHHHCCCCCEEEEE	46.66	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNT2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNT2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNT2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT2A1_HUMAN	ATP2A1	physical	26186194
METL9_HUMAN	METTL9	physical	26186194
GHITM_HUMAN	GHITM	physical	26186194
COEA1_HUMAN	COL14A1	physical	26186194
TRI68_HUMAN	TRIM68	physical	26186194
FAM3C_HUMAN	FAM3C	physical	26186194
DPB1_HUMAN	HLA-DPB1	physical	26186194
TRI68_HUMAN	TRIM68	physical	28514442
AT2A1_HUMAN	ATP2A1	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442
COEA1_HUMAN	COL14A1	physical	28514442
FAM3C_HUMAN	FAM3C	physical	28514442
DPB1_HUMAN	HLA-DPB1	physical	28514442
METL9_HUMAN	METTL9	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.