COEA1_HUMAN - dbPTM
COEA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COEA1_HUMAN
UniProt AC Q05707
Protein Name Collagen alpha-1(XIV) chain
Gene Name COL14A1 {ECO:0000312|HGNC:HGNC:2191}
Organism Homo sapiens (Human).
Sequence Length 1796
Subcellular Localization Secreted, extracellular space, extracellular matrix .
Protein Description Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity)..
Protein Sequence MKIFQRKMRYWLLPPFLAIVYFCTIVQGQVAPPTRLRYNVISHDSIQISWKAPRGKFGGYKLLVTPTSGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDLEKRKDPKPRVKVVDRGNGSRPSSPEEVKFVCQTPAIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTLCSRVEEQDREIKASAHAITGPPTELITSEVTARSFMVNWTHAPGNVEKYRVVYYPTRGGKPDEVVVDGTVSSTVLKNLMSLTEYQIAVFAIYAHTASEGLRGTETTLALPMASDLLLYDVTENSMRVKWDAVPGASGYLILYAPLTEGLAGDEKEMKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQETTLALSPPRNLRISNVGSNSARLTWDPTSRQINGYRIVYNNADGTEINEVEVDPITTFPLKGLTPLTEYTIAIFSIYDEGQSEPLTGVFTTEEVPAQQYLEIDEVTTDSFRVTWHPLSADEGLHKLMWIPVYGGKTEEVVLKEEQDSHVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPATTIVPTTSVTSVFQTGIRNLVVGDETTSSLRVKWDISDSDVQQFRVTYMTAQGDPEEEVIGTVMVPGSQNNLLLKPLLPDTEYKVTVTPIYTDGEGVSVSAPGKTLPSSGPQNLRVSEEWYNRLRITWDPPSSPVKGYRIVYKPVSVPGPTLETFVGADINTILITNLLSGMDYNVKIFASQASGFSDALTGMVKTLFLGVTNLQAKHVEMTSLCAHWQVHRHATAYRVVIESLQDRQKQESTVGGGTTRHCFYGLQPDSEYKISVYTKLQEIEGPSVSIMEKTQSLPTRPPTFPPTIPPAKEVCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFVCETASATCPVVHKDGIDLAGFKMMEMFGLVEKDFSSVEGVSMEPGTFNVFPCYQLHKDALVSQPTRYLHPEGLPSDYTISFLFRILPDTPQEPFALWEILNKNSDPLVGVILDNGGKTLTYFNYDQSGDFQTVTFEGPEIRKIFYGSFHKLHIVVSETLVKVVIDCKQVGEKAMNASANITSDGVEVLGKMVRSRGPGGNSAPFQLQMFDIVCSTSWANTDKCCELPGLRDDESCPDLPHSCSCSETNEVALGPAGPPGGPGLRGPKGQQGEPGPKGPDGPRGEIGLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRDGSPGQRGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGERGDLQSQAMVRSVARQVCEQLIQSHMARYTAILNQIPSHSSSIRTVQGPPGEPGRPGSPGAPGEQGPPGTPGFPGNAGVPGTPGERGLTGIKGEKGNPGVGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVRAPHPDQPEFTPVQDELEAMELWGPGV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
94N-linked_GlycosylationQGLMPDQNYTVQIIA
HCCCCCCCEEEEEEE		41.6519159218
137N-linked_GlycosylationVKVVDRGNGSRPSSP
EEEEECCCCCCCCCH		46.27UniProtKB CARBOHYD
202PhosphorylationTRIGLAQYSGDPRIE
EEEEEEECCCCCCEE		14.7130576142
203PhosphorylationRIGLAQYSGDPRIEW
EEEEEECCCCCCEEE		25.3330576142
230PhosphorylationEAVRNLPYKGGNTLT
HHHHCCCCCCCCCHH		25.9822461510
235PhosphorylationLPYKGGNTLTGLALN
CCCCCCCCHHHHHHH		29.0422210691
237PhosphorylationYKGGNTLTGLALNYI
CCCCCCHHHHHHHHH		28.2722210691
353O-linked_GlycosylationKASAHAITGPPTELI
HHHHHHCCCCCCHHC		44.40OGP
372N-linked_GlycosylationTARSFMVNWTHAPGN
CCCCEEEECCCCCCC		26.5819159218
383PhosphorylationAPGNVEKYRVVYYPT
CCCCEEEEEEEEECC		8.6430576142
390PhosphorylationYRVVYYPTRGGKPDE
EEEEEECCCCCCCCC		26.3130576142
403PhosphorylationDEVVVDGTVSSTVLK
CCEEECCCCCHHHHH		16.8622210691
407PhosphorylationVDGTVSSTVLKNLMS
ECCCCCHHHHHHHHC		23.5022210691
439PhosphorylationEGLRGTETTLALPMA
CCCCCCCHHCHHCCC		27.26-
536PhosphorylationQETTLALSPPRNLRI
CEEEEEECCCCCEEE		27.5324719451
643O-linked_GlycosylationTTDSFRVTWHPLSAD
ECCCEEEEECCCCCC		17.5055826105
648PhosphorylationRVTWHPLSADEGLHK
EEEECCCCCCCCHHH		37.8227251275
662PhosphorylationKLMWIPVYGGKTEEV
HEEEEEEECCCEEEE		18.1421406692
727O-linked_GlycosylationPATTIVPTTSVTSVF
CCCEECCCCCCHHHH		22.32OGP
731O-linked_GlycosylationIVPTTSVTSVFQTGI
ECCCCCCHHHHCCCC		20.95OGP
747PhosphorylationNLVVGDETTSSLRVK
EEEECCCCCCCEEEE		36.4023403867
748PhosphorylationLVVGDETTSSLRVKW
EEECCCCCCCEEEEE		17.8023403867
749PhosphorylationVVGDETTSSLRVKWD
EECCCCCCCEEEEEE		34.4923403867
750PhosphorylationVGDETTSSLRVKWDI
ECCCCCCCEEEEEEC		20.3623403867
933PhosphorylationQAKHVEMTSLCAHWQ
CCCCHHHHHHHHHHH		12.6822210691
948PhosphorylationVHRHATAYRVVIESL
HHHHHHHHHHHHHHH		10.2924719451
954PhosphorylationAYRVVIESLQDRQKQ
HHHHHHHHHHHHHHH		21.8724719451
963PhosphorylationQDRQKQESTVGGGTT
HHHHHHHCCCCCCCC		26.3721406692
964PhosphorylationDRQKQESTVGGGTTR
HHHHHHCCCCCCCCC		23.5521406692
969PhosphorylationESTVGGGTTRHCFYG
HCCCCCCCCCCEEEE		24.7521406692
970PhosphorylationSTVGGGTTRHCFYGL
CCCCCCCCCCEEEEC		22.9921406692
986PhosphorylationPDSEYKISVYTKLQE
CCCCEEEEEEEEEEE		12.6222210691
988PhosphorylationSEYKISVYTKLQEIE
CCEEEEEEEEEEECC		7.4318491316
989PhosphorylationEYKISVYTKLQEIEG
CEEEEEEEEEEECCC		24.1118491316
998PhosphorylationLQEIEGPSVSIMEKT
EEECCCCCCCHHHCC		39.0822210691
1000PhosphorylationEIEGPSVSIMEKTQS
ECCCCCCCHHHCCCC		22.1322210691
1007PhosphorylationSIMEKTQSLPTRPPT
CHHHCCCCCCCCCCC		41.3624719451
1010O-linked_GlycosylationEKTQSLPTRPPTFPP
HCCCCCCCCCCCCCC		62.19OGP
1053PhosphorylationENFNKIISFLYSTVG
CCHHHHHHHHHHHHH		16.8129449344
1056PhosphorylationNKIISFLYSTVGALN
HHHHHHHHHHHHHHH		10.5729449344
1057PhosphorylationKIISFLYSTVGALNK
HHHHHHHHHHHHHHH		20.8229449344
1058PhosphorylationIISFLYSTVGALNKI
HHHHHHHHHHHHHHH		14.9229449344
1067PhosphorylationGALNKIGTDGTQVAM
HHHHHHCCCCCEEEE		34.4323911959
1070PhosphorylationNKIGTDGTQVAMVQF
HHHCCCCCEEEEEEE		23.7623911959
1078PhosphorylationQVAMVQFTDDPRTEF
EEEEEEECCCCCCCE		23.5423911959
1086AcetylationDDPRTEFKLNAYKTK
CCCCCCEEECEECCH		34.3027178108
1117UbiquitinationTKTGKAIKYVRDTLF
CCCCHHHHHHHHHEE		42.4232015554
1118PhosphorylationKTGKAIKYVRDTLFT
CCCHHHHHHHHHEEE		8.46-
1122PhosphorylationAIKYVRDTLFTAESG
HHHHHHHHEEECCCC		17.1328348404
1125PhosphorylationYVRDTLFTAESGTRR
HHHHHEEECCCCCCC		32.40-
1128PhosphorylationDTLFTAESGTRRGIP
HHEEECCCCCCCCCC		42.89-
1142PhosphorylationPKVIVVITDGRSQDD
CEEEEEEECCCCHHH		22.3132142685
1214O-linked_GlycosylationTFVCETASATCPVVH
HHHHHHCCCCCCEEE		31.37OGP
1244PhosphorylationGLVEKDFSSVEGVSM
CCEECCCCCCCCEEC		43.5427251275
1245PhosphorylationLVEKDFSSVEGVSME
CEECCCCCCCCEECC		24.9627251275
1284PhosphorylationLHPEGLPSDYTISFL
CCCCCCCCCCEEEEE		48.5730087585
1336O-linked_GlycosylationTYFNYDQSGDFQTVT
EEEEECCCCCEEEEE		37.11OGP
1384N-linked_GlycosylationQVGEKAMNASANITS
HHHHHHHHCCCCCCC		35.2919159218
1386PhosphorylationGEKAMNASANITSDG
HHHHHHCCCCCCCCH		19.4923532336
1388N-linked_GlycosylationKAMNASANITSDGVE
HHHHCCCCCCCCHHH		35.2619159218
1391PhosphorylationNASANITSDGVEVLG
HCCCCCCCCHHHHHH		28.6823532336
1467HydroxylationALGPAGPPGGPGLRG
EECCCCCCCCCCCCC		60.507827751
1470HydroxylationPAGPPGGPGLRGPKG
CCCCCCCCCCCCCCC		44.567827751
1476HydroxylationGPGLRGPKGQQGEPG
CCCCCCCCCCCCCCC		72.657827751
1476O-linked_GlycosylationGPGLRGPKGQQGEPG
CCCCCCCCCCCCCCC		72.657827751
1482HydroxylationPKGQQGEPGPKGPDG
CCCCCCCCCCCCCCC		71.817827751
1485HydroxylationQQGEPGPKGPDGPRG
CCCCCCCCCCCCCCC		84.627827751
1485O-linked_GlycosylationQQGEPGPKGPDGPRG
CCCCCCCCCCCCCCC		84.627827751
1497HydroxylationPRGEIGLPGPQGPPG
CCCCCCCCCCCCCCC		47.407827751
1503HydroxylationLPGPQGPPGPQGPSG
CCCCCCCCCCCCCCC		74.137827751
1517HydroxylationGLSIQGMPGMPGEKG
CCCCCCCCCCCCCCC		42.637827751
1520HydroxylationIQGMPGMPGEKGEKG
CCCCCCCCCCCCCCC		54.427827751
1523HydroxylationMPGMPGEKGEKGDTG
CCCCCCCCCCCCCCC		77.587827751
1523O-linked_GlycosylationMPGMPGEKGEKGDTG
CCCCCCCCCCCCCCC		77.587827751
1526HydroxylationMPGEKGEKGDTGLPG
CCCCCCCCCCCCCCC		71.417827751
1526O-linked_GlycosylationMPGEKGEKGDTGLPG
CCCCCCCCCCCCCCC		71.417827751
1532HydroxylationEKGDTGLPGPQGIPG
CCCCCCCCCCCCCCC		54.487827751
1538HydroxylationLPGPQGIPGGVGSPG
CCCCCCCCCCCCCCC		40.077827751
1544HydroxylationIPGGVGSPGRDGSPG
CCCCCCCCCCCCCCC		35.597827751
1549PhosphorylationGSPGRDGSPGQRGLP
CCCCCCCCCCCCCCC		30.1023879269
1550HydroxylationSPGRDGSPGQRGLPG
CCCCCCCCCCCCCCC		48.767827751
1556HydroxylationSPGQRGLPGKDGSSG
CCCCCCCCCCCCCCC		51.087827751
1565HydroxylationKDGSSGPPGPPGPIG
CCCCCCCCCCCCCCC		72.027827751
1568HydroxylationSSGPPGPPGPIGIPG
CCCCCCCCCCCCCCC		68.087827751
1574HydroxylationPPGPIGIPGTPGVPG
CCCCCCCCCCCCCCC		35.087827751
1577HydroxylationPIGIPGTPGVPGITG
CCCCCCCCCCCCCCC		47.937827751
1580HydroxylationIPGTPGVPGITGSMG
CCCCCCCCCCCCCCC		34.097827751
1595HydroxylationPQGALGPPGVPGAKG
CCCCCCCCCCCCCCC		55.407827751
1598HydroxylationALGPPGVPGAKGERG
CCCCCCCCCCCCCCC		42.837827751
1601HydroxylationPPGVPGAKGERGERG
CCCCCCCCCCCCCCC		68.197827751
1601O-linked_GlycosylationPPGVPGAKGERGERG
CCCCCCCCCCCCCCC		68.197827751
1635PhosphorylationIQSHMARYTAILNQI
HHHHHHHHHHHHHHC		7.3223312004
1636PhosphorylationQSHMARYTAILNQIP
HHHHHHHHHHHHHCC		11.1523312004
1643HydroxylationTAILNQIPSHSSSIR
HHHHHHCCCCCCCCE		19.077827751
1644PhosphorylationAILNQIPSHSSSIRT
HHHHHCCCCCCCCEE		37.3228857561
1646PhosphorylationLNQIPSHSSSIRTVQ
HHHCCCCCCCCEEEC		30.0728857561
1647PhosphorylationNQIPSHSSSIRTVQG
HHCCCCCCCCEEECC		25.1028857561
1648PhosphorylationQIPSHSSSIRTVQGP
HCCCCCCCCEEECCC		21.0728857561
1651PhosphorylationSHSSSIRTVQGPPGE
CCCCCCEEECCCCCC		18.6027174698
1656HydroxylationIRTVQGPPGEPGRPG
CEEECCCCCCCCCCC		67.617827751
1659HydroxylationVQGPPGEPGRPGSPG
ECCCCCCCCCCCCCC		50.437827751
1662HydroxylationPPGEPGRPGSPGAPG
CCCCCCCCCCCCCCC		54.237827751
1664PhosphorylationGEPGRPGSPGAPGEQ
CCCCCCCCCCCCCCC		23.8928857561
1665HydroxylationEPGRPGSPGAPGEQG
CCCCCCCCCCCCCCC		49.217827751
1668HydroxylationRPGSPGAPGEQGPPG
CCCCCCCCCCCCCCC		53.417827751
1674HydroxylationAPGEQGPPGTPGFPG
CCCCCCCCCCCCCCC		67.147827751
1676PhosphorylationGEQGPPGTPGFPGNA
CCCCCCCCCCCCCCC		26.4727251275
1677HydroxylationEQGPPGTPGFPGNAG
CCCCCCCCCCCCCCC		48.637827751
1680HydroxylationPPGTPGFPGNAGVPG
CCCCCCCCCCCCCCC		40.837827751
1686HydroxylationFPGNAGVPGTPGERG
CCCCCCCCCCCCCCC		39.777827751
1688PhosphorylationGNAGVPGTPGERGLT
CCCCCCCCCCCCCCC		23.2728857561
1689HydroxylationNAGVPGTPGERGLTG
CCCCCCCCCCCCCCC		48.877827751
1698HydroxylationERGLTGIKGEKGNPG
CCCCCCCCCCCCCCC		63.467827751
1698O-linked_GlycosylationERGLTGIKGEKGNPG
CCCCCCCCCCCCCCC		63.467827751
1701HydroxylationLTGIKGEKGNPGVGT
CCCCCCCCCCCCCCC		73.067827751
1701O-linked_GlycosylationLTGIKGEKGNPGVGT
CCCCCCCCCCCCCCC		73.067827751
1704HydroxylationIKGEKGNPGVGTQGP
CCCCCCCCCCCCCCC		47.737827751
1715HydroxylationTQGPRGPPGPAGPSG
CCCCCCCCCCCCCCC		65.317827751
1721PhosphorylationPPGPAGPSGESRPGS
CCCCCCCCCCCCCCC		55.0326699800
1724PhosphorylationPAGPSGESRPGSPGP
CCCCCCCCCCCCCCC		47.5026699800
1726HydroxylationGPSGESRPGSPGPPG
CCCCCCCCCCCCCCC		57.827827751
1728PhosphorylationSGESRPGSPGPPGSP
CCCCCCCCCCCCCCC		29.3926699800
1729HydroxylationGESRPGSPGPPGSPG
CCCCCCCCCCCCCCC		66.297827751
1732HydroxylationRPGSPGPPGSPGPRG
CCCCCCCCCCCCCCC		62.917827751
1734PhosphorylationGSPGPPGSPGPRGPP
CCCCCCCCCCCCCCC		32.2424719451
1735HydroxylationSPGPPGSPGPRGPPG
CCCCCCCCCCCCCCC		63.827827751
1741HydroxylationSPGPRGPPGHLGVPG
CCCCCCCCCCCCCCC		45.737827751
1747HydroxylationPPGHLGVPGPQGPSG
CCCCCCCCCCCCCCC		47.127827751
1756HydroxylationPQGPSGQPGYCDPSS
CCCCCCCCCCCCHHH		38.977827751
1758PhosphorylationGPSGQPGYCDPSSCS
CCCCCCCCCCHHHCC		10.60-
1767PhosphorylationDPSSCSAYGVRAPHP
CHHHCCCCCCCCCCC		10.40-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COEA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COEA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COEA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PGS2_HUMANDCNphysical
9252349
CD44_HUMANCD44physical
8986622
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COEA1_HUMAN

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Related Literatures of Post-Translational Modification
Hydroxylation
ReferencePubMed
"Structure and stability of the triple-helical domains of humancollagen XIV.";
Brown J.C., Golbik R., Mann K., Timpl R.;
Matrix Biol. 14:287-295(1994).
Cited for: PROTEIN SEQUENCE OF 1459-1635 AND 1640-1767, HYDROXYLATION ATPRO-1467; PRO-1470; LYS-1476; PRO-1482; LYS-1485; PRO-1497; PRO-1503;PRO-1517; PRO-1520; LYS-1523; LYS-1526; PRO-1532; PRO-1538; PRO-1544;PRO-1550; PRO-1556; PRO-1565; PRO-1568; PRO-1574; PRO-1577; PRO-1580;PRO-1595; PRO-1598; LYS-1601; PRO-1643; PRO-1656; PRO-1659; PRO-1662;PRO-1665; PRO-1668; PRO-1674; PRO-1677; PRO-1680; PRO-1686; PRO-1689;LYS-1698; LYS-1701; PRO-1704; PRO-1715; PRO-1726; PRO-1729; PRO-1732;PRO-1735; PRO-1741; PRO-1747 AND PRO-1756, AND GLYCOSYLATION ATLYS-1476; LYS-1485; LYS-1523; LYS-1526; LYS-1601; LYS-1698 ANDLYS-1701.
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94; ASN-372; ASN-1384 ANDASN-1388, AND MASS SPECTROMETRY.
O-linked Glycosylation
ReferencePubMed
"Structure and stability of the triple-helical domains of humancollagen XIV.";
Brown J.C., Golbik R., Mann K., Timpl R.;
Matrix Biol. 14:287-295(1994).
Cited for: PROTEIN SEQUENCE OF 1459-1635 AND 1640-1767, HYDROXYLATION ATPRO-1467; PRO-1470; LYS-1476; PRO-1482; LYS-1485; PRO-1497; PRO-1503;PRO-1517; PRO-1520; LYS-1523; LYS-1526; PRO-1532; PRO-1538; PRO-1544;PRO-1550; PRO-1556; PRO-1565; PRO-1568; PRO-1574; PRO-1577; PRO-1580;PRO-1595; PRO-1598; LYS-1601; PRO-1643; PRO-1656; PRO-1659; PRO-1662;PRO-1665; PRO-1668; PRO-1674; PRO-1677; PRO-1680; PRO-1686; PRO-1689;LYS-1698; LYS-1701; PRO-1704; PRO-1715; PRO-1726; PRO-1729; PRO-1732;PRO-1735; PRO-1741; PRO-1747 AND PRO-1756, AND GLYCOSYLATION ATLYS-1476; LYS-1485; LYS-1523; LYS-1526; LYS-1601; LYS-1698 ANDLYS-1701.

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