PGS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGS2_HUMAN
• UniProt AC: P07585
• Protein Name: Decorin
• Gene Name: DCN
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: May affect the rate of fibrils formation..
• Protein Sequence: MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	O-linked_Glycosylation	----MKATIILLLLA ----CCHHHHHHHHH	11.75	2108171
34	O-linked_Glycosylation	FMLEDEASGIGPEVP EEECCCCCCCCCCCC	28.97	3484330
67	S-nitrosylation	CHLRVVQCSDLGLDK EEEEEEECHHHCCCC	2.00	25040305
92	Ubiquitination	LLDLQNNKITEIKDG EEECCCCCEEECCCC	59.56	-
102	Acetylation	EIKDGDFKNLKNLHA ECCCCCCCCCCCCEE	67.14	30585717
126	Phosphorylation	KVSPGAFTPLVKLER CCCCCCCCHHHHHHH	18.38	-
138	Acetylation	LERLYLSKNQLKELP HHHHHCCHHHHHHCH	46.23	87831
147	Acetylation	QLKELPEKMPKTLQE HHHHCHHHCCHHHHH	59.57	87835
200	Acetylation	NGAFQGMKKLSYIRI CCCCCCCCCCEEEEE	58.34	7669741
201	Acetylation	GAFQGMKKLSYIRIA CCCCCCCCCEEEEEE	33.50	30585723
211	N-linked_Glycosylation	YIRIADTNITSIPQG EEEEECCCCCCCCCC	35.77	19159218
214	Phosphorylation	IADTNITSIPQGLPP EECCCCCCCCCCCCC	28.60	22210691
234	Phosphorylation	HLDGNKISRVDAASL EECCCCCCCCHHHHH	28.06	22210691
262	N-linked_Glycosylation	NSISAVDNGSLANTP CCEEEECCCCCCCCC	35.04	19159218
280	Ubiquitination	ELHLDNNKLTRVPGG EEECCCCCCCCCCCC	58.45	-
303	N-linked_Glycosylation	VVYLHNNNISVVGSS EEEEECCCEEEEECC	32.98	UniProtKB CARBOHYD
328	Phosphorylation	KASYSGVSLFSNPVQ CCEECCEECCCCCEE	27.50	-
331	Phosphorylation	YSGVSLFSNPVQYWE ECCEECCCCCEEEEE	45.58	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGFR_HUMAN	EGFR	physical	12105206
FLNA_HUMAN	FLNA	physical	12106908
CO6A1_HUMAN	COL6A1	physical	1544908
TGFB1_HUMAN	TGFB1	physical	9675033
FETUA_HUMAN	AHSG	physical	12071714
EGFR_HUMAN	EGFR	physical	9988678
TGFB1_HUMAN	TGFB1	physical	7798269
CHSS1_HUMAN	CHSY1	physical	26186194
KLH17_HUMAN	KLHL17	physical	26186194
KAISO_HUMAN	ZBTB33	physical	26186194
LONP2_HUMAN	LONP2	physical	26186194
TPA_HUMAN	PLAT	physical	26186194
CHSS1_HUMAN	CHSY1	physical	28514442
KLH17_HUMAN	KLHL17	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610048: Corneal dystrophy, congenital stromal (CSCD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-211 AND ASN-262, AND MASSSPECTROMETRY.
PubMed: 19159218

O-linked Glycosylation

"Primary structure of an extracellular matrix proteoglycan coreprotein deduced from cloned cDNA.";
Krusius T., Ruoslahti E.;
Proc. Natl. Acad. Sci. U.S.A. 83:7683-7687(1986).
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
PubMed: 3484330