CO6A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO6A1_HUMAN
• UniProt AC: P12109
• Protein Name: Collagen alpha-1(VI) chain
• Gene Name: COL6A1
• Organism: Homo sapiens (Human).
• Sequence Length: 1028
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Collagen VI acts as a cell-binding protein..
• Protein Sequence: MRAARALLPLLLQACWTAAQDEPETPRAVAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIQGLTRMPGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLLVGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGVKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGQSRDAEEAISQTIDTIVDMIKNNVEQVCCSFECQPARGPPGLRGDPGFEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGVKGEMGYPGLPGCKGSPGFDGIQGPPGPKGDPGAFGLKGEKGEPGADGEAGRPGSSGPSGDEGQPGEPGPPGEKGEAGDEGNPGPDGAPGERGGPGERGPRGTPGTRGPRGDPGEAGPQGDQGREGPVGVPGDPGEAGPIGPKGYRGDEGPPGSEGARGAPGPAGPPGDPGLMGERGEDGPAGNGTEGFPGFPGYPGNRGAPGINGTKGYPGLKGDEGEAGDPGDDNNDIAPRGVKGAKGYRGPEGPQGPPGHQGPPGPDECEILDIIMKMCSCCECKCGPIDLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFTGEALQYTRDQLLPPSPNNRIALVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGLSLVKENYAELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAVDAMDFINDATDVNDALGYVTRFYREASSGAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGIEIFVVVVGRQVNEPHIRVLVTGKTAEYDVAYGESHLFRVPSYQALLRGVFHQTVSRKVALG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	ALVDKVKSFTKRFID HHHHHHHHHHHHHHH	40.93	24719451
93	Phosphorylation	WNAGALHYSDEVEII ECCCCCCCCCHHHHH	20.76	24275569
104	Phosphorylation	VEIIQGLTRMPGGRD HHHHHHHHCCCCCHH	31.57	-
115	Phosphorylation	GGRDALKSSVDAVKY CCHHHHHHHHHHHHH	36.12	23312004
116	Phosphorylation	GRDALKSSVDAVKYF CHHHHHHHHHHHHHH	23.56	23312004
121	Acetylation	KSSVDAVKYFGKGTY HHHHHHHHHHCCCCH	36.26	129835
121	Ubiquitination	KSSVDAVKYFGKGTY HHHHHHHHHHCCCCH	36.26	-
125	Acetylation	DAVKYFGKGTYTDCA HHHHHHCCCCHHHHH	37.87	27178108
129	Phosphorylation	YFGKGTYTDCAIKKG HHCCCCHHHHHHHHC	25.17	29759185
134	Acetylation	TYTDCAIKKGLEQLL CHHHHHHHHCHHHHH	23.43	30587825
148	Acetylation	LVGGSHLKENKYLIV HCCCHHCCCCCEEEE	54.54	27178108
152	Phosphorylation	SHLKENKYLIVVTDG HHCCCCCEEEEEECC	17.16	-
157	Phosphorylation	NKYLIVVTDGHPLEG CCEEEEEECCCCCCC	25.93	-
165	Phosphorylation	DGHPLEGYKEPCGGL CCCCCCCCCCCCCCH	11.64	-
201	Phosphorylation	DHLEPRLSIIATDHT CCCCCCEEEEEECCC	17.15	23312004
212	N-linked_Glycosylation	TDHTYRRNFTAADWG ECCCHHCCCCHHHHC	29.62	19159218
301	Ubiquitination	PVGYQGMKGEKGSRG CCCCCCCCCCCCCCC	71.40	2190698
348	Phosphorylation	GLPGCKGSPGFDGIQ CCCCCCCCCCCCCCC	13.82	25159151
387	Phosphorylation	GEAGRPGSSGPSGDE CCCCCCCCCCCCCCC	34.50	23663014
388	Phosphorylation	EAGRPGSSGPSGDEG CCCCCCCCCCCCCCC	61.71	23663014
391	Phosphorylation	RPGSSGPSGDEGQPG CCCCCCCCCCCCCCC	63.50	23663014
477	Phosphorylation	GPIGPKGYRGDEGPP CCCCCCCCCCCCCCC	19.97	-
486	Phosphorylation	GDEGPPGSEGARGAP CCCCCCCCCCCCCCC	38.33	21902226
505	Sulfoxidation	PPGDPGLMGERGEDG CCCCCCCCCCCCCCC	6.94	30846556
516	N-linked_Glycosylation	GEDGPAGNGTEGFPG CCCCCCCCCCCCCCC	57.21	19159218
537	N-linked_Glycosylation	NRGAPGINGTKGYPG CCCCCCCCCCCCCCC	58.98	UniProtKB CARBOHYD
601	Sulfoxidation	CEILDIIMKMCSCCE HHHHHHHHHHHCCCC	2.01	30846556
640	Acetylation	IAKDFVVKVIDRLSR HCHHHHHHHHHHCCH	28.33	27178108
670	Sulfoxidation	VQYSHSQMQEHVSLR EEECHHHHHHHCCCC	5.90	30846556
688	Acetylation	IRNVQELKEAIKSLQ CCCHHHHHHHHHHCH	44.33	27178108
688	Ubiquitination	IRNVQELKEAIKSLQ CCCHHHHHHHHHHCH	44.33	-
701	O-linked_Glycosylation	LQWMAGGTFTGEALQ CHHHHCCCCCHHHHH	19.67	OGP
701	Phosphorylation	LQWMAGGTFTGEALQ CHHHHCCCCCHHHHH	19.67	27251275
703	O-linked_Glycosylation	WMAGGTFTGEALQYT HHHCCCCCHHHHHHC	33.67	OGP
703	Phosphorylation	WMAGGTFTGEALQYT HHHCCCCCHHHHHHC	33.67	27251275
746	Phosphorylation	TPLNVLCSPGIQVVS CCCCEEECCCEEEEE	23.23	28348404
766	Phosphorylation	VFDFIPGSDQLNVIS HHHCCCCCCCEEEEE	19.48	26657352
787	Phosphorylation	SQGRPGLSLVKENYA CCCCCCHHHHHHHHH	36.71	24719451
793	Phosphorylation	LSLVKENYAELLEDA HHHHHHHHHHHHHHH	11.53	27642862
804	N-linked_Glycosylation	LEDAFLKNVTAQICI HHHHHHHCCEEEEEC	38.22	19159218
878	Phosphorylation	VRVAVVQYSGTGQQR EEEEEEEECCCCCCC	9.47	-
896	N-linked_Glycosylation	ASLQFLQNYTALASA HHHHHHHHHHHHHHH	37.97	19159218
1008	Phosphorylation	SHLFRVPSYQALLRG CCCCCCHHHHHHHHH	27.33	23312004
1009	Phosphorylation	HLFRVPSYQALLRGV CCCCCHHHHHHHHHH	7.55	23312004
1020	Phosphorylation	LRGVFHQTVSRKVAL HHHHHHHHHCCHHHC	16.33	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO6A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO6A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO6A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDGFA_HUMAN	PDGFA	physical	8900172
PDGFB_HUMAN	PDGFB	physical	8900172

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 158810: Bethlem myopathy 1 (BTHLM1)
• 254090: Ullrich congenital muscular dystrophy 1 (UCMD1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212; ASN-516; ASN-804 ANDASN-896, AND MASS SPECTROMETRY.
PubMed: 19159218