PDGFA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDGFA_HUMAN
• UniProt AC: P04085
• Protein Name: Platelet-derived growth factor subunit A
• Gene Name: PDGFA
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Secreted. Released by platelets upon wounding.
• Protein Description: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)..
• Protein Sequence: MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	LARSQIHSIRDLQRL HHHHHCCCHHHHHHH	22.43	24719451
87	Phosphorylation	LPIRRKRSIEEAVPA CCCCCCCCHHHHHHH	37.07	20873877
98	Phosphorylation	AVPAVCKTRTVIYEI HHHHHHCCCEEEEEC	26.84	20873877
100	Phosphorylation	PAVCKTRTVIYEIPR HHHHCCCEEEEECCH	19.25	20873877
103	Phosphorylation	CKTRTVIYEIPRSQV HCCCEEEEECCHHHC	11.94	20873877
108	Phosphorylation	VIYEIPRSQVDPTSA EEEECCHHHCCCCCC	29.24	-
113	Phosphorylation	PRSQVDPTSANFLIW CHHHCCCCCCCEEEE	35.69	-
114	Phosphorylation	RSQVDPTSANFLIWP HHHCCCCCCCEEEEC	26.97	-
134	N-linked_Glycosylation	KRCTGCCNTSSVKCQ EECCCCCCCCCCCCC	47.26	UniProtKB CARBOHYD
136	Phosphorylation	CTGCCNTSSVKCQPS CCCCCCCCCCCCCCC	21.10	-
137	Phosphorylation	TGCCNTSSVKCQPSR CCCCCCCCCCCCCCC	24.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:17620338

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDGFA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDGFA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLCG1_HUMAN	PLCG1	physical	8443409
PGFRA_HUMAN	PDGFRA	physical	25241761
CDN2A_MOUSE	Cdkn2a	genetic	25117714
ARF_MOUSE	Cdkn2a	genetic	25117714
P53_MOUSE	Trp53	genetic	25117714
PTEN_MOUSE	Pten	genetic	25117714

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.