dbPTM

P53_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	P53_MOUSE
UniProt AC	P02340
Protein Name	Cellular tumor antigen p53
Gene Name	Tp53
Organism	Mus musculus (Mouse).
Sequence Length	387
Subcellular Localization	Cytoplasm . Nucleus . Nucleus, PML body . Endoplasmic reticulum . Mitochondrion matrix . Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Transloca
Protein Description	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2. [PubMed: 24051492]
Protein Sequence	MEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEESQSDISLE ----CCCCCCCCEEE	22.98	1584757
6	Phosphorylation	--MEESQSDISLELP --CCCCCCCCEEECC	46.31	1584757
9	Phosphorylation	EESQSDISLELPLSQ CCCCCCCEEECCCCC	22.30	26643407
12	Phosphorylation	QSDISLELPLSQETF CCCCEEECCCCCHHH	6.66	18022393
15	Phosphorylation	ISLELPLSQETFSGL CEEECCCCCHHHCCH	24.83	21151168
18	Phosphorylation	ELPLSQETFSGLWKL ECCCCCHHHCCHHHH	18.57	15195100
20	Phosphorylation	PLSQETFSGLWKLLP CCCCHHHCCHHHHCC	40.16	18519674
21	Phosphorylation	LSQETFSGLWKLLPP CCCHHHCCHHHHCCH	31.22	-
23	Phosphorylation	QETFSGLWKLLPPED CHHHCCHHHHCCHHH	7.87	-
34	Phosphorylation	PPEDILPSPHCMDDL CHHHCCCCCCCHHCC	24.67	1584757
37	Phosphorylation	DILPSPHCMDDLLLP HCCCCCCCHHCCCCC	3.48	17254968
55	Phosphorylation	EEFFEGPSEALRVSG HHHHHCCHHHHHHCC	46.49	19118006
114	Acetylation	FLQSGTAKSVMCTYS EECCCCCCEEEEECC	43.34	128765
117	Acetylation	SGTAKSVMCTYSPPL CCCCCEEEEECCCCH	1.50	-
126	Acetylation	TYSPPLNKLFCQLAK ECCCCHHHHHHHHHC	51.10	22826441
142	Phosphorylation	CPVQLWVSATPPAGS CCEEEEEECCCCCCC	18.16	26643407
144	Phosphorylation	VQLWVSATPPAGSRV EEEEEECCCCCCCHH	23.46	26643407
149	Phosphorylation	SATPPAGSRVRAMAI ECCCCCCCHHHEEEE	29.70	16964247
177	Phosphorylation	CPHHERCSDGDGLAP CCCCCCCCCCCCCCC	51.34	-
180	Phosphorylation	HERCSDGDGLAPPQH CCCCCCCCCCCCCHH	54.65	-
221	Phosphorylation	YEPPEAGSEYTTIHY CCCCCCCCCCEEEEE	34.18	22499769
223	Phosphorylation	PPEAGSEYTTIHYKY CCCCCCCCEEEEEEE	15.75	22499769
224	Phosphorylation	PEAGSEYTTIHYKYM CCCCCCCEEEEEEEE	18.41	22499769
225	Phosphorylation	EAGSEYTTIHYKYMC CCCCCCEEEEEEEEC	12.59	22499769
228	Phosphorylation	SEYTTIHYKYMCNSS CCCEEEEEEEECCCC	10.44	22499769
230	Phosphorylation	YTTIHYKYMCNSSCM CEEEEEEEECCCCCC	10.34	28576409
263	Phosphorylation	GNLLGRDSFEVRVCA CCCCCCCCEEEEEEE	23.19	-
266	Phosphorylation	LGRDSFEVRVCACPG CCCCCEEEEEEECCC	5.39	-
278	Phosphorylation	CPGRDRRTEEENFRK CCCCCCCCHHHCCCC	48.95	-
281	Phosphorylation	RDRRTEEENFRKKEV CCCCCHHHCCCCCCC	56.27	-
286	Ubiquitination	EEENFRKKEVLCPEL HHHCCCCCCCCCCCC	49.12	-
297	Phosphorylation	CPELPPGSAKRALPT CCCCCCCCHHHHCCC	36.07	27149854
299	Acetylation	ELPPGSAKRALPTCT CCCCCCHHHHCCCCC	39.64	23806337
299	Ubiquitination	ELPPGSAKRALPTCT CCCCCCHHHHCCCCC	39.64	-
302	Acetylation	PGSAKRALPTCTSAS CCCHHHHCCCCCCCC	4.13	-
304	Phosphorylation	SAKRALPTCTSASPP CHHHHCCCCCCCCCC	29.30	25619855
306	Phosphorylation	KRALPTCTSASPPQK HHHCCCCCCCCCCCC	29.79	25619855
307	Phosphorylation	RALPTCTSASPPQKK HHCCCCCCCCCCCCC	28.97	22942356
309	Phosphorylation	LPTCTSASPPQKKKP CCCCCCCCCCCCCCC	36.56	3006031
312	Phosphorylation	CTSASPPQKKKPLDG CCCCCCCCCCCCCCC	73.85	3006031
313	Acetylation	TSASPPQKKKPLDGE CCCCCCCCCCCCCCC	69.41	60803
314	Ubiquitination	SASPPQKKKPLDGEY CCCCCCCCCCCCCCC	55.14	-
314	Acetylation	SASPPQKKKPLDGEY CCCCCCCCCCCCCCC	55.14	22826441
315	Ubiquitination	ASPPQKKKPLDGEYF CCCCCCCCCCCCCCE	58.82	-
315	Acetylation	ASPPQKKKPLDGEYF CCCCCCCCCCCCCCE	58.82	23806337
318	Acetylation	PQKKKPLDGEYFTLK CCCCCCCCCCCEEEE	57.30	23806337
321	Phosphorylation	KKPLDGEYFTLKIRG CCCCCCCCEEEEECC	13.85	-
325	Acetylation	DGEYFTLKIRGRKRF CCCCEEEEECCCHHH	27.57	23806337
330	Methylation	TLKIRGRKRFEMFRE EEEECCCHHHHHHHH	65.35	-
332	Methylation	KIRGRKRFEMFRELN EECCCHHHHHHHHHH	10.02	-
334	Methylation	RGRKRFEMFRELNEA CCCHHHHHHHHHHHH	3.36	-
360	Phosphorylation	SGDSRAHSSYLKTKK CCCCCHHHHHCCCCC	21.50	9183006
361	Phosphorylation	GDSRAHSSYLKTKKG CCCCHHHHHCCCCCC	25.31	28418008
363	Phosphorylation	SRAHSSYLKTKKGQS CCHHHHHCCCCCCCC	6.49	9183006
364	"N6,N6-dimethyllysine"	RAHSSYLKTKKGQST CHHHHHCCCCCCCCC	50.49	-
364	Methylation	RAHSSYLKTKKGQST CHHHHHCCCCCCCCC	50.49	-
364	Acetylation	RAHSSYLKTKKGQST CHHHHHCCCCCCCCC	50.49	23806337
364	Ubiquitination	RAHSSYLKTKKGQST CHHHHHCCCCCCCCC	50.49	-
365	Phosphorylation	AHSSYLKTKKGQSTS HHHHHCCCCCCCCCC	35.08	9183006
366	Methylation	HSSYLKTKKGQSTSR HHHHCCCCCCCCCCH	54.01	-
366	Acetylation	HSSYLKTKKGQSTSR HHHHCCCCCCCCCCH	54.01	22826441
366	Ubiquitination	HSSYLKTKKGQSTSR HHHHCCCCCCCCCCH	54.01	-
367	Ubiquitination	SSYLKTKKGQSTSRH HHHCCCCCCCCCCHH	68.37	-
367	"N6,N6-dimethyllysine"	SSYLKTKKGQSTSRH HHHCCCCCCCCCCHH	68.37	-
367	Acetylation	SSYLKTKKGQSTSRH HHHCCCCCCCCCCHH	68.37	22826441
367	Methylation	SSYLKTKKGQSTSRH HHHCCCCCCCCCCHH	68.37	-
368	Phosphorylation	SYLKTKKGQSTSRHK HHCCCCCCCCCCHHC	28.38	9183006
369	Methylation	YLKTKKGQSTSRHKK HCCCCCCCCCCHHCC	53.03	-
370	Phosphorylation	LKTKKGQSTSRHKKT CCCCCCCCCCHHCCC	36.70	9183006
370	Methylation	LKTKKGQSTSRHKKT CCCCCCCCCCHHCCC	36.70	-
370	Acetylation	LKTKKGQSTSRHKKT CCCCCCCCCCHHCCC	36.70	-
372	Phosphorylation	TKKGQSTSRHKKTMV CCCCCCCCHHCCCCC	37.32	9739174
373	Phosphorylation	KKGQSTSRHKKTMVK CCCCCCCHHCCCCCC	45.81	9183006
375	Ubiquitination	GQSTSRHKKTMVKKV CCCCCHHCCCCCCCC	49.15	-
375	Acetylation	GQSTSRHKKTMVKKV CCCCCHHCCCCCCCC	49.15	23806337
376	Methylation	QSTSRHKKTMVKKVG CCCCHHCCCCCCCCC	35.41	-
376	Ubiquitination	QSTSRHKKTMVKKVG CCCCHHCCCCCCCCC	35.41	-
376	"N6,N6-dimethyllysine"	QSTSRHKKTMVKKVG CCCCHHCCCCCCCCC	35.41	-
376	Acetylation	QSTSRHKKTMVKKVG CCCCHHCCCCCCCCC	35.41	23806337
377	Phosphorylation	STSRHKKTMVKKVGP CCCHHCCCCCCCCCC	31.81	9183006
378	Acetylation	TSRHKKTMVKKVGPD CCHHCCCCCCCCCCC	5.97	-
379	Acetylation	SRHKKTMVKKVGPDS CHHCCCCCCCCCCCC	7.03	-
379	Methylation	SRHKKTMVKKVGPDS CHHCCCCCCCCCCCC	7.03	-
380	Acetylation	RHKKTMVKKVGPDSD HHCCCCCCCCCCCCC	30.80	22826441
380	Phosphorylation	RHKKTMVKKVGPDSD HHCCCCCCCCCCCCC	30.80	9183006
380	Ubiquitination	RHKKTMVKKVGPDSD HHCCCCCCCCCCCCC	30.80	-
381	Ubiquitination	HKKTMVKKVGPDSD- HCCCCCCCCCCCCC-	40.80	-
386	Phosphorylation	VKKVGPDSD------ CCCCCCCCC------	48.64	3006031
389	Phosphorylation	VGPDSD--------- CCCCCC---------		3006031

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	S	Phosphorylation	Kinase	CSNK1E	P49674	GPS
7	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
7	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
7	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
9	S	Phosphorylation	Kinase	HIPK4	Q3V016	GPS
9	S	Phosphorylation	Kinase	CSNK1E	P49674	GPS
9	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
9	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
12	S	Phosphorylation	Kinase	CSNK1E	P49674	GPS
12	S	Phosphorylation	Kinase	HIPK4	Q3V016	Uniprot
12	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
12	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
15	S	Phosphorylation	Kinase	NUAK1	Q641K5	GPS
15	S	Phosphorylation	Kinase	CDK5	P49615	GPS
15	S	Phosphorylation	Kinase	TP53RK	Q99PW4	GPS
15	S	Phosphorylation	Kinase	ATM	Q62388	GPS
15	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
18	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
18	S	Phosphorylation	Kinase	PRKCD	P28867	GPS
18	S	Phosphorylation	Kinase	AMPKA2	P54646	PSP
18	S	Phosphorylation	Kinase	MELK	Q61846	PSP
18	S	Phosphorylation	Kinase	MAPK3	Q63844	GPS
18	S	Phosphorylation	Kinase	MAPK14	P47811	GPS
18	S	Phosphorylation	Kinase	NUAK1	Q641K5	Uniprot
18	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
18	S	Phosphorylation	Kinase	PRPK	Q61136	Uniprot
18	S	Phosphorylation	Kinase	VRK2	Q86Y07-2	GPS
18	S	Phosphorylation	Kinase	AMPK	-	Uniprot
18	S	Phosphorylation	Kinase	PRKAA2	Q8BRK8	GPS
18	S	Phosphorylation	Kinase	ATR	Q9JKK8	PSP
18	S	Phosphorylation	Kinase	CDK5	P49615	Uniprot
18	S	Phosphorylation	Kinase	ATM	Q62388	Uniprot
20	S	Phosphorylation	Kinase	MAPKAPK2	P49138	GPS
20	S	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
21	T	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
21	T	Phosphorylation	Kinase	VRK1	Q99986	PSP
21	T	Phosphorylation	Kinase	VRK1	Q80X41	Uniprot
21	T	Phosphorylation	Kinase	VRK2	Q86Y07	PSP
21	T	Phosphorylation	Kinase	VRK2 ISO2	Q86Y07-2	PSP
21	T	Phosphorylation	Kinase	VRK2	Q8BN21	Uniprot
21	T	Phosphorylation	Kinase	CK1	-	Uniprot
23	S	Phosphorylation	Kinase	PLK3	Q60806	Uniprot
23	S	Phosphorylation	Kinase	CHEK2	Q9Z265	Uniprot
23	S	Phosphorylation	Kinase	CK1	-	Uniprot
34	S	Phosphorylation	Kinase	MAPK10	Q61831	GPS
34	S	Phosphorylation	Kinase	MAPK9	Q9WTU6	GPS
34	S	Phosphorylation	Kinase	MAPK8	Q91Y86	GPS
34	S	Phosphorylation	Kinase	MAPKAPK5	O54992	GPS
37	S	Phosphorylation	Kinase	MAPKAPK5	O54992	Uniprot
58	S	Phosphorylation	Kinase	HIPK2	Q9H2X6	PSP
73	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
83	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
180	S	Phosphorylation	Kinase	AURKB	O70126	Uniprot
266	S	Phosphorylation	Kinase	AURKB	O70126	Uniprot
281	T	Phosphorylation	Kinase	AURKB	O70126	Uniprot
312	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot
312	S	Phosphorylation	Kinase	CDK2	P97377	Uniprot
312	S	Phosphorylation	Kinase	AURKA	P97477	Uniprot
365	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
370	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
371	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
372	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
377	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
386	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
389	S	Phosphorylation	Kinase	NUAK1	Q641K5	Uniprot
389	S	Phosphorylation	Kinase	CDK2	P97377	Uniprot
389	S	Phosphorylation	Kinase	CK2A1	Q60737	PSP
389	S	Phosphorylation	Kinase	CK2	-	Uniprot
389	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	E4f1	Q8CCE9	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Fbxo11	Q7TPD1	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Huwe1	Q7TMY8	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Mdm2	P23804	PMID:31847675
-	K	Ubiquitination	E3 ubiquitin ligase	Mkrn1	Q9QXP6	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Rffl	Q6ZQM0	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Rfwd3	Q8CIK8	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Syvn1	Q9DBY1	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Ube3a	O08759	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Wwp1	Q8BZZ3	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
12	S	Phosphorylation	2145148
Phosphorylation at Ser-12 by HIPK4 increases repression activity on BIRC5 promoter.
18	S	Phosphorylation	2145148
Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-18 leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes (By similarity).
18	S	Phosphorylation	2145148
Phosphorylation at Ser-18 is required for interaction with DDX3X and gamma-tubulin (By similarity).
18	S	Phosphorylation	2145148
Phosphorylated on Ser-18 upon ultraviolet irradiation; which is enhanced by interaction with BANP (By similarity).
18	S	Oxidation	2145148
Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-18 leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes (By similarity).
21	T	Phosphorylation	2145148
Phosphorylated on Thr-21 by VRK1.
23	S	ubiquitylation	2145148
Phosphorylated on Ser-23 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.
23	S	Phosphorylation	2145148
Phosphorylated on Ser-23 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis.
23	S	Phosphorylation	2145148
Phosphorylated on Ser-23 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2.
27	K	ubiquitylation	-
Polyubiquitinated by MUL1 at Lys-27 which leads to proteasomal degradation (By similarity).
288	K	ubiquitylation	25732823
Ubiquitinated by MKRN1 at Lys-288 and Lys-289, which leads to proteasomal degradation.
289	K	ubiquitylation	25732823
Ubiquitinated by MKRN1 at Lys-288 and Lys-289, which leads to proteasomal degradation.
330	R	Methylation	-
Monomethylated at Arg-330 and dimethylated at Arg-332 and Arg-334 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
332	R	Methylation	-
Monomethylated at Arg-330 and dimethylated at Arg-332 and Arg-334 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
334	R	Methylation	-
Monomethylated at Arg-330 and dimethylated at Arg-332 and Arg-334 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
367	K	Methylation	-
Monomethylated at Lys-367 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity.
367	K	Methylation	-
Lys-369 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-367.
367	K	Methylation	-
Demethylation of dimethylated Lys-367 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity).
369	K	Methylation	-
Monomethylated at Lys-369 by SETD7, leading to stabilization and increased transcriptional activation.
369	K	Methylation	-
Lys-369 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-367.
370	K	Methylation	-
Dimethylated at Lys-370 by EHMT1 and EHMT2.
379	K	Methylation	-
Monomethylated at Lys-379 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity.
383	K	Sumoylation	-
Sumoylated at Lys-383 by UBC9 (By similarity).
389	S	Phosphorylation	2145148
Phosphorylated on Ser-389 following UV but not gamma irradiation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of P53_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOPRS_HUMAN	TOPORS	physical	10415337
MDM2_MOUSE	Mdm2	physical	18309296
MDM2_MOUSE	Mdm2	physical	17936560
ING4_HUMAN	ING4	physical	17325660
UBE2N_MOUSE	Ube2n	physical	17000756
P53_MOUSE	Trp53	physical	20211142
P63_MOUSE	Trp63	physical	20211142
P73_MOUSE	Trp73	physical	20211142
ZN292_MOUSE	Zfp292	physical	20211142
MED16_MOUSE	Med16	physical	20211142
KMT2E_MOUSE	Kmt2e	physical	21423215
NPM_MOUSE	Npm1	physical	17277230
PIAS4_MOUSE	Pias4	physical	16816390
PIAS1_MOUSE	Pias1	physical	16816390
PIAS2_MOUSE	Pias2	physical	16816390
MDM2_MOUSE	Mdm2	physical	17086174
SIR1_MOUSE	Sirt1	physical	20157588
SP1_MOUSE	Sp1	physical	20157588
MDM4_MOUSE	Mdm4	physical	20697359
MDM2_MOUSE	Mdm2	physical	20697359
FAK2_MOUSE	Ptk2b	physical	19880522
MDM2_MOUSE	Mdm2	physical	22216266
PAX3_MOUSE	Pax3	physical	22216266
MDM2_MOUSE	Mdm2	physical	20818388
CDN1A_MOUSE	Cdkn1a	physical	22666487
MDM2_MOUSE	Mdm2	physical	22666487
EP300_MOUSE	Ep300	physical	22666487
SMCA4_MOUSE	Smarca4	physical	18303029
SMRD1_MOUSE	Smarcd1	physical	18303029
KMT5A_MOUSE	Setd8	genetic	22117221
MCM4_MOUSE	Mcm4	genetic	21611832
SKIL_MOUSE	Skil	physical	22805162
MDM2_MOUSE	Mdm2	physical	22805162
NUMB_HUMAN	NUMB	physical	9632782
CCNG1_MOUSE	Ccng1	physical	11983168
MDM2_MOUSE	Mdm2	physical	8058315
PARK7_MOUSE	Park7	physical	19680261
HUWE1_MOUSE	Huwe1	genetic	22213803
EP300_MOUSE	Ep300	physical	21057544
MDM2_MOUSE	Mdm2	physical	10205143
TOPRS_MOUSE	Topors	physical	15735665
HS71B_MOUSE	Hspa1b	physical	23251530
P63_MOUSE	Trp63	physical	23251530
P73_MOUSE	Trp73	physical	23251530
MDM2_MOUSE	Mdm2	physical	10706102
MK08_MOUSE	Mapk8	physical	10706102
EP300_MOUSE	Ep300	physical	10706102
CDN2A_MOUSE	Cdkn2a	physical	10706102
ARF_MOUSE	Cdkn2a	physical	10706102
AXIN1_MOUSE	Axin1	physical	15526030
HIPK2_MOUSE	Hipk2	physical	15526030
BARD1_MOUSE	Bard1	physical	11779501
PTEN_MOUSE	Pten	physical	18332125
WWOX_MOUSE	Wwox	physical	15580310
MK08_MOUSE	Mapk8	physical	15580310
CDN2A_MOUSE	Cdkn2a	physical	15989966
ARF_MOUSE	Cdkn2a	physical	15989966
RL11_MOUSE	Rpl11	physical	15989966
B2CL1_MOUSE	Bcl2l1	physical	14963330
RS26_MOUSE	Rps26	physical	23728348
NECD_MOUSE	Ndn	physical	24911587
RN128_MOUSE	Rnf128	physical	23370271
MK14_MOUSE	Mapk14	physical	21050851
MDM2_MOUSE	Mdm2	physical	9732264
MDM2_MOUSE	Mdm2	physical	11953423
MDM4_MOUSE	Mdm4	physical	11953423
REV1_MOUSE	Rev1	physical	25614517
BRNP1_MOUSE	Brinp1	physical	25732823
MDM2_MOUSE	Mdm2	physical	25732823
P53_MOUSE	Trp53	physical	8035799
LT_SV40	SV40gp6	physical	21502952
KCMA1_MOUSE	Kcnma1	physical	25581503
MDM2_MOUSE	Mdm2	genetic	21437245
OLIG2_MOUSE	Olig2	genetic	21397859
PALB2_MOUSE	Palb2	genetic	23657012
XRCC2_MOUSE	Xrcc2	genetic	23435420
SPO11_MOUSE	Spo11	genetic	23435420
TREX2_MOUSE	Trex2	genetic	23435420
MD2L2_MOUSE	Mad2l2	genetic	23435420
PALB2_MOUSE	Palb2	genetic	23435420
ACACA_MOUSE	Acaca	genetic	23435420
PLM_MOUSE	Fxyd1	genetic	23435420
XPF_MOUSE	Ercc4	genetic	23435420
PAXI1_MOUSE	Paxip1	genetic	23435420
RDM1_MOUSE	Rdm1	genetic	23435420
HM20B_MOUSE	Hmg20b	genetic	23435420
DPOE1_MOUSE	Pole	genetic	23435420
POLK_MOUSE	Polk	genetic	23435420
FANCB_MOUSE	Fancb	genetic	23435420
BLM_MOUSE	Blm	genetic	23435420
POLH_MOUSE	Polh	genetic	23435420
EXO1_MOUSE	Exo1	genetic	23435420
REV3L_MOUSE	Rev3l	genetic	23435420
RECQ1_MOUSE	Recql	genetic	23435420
DPOE3_MOUSE	Pole3	genetic	23435420
UBP1_MOUSE	Usp1	genetic	23435420
REV1_MOUSE	Rev1	genetic	23435420
XRCC3_MOUSE	Xrcc3	genetic	23435420
MDM2_MOUSE	Mdm2	physical	14555661
EP300_MOUSE	Ep300	physical	14555661
MDM2_HUMAN	MDM2	physical	14555661
PRKN_MOUSE	Park2	physical	28395174

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of P53_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Novel homeodomain-interacting protein kinase family member, HIPK4,phosphorylates human p53 at serine 9."; Arai S., Matsushita A., Du K., Yagi K., Okazaki Y., Kurokawa R.; FEBS Lett. 581:5649-5657(2007). Cited for: PHOSPHORYLATION AT SER-9.	18022393 [Abstract]
"PRAK is essential for ras-induced senescence and tumor suppression."; Sun P., Yoshizuka N., New L., Moser B.A., Li Y., Liao R., Xie C.,Chen J., Deng Q., Yamout M., Dong M.Q., Frangou C.G., Yates J.R. III,Wright P.E., Han J.; Cell 128:295-308(2007). Cited for: PHOSPHORYLATION AT SER-34.	17254968 [Abstract]
"PML regulates p53 stability by sequestering Mdm2 to the nucleolus."; Bernardi R., Scaglioni P.P., Bergmann S., Horn H.F., Vousden K.H.,Pandolfi P.P.; Nat. Cell Biol. 6:665-672(2004). Cited for: PHOSPHORYLATION AT SER-15, LYSINE ACETYLATION, UBIQUITINATION, ANDSUBCELLULAR LOCATION.	15195100 [Abstract]

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