PAXI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAXI1_MOUSE
• UniProt AC: Q6NZQ4
• Protein Name: PAX-interacting protein 1
• Gene Name: Paxip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1056
• Subcellular Localization: Nucleus matrix . Chromosome . Localizes to DNA damage foci upon ionizing radiation.
• Protein Description: Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes such as the MLL2/MLL3 complex. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires Rnf8 and Ube2n. Recruits Tp53bp1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with Tp53bp1 phosphorylated by Atm. Together with Tp53bp1 regulates Atm association (By similarity). Proposed to recruit Pagr1 to sites of DNA damage and the Pagr1:Paxip1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, this function has been questioned. [PubMed: 19124460]
• Protein Sequence: MSEPAPEVPEELFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNALASHIISEDGDNPEVGEAREVFDLPVVKPSWVTLSVQCGALLPVNGFSPESCQIFFGLTACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRKDEAFYHPRLIIYEEEEEEEEEGDNEEQDSQNEGSTEKSSVASSAVASPAEQPCSPKPRAEVSKGELMFDDSSDSSPEKQERSLNWAPAEAPPLNTAQRRLPQGKGPGLINLCANVPPVPGDILPPDMRGNLMAPGQNLQNSERSEILGTWSPAVRTLRNITNNADIQQINRPSNVAHILQSLSAPTKSLEQQVARGQQGHPNASAVLFGQAKGAPETHVLQQHHPPQQPQQQHPALHLQPQIMQLQQQQQQQQQQQQQPQPYPQPPSHQFPQQVHQHQFSQQQLQFPQQPLHPQQQLHRPQQQLQPFQQQHALQQQLHQLQQQQLQHHQLAQLQQQQQQQHNLLQQQQQQQQLQRLQQQQQMQNQAAHLSQASQALQHQVLPQQPLQLSLQPPPQQQQQQQLFGHDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKKKKLMPPHRALHFPVAFPPGGKPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQVQYSRYTAFNMPDPFVPTPHLVLGLLDAWRTPVKVTAELLMGVRLPPKLKPNEVANIQPSSKRARIEDLPPPTKKLTPELTPLVLFTGFEPVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTPDWLEECFKRQTFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFKTKYFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLMEHKQNKSLSEIILISCENDLHLCREYFARGIDVHNAEFVLTGVLTQTLDYESYKFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEPAPEVP ------CCCCCCCCC	64.69	29472430
41	Phosphorylation	AGKAKEVSYNALASH HCCCCEECHHHHHHH	17.48	26643407
42	Phosphorylation	GKAKEVSYNALASHI CCCCEECHHHHHHHH	15.05	26643407
47	Phosphorylation	VSYNALASHIISEDG ECHHHHHHHHHCCCC	18.97	26643407
51	Phosphorylation	ALASHIISEDGDNPE HHHHHHHCCCCCCCC	29.09	26643407
171	Phosphorylation	DWVLDCVSEKRRKDE HHHHHHHCCCCCCCC	43.67	26160508
218	Phosphorylation	TEKSSVASSAVASPA CCHHHHHHHHCCCCC	19.37	25619855
219	Phosphorylation	EKSSVASSAVASPAE CHHHHHHHHCCCCCC	19.61	25619855
223	Phosphorylation	VASSAVASPAEQPCS HHHHHCCCCCCCCCC	20.32	22942356
230	Phosphorylation	SPAEQPCSPKPRAEV CCCCCCCCCCCCCCC	42.51	23684622
247	Phosphorylation	GELMFDDSSDSSPEK CEECCCCCCCCCHHH	37.58	29550500
248	Phosphorylation	ELMFDDSSDSSPEKQ EECCCCCCCCCHHHH	48.81	29550500
250	Phosphorylation	MFDDSSDSSPEKQER CCCCCCCCCHHHHHH	50.14	29550500
251	Phosphorylation	FDDSSDSSPEKQERS CCCCCCCCHHHHHHC	41.91	29550500
258	Phosphorylation	SPEKQERSLNWAPAE CHHHHHHCCCCCCCC	25.87	14729942
271	Phosphorylation	AEAPPLNTAQRRLPQ CCCCCCCHHHHHCCC	31.67	14729942
325	Phosphorylation	ERSEILGTWSPAVRT HHHHHHHCCCHHHHH	21.23	28066266
327	Phosphorylation	SEILGTWSPAVRTLR HHHHHCCCHHHHHHH	11.65	26643407
834	Acetylation	ANIQPSSKRARIEDL CCCCCCCCCCCHHCC	55.18	7614295
849	Phosphorylation	PPPTKKLTPELTPLV CCCCCCCCCCCCEEE	24.48	26643407
853	Phosphorylation	KKLTPELTPLVLFTG CCCCCCCCEEEEECC	16.96	26643407
1003	Ubiquitination	FRKLMEHKQNKSLSE HHHHHHHHCCCCHHH	42.11	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAXI1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAXI1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAXI1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PAXI1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.