P63_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P63_MOUSE
• UniProt AC: O88898
• Protein Name: Tumor protein 63
• Gene Name: Tp63
• Organism: Mus musculus (Mouse).
• Sequence Length: 680
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge..
• Protein Sequence: MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	SYYRSAMSQSTQTSE HHHHHHHCCCCCCHH	22.24	-
193	Phosphorylation	TAKSATWTYSTELKK CCCCCEEEEEHHHHH	11.84	28576409
395	Phosphorylation	TSIKKRRSPDDELLY CCEEECCCCCCCCEE	36.39	28507225
462	Phosphorylation	SQSSYGNSSPPLNKM HHHHCCCCCCCHHHC	39.60	28507225
522	Phosphorylation	DMNGLSPTQALPPPL CCCCCCCCCCCCCCC	24.09	21325887
567	Phosphorylation	SCLDYFTTQGLTTIY HHHHHHHCCCCCEEE	15.67	21325887
612	Phosphorylation	RQLHDFSSPPHLLRT HHHCCCCCCCCCCCC	42.30	28507225
630	Phosphorylation	ASTVSVGSSETRGER CCEEECCCCCCCCCH	23.89	-
631	Phosphorylation	STVSVGSSETRGERV CEEECCCCCCCCCHH	36.74	-
643	Dimethylation	ERVIDAVRFTLRQTI CHHHHHHHEEEEECC	22.13	-
643	Methylation	ERVIDAVRFTLRQTI CHHHHHHHEEEEECC	22.13	54541029
651	Phosphorylation	FTLRQTISFPPRDEW EEEEECCCCCCCCCC	34.78	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
41	S	Phosphorylation	Kinase	ATM	Q13315	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Itch	Q8C863	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P63_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P63_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P73_MOUSE	Trp73	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.