P73_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P73_MOUSE
• UniProt AC: Q9JJP2
• Protein Name: Tumor protein p73 {ECO:0000250|UniProtKB:O15350}
• Gene Name: Tp73
• Organism: Mus musculus (Mouse).
• Sequence Length: 631
• Subcellular Localization: Nucleus . Cytoplasm. Accumulates in the nucleus in response to DNA damage.
• Protein Description: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein..
• Protein Sequence: MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLAQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGPMGSGMLNSHGHSMPANGEMNGGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKVPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGAVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	TSSSSSSTFEHLWSS CCCCCCHHHHHHHHH	34.68	19218448
24	Phosphorylation	SSLEPDSTYFDLPQP HHCCCCCCCCCCCCC	35.27	-
25	Phosphorylation	SLEPDSTYFDLPQPS HCCCCCCCCCCCCCC	10.07	-
91	Phosphorylation	SAPTHSPYAQPSSTF CCCCCCCCCCCCCCC	22.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
24	T	Phosphorylation	Kinase	PLK1	Q07832	Uniprot
25	Y	Phosphorylation	Kinase	HCK	P08103	Uniprot
25	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot
91	Y	Phosphorylation	Kinase	ABL1	P00520	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Itch	Q8C863	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
622	K	Sumoylation	Sumoylated on Lys-622, which potentiates proteasomal degradation but does not affect transcriptional activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P73_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P73_MOUSE	Trp73	physical	20211142
MED16_MOUSE	Med16	physical	20211142
MK08_MOUSE	Mapk8	physical	15483136

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.