BLM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BLM_MOUSE
• UniProt AC: O88700
• Protein Name: Bloom syndrome protein homolog
• Gene Name: Blm
• Organism: Mus musculus (Mouse).
• Sequence Length: 1416
• Subcellular Localization: Nucleus. Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner (By similarity)..
• Protein Description: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. [PubMed: 9840919 Participates in DNA replication and repair (By similarity Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA]
• Protein Sequence: MAAVPLNNLQEQLQRHSARKLNNQPSLSKPKSLGFTFKKKTSEGDVSVTSVSVVKTPALSDKDVNVSEAFSFTESPLHKPKQQAKIEGFFKHFPGRQQSKGTCSEPSLPATVQTAQDTLCTTPKTPTAKKLPVAVFKKLEFSSSADSLSDWADMDDFDMSASDAFASLAKNPATRVSTAQKMKKTKRNFFKPPPRKANAVKTDLTPPSPECLQVDLTKESEEEEEEEEEAEGADCLSRDVICIDNDSASEELTEKDTQESQSLKAHLGAERGDSEKKSHEDEAVFHSVQNTEYFEHNDNDYDIDFVPPSPEEIISTASSSLKCSSMLKDLDDSDKEKGILSTSEELLSKPEEMTTHKSDAGTSKDCDAQQIRIQQQLIHVMEHICKLVDTVPTDELEALNCGTELLQQRNIRRKLLAEAGFNGNDVRLLGSLWRHRPDSLDNTVQGDSCPVGHPNKELNSPYLLSHSPSTEECLPTTTPGKTGFSATPKNLFERPLLNSHLQKSFVSSNWAETPRMENRNESTDFPGSVLTSTTVKAQSKQAASGWNVERHGQASYDIDNFNIDDFDDDDDDDDWENIMHNFPASKSSTATYPPIKEGGPVKSLSERISSAKAKFLPVVSTAQNTNLSESIQNCSDKLAQNLSSKNPKHEHFQSLNFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSFDIPATYLTGDKTDSEAANIYLQLSKKDPIIKLLYVTPEKVCASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQREGLAALAYHAGLSDSARDEVQHKWINQDNCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAGRDGEISHCVLFYTYHDVTRLKRLIMMEKDGNYHTKETHVNNLYSMVHYCENITECRRIQLLAYFGEKGFNPDFCKKYPDVSCDNCCKTKDYKTKDVTDDVKNIIRFVQEHSSSPGTRNIGPAGRFTLNMLVDIFLGSKSAKVKSGIFGKGTTYSRHNAERLFKKLILDKILDEDLYINANDQPIAYVMLGTKAHSVLSGHLKVDFMETENSSSIKKQKALVAKVSQREEVVKKCLGELTEVCKLLGKVFGVHYFNIFNTATLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVIPVLQKYSEWTVPAEDGSPGARGAPEDTEEEEEEAPVSSHYFANQTRNERKRKKMSATHKPKRRRTSYGGFRAKGGSTTCRKTTSKSKFYGVTGSRSASCASQATSSASRKLGIMAPPKPVNRTFLRPSYAFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	QEQLQRHSARKLNNQ HHHHHHHHHHHHCCC	31.77	24759943
26	Phosphorylation	RKLNNQPSLSKPKSL HHHCCCCCCCCCCCC	35.20	28066266
28	Phosphorylation	LNNQPSLSKPKSLGF HCCCCCCCCCCCCCE	51.77	28066266
32	Phosphorylation	PSLSKPKSLGFTFKK CCCCCCCCCCEEEEE	42.10	22006019
41	Phosphorylation	GFTFKKKTSEGDVSV CEEEEECCCCCCEEE	40.67	28066266
42	Phosphorylation	FTFKKKTSEGDVSVT EEEEECCCCCCEEEE	48.76	28066266
47	Phosphorylation	KTSEGDVSVTSVSVV CCCCCCEEEEEEEEE	25.15	28066266
56	Phosphorylation	TSVSVVKTPALSDKD EEEEEEECCCCCCCC	11.37	-
67	Phosphorylation	SDKDVNVSEAFSFTE CCCCCCHHHHCCCCC	20.29	26643407
71	Phosphorylation	VNVSEAFSFTESPLH CCHHHHCCCCCCCCC	38.00	26643407
73	Phosphorylation	VSEAFSFTESPLHKP HHHHCCCCCCCCCCH	34.06	26643407
75	Phosphorylation	EAFSFTESPLHKPKQ HHCCCCCCCCCCHHH	29.69	26643407
111	Phosphorylation	SEPSLPATVQTAQDT CCCCCCCEEEECHHH	15.94	20139300
114	Phosphorylation	SLPATVQTAQDTLCT CCCCEEEECHHHCCC	23.19	20139300
118	Phosphorylation	TVQTAQDTLCTTPKT EEEECHHHCCCCCCC	16.20	20139300
127	Phosphorylation	CTTPKTPTAKKLPVA CCCCCCCCCCCCCEE	57.23	20139300
142	Phosphorylation	VFKKLEFSSSADSLS EEEECEECCCCCCHH	17.63	-
144	Phosphorylation	KKLEFSSSADSLSDW EECEECCCCCCHHHC	34.59	-
177	Phosphorylation	KNPATRVSTAQKMKK CCCHHCCCHHHHHHH	18.09	-
208	Phosphorylation	KTDLTPPSPECLQVD CCCCCCCCHHHEEEE	34.24	25293948
217	Phosphorylation	ECLQVDLTKESEEEE HHEEEECCCCCHHHH	28.44	25293948
247	Phosphorylation	VICIDNDSASEELTE EEEECCCCCCHHHCH	39.69	27087446
249	Phosphorylation	CIDNDSASEELTEKD EECCCCCCHHHCHHH	35.24	27087446
253	Phosphorylation	DSASEELTEKDTQES CCCCHHHCHHHHHHH	44.24	28066266
260	Phosphorylation	TEKDTQESQSLKAHL CHHHHHHHHHHHHHH	18.43	27841257
333	Phosphorylation	MLKDLDDSDKEKGIL HHCCCCCCHHHHCCC	50.69	25266776
341	Phosphorylation	DKEKGILSTSEELLS HHHHCCCCCHHHHHC	28.15	26643407
342	Phosphorylation	KEKGILSTSEELLSK HHHCCCCCHHHHHCC	36.39	26643407
343	Phosphorylation	EKGILSTSEELLSKP HHCCCCCHHHHHCCH	26.20	26643407
348	Phosphorylation	STSEELLSKPEEMTT CCHHHHHCCHHHHCC	59.81	28066266
363	Phosphorylation	HKSDAGTSKDCDAQQ CCCCCCCCCCCCHHH	26.11	-
431	Phosphorylation	NDVRLLGSLWRHRPD CHHHHHHHHHHCCCC	25.40	-
439	Phosphorylation	LWRHRPDSLDNTVQG HHHCCCCCCCCCCCC	40.06	25266776
443	Phosphorylation	RPDSLDNTVQGDSCP CCCCCCCCCCCCCCC	17.55	28066266
448	Phosphorylation	DNTVQGDSCPVGHPN CCCCCCCCCCCCCCC	27.43	25266776
460	Phosphorylation	HPNKELNSPYLLSHS CCCCCCCCCCCCCCC	27.78	22942356
462	Phosphorylation	NKELNSPYLLSHSPS CCCCCCCCCCCCCCC	21.79	25159016
465	Phosphorylation	LNSPYLLSHSPSTEE CCCCCCCCCCCCCCC	21.23	25159016
467	Phosphorylation	SPYLLSHSPSTEECL CCCCCCCCCCCCCCC	19.71	21082442
469	Phosphorylation	YLLSHSPSTEECLPT CCCCCCCCCCCCCCC	52.01	25159016
470	Phosphorylation	LLSHSPSTEECLPTT CCCCCCCCCCCCCCC	38.91	25159016
476	Phosphorylation	STEECLPTTTPGKTG CCCCCCCCCCCCCCC	30.28	28066266
477	Phosphorylation	TEECLPTTTPGKTGF CCCCCCCCCCCCCCC	29.11	25159016
478	Phosphorylation	EECLPTTTPGKTGFS CCCCCCCCCCCCCCC	32.30	25777480
499	Phosphorylation	FERPLLNSHLQKSFV HCCHHHHHHHHHHHH	26.08	28066266
504	Phosphorylation	LNSHLQKSFVSSNWA HHHHHHHHHHCCCCC	20.23	28066266
508	Phosphorylation	LQKSFVSSNWAETPR HHHHHHCCCCCCCCC	30.96	28066266
513	Phosphorylation	VSSNWAETPRMENRN HCCCCCCCCCCCCCC	14.40	28066266
534	Phosphorylation	GSVLTSTTVKAQSKQ CCEEEEEEEEECCCC	21.56	28576409
620	Phosphorylation	AKFLPVVSTAQNTNL HHHCCEECHHCCCCH	20.47	26745281
621	Phosphorylation	KFLPVVSTAQNTNLS HHCCEECHHCCCCHH	22.20	26745281
625	Phosphorylation	VVSTAQNTNLSESIQ EECHHCCCCHHHHHH	26.00	26745281
628	Phosphorylation	TAQNTNLSESIQNCS HHCCCCHHHHHHHHH	31.22	26745281
630	Phosphorylation	QNTNLSESIQNCSDK CCCCHHHHHHHHHHH	26.54	26745281
635	Phosphorylation	SESIQNCSDKLAQNL HHHHHHHHHHHHHHH	45.38	26745281
774	Phosphorylation	IIKLLYVTPEKVCAS CEEEEEECHHHHHHC	16.51	-
871	Acetylation	SFNRHNLKYYVLPKK EECCCCCEEEECCCC	39.59	-
1100	Phosphorylation	IRFVQEHSSSPGTRN HHHHHHHCCCCCCCC	31.58	29895711
1101	Phosphorylation	RFVQEHSSSPGTRNI HHHHHHCCCCCCCCC	42.32	28066266
1102	Phosphorylation	FVQEHSSSPGTRNIG HHHHHCCCCCCCCCC	30.29	29895711
1133	Phosphorylation	SKSAKVKSGIFGKGT CCCCEECCCCCCCCC	39.86	-
1202	Phosphorylation	METENSSSIKKQKAL EECCCCCHHHHHHHH	37.94	28059163
1221	Acetylation	SQREEVVKKCLGELT HCHHHHHHHHHHHHH	42.83	7718867
1222	Acetylation	QREEVVKKCLGELTE CHHHHHHHHHHHHHH	24.07	7718877
1294	Phosphorylation	LQKYSEWTVPAEDGS HHHHCCCEECCCCCC	16.74	27600695
1301	Phosphorylation	TVPAEDGSPGARGAP EECCCCCCCCCCCCC	32.27	25159016
1311	Phosphorylation	ARGAPEDTEEEEEEA CCCCCCCCHHHHHHC	43.57	21082442
1350	Phosphorylation	KPKRRRTSYGGFRAK CCCCCCCCCCCCCCC	21.70	25338131
1378	Phosphorylation	KFYGVTGSRSASCAS CEEEECCCCCHHHHH	17.44	28059163
1388	Phosphorylation	ASCASQATSSASRKL HHHHHHCCCCHHHHH	18.64	28059163
1416	Phosphorylation	LRPSYAFS------- CCCHHCCC-------	31.01	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BLM_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
264	K	ubiquitylation	Poly-ubiquitinated by TRIM25 at Lys-264.	29125140

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BLM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BLM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.